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sodium floride
sodium monofluoride

Sponsors

CAS Number: 7681-49-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:231-667-8
FDA UNII:8ZYQ1474W7
Nikkaji Web:J44.030B
MDL:MFCD00003524
Molecular Weight:41.98817248
Formula:F Na
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:food contact resinous and polymeric coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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FDA Mainterm: SODIUM FLUORIDE
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2800 Textiles and textile fibers.
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 993.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 water, 5.95e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antiplaque agents
oral care agents
 
Suppliers:
American Elements
Sodium Floride 99%
Odor: characteristic
Use: Sodium Fluoride is a water insoluble Sodium source for use in oxygen-sensitive applications, such as metal production. Fluoride compounds have diverse applications in current technologies and science, from oil refining and etching to synthetic organic chemistry and the manufacture of pharmaceuticals. Magnesium Fluoride, for example, was used by researchers at the Max Planck Institute for Quantum Optics in 2013 to create a novel mid-infrared optical frequency comb composed of crystalline microresonators, a development that may lead to future advances in molecular spectroscopy. Fluorides are also commonly used to alloy metals and for optical deposition. Sodium Fluoride is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Sodium Fluoride
Charkit Chemical
SODIUM FLUORIDE USP TABLETS
Charkit Chemical
SODIUM FLUORIDE USP
EMD Millipore
For experimental / research use only.
Sodium Floride
Penta International
SODIUM FLOURIDE, POWDER
Santa Cruz Biotechnology
For experimental / research use only.
Sodium Floride ≥99%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sodium Floride 99.99% trace metals basis
Strem Chemicals
For experimental / research use only.
Sodium fluoride, 99% (ACS)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 52 mg/kg
National Technical Information Service. Vol. UR-3490-95

oral-bird - wild LD50 110 mg/kg
Archives of Environmental Contamination and Toxicology. Vol. 16, Pg. 483, 1987.

intraperitoneal-dog LDLo 50 mg/kg
U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. Vol. UR-154, Pg. 1951

oral-human LDLo 71 mg/kg
BEHAVIORAL: TREMOR MUSCULOSKELETAL: CHANGES IN TEETH AND SUPPORTING STRUCTURES MUSCULOSKELETAL: OTHER CHANGES
"Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 1361, 1989.

oral-human LDLo 75 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 1033, 1966.

oral-human TDLo 214 ug/kg
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: HEADACHE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Revue Medicale de Liege. Vol. 12, Pg. 408, 1957.

oral-man TDLo 1662 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: NAUSEA OR VOMITING CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
JAMA, Journal of the American Medical Association. Vol. 222, Pg. 816, 1972.

intraperitoneal-mouse LD50 38 mg/kg
GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 237, 1982.

intravenous-mouse LD50 50830 ug/kg
GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 237, 1982.

oral-mouse LD50 57 mg/kg
Shika Gakuho. Journal of Dentistry. Vol. 80, Pg. 1519, 1980.

oral-rabbit LD50 200 mg/kg
Journal of Economic Entomology. Vol. 61, Pg. 751, 1968.

intraperitoneal-rat LD50 22 mg/kg
U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. Vol. UR-154, Pg. 1951

intravenous-rat LD50 26 mg/kg
SENSE ORGANS AND SPECIAL SENSES: TUMORS: OLFACTION SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Toxicology and Applied Pharmacology. Vol. 3, Pg. 278, 1961.

Dermal Toxicity:
subcutaneous-rat LD50 175 mg/kg
Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 411, 1968.

subcutaneous-cat LDLo 14 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935.

subcutaneous-dog LDLo 155 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935.

subcutaneous-frog LDLo 448 mg/kg
Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 124, Pg. 133, 1937.

subcutaneous-guinea pig LDLo 100 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935.

subcutaneous-mouse LD50 115 ug/kg
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 68(3), Pg. 55P-74P, 1972.

skin-mouse LDLo 300 mg/kg
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 183, Pg. 427, 1936.

subcutaneous-rabbit LDLo 100 mg/kg
"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: food contact resinous and polymeric coatings
Recommendation for sodium floride usage levels up to:
 not for fragrance use.
 
Recommendation for sodium floride flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):7681-49-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5235
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
sodium fluoride
Chemidplus:0007681494
EPA/NOAA CAMEO:hazardous materials
RTECS:7681-49-4
 
References:
 sodium fluoride
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7681-49-4
Pubchem (cid):5235
Pubchem (sid):134988532
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C08142
HMDB (The Human Metabolome Database):Search
FooDB:FDB015440
Haz-Map:View
Household Products:Search
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
•commercial grade (purity 93-99%) is used to prepare baits •technical grades are 90% and 95% naf, light (37 cu inlb) and dense (23 cu inlb), and 98% •sodium fluoride solution contains not less than 95% and not more than 105.0% of the labelled amount of sodium fluoride, usp xxi •the purity of the commercial material is about 98% •commercially available as tablets or solutions for oral admin and in dentifrices or as oral gels, pastes, or rinsing solutions for topical administration. •oral, topical use only: cream 1.1% (0.5% fluoride ion) control rx, omnii international prevident 5000 plus, (colgate oral), sf 5000 plus, cypress foam sodium fluoride 2% (0.9% fluoride ion) neutra-foam, (oral-b) gel 1.1% (0.5% fluoride ion) (karigel), maintenance-neutral, (young dental), neutracare, (oral-b), prevident brush-on gel ( with parabens), (colgate) oral sf gel, cypress thera-flur-n gel-drops ( with parabens), (colgate) oral rinsing solution 0.05% (0.02% fluoride ion) act, (johnson & johnson) fluorigard anti-cavity dental rinse ( with alcohol 6%, glycerin 15%, and tartrazine), (colgate) oral 0.2% (0.09% fluoride ion) fluorinse ( with parabens), (oral-b) prevident dental rinse ( with alcohol 5.8% and glycerin), (colgate oral). •oral: solution: 1.1 mgml (0.5 mg of fluoride ion per ml) luride drops ( with parabens and propylene glycol), (colgate) oral pediaflor drops ( with alcohol < 0.5% and parabens), (ross); 4.42 mgml (2.21 mg of fluoride ion per ml) karidium, (young dental); 11 mgml (5 mg of fluoride ion per ml) fluoritab liquid, fluoritab flura-drops, (kirkman). tablets: 2.2 mg (1 mg of fluoride ion) flura-tab, (kirkman). tablets, chewable: 0.55 mg (0.25 mg of fluoride ion) fluoritab, fluoritab luride f lozi-tabs quarter-strength ( with povidone), (colgate oral); 1.1 mg (0.5 mg of fluoride ion) fluoritab, fluoritab luride f lozi-tabs half-strength ( with povidone), (colgate oral); 2.2 mg (1 mg of fluoride ion) fluoritab, fluoritab flura-loz, kirkman luride f lozi-tabs full-strength ( with povidone), (colgate oral). •trade names for sodium fluoride include floridine, florocid, flura-drops, karidium, pergantine, t-fluoride, and villiaumite.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 oral care agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 disodium difluoride
 sodium flouride, powder
 sodium fluoride granular meets AWWA
 sodium fluoride USP
 sodium hydrofluoride
 sodium monofluoride
 sodiumfluoride
 
 
Notes:
a source of inorganic fluoride which is used topically to prevent dental caries. Indirect food contaminant arising from its use in adhesives for aluminium foil
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