EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

dextro,laevo-leucine
DL-2-amino-4-methylpentanoic acid

Supplier Sponsors

Name:2-amino-4-methylpentanoic acid
CAS Number: 328-39-2Picture of molecule3D/inchi
Other(deleted CASRN):1105707-16-1
ECHA EINECS - REACH Pre-Reg:206-328-2
FDA UNII: 1QSS9D5DR6
Nikkaji Web:J1.285H
Beilstein Number:636005
MDL:MFCD00063087
Molecular Weight:131.17501000
Formula:C6 H13 N O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystals (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 293.00 to 296.00 °C. @ 760.00 mm Hg
Boiling Point: 225.77 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.031000 mmHg @ 25.00 °C. (est)
Flash Point: 195.00 °F. TCC ( 90.30 °C. ) (est)
logP (o/w): 0.799 (est)
Soluble in:
 water, 1.18E+04 mg/L @ 25 °C (exp)
 water, 1.538e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor Description:odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
DL-Leucine N/A
EMD Millipore
For experimental / research use only.
DL-Leucine
sds
Glentham Life Sciences
DL-Leucine
sds
Penta International
DL-LEUCINE
Santa Cruz Biotechnology
For experimental / research use only.
DL-Leucine
Sigma-Aldrich: Sigma
For experimental / research use only.
DL-Leucine ≥99% (TLC)
sds
TCI AMERICA
For experimental / research use only.
DL-Leucine >98.0%(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for dextro,laevo-leucine usage levels up to:
 not for fragrance use.
 
Recommendation for dextro,laevo-leucine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):328-39-2
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :857
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-amino-4-methylpentanoic acid
Chemidplus:0000328381
 
References:
 2-amino-4-methylpentanoic acid
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:328-39-2
Pubchem (cid):857
Pubchem (sid):134973452
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
KEGG (GenomeNet):C16439
HMDB (The Human Metabolome Database):Search
FooDB:FDB000899
Export Tariff Code:2922.49.4050
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antistatic agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2-amino-4-methylpentanoic acid
DL-2-amino-4-methylpentanoic acid
2-amino-4-methylvaleric acid
DL-2-amino-4-methylvaleric acid
a-aminoisocaproic acid
(±)-leucine
(RS)-leucine
 leucine, DL-
 pentanoic acid, 2-amino-4-methyl-
 valeric acid, 2-amino-4-methyl-
 

Articles:

PubMed:Isolation and characterization of awamori yeast mutants with l-leucine accumulation that overproduce isoamyl alcohol.
PubMed:Thiol-ene click chemistry derived cationic cyclodextrin chiral stationary phase and its enhanced separation performance in liquid chromatography.
PubMed:The treatment and natural course of peripheral and central vertigo.
PubMed:Intermolecular vibrations in hydrophobic amino acid crystals: experiments and calculations.
PubMed:Effects of acetyl-DL-leucine in patients with cerebellar ataxia: a case series.
PubMed:One-step synthesis of silver/dopamine nanoparticles and visual detection of melamine in raw milk.
PubMed:Non-ionic surfactant modified ligand exchange chromatography using copper (II) complex of N,N-dimethyl-L-phenylalanine as the chiral additive for enantioselective amino acids separation.
PubMed:Dual role of hydrophobic racemic thioesters of alpha-amino acids in the generation of isotactic peptides and co-peptides in water; implications for the origin of homochirality.
PubMed:Highly sensitive detection of chiral amino acids by CE based on on-line stacking techniques.
PubMed:Mixed ligand complexes of benzimidazole and pyrimidine hydroxy azo dyes with some transition metals and glycine, dl-alanine or dl-leucine.
PubMed:Effects of acetyl-DL-leucine in vestibular patients: a clinical study following neurotomy and labyrinthectomy.
PubMed:Oligopeptides and copeptides of homochiral sequence, via beta-sheets, from mixtures of racemic alpha-amino acids, in a one-pot reaction in water; relevance to biochirogenesis.
PubMed:Direct lung delivery of a dry powder formulation of DTPA with improved aerosolization properties: effect on lung and systemic decorporation of plutonium.
PubMed:Partial molar volumes of some alpha-amino acids in aqueous sodium acetate solutions at 308.15 K.
PubMed:Isolation of Saccharomyces cerevisiae strains producing higher levels of flavoring compounds for production of "cachaça" the Brazilian sugarcane spirit.
PubMed:Asp578 in LEU4p is one of the key residues for leucine feedback inhibition release in sake yeast.
PubMed:Construction of two new vectors for transformation of laboratory, natural and industrial Saccharomyces cerevisiae strains to trifluoroleucine and G418 resistance.
PubMed:Evaluation of in vitro antimicrobial and in vivo cytotoxic properties of some novel titanium-based coordination complexes.
PubMed:Viscosity behavior of some alpha-amino acids and their groups in water-sodium acetate mixtures.
PubMed:Autoradiography in brain of Macaca fascicularis monkeys after injection of acetyl-DL-leucine [2-14C] (Tanganil).
PubMed:Supported liquid membrane stability in chiral resolution by chemically and physically modified membranes.
PubMed:Cryo-bioorganic chemistry: freezing effect on stereoselection of L- and DL-leucine cooligomerization in aqueous solution.
PubMed:In vitro effects of acetyl-DL-leucine (tanganil) on central vestibular neurons and vestibulo-ocular networks of the guinea-pig.
PubMed:Racemic dipeptide glycyl-DL-leucine at 120 K.
PubMed:Effect of temperature on viscosity properties of some alpha-amino acids in aqueous urea solutions.
PubMed:Direct thin layer chromatography enantioresolution of some basic DL-amino acids using a pharmaceutical industry waste as chiral impregnating reagent.
PubMed:Trifluoroleucine resistance as a dominant molecular marker in transformation of strains of Saccharomyces cerevisiae isolated from wine.
PubMed:Trifluoroleucine resistance and regulation of alpha-isopropyl malate synthase in Saccharomyces cerevisiae.
PubMed:[Effects of acetyl-DL-leucine on the recovery of the locomotor equilibrium and spontaneous discharge of lateral vestibular nucleus neurons in unilateral vestibular neurectomized cats].
PubMed:DL-leucine transport in a Saccharomyces cerevisiae mutant resistant to quaternary ammonium salts.
PubMed:Enhanced formation of isoamyl alcohol in Zygosaccharomyces rouxii due to elimination of feedback inhibition of alpha-isopropylmalate synthase.
PubMed:[Drug therapy of vertigo].
PubMed:On the 13C CP/MAS spectra of leucine.
PubMed:Production and immobilization of D-aminoacylase of Alcaligenes faecalis DA1 for optical resolution of N-acyl-DL-amino acids.
PubMed:Retinamides: hydrolytic conversion of retinoylglycine to retinoic acid in pregnant mice contributes to teratogenicity.
PubMed:Genetic analysis of the Pseudomonas aeruginosa PAO high-affinity branched-chain amino acid transport system by use of plasmids carrying the bra genes.
PubMed:Thiol-based inhibitors of mammalian collagenase. Substituted amide and peptide derivatives of the leucine analogue, 2-[(R,S)-mercaptomethyl]-4-methylpentanoic acid.
PubMed:Inhibition of Moloney murine lymphoma and sarcoma growth in vivo by dietary retinoids.
PubMed:Production of d-Aminoacylase from Alcaligenes denitrificans subsp. xylosoxydans MI-4.
PubMed:Toxicologic and immunologic evaluations of N-(all-trans-retinoyl)-DL-leucine and N-(all-trans-retinoyl)glycine.
PubMed:Production and Purification of d-Aminoacylase from Alcaligenes denitrificans and Taxonomic Study of the Strain.
PubMed:Soft agar colony formation of bladder cells during carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine and application to detection of bladder cancer promoters.
PubMed:Characterization of novel viral polyproteins detected in cells infected by the flavivirus Kunjin and radiolabelled in the presence of the leucine analogue hydroxyleucine.
PubMed:Models of molecular evolution. 2. Stereospecificity of dipeptide syntheses by means of cyanamides and carbodiimides.
PubMed:A comparison of cationic polymerization and esterification for end-point detection in the catalytic thermometric titration of organic bases.
PubMed:[Comparative distribution study of 14C labeled amino acids, glucose-analogue and precursor of nuclei acid, as tumor seeking agents].
PubMed:On the stereoselective aminoacylation of RNA.
PubMed:Beta-decay, bremsstrahlen, and the origin of molecular chirality.
PubMed:Metabolism of leucine by the isolated perfused goat udder.
PubMed:Evidence that repression mechanisms can exert control over the thr, leu, and ilv operons of Escherichia coli K-12.
PubMed:Rapid enzymatic preparation of [14C]D-leucine from [14C]DL-leucine.
PubMed:The radiolysis and racemization of leucine on proton irradiation.
PubMed:Search for effect of longitudinally polarized protons on optically active amino acid.
PubMed:Liver microsomal drug-metabolizing enzyme activity: enhancement by blockade of degradative processes in promethazine-treated rats.
PubMed:The radiolysis of tryptophan and leucine with 32P beta-radiation.
PubMed:Th activities of perfused livers of control and streptozotocin diabetic rats in the synthesis of some plasma proteins and peptides.
PubMed:[Effect of raised temperatures on the protein and RNA synthesis rate in yeasts].
PubMed:[Effect of increased temperatures on RNA and protein synthesis in the cells of a synchronous Candida utilis culture].
PubMed:[Synthesis of amino acid antipyrine-4-amides. II. 4-antipyrinamides of DL-leucine, phenylalanine, tyrosine, glutaminic acid and epsilon-aminocaproic acid].
PubMed:Asymmetric degradation of DL-leucine with longitudinally polarised electrons.
PubMed:Asymmetric degradation of DL-leucine with longitudinally polarised electrons.
PubMed:Raman spectra of D and L amino acid copolymers. Poly-DL-alanine, poly-DL-leucine, and poly-DL-lysine.
PubMed:Distribution of lactic dehydrogenase in X-irradiated tissues.
PubMed:Differences in the incorporation of L- and DL-Amino acids into renal tubular cells. An autoradiographic study.
PubMed:Regulation of leucine catabolism in Pseudomonas putida.
PubMed:New amino acid regulatory locus having unusual properties in heterozygous merodiploids.
PubMed:Oxidation of DL-3-phenylalanine-1- 14 C, DL-leucine-1- 14 C, and D-glucose-1- 14 C-6-phosphate to 14 CO 2 in human placenta.
PubMed:[Incorporation in vitro of DL-leucine-1-C14 into proteins of the rat liver, kidney and diaphragm in presence of various concentrations of albumin].
PubMed:[Incorporation in vitro of DL-leucine-1-C14 into the proteins of the cells of Yoshida's ascites hepatoma and of ascitic sarcoma 180 in presence of various concentrations of albumin].
PubMed:Regulation of branched-chain amino acid biosynthesis in Salmonella typhimurium: isolation of regulatory mutants.
PubMed:Effect of steroid hormones on dl-leucine-1-14C uptake by the uterus of pregnant rats maintained on a protein-free diet.
PubMed:Uptake of 3-H-DL-leucine and 3-H-uridine by the caudal neurosecretory system of the loach (Misgurnus anguillicaudatus) maintained in vitro.
PubMed:[Studies on the dependency upon radiation dose of microwaves saturation in electron spin resonance radiation-induced free radicals of DL-valine and DL-leucine].
PubMed:Liver adenine nucleotides: fructose-induced depletion and its effect on protein synthesis.
PubMed:[Quantitative study by radioautography and electron microscopy of the utilization of DL-leucine-H3 by duck hypophyseal cells in organ culture].
PubMed:Protein biosynthesis in trypanosomidae. II. The metabolic fate of DL-leucine-1-C14 in Trypanosoma cruzi.
PubMed:PROTEIN SYNTHESIS, STORAGE, AND DISCHARGE IN THE PANCREATIC EXOCRINE CELL. AN AUTORADIOGRAPHIC STUDY.
PubMed:IN VIVO AND IN VITRO EFFECT OF GLUCAGON DL-LEUCINE-1-C14 INCORPORATION INTO PROTEIN OF RAT PANCREAS.
PubMed:STUDIES ON THE METABOLISM OF THE RETINA AND LATERAL GENICULATE NUCLEUS. IN VIVO INCORPORATION OF H-3-DL-LEUCINE IN ALBINO RATS.
PubMed:Biosynthesis of chloramphenicol. IV. Incorporation of carbon 14-labled precursors.
PubMed:Studies on the metabolic function of branched-chain volatile fatty acids, growth factors for ruminococci. I. Incorporation of isovalerate into leucine.
PubMed:Physiological studies of the rumen protozoan Ophryoscolex caudatus Eberlein.
PubMed:[Experimental research on the behavior of vestibular function after the administration of certain drugs. II. Acetyl-DL-leucine].
PubMed:A cytochemical study on the pancreas of the guinea pig. 5. In vivo incorporation of leucine-1-C14 into the chymotrypsinogen of various cell fractions.
PubMed:[Incorporation of tritium-labeled DL-leucine into the blood cells in acute leukosis and in chronic myeloid leukemia].
PubMed:[Data on protein metabolism in normal bone marrow. Incorporation of tritium-labeled DL-leucine and tritium-labeled DL-beta-phenylalanine].
PubMed:Effects of thyroxin on amino acid incorporation into protein.
PubMed:A cyto-chemical study on the pancreas of the guinea pig. III. In vivo incorporation of leucine-1-C14 into the proteins of cell fractions.
PubMed:[Trial therapy of labyrinthine vertigo by acetyl-DL-leucine].
PubMed:In vitro incorporation of C14-DL-leucine into normal and leukemic white cells.
PubMed:Acylchlorides of amino acids and peptides as monomers for the preparation of polymeric polypeptides. I. Syntheses of poly-beta-alanine, poly-DL-alanine, poly-L-leucine and poly-glycyl-DL-leucine.
PubMed:PLASMA PROTEIN PRODUCTION INFLUENCED BY AMINO ACID MIXTURES AND LACK OF ESSENTIAL AMINO ACIDS : A DEFICIENCY STATE RELATED TO UNKNOWN FACTORS.
 
Notes:
Dietary supplement, nutrient [DFC]
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