EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

dextro-phenyl alanine
D-a-amino-b-phenylpropionic acid

Supplier Sponsors

Name:(2R)-2-amino-3-phenylpropanoic acid
CAS Number: 673-06-3Picture of molecule3D/inchi
Other(deleted CASRN):10549-11-8
ECHA EINECS - REACH Pre-Reg:211-603-5
FDA UNII: 032K16VRCU
Nikkaji Web:J9.200B
Beilstein Number:2804068
MDL:MFCD00004270
XlogP3:-1.50 (est)
Molecular Weight:165.19207000
Formula:C9 H11 N O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white needles or prisms (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 283.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 273.00 to 276.00 °C. @ 760.00 mm Hg
Vapor Pressure:1.760000 mmHg @ 25.00 °C. (est)
Flash Point: 284.00 °F. TCC ( 139.80 °C. ) (est)
logP (o/w): 0.235 (est)
Soluble in:
 water, 2.82E+04 mg/L @ 16C (exp)
 water, 9357 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Anhui Haibei
D-Phenylalanine
BOC Sciences
For experimental / research use only.
D-Phenylalanine >98%
Odor: characteristic
Use: D-Phenylalanine, a carboxypeptidase A, endorphinase and enkephalinase inhibitor, enhances endorphin production and diminishes pain.
Changzhou Longo Chemical
D-Phenylalanine
Glentham Life Sciences
D-Phenylalanine
sds
Penta International
D-PHENYLALANINE
Santa Cruz Biotechnology
For experimental / research use only.
D-Phenylalanine ≥98% (tlc)
Sigma-Aldrich: Sigma
For experimental / research use only.
D-Phenylalanine ≥98% (TLC)
sds
TCI AMERICA
For experimental / research use only.
D-Phenylalanine >98.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-human TDLo 500 mg/kg/5W-I
GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of the American College of Toxicology. Vol. 1(3), Pg. 124, 1982.

intraperitoneal-rat LD50 5452 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Archives of Biochemistry and Biophysics. Vol. 64, Pg. 319, 1956.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for dextro-phenyl alanine usage levels up to:
 not for fragrance use.
 
Recommendation for dextro-phenyl alanine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):673-06-3
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :71567
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2R)-2-amino-3-phenylpropanoic acid
Chemidplus:0000673063
EPA/NOAA CAMEO:hazardous materials
RTECS:AY533000 for cas# 673-06-3
 
References:
 (2R)-2-amino-3-phenylpropanoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):71567
Pubchem (sid):135030679
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C02265
HMDB (The Human Metabolome Database):Search
YMDB (Yeast Metabolome Database):YMDB00995
Export Tariff Code:2922.49.1000
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•grades: technical, fcc[lewis rj sr; hawley's condensed chemical dictionary 15th ed wiley (2007) •available commercially as dl-dihydroxyphenylalanine and as dl-phenylalanine.[lewis rj sr; hawley's condensed chemical dictionary 15th ed wiley (2007) •available commercially as the naturally occurring l(+)-enantiomer
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(2R)-2-amino-3-phenylpropanoic acid
(R)-2-amino-3-phenylpropionic acid
D-a-amino-b-phenylpropionic acid
D-fenylalanine
(R)-(+)-phenyl alanine
(R)-phenylalanine
(R)-(+)-phenylalanine
D-phenylalanine
D-(+)-phenylalanine
D-phenylalaninol
 sabiden
 

Articles:

PubMed:Flavonolignans and Other Constituents from Lepidium meyenii with Activities in Anti-inflammation and Human Cancer Cell Lines.
PubMed:Effects of conversion of the zinc-binding motif sequence of thermolysin, HEXXH, to that of dipeptidyl peptidase III, HEXXXH, on the activity and stability of thermolysin.
PubMed:Characterization of ergothionase from Burkholderia sp. HME13 and its application to enzymatic quantification of ergothioneine.
PubMed:Relative fasting bioavailability of two formulations of nateglinide 60 mg in healthy male Chinese volunteers: an open-label, randomized-sequence, single-dose, two-way crossover study.
PubMed:The use of a food supplementation with D-phenylalanine, L-glutamine and L-5-hydroxytriptophan in the alleviation of alcohol withdrawal symptoms.
PubMed:[Intestinal absorption and secretion mechanism of carboxylate drugs].
PubMed:Allelic variation of the Tas1r3 taste receptor gene selectively affects taste responses to sweeteners: evidence from 129.B6-Tas1r3 congenic mice.
PubMed:Improvement in performance of affinity gels containing Gly-D-Phe as a ligand to thermolysin due to increasing the spacer chain length.
PubMed:Exenatide: a new option for the treatment of type 2 diabetes.
PubMed:Gas chromatographic determination and mechanism of formation of D-amino acids occurring in fermented and roasted cocoa beans, cocoa powder, chocolate and cocoa shell.
PubMed:Performance of D-amino acid oxidase in presence of ionic liquids.
PubMed:Characterization of Gly-D-Phe, Gly-L-Leu, and D-Phe as affinity ligands to thermolysin.
PubMed:A new strategy for the selective determination of D-amino acids: enzymatic and chemical modifications for pre-column derivatization.
PubMed:Distribution and characteristics of D-amino acid and D-aspartate oxidases in fish tissues.
PubMed:The tripeptide FEG ameliorates systemic inflammatory responses to rat intestinal anaphylaxis.
PubMed:Sweetener preference of C57BL/6ByJ and 129P3/J mice.
PubMed:Importance of postprandial glucose control.
PubMed:[Pharmacological properties of nateglinide, rapid-onset/short-duration insulinotropic agent, in the treatment of type 2 diabetes].
PubMed:Stabilization of D-amino acid oxidase and catalase in permeabilized Rhodotorula gracilis cells and its application for the preparation of alpha-ketoacids*.
PubMed:Chemistry, nutrition, and microbiology of D-amino acids.
PubMed:Calcium-deprived rats avoid sweet compounds.
PubMed:Effect of food on the bioavailability of SDZ DJN 608, an oral hypoglycemic agent, from a tablet and a liquid-filled capsule in the dog.
PubMed:Suppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation.
PubMed:The genetic basis of preference for sweet substances among inbred strains of mice: preference ratio phenotypes and the alleles of the Sac and dpa loci.
PubMed:Separation of amino-acid enantiomers using micellar-enhanced ultrafiltration.
PubMed:Formation, nutritional value, and safety of D-amino acids.
PubMed:Treatment of hyperactive children with D-phenylalanine.
PubMed:The availability of D-phenylalanine and DL-phenylalanine.
PubMed:The nutritive value and safety of D-phenylalanine and D-tyrosine in mice.
PubMed:Racemization of aspartic acid and phenylalanine in the sweetener aspartame at 100 degrees C.
PubMed:Feeding, drinking, urine osmolality in DI Brattleboro rats: changes by morphine, naloxone, D-amino acids, prolyl-leucyl-glycinamide (PLG).
PubMed:Modulation of deprivation-induced food intake by D-phenylalanine.
PubMed:The effect of gastric loads of sugars and amino acids on milk intake of suckling pigs.
PubMed:Ontogeny of cholecystokinin satiety in rats.
PubMed:Cholecystokinin and satiety in rats and rhesus monkeys.
PubMed:Cholecystokinin-decreased food intake in rhesus monkeys.
 
Notes:
None found
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