EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

polysorbate 40
tween 40

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CAS Number: 9005-66-7Picture of molecule3D/inchi
XlogP3-AA:2.50 (est)
Molecular Weight:522.67650000
Formula:C26 H50 O10
NMR Predictor:Predict (works with chrome or firefox)
Category:emulsifiers, surfactants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
EU SANCO Polysorbates View - review
EU SANCO Polyoxyethylene sorbitan monopalmitate (polysorbate 40) View - review
JECFA Food Additive: Polyoxyethylene (20) Sorbitan Monopalmitate
GSFA Codex: Polyoxyethylene (20) sorbitan monopalmitate (434)
DG SANTE Food Additives:polysorbate 40
DG SANTE Food Contact Materials:polysorbate 40
FDA Mainterm (IAUFC):9005-66-7 ; POLYSORBATE 40

Physical Properties:
Appearance:pale yellow to orange viscous liquid (est)
Food Chemicals Codex Listed: No
Specific Gravity:1.08300 @ 25.00 °C.
Refractive Index:1.47000 @ 20.00 °C.
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
Soluble in:
 ethyl acetate
 water, 0.1365 mg/L @ 25 °C (est)
Insoluble in:
 mineral oil
Organoleptic Properties:
Substantivity:400 Hour(s)
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: emulsifying agents
Covalent Chemical
Polysorbate 40
ECSA Chemicals
Polysorbate 40
Company Profile
Glentham Life Sciences
Tween 40
Kao Corporation
Odor: characteristic
Use: Emulsifier and conditioning agent (low substantive effect). Detoxifying agent in shampoos (low irritation). Fragrances solubilizer.
Kao Corporation
Odor: characteristic
Use: Emulsifier for pharmaceuticals and cosmetics, Stabilizer for color materials, Stabilizer for emulsion polymerizations, Emulsifier for adjuvant of agrochemicals, Emulsifier for water based metal process cutting oils, Surface coating type antistatic agents.
Lonza Group
Lonzest™ SMP-20
Mohini Organics
Odor: characteristic
Use: MONEBATT - 40 is used as a emulsifier, dispersant, penetrant, levelling agent, lubricant, antistat for textiles, cosmetics, pharmaceutical, polishes, insecticides, herbicides.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 38400 mg/kg
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 254, 1974.

intravenous-mouse LD50 50000 mg/kg
Bollettino Chimico Farmaceutico. Vol. 101, Pg. 173, 1962.

intravenous-rat LD50 1580 mg/kg
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 254, 1974.

intraperitoneal-rat LDLo > 4000 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 11, Pg. 150, 1959.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
Category: emulsifiers, surfactants
Recommendation for polysorbate 40 usage levels up to:
 not for fragrance use.
Recommendation for polysorbate 40 flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene
View page or View pdf

EPI System: View
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):9005-66-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :443314
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
RTECS:WG2933000 for cas# 9005-66-7
 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:9005-66-7
Pubchem (cid):443314
Pubchem (sid):135360886
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
KEGG (GenomeNet):C11624
HMDB (The Human Metabolome Database):HMDB37182
Export Tariff Code:3402.13.2020
FDA Listing of Food Additive Status:View
RSC Learn Chemistry:View
Potential Blenders and core components note
None Found
Potential Uses:
 emulsifying agents
Occurrence (nature, food, other):note
 not found in nature
 hetsorb p-20
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
 kaopan TW-P-120
 liposorb p-20
 lonzest SMP-20
 monebatt - 40
 poe-20 sorbitan monopalmitate
 polyoxyethylene (20) sorbitan monopalmitate
 rheodol TW-P120
 sorbimacrogol palmitate 300
 tween 40
Emulsifier, dough improver, crystallisation retarder, solubiliser, stabiliser, flavour dispersant, wetting agent, fruit or vegetable coating, defoamer for yeast/sugar Polysorbates are a class of emulsifiers used in some pharmaceuticals and food preparation. They are often used in cosmetics to solubilize essential oils into water-based products. Polysorbates are oily liquids derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids. (Wikipedia)
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