peonol
acetophenone, 2'-hydroxy-4'-methoxy- (7CI,8CI)
 
Notes:
None found
  • Apiscent Labs
    • Apiscent Labs, LLC
      Delivery of Quality
      Custom manufacturer and international supplier of fine ingredients.
      We believe inspired chemistry enriches lives. That's why our team is guided by a mission to provide fine ingredients to the worldwide pharmaceutical, flavor and fragrance markets with a primary focus on the manufacturing of value-added, research-based molecules. We're innovative problem solvers committed to excellence at every phase. Our work builds the foundation for our clients' continued success.
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      2-Hydroxy-4-methoxyacetophenone
       
  • O'Laughlin Industries
    • O'Laughlin Industries Inc.
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      774-7136 Paeonol 90
       
  • TCI AMERICA
    • TCI AMERICA
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      Product(s):
      H0789 2'-Hydroxy-4'-methoxyacetophenone >98.0%(GC)
       
Synonyms   Articles   Notes   Search
1-(2-hydroxy-4-methoxyphenyl)ethanone (Click)
CAS Number: 552-41-0Picture of molecule
ECHA EINECS - REACH Pre-Reg: 209-012-2
FDA UNII: 3R834EPI82
Nikkaji Web: J4.483K
Beilstein Number: 1282794
MDL: MFCD00008730
XlogP3: 2.00 (est)
Molecular Weight: 166.17630000
Formula: C9 H10 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antioxidants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.13100 @  81.20 °C.
Refractive Index: 1.54320 @  81.20 °C.
Melting Point: 50.00 to  53.00 °C. @ 760.00 mm Hg
Boiling Point: 301.00 to  302.00 °C. @ 760.00 mm Hg (est)
Boiling Point: 154.00 °C. @ 20.00 mm Hg
Vapor Pressure: 0.001000 mm/Hg @ 25.00 °C. (est)
Flash Point: > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w): 1.980
Soluble in:
 alcohol
 water, 4965 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antioxidants
skin conditioning
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Suppliers:
Apiscent Labs
2-Hydroxy-4-methoxyacetophenone
Coompo
For experimental / research use only.
Peonol from Plants ≥96%
Odor: characteristic
Use: Paeonol increases levels of cortical cytochrome oxidase and vascular actin and improves behavior in a rat model of Alzheimer's disease. Paeonol also reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats. It shows antimutagenic activities. It also has anti-inflammatory and analgesic effects in carrageenan-evoked thermal hyperalgesia. Paeonol inhibits anaphylactic reaction by regulating histamine and TNF-a. It has demonstrated significant MAOI activity. MAO-A and MAO-B inhibiting effects with IC50 values of 54.6 M and 42.5 M respectively.
ExtraSynthese
For experimental / research use only.
Peonol (HPLC) ≥95%
Jalor-Chem
For experimental / research use only.
2'-Hydroxy-4'-methoxyacetophenone
O'Laughlin Industries
Paeonol 90
Santa Cruz Biotechnology
For experimental / research use only.
Paeonol
Sigma-Aldrich: Aldrich
For experimental / research use only.
2'-Hydroxy-4'-methoxyacetophenone 99%
TCI AMERICA
For experimental / research use only.
2'-Hydroxy-4'-methoxyacetophenone >98.0%(GC)
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50  490 mg/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 49, Pg. 84, 1953.

intravenous-mouse LD50  196 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 1205, 1969.

intraperitoneal-mouse LD50  781 mg/kg
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 1205, 1969.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antioxidants
Recommendation for peonol usage levels up to:
 not for fragrance use.
 
Recommendation for peonol flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 11092
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 1-(2-hydroxy-4-methoxyphenyl)ethanone
Chemidplus: 0000552410
RTECS: RT1215000 for cas# 552-41-0
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References:
 1-(2-hydroxy-4-methoxyphenyl)ethanone
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 11092
Pubchem (sid): 134978632
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2914.50.5000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 campsis grandiflora flower
Search Trop  Picture
 cynanchum stauntonii root
Search Trop  Picture
 daucus gingidium leaf
Search Trop  Picture
 dioscorea japonica root
Search Trop  Picture
 paeonia montana
Search Trop  Picture
 primula auricula
Search Trop  Picture
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Synonyms:
 acetophenone, 2'-hydroxy-4'-methoxy-
 acetophenone, 2'-hydroxy-4'-methoxy- (7CI,8CI)
1-acetyl-2-hydroxy-4-methoxybenzene
2-acetyl-5-methoxy-phenol
 ethanone, 1-(2-hydroxy-4-methoxyphenyl)-
1-[2-hydroxy-4-(methyloxy)phenyl]ethanone
1-(2-hydroxy-4-methoxy-phenyl)-ethanone
2-hydroxy-4-methoxyacetophenone
1-(2-hydroxy-4-methoxyphenyl) ethanone
1-(2-hydroxy-4-methoxyphenyl)ethanone
2'-hydroxy-4'-methoxyacetophenone
4-methoxy-2-hydroxyacetophenone
4'-methoxy-2'-hydroxyacetophenone
4-O-methyl resacetophenone
4-O-methylresacetophenone
 paeonol
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Articles:
PubMed: Paeonol attenuates advanced oxidation protein product-induced oxidative stress injury in THP-1 macrophages.
PubMed: Paeonol suppresses chondrosarcoma metastasis through up-regulation of miR-141 by modulating PKCδ and c-Src signaling pathway.
PubMed: Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury in vitro via downregulating microRNA-21 expression and TNF-α release.
PubMed: Acaricidal potentials of active properties isolated from Cynanchum paniculatum and acaricidal changes by introducing functional radicals.
PubMed: Paeonol suppresses lipopolysaccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock.
PubMed: Action potential bursts in central snail neurons elicited by paeonol: roles of ionic currents.
PubMed: Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases.
PubMed: Paeonol from Paeonia suffruticosa prevents TNF-alpha-induced monocytic cell adhesion to rat aortic endothelial cells by suppression of VCAM-1 expression.
PubMed: Paeonol inhibits RANKL-induced osteoclastogenesis by inhibiting ERK, p38 and NF-kappaB pathway.
PubMed: Peroxynitrite mediates high glucose-induced osteoblast apoptosis.
PubMed: Paeonol suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking p38, ERK and nuclear factor-kappaB signaling pathways.
PubMed: Acaricidal activities of paeonol and benzoic acid from Paeonia suffruticosa root bark and monoterpenoids against Tyrophagus putrescentiae (Acari: Acaridae).
PubMed: Insecticides in Chinese medicinal plants: survey leading to jacaranone, a neurotoxicant and glutathione-reactive quinol.
PubMed: Defensive chemistry of the flour beetleTribolium brevicornis (LeC): : Presence of known and potential prostaglandin synthetase inhibitors.
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