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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 261.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 849.60 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 483.00 °F. TCC ( 250.70 °C. ) (est)
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| logP (o/w): | 8.370 (est) |
| Soluble in: |
| | water, 0.006577 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 1800 mg/kg
Annales Pharmaceutiques Francaises. Vol. 38, Pg. 545, 1980.
oral-mouse LD50 > 4000 mg/kg
Annales Pharmaceutiques Francaises. Vol. 38, Pg. 545, 1980.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for alpha-hederin hydrate usage levels up to: | | | not for fragrance use.
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| Recommendation for alpha-hederin hydrate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (4a)-3b-((2-O-(6- | deoxy-a-L-mannopyranosyl)-a-L-arabinopyranosyl)oxy)-23-hydroxyolean-12-en-28-oic acid | | (4a)-3b-[[2-O-(6- | deoxy-a-L-mannopyranosyl)-a-L-arabinopyranosyl]oxy]-23-hydroxyolean-12-en-28-oic acid | | (3b)-3-{[2-O-(6- | deoxy-a-L-mannopyranosyl)-a-L-arabinopyranosyl]oxy}-23-hydroxyolean-12-en-28-oic acid | | (4alpha)-3beta-((2-O-(6- | deoxy-alpha-laevo-mannopyranosyl)-alpha-laevo-arabinopyranosyl)oxy)-23-hydroxyolean-12-en-28-oic acid | | | glycoside L-E1 | | a- | hederin (8CI) | | alpha- | hederin hydrate | | | hederoside C | | 23- | hydroxy-3b-[(O-a-L-rhamnopyranosyl-(1->2)-a-L-arabinopyranosyl)oxy]olean-12-en-28-oic acid | | | kalopanaxsaponin A | | | koronaroside A | | | nepalin 2 | | | olean-12-en-28-oic acid, 3-[[2-O-(6-deoxy-a-L-mannopyranosyl)-a-L-arabinopyranosyl]oxy]-23-hydroxy-, (3b)- | | | pulsatilla saponin A | | | sapindoside A | | | tauroside e |
Articles:
| PubMed:Determination of Saponins and Flavonoids in Ivy Leaf Extracts Using HPLC-DAD. |
| PubMed:The anticancer effect and mechanism of α-hederin on breast cancer cells. |
| PubMed:Domain formation and permeabilization induced by the saponin α-hederin and its aglycone hederagenin in a cholesterol-containing bilayer. |
| PubMed:The apoptotic effect of D Rhamnose β-Hederin, a novel oleanane-type triterpenoid saponin on breast cancer cells. |
| PubMed:Cytotoxicity and modes of action of five Cameroonian medicinal plants against multi-factorial drug resistance of tumor cells. |
| PubMed:The haploinsufficiency profile of α-hederin suggests a caspofungin-like antifungal mode of action. |
| PubMed:Kalopanaxsaponin A Exerts Anti-Inflammatory Effects in Lipopolysaccharide-Stimulated Microglia via Inhibition of JNK and NF-κB/AP-1 Pathways. |
| PubMed:Induction of highly curved structures in relation to membrane permeabilization and budding by the triterpenoid saponins, α- and δ-Hederin. |
| PubMed:Participation of extracellular calcium in α-hederin-induced contractions of rat isolated stomach strips. |
| PubMed:Methyl syringate, a low-molecular-weight phenolic ester, as an activator of the chemosensory ion channel TRPA1. |
| PubMed:Synthesis of novel diosgenyl saponin analogues and apoptosis-inducing activity on A549 human lung adenocarcinoma. |
| PubMed:Distribution of primary and specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses. |
| PubMed:Participation of cholinergic pathways in α-hederin-induced contraction of rat isolated stomach strips. |
| PubMed:Kalopanaxsaponin A inhibits the invasion of human oral squamous cell carcinoma by reducing metalloproteinase-9 mRNA stability and protein trafficking. |
| PubMed:[Mass spectrometry of triterpene glycosides molecular complexation with purine bases of nucleic acids]. |
| PubMed:HPLC-PDA method for quinovic acid glycosides assay in Cat's claw (Uncaria tomentosa) associated with UPLC/Q-TOF-MS analysis. |
| PubMed:Anticancer activity of Nigella sativa (black seed) - a review. |
| PubMed:The effect of the whole extract of common ivy (Hedera helix) leaves and selected active substances on the motoric activity of rat isolated stomach strips. |
| PubMed:Kalopanaxsaponin A ameliorates experimental colitis in mice by inhibiting IRAK-1 activation in the NF-κB and MAPK pathways. |
| PubMed:Synthesis and tumor cytotoxicity of novel amide derivatives of β-hederin. |
| PubMed:Nigella sativa: reduces the risk of various maladies. |
| PubMed:Pre-treatment with α-hederin increases β-adrenoceptor mediated relaxation of airway smooth muscle. |
| PubMed:African descents are more sensitive than European descents to the antitumor compounds α-hederin and kalopanaxsaponin I. |
| PubMed:Rapid quantification of 14 saponins of Maesa lanceolata by UPLC-MS/MS. |
| PubMed:Resistance in the plant, Barbarea vulgaris, and counter-adaptations in flea beetles mediated by saponins. |
| PubMed:Triterpenoid saponins from the stems of Clematis parviloba. |
| PubMed:Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells. |
| PubMed:Methyl jasmonate induced accumulation of kalopanaxsaponin I in Nigella sativa. |
| PubMed:Alpha-hederin, but not hederacoside C and hederagenin from Hedera helix, affects the binding behavior, dynamics, and regulation of beta 2-adrenergic receptors. |
| PubMed:Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins. |
| PubMed:Biologically active triterpenoids from Cephalaria ambrosioides. |
| PubMed:Kalopanaxsaponin A induces apoptosis in human leukemia U937 cells through extracellular Ca2+ influx and caspase-8 dependent pathways. |
| PubMed:Alpha-hederin potentiates 5-FU antitumor activity in human colon adenocarcinoma cells. |
| PubMed:A convenient preparation of a disaccharide motif and its role in the cytotoxicity of the triterpenoid saponin, alpha-hederin. |
| PubMed:Structure-activity relationships of some hederagenin diglycosides: haemolysis, cytotoxicity and apoptosis induction. |
| PubMed:Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells. |
| PubMed:Synthesis of beta-hederin and Hederacolchiside A1: triterpenoid saponins bearing a unique cytotoxicity-inducing disaccharide moiety. |
| PubMed:[Studies on chemical constituents in the seeds of Nigella glandulifera]. |
| PubMed:Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. |
| PubMed:Involvement of cytokines in the hepatic metallothionein expression by alpha-hederin. |
| PubMed:Acute anti-inflammatory activity of four saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F in carrageenan-induced rat paw edema. |
| PubMed:Saponins and other constituents from the leaves of Aralia elata. |
| PubMed:Antinociceptive and anti-inflammatory effects of the saponin and sapogenins obtained from the stem of Akebia quinata. |
| PubMed:Simultaneous determination of glycyrrhizin, a marker component in radix Glycyrrhizae, and its major metabolite glycyrrhetic acid in human plasma by LC-MS/MS. |
| PubMed:HPLC profiling and quantification of active principles in leaves of Hedera helix L. |
| PubMed:Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ETA and angiotensin AT1 receptors. |
| PubMed:Antioxidant activity of saponins isolated from ivy: alpha-hederin, hederasaponin-C, hederacolchiside-E and hederacolchiside-F. |
| PubMed:Dynamics of beta2-adrenergic receptor-ligand complexes on living cells. |
| PubMed:Structure-activity relationship of oleanane disaccharides isolated from Akebia quinata versus cytotoxicity against cancer cells and NO inhibition. |
| PubMed:An unusual case of death: suffocation caused by leaves of common ivy (Hedera helix). Detection of hederacoside C, alpha-hederin, and hederagenin by LC-EI/MS-MS. |
| PubMed:Intracellular glutathione depletion and reactive oxygen species generation are important in alpha-hederin-induced apoptosis of P388 cells. |
| PubMed:Antiinflammatory activity of alpha-hederin methyl ester from the alkaline hydrolysate of the butanol fraction of Kalopanax pictus bark extract. |
| PubMed:Activity-guided isolation of saponins from Kalopanax pictus with anti-inflammatory activity. |
| PubMed:Expression of inducible nitric oxide synthase by alpha-hederin in macrophages. |
| PubMed:In vitro antiinflammatory activity of kalopanaxsaponin A isolated from Kalopanax pictus in murine macrophage RAW 264.7 cells. |
| PubMed:Metabolism of kalopanaxsaponin K by human intestinal bacteria and antirheumatoid arthritis activity of their metabolites. |
| PubMed:Antinociceptive and anti-rheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals. |
| PubMed:Anti-lipid peroxidative principles from the stem bark of Kalopanax pictus Nakai. |
| PubMed:Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent. |
| PubMed:Triterpenoid saponins from Clematis tangutica. |
| PubMed:In vitro antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A(1), in association with pentamidine and amphotericin B. |
| PubMed:[In vitro study of the antimutagenic activity of alphahederin]. |
| PubMed:Triterpenoid saponins from the stem bark of Elattostachys apetala. |
| PubMed:Toxicology of Kalopanax pictus extract and hematological effect of the isolated anti-rheumatoidal kalopanaxsaponin A on the Freunds complete adjuvant reagent-treated rat. |
| PubMed:Kalopanaxsaponin A is a basic saponin structure for the anti-tumor activity of hederagenin monodesmosides. |
| PubMed:Extraction, isolation and characterisation of antitumor principle, alpha-hederin, from the seeds of Nigella sativa. |
| PubMed:Antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro. |
| PubMed:Essential moiety for antimutagenic and cytotoxic activity of hederagenin monodesmosides and bisdesmosides isolated from the stem bark of Kalopanax pictus. |
| PubMed:The protective activity of alpha-hederine against H2O2 genotoxicity in HepG2 cells by alkaline comet assay. |
| PubMed:Suppressive effects of alpha-Hederin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated murine Cyp1a-1 expression in the mouse hepatoma Hepa-1c1c7 cells. |
| PubMed:Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida. |
| PubMed:Study of the action of alpha-hederin on the ultrastructure of Candida albicans. |
| PubMed:A potent anti-diabetic agent from Kalopanax pictus. |
| PubMed:Growth inhibitory activities of kalopanaxsaponins A and I against human pathogenic fungi. |
| PubMed:Suppression of constitutive and inducible cytochrome P450 gene expression by alpha-hederin in mice. |
| PubMed:The prevention of carbon tetrachloride-induced hepatotoxicity in mice by alpha-hederin: inhibiton of cytochrome P450 2E1 expression. |
| PubMed:Metabolism of kalopanaxsaponin B and H by human intestinal bacteria and antidiabetic activity of their metabolites. |
| PubMed:Repeated administration of alpha-hederin results in alterations in maternal zinc status and adverse developmental outcome in the rat. |
| PubMed:In vitro antispasmodic compounds of the dry extract obtained from Hedera helix. |
| PubMed:Effect of alpha-hederin on hepatic detoxifying systems in mice. |
| PubMed:Effect of alpha-hederin and sapindoside B on hepatic microsomal cytochrome P-450 in mice. |
| PubMed:Protective effects of alpha-hederin, chlorophyllin and ascorbic acid towards the induction of micronuclei by doxorubicin in cultured human lymphocytes. |
| PubMed:Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats. |
| PubMed:Anti-elastase and anti-hyaluronidase activities of saponins and sapogenins from Hedera helix, Aesculus hippocastanum, and Ruscus aculeatus: factors contributing to their efficacy in the treatment of venous insufficiency. |
| PubMed:Suppression of liver cytochrome P450 by alpha-hederin: relevance to hepatoprotection. |
| PubMed:[Protective effect of the fulvotomentosides on paracetamol-induced hepatotoxicity in mice]. |
| PubMed:Zinc-induced arsenite tolerance in mice. |
| PubMed:In vitro antifungal activity of triterpenoid saponins. |
| PubMed:Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro. |
| PubMed:Altered maternal zinc metabolism following exposure to diverse developmental toxicants. |
| PubMed:Altered Zn status by alpha-hederin in the pregnant rat and its relationship to adverse developmental outcome. |
| PubMed:The effects of 10 triterpenoid compounds on experimental liver injury in mice. |
| PubMed:Induction of metallothionein by alpha-hederin. |
| PubMed:Saponins of the ivy plant, Hedera helix, and their leishmanicidic activity. |
| PubMed:[Studies on the saponin constituents of Kalopanax septemlobus (Thunb.) koidz]. |
| PubMed:[Studies on the chemical constituents of Lonicera fulvotomentosa Hsu et S.C. Cheng]. |
| PubMed:Rapid analysis of alpha-hederin in a crude plant extract by collisional mass spectrometry (CAD MIKES). |
| PubMed:Role of glycosidases in the membranlytic, antifungal action of Saponins. |
| PubMed:Letter: Antiviral activity of hederin. |
| PubMed:Isolation of a saponin, hederin, and its sapogenin, hederagenin, from bur clover (Medicago hispida). |
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3D/inchi