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sodium hyaluronate
hyaluronic acid, sodium salt

Supplier Sponsors

Name:sodium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carbo
CAS Number: 9067-32-7Picture of molecule3D/inchi
Other(deleted CASRN):34448-35-6
FDA UNII: YSE9PPT4TH
MDL:MFCD01773053
Molecular Weight:799.64404928
Formula:C28 H44 N2 Na O23 +
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:dietary supplements: EFSA: cannot be assessed.
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance:white powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point:1274.00 to 1275.00 °C. @ 760.00 mm Hg (est)
Flash Point:1336.00 °F. TCC ( 724.50 °C. ) (est)
logP (o/w): -6.623 (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: humectants
skin conditioning
 
Suppliers:
AIDP
Hyaluronic Acid Sodium 99% HA 99% min.
American International Chemical, LLC.
Sodium Hyaluronate
AuNutra® Industries
Hyaluronic Acid Sodium
BOC Sciences
For experimental / research use only.
Hyaluronic acid sodium
Odor: characteristic
Use: Hyaluronic Acid, Sodium Salt is sodium salt form of Hyaluronic Acid. Hyaluronic acid, a mucopolysaccharide with high-viscosity, traditionally extracted from rooster combs, but now it is mainly produced via streptococcal fermentation.
Charkit Chemical
SODIUM HYALURONATE (HYALURONIC ACID)
Charkit Chemical
SODIUM HYALURONATE 1% SOLUTION
Charkit Chemical
SODIUM HYALURONATE POWDER
Chemical-navi - Nikkol
SODIUM HYALURONATE POWDER (CHA)
Contipro
Hyaluronan Oligosaccharides
Odor: characteristic
Use: Sodium hyaluronate oligosaccharides (hyaluronan oligomers) are non-sulphated glycosaminoglycans. The structure is given by an enzyme used for the digestion that cleaves selectively β (1?4) glycosidic bonds between disaccharide units of sodium hyaluronate. The enzymatic digestion is followed by chromatographic separation when the pure, size-uniformed species are obtained.
Contipro
Sodium hyaluronate LMW
Odor: characteristic
Use: Sodium hyaluronate (hyaluronan, sodium salt of hyaluronic acid) is a non-sulphated glycosaminoglycan, a naturally occuring polysaccharide.
Contipro
Sodium Hyaluronate
Odor: characteristic
Use: Sodium hyaluronate is a non-sulphated glycosaminoglycan, a naturally occuring polysaccharide.
ECSA Chemicals
SODIUM HYALURONATE 0.2-0.4MDa
ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY
ECSA Chemicals
SODIUM HYALURONATE 1.0-1.4 Mda
ECSA Chemicals
SODIUM HYALURONATE 1.00MDA - 1.80MDA
Glentham Life Sciences
Hyaluronic acid sodium salt, m.w. 1.0 - 1.5 MDa
Glentham Life Sciences
Hyaluronic acid sodium salt, m.w. 3,000 - 5,000
Glentham Life Sciences
Hyaluronic acid sodium salt, m.w. 30,000 - 50,000
Glentham Life Sciences
Hyaluronic acid sodium salt, m.w. 50,000 - 100,000
Jiangyin Healthway
Sodium Hyaluronate
New functional food ingredients
Jiangyin Healthway
Sodium Hyaluronate
Lipo Chemicals
Lipo® Hyaluronic Acid - 1% Solution
Odor: characteristic
Use: Hyaluronic Acid (HA) is a naturally-occurring polyanionic polysaccharide. It is present in the intercellular domains of connective tissues and especially in the skin. Because of its unique rheological, viscoelastic and hygroscopic properties, HA plays a key role in protecting and stabilizing the skin at the cellular level.
Lipo Chemicals
Lipo® Hyaluronic Acid
Odor: characteristic
Use: Hyaluronic Acid (HA) is a naturally-occurring polyanionic polysaccharide. It is present in the intercellular domains of connective tissues and especially in the skin. Because of its unique rheological, viscoelastic and hygroscopic properties, HA plays a key role in protecting and stabilizing the skin at the cellular level.
Lipo Chemicals
Orgasol® Hydra+
Odor: characteristic
Use: Orgasol® Hydra+ brings immediate sensorial and visual effects combined with long-term efficacy. It offers a perfect velvet finish and an immediate optical smoothing effect to color cosmetics, turning daily makeup application into a moisturizing treatment. Orgasol® Hydra+ delivers hyaluronic acid to the skin.
Lipotec USA
Actiglide®
Lipotec USA
Actimoist® Bio 1
Lipotec USA
Actimoist® Bio 2
M.C.Biotec
Sodium Hyaluronate
Maypro Industries
Sodium Hyaluronate
Meafo
For experimental / research use only.
Sodium Hyaluronate 95%
Santa Cruz Biotechnology
For experimental / research use only.
Hyaluronic Acid, Sodium Salt
Sigma-Aldrich: Sigma
For experimental / research use only.
Hyaluronic acid sodium salt
Solabia
Hyaluronic Acid BT
Odor: characteristic
Use: Given its high molecular weight, Hyaluronic Acid BT maintains an optimum level of hydration.
Spec-Chem Industry
SpecKareTM HA (Sodium Hyaluronate)
TRI-K Industries
HyaClear® Solution
Odor: characteristic
Use: A crystal clear solution of 1% sodium hyaluronate in water, HyaClear™ Solution helps skin retain moisture, decreases skin roughness, improves barrier function and decreases desquamation for smoother, healthier looking skin. It has a stable viscosity, clarity and pH at high formulating temperatures for easy formulation.
TRI-K Industries
Sodium Hyaluronate Powder
Odor: characteristic
Use: A natural mucopolysaccharide produced by an all-natural fermentation and purification process. This natural humectant preserves skin’s elasticity and firmness.
United International
Sodium hyaluronate Nat.
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 800 mg/kg
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.

intraperitoneal-rat LD50 1770 mg/kg
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BLOOD: NORMOCYTIC ANEMIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.

oral-rabbit LD50 > 1000 mg/kg
Drugs in Japan Vol. -, Pg. 849, 1990.

intraperitoneal-rabbit LD50 1820 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BLOOD: NORMOCYTIC ANEMIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.

oral-mouse LD50 > 2400 mg/kg
Drugs in Japan Vol. -, Pg. 849, 1990.

intraperitoneal-mouse LD50 1500 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 1013, 1984.

Dermal Toxicity:
subcutaneous-rat LD50 > 4000 mg/kg
BEHAVIORAL: ATAXIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.

subcutaneous-rabbit LD50 > 2000 mg/kg
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.

subcutaneous-mouse LD50 > 4000 mg/kg
BEHAVIORAL: ATAXIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.

subcutaneous-dog LD50 > 50 mg/kg
GASTROINTESTINAL: NAUSEA OR VOMITING SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
dietary supplements: EFSA: cannot be assessed.
Recommendation for sodium hyaluronate usage levels up to:
 not for fragrance use.
 
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Inability to assess the safety of sodium hyaluronate added for nutritional purposes as a source of sodium in food supplements and the bioavailability of sodium from this source, based on the supporting dossier [1]
View page or View pdf

ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
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Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :3084049
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
sodium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carbo
Chemidplus:0009067327
RTECS:MT7250000 for cas# 9067-32-7
 
References:
 sodium;(2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carbo
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):3084049
Pubchem (sid):135232288
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 actiglide
 actimoist Bio 1
 actimoist Bio 2
 chlamyhyaluronic acid sodium salt
 chronosphere hyaluronic
 hyaluronate sodium
 hyaluronic acid sodium
 hyaluronic acid, sodium salt
 orgasol hydra+
 sodium hyaluronate 1 solution macronan S
 sodium hyaluronate LMW
 sodium hyaluronate macronan PF
 sodium hyaluronate macronan-P
 sodium hyaluronate powder (CHA)
 

Articles:

PubMed:Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation.
PubMed:Systematical method for polyacrylamide and residual acrylamide detection in cosmetic surgery products and example application.
PubMed:[Evaluation of postsurgical adhesion prevention using different formulated sodium hyaluronate membranes].
PubMed:[Ideas about registration for sodium hyaluronate facial derma fillers].
PubMed:Genotoxicity, acute and subchronic toxicity studies in rats of a rooster comb extract rich in sodium hyaluronate.
PubMed:Demonstration of efficacy in the treatment of dry eye disease with 0.18% sodium hyaluronate ophthalmic solution (vismed, rejena).
PubMed:Nonheme iron absorption in young women is not influenced by purified sulfated and unsulfated glycosaminoglycans.
PubMed:Intra-articular hyaluronans: a review of product-specific safety profiles.
 
Notes:
a natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. it is found in the umbilical cord, in vitreous humor, in synovial fluid, in pathologic joints, in group a and c hemolytic streptococci, and in wharton's jelly. a high urinary level is found in progeria.
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