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orthosilicic acid

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Name:silicic acid (H4SiO4)
CAS Number: 10193-36-9Picture of molecule3D/inchi
Other(deleted CASRN):23643-07-4
ECHA EINECS - REACH Pre-Reg:233-477-0
FDA UNII: 623B93YABH
Nikkaji Web:J148.210F
MDL:MFCD01941556
Molecular Weight:96.11398000
Formula:H4 O4 Si
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:food additive: EFSA: as choline-stabilised orthosilicic acid only
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -0.304 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Silicic acid (H4SiO4)
Carbosynth
For experimental / research use only.
Orthosilicic acid
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-guinea pig LDLo 120 mg/kg
BEHAVIORAL: TREMOR BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
British Journal of Experimental Pathology. Vol. 3, Pg. 75, 1922.

intravenous-guinea pig LDLo 100 mg/kg
BEHAVIORAL: TREMOR BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
British Journal of Experimental Pathology. Vol. 3, Pg. 75, 1922.

intraperitoneal-mouse LDLo 40 mg/kg
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
British Journal of Experimental Pathology. Vol. 3, Pg. 75, 1922.

intravenous-mouse LDLo 100 mg/kg
BLOOD: CHANGE IN CLOTTING FACTORS BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
British Journal of Experimental Pathology. Vol. 3, Pg. 75, 1922.

intravenous-rabbit LDLo 100 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: EXCITEMENT CARDIAC: OTHER CHANGES
British Journal of Experimental Pathology. Vol. 3, Pg. 75, 1922.

intravenous-rat LDLo 100 mg/kg
BLOOD: CHANGE IN CLOTTING FACTORS
British Journal of Experimental Pathology. Vol. 3, Pg. 75, 1922.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
food additive: EFSA: as choline-stabilised orthosilicic acid only
Recommendation for orthosilicic acid usage levels up to:
 not for fragrance use.
 
Recommendation for orthosilicic acid flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Choline-stabilised orthosilicic acid added for nutritional purposes to food supplements
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):10193-36-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :14942
National Institute of Allergy and Infectious Diseases:Data
silicic acid (H4SiO4)
Chemidplus:0010193369
 
References:
 silicic acid (H4SiO4)
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:10193-36-9
Pubchem (cid):14942
Pubchem (sid):135042008
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 silicic acid (H4SiO4)
 tetrahydroxysilane
 

Articles:

PubMed:Determination of plant silicon content with near infrared reflectance spectroscopy.
PubMed:Silicon: The evolution of its use in biomaterials.
PubMed:There are not enough data to conclude that Monomethylsilanetriol is safe.
PubMed:Silicon: the health benefits of a metalloid.
PubMed:Silicon balance in human volunteers; a pilot study to establish the variance in silicon excretion versus intake.
PubMed:Aquaglyceroporins: generalized metalloid channels.
PubMed:The performance of an orthosilicic acid-releasing silica gel fiber fleece in wound healing.
PubMed:The silicon supplement 'Monomethylsilanetriol' is safe and increases the body pool of silicon in healthy Pre-menopausal women.
PubMed:Silicon absorption and excretion is independent of age and sex in adults.
PubMed:Instant food products as a source of silicon.
PubMed:Taste and mouthfeel assessment of porous and non-porous silicon microparticles.
PubMed:Modification of alginate degradation properties using orthosilicic acid.
PubMed:Zwitterionic and anionic multinuclear pentacoordinate silicon(IV) complexes with bridging (R,R)-tartrato(4-) ligands and SiO5 skeletons: synthesis and reactivity in aqueous solution.
PubMed:A theoretical kinetic model of the temperature and pH dependent dimerization of orthosilicic acid in aqueous solution.
PubMed:Interactions of amines with silicon species in undersaturated solutions leads to dissolution and/or precipitation of silica.
PubMed:Reactions at interfaces: oxygenation of n-butyl ligands anchored on silica surfaces with methyl(trifluoromethyl)dioxirane.
PubMed:A solution study of silica condensation and speciation with relevance to in vitro investigations of biosilicification.
PubMed:Efficient and stable enzyme immobilization in a block copolypeptide vesicle-templated biomimetic silica support.
PubMed:[Progress in silicatein from sponges].
PubMed:The comparative absorption of silicon from different foods and food supplements.
PubMed:Moderate ingestion of alcohol is associated with acute ethanol-induced suppression of circulating CTX in a PTH-independent fashion.
PubMed:An overview of silica in biology: its chemistry and recent technological advances.
PubMed:Divergent effects of orthosilicic acid and dimethylsilanediol on cell survival and adhesion in human osteoblast-like cells.
PubMed:Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial.
PubMed:Avoidance of aluminum toxicity in freshwater snails involves intracellular silicon-aluminum biointeraction.
PubMed:Mineral balance in horses fed two supplemental silicon sources.
PubMed:Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair.
PubMed:Vitamins and minerals: their role in nail health and disease.
PubMed:The chemistry of silica and its potential health benefits.
PubMed:Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid.
PubMed:Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin.
PubMed:Role of exogenous and endogenous silicon in ameliorating behavioural responses to aluminium in a freshwater snail.
PubMed:The silicon content of beer and its bioavailability in healthy volunteers.
PubMed:Emission, fate and effects of soluble silicates (waterglass) in the aquatic environment.
PubMed:Silica deposition by a strongly cationic proline-rich protein from systemically resistant cucumber plants.
PubMed:Effect of orthosilicic acid on the accumulation of trace metals by the pond snail Lymnaea stagnalis.
PubMed:Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro.
PubMed:Associations of squaric acid and its anions as multiform building blocks of hydrogen-bonded molecular crystals.
PubMed:Near-infrared spectroscopic study of [AlO4Al12(OH)23(H2O)12]7+-O-Si(OH)3 nitrate crystals formed by forced hydrolysis of Al3+ in the presence of TEOS.
PubMed:Silica deposition in Demosponges: spiculogenesis in Crambe crambe.
PubMed:Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion.
PubMed:Supplementation of calves with stabilized orthosilicic acid. Effect on the Si, Ca, Mg, and P concentrations in serum and the collagen concentration in skin and cartilage.
PubMed:[Biological and pharmacological properties of orthosilicic acid and its derivatives and their effect on the body].
PubMed:[Determination of triethoxysilane and the ethyl ether of orthosilicic acid (tetraethoxysilane) in the air].
PubMed:[Determination of small quantities ethyl ether of orthosilicic acid (ethylsilicate) in the air].
 
Notes:
None found
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