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CAS Number: 138-52-3Picture of molecule3D/inchi
Other(deleted CASRN):30370-90-2
ECHA EINECS - REACH Pre-Reg:205-331-6
FDA UNII: 4649620TBZ
Nikkaji Web:J5.634K
Beilstein Number:089593
XlogP3:-1.20 (est)
Molecular Weight:286.28086000
Formula:C13 H18 O7
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 197.00 to 200.00 °C. @ 760.00 mm Hg
Boiling Point: 549.09 °C. @ 760.00 mm Hg (est)
Flash Point: 547.00 °F. TCC ( 285.90 °C. ) (est)
logP (o/w): -1.232 (est)
Soluble in:
 water, 4.00E+04 mg/L @ 25 °C (exp)
 water, 1.624e+005 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
Alfa Biotechnology
For experimental / research use only.
Salicin 98%
BOC Sciences
For experimental / research use only.
For experimental / research use only.
Changsha Organic Herb
White Willow Extract
For experimental / research use only.
D-(-)-Salicin from Plants ≥95%
Odor: characteristic
Use: Salicin is an alcoholic β-glucoside. Salicin is an anti-inflammatory agent. Salicin is a prodrug which is gradually transported to the lower part of the intestine, hydrolyzed to saligenin by intestinal bacteria, and converted to salicylic acid after absorption. It thus produces an antipyretic action without causing gastric injury.
For experimental / research use only.
D-(-)-Salicin (HPLC) ≥99%
Glentham Life Sciences
Jiangyin Healthway
New functional food ingredients
Santa Cruz Biotechnology
For experimental / research use only.
Shaanxi Y-Herb Biotechnology
White Willow Tree Bark Extract Salicin Powder 10% - 98% CAS 138-52-3
Sigma-Aldrich: Sigma
For experimental / research use only.
D-(-)-Salicin ≥99% (GC)
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD > 500 mg/kg
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 63, 1954.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for salicin usage levels up to:
 not for fragrance use.
Recommendation for salicin flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):138-52-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :439503
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
RTECS:LZ5901700 for cas# 138-52-3
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:138-52-3
Pubchem (cid):439503
Pubchem (sid):134973922
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Golm Metabolome Database:Search
KEGG (GenomeNet):C01451
HMDB (The Human Metabolome Database):HMDB03546
VCF-Online:VCF Volatile Compounds in Food
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
Search Picture
 benzyl alcohol, o-hydroxy-, o-glucoside
b-D-glucopyranoside, 2-(hydroxymethyl)phenyl
a-hydroxy-o-tolyl b-D-glucopyranoside
(2S,4S,5S,3R,6R)-6-(hydroxymethyl)-2-[2-(hydroxymethyl)phenoxy]-2H-3,4,5,6-tet rahydropyran-3,4,5-triol
o-(hydroxymethyl)phenyl β-D-glucopyranoside
 salicyl alcohol glucoside
 salicylalcohol glucoside
 saligenin glucoside


PubMed:The study of interactions between active compounds of coffee and willow (Salix sp.) bark water extract.
PubMed:Hydroxybenzoic acid isomers and the cardiovascular system.
PubMed:Tissue-specific transcript profiling for ABC transporters in the sequestering larvae of the phytophagous leaf beetle Chrysomela populi.
PubMed:Recombinant expression and characterization of the cytoplasmic rice β-glucosidase Os1BGlu4.
PubMed:Comparisons of contact chemoreception and food acceptance by larvae of polyphagous Helicoverpa armigera and oligophagous Bombyx mori.
PubMed:Hydrolysis of aromatic β-glucosides by non-pathogenic bacteria confers a chemical weapon against predators.
PubMed:Pectinatus sottacetonis sp. nov., isolated from a commercial pickle spoilage tank.
PubMed:High-performance liquid chromatographic analysis of biogenic amines in pharmaceutical products containing Citrus aurantium.
PubMed:Biochemical properties of a novel glycoside hydrolase family 1 β-glucosidase (PtBglu1) from Paecilomyces thermophila expressed in Pichia pastoris.
PubMed:Evaluation of the microbial community in industrial rye sourdough upon continuous back-slopping propagation revealed Lactobacillus helveticus as the dominant species.
PubMed:A rapid and simple screening method of Cronobacter spp. in cell suspension and tofu.
PubMed:Toxin profile, antibiotic resistance, and phenotypic and molecular characterization of Bacillus cereus in Sunsik.
PubMed:Genetic analysis of the electrophysiological response to salicin, a bitter substance, in a polyphagous strain of the silkworm Bombyx mori.
PubMed:Functional diversity of bitter taste receptor TAS2R16 in primates.
PubMed:Prevalence, phenotypic traits and molecular characterization of emetic toxin-producing Bacillus cereus strains isolated from human stools in Korea.
PubMed:Lactobacillus brantae sp. nov., isolated from faeces of Canada geese (Branta canadensis).
PubMed:A new cost-effective, selective and differential medium for the isolation of Cronobacter spp.
PubMed:Comparison of three thermostable β-glucosidases for application in the hydrolysis of soybean isoflavone glycosides.
PubMed:Purification and characterization of an intracellular beta-glucosidase from the protoplast fusant of Aspergillus oryzae and Aspergillus niger.
PubMed:Anti-acetylcholinesterase and antioxidant assets of the major components (salicin, amentoflavone, and chlorogenic acid) and the extracts of Viburnum opulus and Viburnum lantana and their total phenol and flavonoid contents.
PubMed:The human bitter taste receptor, hTAS2R16, discriminates slight differences in the configuration of disaccharides.
PubMed:Comparison of enterotoxin production and phenotypic characteristics between emetic and enterotoxic Bacillus cereus.
PubMed:Characterization of the beta-D-glucopyranoside binding site of the human bitter taste receptor hTAS2R16.
PubMed:Ogataea pignaliae sp. nov., the teleomorph of Candida pignaliae.
PubMed:Gustatory responsiveness to six bitter tastants in three species of nonhuman primates.
PubMed:pH-Dependent inhibition of the human bitter taste receptor hTAS2R16 by a variety of acidic substances.
PubMed:Structural analogues of homoeriodictyol as flavor modifiers. Part III: short chain gingerdione derivatives.
PubMed:Characterization of a thermostable extracellular beta-glucosidase with activities of exoglucanase and transglycosylation from Paecilomyces thermophila.
PubMed:Lactobacillus ghanensis sp. nov., a motile lactic acid bacterium isolated from Ghanaian cocoa fermentations.
PubMed:Cryptococcus anemochoreius sp. nov., a novel anamorphic basidiomycetous yeast isolated from the atmosphere in central South Africa.
PubMed:Sequestration of plant-derived phenolglucosides by larvae of the leaf beetle Chrysomela lapponica: thioglucosides as mechanistic probes.
PubMed:Molecular typing and virulence markers of Yersinia enterocolitica strains from human, animal and food origins isolated between 1968 and 2000 in Brazil.
PubMed:Conflicting demands on detoxification pathways influence how common brushtail possums choose their diets.
PubMed:Potential role for gut microbiota in cell wall digestion and glucoside detoxification in Tenebrio molitor larvae.
PubMed:Stable isotope characterization of the ortho-oxygenated phenylpropanoids: coumarin and melilotol.
PubMed:Application of hydrophilic interaction liquid chromatography/comparative taste dilution analysis for identification of a bitter inhibitor by a combinatorial approach based on Maillard reaction chemistry.
PubMed:Evaluation of bitter masking flavanones from Herba Santa (Eriodictyon californicum (H. and A.) Torr., Hydrophyllaceae).
PubMed:Semi-industrial isolation of salicin and amygdalin from plant extracts using slow rotary counter-current chromatography.
PubMed:Emetic toxin formation of Bacillus cereus is restricted to a single evolutionary lineage of closely related strains.
PubMed:Differentiation of extractive and synthetic salicin. The 2H aromatic pattern of natural 2-hydroxybenzyl alcohol.
PubMed:[Life threatening intestinal bleeding in a Bearded Collie associated with a food supplement for horses].
PubMed:Catabolite repression and virulence gene expression in Listeria monocytogenes.
PubMed:Optimization of carbohydrate silylation for gas chromatography.
PubMed:Staphylococcus equorum subsp. linens, subsp. nov., a starter culture component for surface ripened semi-hard cheeses.
PubMed:Purification and characterization of vanilla bean (Vanilla planifolia Andrews) beta-D-glucosidase.
PubMed:Modification of an approved medium for fecal coliform detection in seawater: A-1 medium minus salicin.
PubMed:Characterization of an extracellular salicyl alcohol oxidase from larval defensive secretions of Chrysomela populi and Phratora vitellinae (Chrysomelina).
PubMed:The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides.
PubMed:Weissella kimchii sp. nov., a novel lactic acid bacterium from kimchi.
PubMed:Evaluation of sorbitol-salicin MacConkey medium containing cefixime and tellurite (CT-SSMAC medium) for isolation of Escherichia coli O157:H7 from raw vegetables.
PubMed:Selective adaptation to noxious foods by a herbivorous insect.
PubMed:Purification and characterization of a beta-glucosidase from Citrus sinensis var. Valencia fruit tissue.
PubMed:Differences in host use efficiency of larvae of a generalist moth, Operophtera brumata on three chemically divergent Salix species.
PubMed:Does excretion of secondary metabolites always involve a measurable metabolic cost? Fate of plant antifeedant salicin in common brushtail possum, Trichosurus vulpecula.
PubMed:[Development of chromogenic agar medium for isolation of enterohaemorrhagic Escherichia coli O26].
PubMed:Heterologous Expression of a Candida molischiana Anthocyanin-beta-glucosidase in a Wine Yeast Strain.
PubMed:Plant secondary metabolites as mammalian feeding deterrents: separating the effects of the taste of salicin from its post-ingestive consequences in the common brushtail possum (Trichosurus vulpecula).
PubMed:Lactobacillus nagelii sp. nov., an organism isolated from a partially fermented wine.
PubMed:Evaluation of media for selective enumeration of Streptococcus thermophilus, Lactobacillus delbrueckii ssp. bulgaricus, Lactobacillus acidophilus, and bifidobacteria.
PubMed:[Characteristics of Yersinia strains from clinical material and from other sources. I. Selected biochemical properties].
PubMed:Yeast succession in the Amazon fruit Parahancornia amapa as resource partitioning among Drosophila spp.
PubMed:The repression of listeriolysin O expression in Listeria monocytogenes by the phenolic beta-D-glucoside, arbutin.
PubMed:Toxins in chrysomelid beetles Possible evolutionary sequence from de novo synthesis to derivation from food-plant chemicals.
PubMed:[Serotype characterization of Escherichia coli potentially producing enterotoxins in foods].
PubMed:Biochemical differentiation between enterotoxigenic heat-sensitive and heat-resistant Clostridium perfringens strains.
PubMed:Chemosensitivity of lobster,Homarus americanus, to secondary plant compounds: Unused receptor capabilities.
PubMed:The incidence of Bacillus cereus in foods in Central Thailand.
PubMed:Biochemical characteristics and identification of Enterobacteriaceae isolated from meats.
PubMed:Yersinia enterocolitica biotype 1 in South Africa.
PubMed:Enrichment methods for recovery of Yersinia enterocolitica from foods and raw milk.
PubMed:Numerical classification of Yersinia enterocolitica and relationship between its subdivision and pathogenicity.
PubMed:The ability of some Yersinia enterocolitica strains to invade HeLa cells.
Salicin is an alcoholic β-glycoside that contains D-glucose. Salicin is an anti-inflammatory agent that is produced from willow bark. Salicin is closely related in chemical make-up to aspirin and has a very similar action in the human body. When consumed by humans, Salicin is metabolized into salicylic acid. [HMDB]
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