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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 303.00 to 304.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 263.00 °F. TCC ( 128.10 °C. ) (est)
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| logP (o/w): | 1.890 |
| Soluble in: |
| | alcohol | | | water, 1592 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 162 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 48, Pg. 722, 1959.
intravenous-frog LDLo 100 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 48, Pg. 722, 1959.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for gamma-thujaplicin usage levels up to: | | | not for fragrance use.
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| Recommendation for gamma-thujaplicin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2,4,6- | cycloheptatrien-1-one, 2-hydroxy-5- (1-methylethyl)- | | 2,4,6- | cycloheptatrien-1-one, 2-hydroxy-5-(1-methylethyl)- | | 2,4,6- | cycloheptatrien-1-one, 2-hydroxy-5-isopropyl- (8CI) | | 2- | hydroxy-5-(1-methyl ethyl)-2,4,6-cycloheptatrien-1-one | | 2- | hydroxy-5-(methylethyl)cyclohepta-2,4,6-trien-1-one | | 2- | hydroxy-5-isopropyl- 2,4,6-cycloheptatrienone | | 2- | hydroxy-5-isopropyl-2,4,6-cycloheptatrien-1-one | | 2- | hydroxy-5-isopropyl-2,4,6-cycloheptatrienone | | 2- | hydroxy-5-isopropylcyclohepta-2,4,6-trien-1-one | | 2- | hydroxy-5-propan-2-yl cyclohepta-2,4,6-trien-1-one | | 2- | hydroxy-5-propan-2-ylcyclohepta-2,4,6-trien-1-one | | 5-iso | propyl tropolone | | 5-iso | propyltropolone |
Articles:
| Google Patents:Synergistic mixtures of at least one 1,2 alkanediol such as 1,2-hexanediol and 1,2-octanediol with a further compound having antimicrobial properties |
| PubMed:Structure-activity relationships of the thujaplicins for inhibition of human tyrosinase. |
| PubMed:Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins. |
| PubMed:Effects of leaching on fungal growth and decay of western redcedar. |
| PubMed:Antifungal properties of ethanolic extract and its active compounds from Calocedrus macrolepis var. formosana (Florin) heartwood. |
| PubMed:Analysis of western redcedar (Thuja plicata Donn) heartwood components by HPLC as a possible screening tool for trees with enhanced natural durability. |
| PubMed:The excellence of Aomori Hiba (Hinokiasunaro) in its use as building materials of Buddhist temples and Shinto shrines. |
| PubMed:Biological activity of beta-dolabrin, gamma-thujaplicin, and 4-acetyltropolone, hinokitiol-related compounds. |
| PubMed:Biological activity of alpha-thujaplicin, the minor component of Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO. |
| PubMed:Cytotoxicity of the hinokitiol-related compounds, gamma-thujaplicin and beta-dolabrin. |
| PubMed:Antifungal activity of Hinokitiol-related compounds on wood-rotting fungi and their insecticidal activities. |
| PubMed:Phytogrowth-Inhibitory activities of beta-dolabrin and gamma-thujaplicin, hinokitiol-related compounds and constituents of Thujopsis dolabrata Sieb. et Zucc. var hondai Makino. |
| PubMed:Antimicrobial activity and metalloprotease inhibition of hinokitiol-related compounds, the constituents of Thujopsis dolabrata S. and Z. hondai MAK. |
| PubMed:Thujaplicins from Thuja plicata as iron transport agents for Salmonella typhimurium. |
| PubMed:A pharmacological study of gamma-thujaplicin. |
| PubMed:Antibiotic substances from the heart wood of Thuja plicata D. Don; the constitution of gamma-thujaplicin. |
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3D/inchi