EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2,5-dihydrofuran
1-oxa-3-cyclopentene

Supplier Sponsors

Name:2,5-dihydrofuran
CAS Number: 1708-29-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:216-957-4
FDA UNII: HD0TIE091T
Nikkaji Web:J41.176K
Beilstein Number:103174
MDL:MFCD00003219
XlogP3:0.50 (est)
Molecular Weight:70.09102000
Formula:C4 H6 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.94400 to 0.94700 @ 20.00 °C.
Pounds per Gallon - (est).: 7.864 to 7.889
Refractive Index:1.43100 to 1.43400 @ 20.00 °C.
Melting Point: 66.50 °C. @ 760.00 mm Hg
Boiling Point: 66.00 to 67.00 °C. @ 760.00 mm Hg
Boiling Point: 69.00 to 70.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:145.436996 mmHg @ 25.00 °C. (est)
Flash Point: 2.00 °F. TCC ( -16.70 °C. ) (est)
logP (o/w): 0.460
Soluble in:
 mineral oil
 paraffin oil
 water, 5.477e+004 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
2,5-Dihydrofuran 95%
EMD Millipore
For experimental / research use only.
2,5-Dihydrofuran
Santa Cruz Biotechnology
For experimental / research use only.
2,5-Dihydrofuran
Sigma-Aldrich: Aldrich
For experimental / research use only.
2,5-Dihydrofuran 97%
TCI AMERICA
For experimental / research use only.
2,5-Dihydrofuran >98.0%(GC)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
information only not used for fragrances or flavors
Recommendation for 2,5-dihydrofuran usage levels up to:
 not for fragrance use.
 
Recommendation for 2,5-dihydrofuran flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):1708-29-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :15570
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 3271
WGK Germany:3
2,5-dihydrofuran
Chemidplus:0001708298
RTECS:LU0660000 for cas# 1708-29-8
 
References:
 2,5-dihydrofuran
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):15570
Pubchem (sid):134979692
Pherobase:View
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2932.19.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 sauromatum guttatum
Search Trop Picture
 
Synonyms:
1-oxa-3-cyclopentene
2,5-dihydro-furan
 furan, 2,5-dihydro-
3-oxolene
 

Articles:

PubMed:Fluorescent push-pull pH-responsive probes for ratiometric detection of intracellular pH.
PubMed:Easily accessible and highly tunable bisphosphine ligands for asymmetric hydroformylation of terminal and internal alkenes.
PubMed:Organic free radicals in clathrate hydrates investigated by muon spin spectroscopy.
PubMed:A general strategy for organocatalytic activation of C-H bonds via photoredox catalysis: direct arylation of benzylic ethers.
PubMed:Anion sensing and F(-)-induced reversible photoreaction of D-π-A type dye containing imidazole moiety as donor.
PubMed:A fluorescent colorimetric pH sensor and the influences of matrices on sensing performances.
PubMed:Nucleoside analogues with a 1,3-diene-Fe(CO)3 substructure: stereoselective synthesis, configurational assignment, and apoptosis-inducing activity.
PubMed:Asymmetric cross-dimerization between methyl methacrylate and substituted alkene by Ru(0)-bicyclononadiene complex.
PubMed:A ratiometric fluorescent probe based on a BODIPY-DCDHF conjugate for the detection of hypochlorous acid in living cells.
PubMed:Libraries of bisdiazaphospholanes and optimization of rhodium-catalyzed enantioselective hydroformylation.
PubMed:Palladium-catalyzed reactions of enol ethers: access to enals, furans, and dihydrofurans.
PubMed:Isolation of thuridillins D-F, diterpene metabolites from the Australian sacoglossan mollusk Thuridilla splendens; relative configuration of the epoxylactone ring.
PubMed:A colorimetric and fluorescent chemosensor for Ni2+ based on donor-pi-acceptor charge transfer dye containing 2-cyanomethylene-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran acceptor and 4-bis(pyridin-2-ylmethyl)aminobenzene donor.
PubMed:Highly selective asymmetric Rh-catalyzed hydroformylation of heterocyclic olefins.
PubMed:Exploiting the ring strain in bicyclo[2.2.1]heptane systems for the stereoselective preparation of highly functionalized cyclopentene, dihydrofuran, pyrroline, and pyrrolidine scaffolds.
PubMed:A new highly selective fluorescent K+ sensor.
PubMed:Divergent synthetic routes for ring expansion or cyclization from 1,4-allylic diol derivatives via gold(I) catalysis or zinc(II) mediation.
PubMed:Ab initio study of the decomposition of 2,5-dimethylfuran.
PubMed:Preparation and characterization of conjugated polymers made by postpolymerization reactions of alternating polyketones.
PubMed:Highly cis-selective Rh(I)-catalyzed cyclopropanation reactions.
PubMed:Tracking bacterial infection of macrophages using a novel red-emission pH sensor.
PubMed:Adsorption and reactivity of 2,3-dihydrofuran and 2,5-dihydrofuran on Pd(111): influence of the C=C position on the reactivity of cyclic ethers.
PubMed:Highly enantioselective hydroformylation of dihydrofurans catalyzed by hybrid phosphine-phosphonite rhodium complexes.
PubMed:Star-shaped donor-pi-acceptor conjugated molecules: synthesis, properties, and modification of their absorptions features.
PubMed:Bright, Red Single-Molecule Emitters: Synthesis and Properties of Environmentally Sensitive Dicyanomethylenedihydrofuran (DCDHF) Fluorophores with Bisaromatic Conjugation.
PubMed:Clickable fluorescent dyes for multimodal bioorthogonal imaging.
PubMed:Synthesis of 3-vinyl-2,5-dihydrofuran ring system via enyne metathesis.
PubMed:Synthesis and property of solvatochromic fluorophore based on D-pi-A molecular system: 2-[[3-cyano-4-(N-ethyl-N-(2-hydroxyethyl)amino)styryl]-5,5-dimethylfuran-2(5H)-ylidene]malononitrile dye.
PubMed:Second-order nonlinear optical activity of dipolar chromophores based on pyrrole-hydrazono donor moieties.
PubMed:C-C reductive elimination in palladium complexes, and the role of coupling additives. A DFT study supported by experiment.
PubMed:DCDHF fluorophores for single-molecule imaging in cells.
PubMed:An efficient double 1,2-addition reaction of 2,3-allenoates with allyl magnesium chloride.
PubMed:Tests for genotoxicity and mutagenicity of furan and its metabolite cis-2-butene-1,4-dial in L5178Y tk+/- mouse lymphoma cells.
PubMed:PdI2-catalyzed coupling-cyclization reactions involving two different 2,3-allenols: an efficient synthesis of 4-(1',3'-dien-2'-yl)-2,5-dihydrofuran derivatives.
PubMed:PdCl2/NaI-catalyzed homodimeric coupling-cyclization reaction of 2,3-allenols: an efficient synthesis of 4-(1',3'-dien-2'-yl)-2,5-dihydrofuran derivatives.
PubMed:Ambient-pressure organic superconductors kappa-(DMEDO-TSeF)2[Au(CN)4](solv.): Tc tuning by modification of the solvent of crystallization.
PubMed:DFT calculations on the cyclic ethers hydrogen-bonded complexes: molecular parameters and the non-linearity of the hydrogen bond.
PubMed:Theoretical study of two-photon absorption properties of a series of ferrocene-based chromophores.
PubMed:Iridium complex-catalyzed [2+2+2] cycloaddition of alpha,omega-diynes with monoynes and monoenes.
PubMed:Rotational spectrum, inversion, and geometry of 2,5-dihydrofuran...ethyne and a generalization about Z...H-C hydrogen bonds.
PubMed:Systematic study of the structure-property relationship of a series of ferrocenyl nonlinear optical chromophores.
PubMed:Ring-opening reactions of methylenecyclopropanes with diphenyl diselenide upon heating; formation of 3-phenylselenyl-2,5-dihydrofuran derivatives.
PubMed:Unsaturated 1,2-amino alcohols and ethers from aziridines and organolithiums.
PubMed:Asymmetric synthesis of oxygen heterocycles via Pd-catalyzed dynamic kinetic asymmetric transformations: application to nucleosides.
PubMed:Role of temperature in controlling performance of photorefractive organic glasses.
PubMed:An expeditious and efficient procedure for the synthesis of unsaturated acyclonucleosides of Z configuration related to D4T.
PubMed:Electroreductive intramolecular cyclization of a bromo propargyloxy ester catalyzed by nickel(i) tetramethylcyclam electrogenerated at carbon cathodes in dimethylformamide.
PubMed:Efficient preparation of highly optically active (S)-(-)-2,3-allenols and (R)-(+)-2,3-allenyl acetates by a clean novozym-435-catalyzed enzymatic separation of racemic 2,3-allenols.
PubMed:Stereoselective synthesis of polysubstituted 2,5-dihydrofurans from reaction of 1,4-dilithio-1,3-dienes with aldehydes.
PubMed:Novel bioactive phospholipids: practical total syntheses of products from the oxidation of arachidonic and linoleic esters of 2-lysophosphatidylcholine(1).
PubMed:Application of the AAA reaction to the synthesis of the furanoside of C-2-epi-hygromycin A: a total synthesis of C-2-epi-hygromycin A.
PubMed:Syntheses of 1,4-benzothiazepines and 1,4-benzoxazepines via cyclizations of 1-[2-arylthio(oxy)ethyl]-5-benzotriazolyl-2-pyrrolidinones and 3-benzotriazolyl-2-[2-arylthio(oxy)ethyl]-1-isoindolinones.
PubMed:Preparation of 1,5-disubstituted pyrrolidin-2-ones.
PubMed:A short total synthesis of (+)-furanomycin.
PubMed:Reactivity of Cl-P(+)-Cl toward cyclic organic ethers.
PubMed:Asymmetric Hydroformylation of Heterocyclic Olefins Catalyzed by Chiral Phosphine-Phosphite-Rh(I) Complexes.
 
Notes:
None found
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