EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sodium octanoate
octanoic acid, sodium salt (1:1)

Supplier Sponsors

CAS Number: 1984-06-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:217-850-5
FDA UNII: 9XTM81VK2B
Nikkaji Web:J43.159A
Beilstein Number:3597723
MDL:MFCD00058511
Molecular Weight:166.19571928
Formula:C8 H15 Na O2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:emulsifiers, surfactants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
FDA Mainterm (SATF):1984-06-1 ; SODIUM CAPRYLATE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.863 Salts of fatty acids.
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 239.00 to 240.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.022000 mmHg @ 25.00 °C. (est)
Flash Point: 225.00 °F. TCC ( 107.40 °C. ) (est)
logP (o/w): 2.903 (est)
Soluble in:
 water, 9.666e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: surfactants
surfactant - emulsifying
 
Suppliers:
Acme Synthetic Chemicals
Sodium Caprylate 98% min (Purity of Caprylic Acid by GC)
American International Chemical, LLC.
Sodium Caprylate
BOC Sciences
For experimental / research use only.
n-Octanoic Acid Sodium Salt 95%
Charkit Chemical
SODIUM CAPRYLATE
EMD Millipore
For experimental / research use only.
Sodium caprylate
Glentham Life Sciences
Sodium caprylate
Penta International
SODIUM CAPRYLATE EP GRADE
Penta International
SODIUM CAPRYLATE
Santa Cruz Biotechnology
For experimental / research use only.
Sodium Octanoate ≥99%
Sigma-Aldrich: Sigma
For experimental / research use only.
Sodium Octanoate ≥99% (capillary GC)
Viva Corporation
Sodium Caprylate
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
emulsifiers, surfactants
Recommendation for sodium octanoate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium octanoate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):1984-06-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23664772
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
sodium octanoate
Chemidplus:0001984061
RTECS:RH0787000 for cas# 1984-06-1
 
References:
 sodium octanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:1984-06-1
Pubchem (cid):23664772
Pubchem (sid):134982987
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D08999
HMDB (The Human Metabolome Database):Search
FooDB:FDB011449
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 emulsifying agents
 surfactants
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 caprylic acid sodium salt
 octanoic acid sodium salt
 octanoic acid sodium salt (1:1)
 octanoic acid, sodium salt
 octanoic acid, sodium salt (1:1)
 sodium caprylate
 sodium caprylate NF
 sodium N-octanoate
 sodium octanoate
 sodium octoate
 sodiumcaprylate
 

Articles:

PubMed:N-acetyl-l-methionine is a superior protectant of human serum albumin against photo-oxidation and reactive oxygen species compared to N-acetyl-l-tryptophan.
PubMed:Effects of small ionic amphiphilic additives on reverse microemulsion morphology.
PubMed:Systemic and renal haemodynamic effects of fluid bolus therapy: sodium chloride versus sodium octanoate-balanced solution.
PubMed:A Novel Suspension Formulation Enhances Intestinal Absorption of Macromolecules Via Transient and Reversible Transport Mechanisms.
PubMed:The role of caprylate ligand ion on the stabilization of human serum albumin.
PubMed:Design and implementation of an automated liquid-phase microextraction-chip system coupled on-line with high performance liquid chromatography.
PubMed:Endogenous amylin and glucagon-like peptide-1 concentrations are not associated with gastric emptying in critical illness.
PubMed:The interaction of long chain sodium carboxylates and sodium dodecylsulfate with lead(II) ions in aqueous solutions.
PubMed:Aggregation thermodynamics of sodium octanoate micelles studied by means of molecular dynamics simulations.
PubMed:Effects of sodium octanoate on innate immune response of mammary epithelial cells during Staphylococcus aureus internalization.
PubMed:Caprylate as the albumin-selective modifier to improve IgG purification with hydrophobic charge-induction chromatography.
PubMed:Biosynthesis and characterization of polyhydroxyalkanoates by Pseudomonas guezennei from alkanoates and glucose.
PubMed:Metabolic imaging of multiple x-nucleus resonances.
PubMed:Purification of polyclonal antibodies from Cohn fraction II + III, skim milk, and whey by affinity chromatography using a hexamer peptide ligand.
PubMed:Development of a three-steps derivatization assay for the localization of double bond in monounsaturated monomers of poly-beta-hydroxyalkanoates by GC-MS.
PubMed:What drives the precipitation of long-chain calcium carboxylates (soaps) in aqueous solution?
PubMed:Modification of the Two-Point Scaling Theory for the Description of the Phase Transition in Solution. Analysis of Sodium Octanoate Aqueous Solutions.
PubMed:Effect of metal ion hydration on the interaction between sodium carboxylates and aluminum(III) or chromium(III) ions in aqueous solution.
PubMed:Solvation of sodium octanoate micelles in concentrated urea solution studied by means of molecular dynamics simulations.
PubMed:Polyhydroxyalkanoate production by antarctic soil bacteria isolated from Casey Station and Signy Island.
PubMed:Mobile phase modifier effects in multimodal cation exchange chromatography.
PubMed:Fibrinogen stability under surfactant interaction.
PubMed:Production and characterization of liquid-stored and lyophilized reconstituted human infusible platelet membranes.
PubMed:Poly-3-hydroxyoctanoate P(3HO), a medium chain length polyhydroxyalkanoate homopolymer from Pseudomonas mendocina.
PubMed:In vitro antimicrobial properties of caprylic acid, monocaprylin, and sodium caprylate against Dermatophilus congolensis.
PubMed:Expression and characterization of (R)-specific enoyl coenzyme A hydratases making a channeling route to polyhydroxyalkanoate biosynthesis in Pseudomonas putida.
PubMed:Rheological properties of ovalbumin hydrogels as affected by surfactants addition.
PubMed:Water administration of the medium-chain fatty acid caprylic acid produced variable efficacy against enteric Campylobacter colonization in broilers.
PubMed:Performance of hexamer peptide ligands for affinity purification of immunoglobulin G from commercial cell culture media.
PubMed:Metabolic engineering for microbial production of polyhydroxyalkanoates consisting of high 3-hydroxyhexanoate content by recombinant Aeromonas hydrophila.
PubMed:Conditional downregulation of brain- derived neurotrophic factor and tyrosine kinase receptor B blocks epileptogenesis in the human temporal lobe epilepsy hippocampus.
PubMed:The influence of nitrogen limitation on mcl-PHA synthesis by two newly isolated strains of Pseudomonas sp.
PubMed:Validation of a simple, rapid and cost effective method for the estimation of caprylic acid and sodium caprylate from biological products using NEFA-C kit.
PubMed:Effect of alkyl chain asymmetry on catanionic mixtures of hydrogenated and fluorinated surfactants.
PubMed:Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion.
PubMed:Rapid determination of surfactant critical micelle concentrations using pressure-driven flow with capillary electrophoresis instrumentation.
PubMed:Evaluation of the 13C-octanoate breath test as a surrogate marker of liver damage in animal models.
PubMed:Inhibition of Salmonella typhimurium by medium-chain fatty acids in an in vitro simulation of the porcine cecum.
PubMed:Pseudomonas extremaustralis sp. nov., a Poly(3-hydroxybutyrate) producer isolated from an antarctic environment.
PubMed:Capillary electrophoresis with indirect UV detection for the determination of stabilizers and citrates present in human albumin solutions.
PubMed:Sodium octanoate to reverse indoxyl sulfate and p-cresyl sulfate albumin binding in uremic and normal serum during sample preparation followed by fluorescence liquid chromatography.
PubMed:Enhanced production of medium-chain-length polyhydroxyalkanoates (PHA) by PHA depolymerase knockout mutant of Pseudomonas putida KT2442.
PubMed:Large-scale production of poly(3-hydroxyoctanoic acid) by Pseudomonas putida GPo1 and a simplified downstream process.
PubMed:Entacapone improves absorption of a coadministered salt in patients with Parkinson's disease.
PubMed:Microbial production of medium-chain-length 3-hydroxyalkanoic acids by recombinant Pseudomonas putida KT2442 harboring genes fadL, fadD and phaZ.
PubMed:Effect of chain length on binding of fatty acids to Pluronics in microemulsions.
PubMed:Electrophoretic and spectroscopic characterization of the protein patterns formed in different surfactant solutions.
PubMed:Linker-based lecithin microemulsions for transdermal delivery of lidocaine.
PubMed:On relationships between surfactant type and globular proteins interactions in solution.
PubMed:Molecular characterization of Pseudomonas sp. LDC-5 involved in accumulation of poly 3-hydroxybutyrate and medium-chain-length poly 3-hydroxyalkanoates.
PubMed:Purification of antibodies using the synthetic affinity ligand absorbent MAbsorbent A2P.
PubMed:Determination of drug and fatty acid binding capacity to pluronic f127 in microemulsions.
PubMed:[Effects of absorption enhancers on intestinal absorption of lumbrokinase].
PubMed:Gastric emptying time of fluids and solids in healthy subjects determined by 13C breath tests: influence of age, sex and body mass index.
PubMed:The role of N-acetyl-methioninate as a new stabilizer for albumin products.
PubMed:Inactivation of escherichia coli O157:H7 in cattle drinking water by sodium caprylate.
PubMed:Structure and polymer form of poly-3-hydroxyalkanoates produced by Pseudomonas oleovorans grown with mixture of sodium octanoate/undecylenic acid and sodium octanoate/5-phenylvaleric acid.
PubMed:Regarding the effect that different hydrocarbon/fluorocarbon surfactant mixtures have on their complexation with HSA.
PubMed:Regulation of polyhydroxyalkanoate synthases (phaC1 and phaC2) gene expression in Pseudomonas corrugata.
PubMed:Deposition of insulin powders for inhalation in vitro and pharmacodynamic evaluation of absorption promoters in rats.
PubMed:Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans.
PubMed:Effects of fluorinated and hydrogenated surfactants on human serum albumin at different pHs.
PubMed:[Examination of gastric emptying rate by means of 13C-octanoic acid breath test. Methods of the test for adults and results of the investigation of healthy volunteers].
PubMed:A molecular modeling study of pentanol solubilized in a sodium octanoate micelle.
PubMed:Preparation of cadmium sulfide nanoparticles in self-reproducing reversed micelles.
PubMed:Binary phase equilibria of three alpha-methyl-substituted sodium alkanoate surfactants.
PubMed:Pharmacokinetics, toxicity of nasal cilia and immunomodulating effects in Sprague-Dawley rats following intranasal delivery of thymopentin with or without absorption enhancers.
PubMed:Absorption enhancement, mechanistic and toxicity studies of medium chain fatty acids, cyclodextrins and bile salts as peroral absorption enhancers.
PubMed:A comparative study of the physicochemical properties of perfluorinated and hydrogenated amphiphiles.
PubMed:Liquid-phase microextraction based on carrier mediated transport combined with liquid chromatography-mass spectrometry. New concept for the determination of polar drugs in a single drop of human plasma.
PubMed:Temperature-sensitive critical micelle transition of sodium octanoate.
PubMed:Conformational peculiarities of alcohols incorporated in lyotropic and thermotropic liquid crystals.
PubMed:Impaired gastric emptying of a solid test meal in patients with Parkinson's disease using 13C-sodium octanoate breath test.
PubMed:Heat capacity of transfer of (Ethylene oxide)13-(propylene oxide)30-(ethylene oxide)13 from water to the aqueous anionic surfactant solutions at 298 K. A quantitative treatment.
PubMed:Structural micellar transition for fluorinated and hydrogenated sodium carboxylates induced by solubilization of benzyl alcohol.
PubMed:[Study on pulmonary delivery of peptide drugs in rats: effects of absorption enhancers on cellular membrane fluidity].
PubMed:Biosynthesis of natural-synthetic hybrid copolymers: polyhydroxyoctanoate-diethylene glycol.
PubMed:Gastric inhibitory polypeptide does not inhibit gastric emptying in humans.
PubMed:Polyhydroxyalkanoate (PHA) biosynthesis in Thermus thermophilus: purification and biochemical properties of PHA synthase.
PubMed:[Study on pulmonary delivery system of salmon calcitonin in rats].
PubMed:Liquid-phase microextraction of hydrophilic drugs by carrier-mediated transport.
PubMed:Fourier transform infrared spectroscopy for screening and quantifying production of PHAs by Pseudomonas grown on sodium octanoate.
PubMed:[Effect of varied sample treatment procedures on detection of hepatitis B virus DNA].
PubMed:Effect of protein-bound uraemic toxins on the thermodynamic characteristics of human albumin.
PubMed:Formation of short chain length/medium chain length polyhydroxyalkanoate copolymers by fatty acid beta-oxidation inhibited Ralstonia eutropha.
PubMed:Effect of meal size and test duration on gastric emptying and gastric myoelectrical activity as determined with simultaneous [13C]octanoate breath test and electrogastrography in normal subjects using a muffin meal.
PubMed:Estimation of absorption enhancement by medium-chain fatty acids in rat large intestine.
PubMed:Isolation of bovine plasma albumin by liquid chromatography and its polymerization for use in immunohematology.
PubMed:Alkane derivative-bacteriorhodopsin interaction: proton transport and protein structure.
PubMed:Spectrochemical investigations in molecularly organized solvent media: evaluation of pyridinium chloride as a selective fluorescence quenching agent of polycyclic aromatic hydrocarbons in aqueous carboxylate-terminated poly(amido) amine dendrimers and anionic micelles.
PubMed:Phase Transition Processes in Surfactant Adsorption Layers.
PubMed:Interactions between Poly(ethylene oxide) and Sodium Alkylcarboxylates As Studied by Conductivity and Gel Permeation Chromatography.
PubMed:Effects of organic acids on lipid synthesis and ecdysis in Triatoma infestans eggs.
PubMed:Albumin purification from human placenta.
PubMed:Rectal absorption of [Bis (acetato) ammine dichloro (cyclohexylamine) platinum(IV)] (BMS-182751), a new anti-tumor agent, in rats.
PubMed:Spectrochemical investigations of fluorescence quenching agents. Part 5. Effect of surfactants of the ability of nitromethane to selectively quench fluorescence emission of alternant PAHs.
PubMed:5-Fluorouracil-loaded chitosan microspheres: preparation and release characteristics.
PubMed:Biophysical studies on the correction of uremic human serum albumin binding defects by in vitro charcoal adsorption treatment.
PubMed:Pressor effects of portal venous oleate infusion. A proposed mechanism for obesity hypertension.
PubMed:Suppression of the inhibitory effect of denatured albumin on the polymerase chain reaction by sodium octanoate: application to routine clinical detection of hepatitis B virus at its infectivity threshold in serum.
PubMed:Dye-ligand affinity purification of human complement factor B and beta 2 glycoprotein I.
PubMed:Role of paracellular pathway in nonelectrolyte permeation across rat colon epithelium enhanced by sodium caprate and sodium caprylate.
PubMed:[The effect of mildronate on carnitine-dependent and carnitine-independent ketogenesis in rats].
PubMed:Oncolytic effects of fatty acids in mice and rats.
PubMed:Continuous Production of Long-Side-Chain Poly-beta-Hydroxyalkanoates by Pseudomonas oleovorans.
PubMed:High-porosity activated carbons for bilirubin removal.
PubMed:[Study of the effect of an inhibitor of carnitine-dependent metabolism of mildronate on the oxidation of fatty acids in the liver mitochondria of intact rats].
PubMed:Intestinal effects of the products of lipid digestion on gastric electrical activity in the cat. Possible involvement of vagal intestinal receptors sensitive to lipids.
PubMed:Duration of absorption-enhancing effect of sodium octanoate, sodium hexanoate or glyceryl-1-monooctanoate on rectal absorption of gentamicin in rabbits.
PubMed:Effect of phenol and sodium octanoate on the astrocyte benzodiazepine receptor.
PubMed:Effect of medium-chain fatty acid salts on penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas.
PubMed:HPLC analysis of brain and plasma for octanoic and decanoic acids.
PubMed:Rectal absorption enhancement of gentamicin in rabbits from hollow type suppositories by sodium salicylate or sodium caprylate.
PubMed:Effect of absorption promoters in intranasal administration of human fibroblast interferon as a powder dosage form in rabbits.
PubMed:On octanoic acid-induced hyperventilation--implications for hepatic encephalopathy and Reye's syndrome.
PubMed:Rate-controlled rectal absorption enhancement of cefoxitin by co-administration of sodium salicylate or sodium octanoate in healthy volunteers.
PubMed:Enhancement of colonic drug absorption by the transcellular permeation route.
PubMed:Quantitative determination of sodium-octanoate in human serum albumin preparations.
PubMed:Absorption enhancement of rectally infused cefoxitin sodium by medium-chain fatty acids in conscious rats: concentration-effect relationship.
PubMed:Enhancement of colonic drug absorption by the paracellular permeation route.
PubMed:Fluorescence study of the membrane-perturbing action of sodium caprylate as related to promotion of drug absorption.
PubMed:Effect of sodium octanoate and sodium perfluorooctanoate on gel-to-liquid-crystalline phase transition of dipalmitoylphosphatidylcholine vesicle membrane.
PubMed:Studies on the promoting effects of medium chain fatty acid salts on the nasal absorption of insulin in rats.
PubMed:Effects of therapeutic agents in a rabbit model of Reye syndrome.
PubMed:Determination of sodium caprylate in plasma volume expanders by gas chromatography.
PubMed:Alterations in serum glucose and hepatic glycogen concentrations during octanoate administration in rabbits.
PubMed:Effect of octanoate on blood-brain barrier permeability using L-dopa as a marker.
PubMed:The effect of DDT on the polymorphism at the G6pd and Pgd loci in Drosophila melanogaster.
PubMed:Pathologic changes in a rabbit model of Reye's syndrome.
PubMed:Selection at the alpha-Gpdh locus in experimental populations of Drosophila melanogaster.
PubMed:Comparison between two preparations of human serum albumin in treatment of neonatal hyperbilirubinaemia.
PubMed:Albumin administration combined with phototherapy in treatment of hyperbilirubinaemia in low-birth-weight infants.
PubMed:Polymorphism at the G6pd and 6Pgd loci in Drosophila melanogaster. IV. Genetic factors modifying enzyme activity.
PubMed:Regional cerebral Na+K+ ATPase activity following octanoate administration.
PubMed:[Hyperoctanoatemia and the hepatic encephalopathy of cirrhosis. 150 dosages in 61 patients (author's transl)].
PubMed:Glucose binding and transport proteins extracted from fast-growing chicken fibroblasts.
PubMed:Short chain fatty acid-induced central hyperventilation in rabbits.
PubMed:Effect of sodium octanoate on leucine incorporation into protein of rat liver slices and of Yoshida ascites hepatoma cells.
PubMed:The effects of intravenous sodium octanoate on the rhesus monkey.
PubMed:Bilirubin displacing effect of stabilizers added to injectable preparations of human serum albumin.
PubMed:Experimental induction of caprylate-dependent albumin antibodies.
PubMed:Serologic activity of fatty acid dependent antibodies in albumin-free systems.
PubMed:Effect of fatty acids on renal ammoniagenesis in in vivo and in vitro studies.
PubMed:Problems in pre-transfusion tests related to drugs and chemicals.
PubMed:Another potential source of error in Rh-hr typing.
PubMed:Effect of long- and medium-chain fatty acids on insulin secretion from pieces of rat pancreas.
PubMed:Purification of fibrinogen using cationic detergent.
PubMed:Platelet reactivity ex vivo and in vivo after acute and chronic treatment with sodium caprylate.
PubMed:[Use of sodium caprylate for the separation of plasma proteins].
PubMed:[Coma induced in Macaca mulatta by intravenous sodium octanoate. Polygraphic study].
PubMed:A new method for evaluation of portasystemic shunting. The rectal octanoate tolerance test.
PubMed:The effect of sodium propionate and sodium caprylate on the fatty acid content of Trichophyton rubrum.
PubMed:Feedback inhibition of key glycolytic enzymes in liver: action of free fatty acids.
PubMed:EFFECTS OF SODIUM CAPRYLATE ON CANDIDA ALBICANS. II. INFLUENCE OF VARIOUS CONCENTRATIONS ON BIOCHEMICAL CHANGES.
PubMed:EFFECTS OF SODIUM CAPRYLATE ON CANDIDA ALBICANS. I. INFLUENCE OF CONCENTRATION ON ULTRASTRUCTURE.
PubMed:THE INTERACTION OF SOME STIMULANT AND DEPRESSANT DRUGS ON THE FROG HEART.
PubMed:[EXPERIMENTAL DATA ON THE PHARMACOLOGY OF SALICYLANILIDE, 5-BROMOSALICYL-4-BROMOANILIDE AND SODIUM CAPRYLATE].
PubMed:Fatty acid oxidation by spores of Penicillium roqueforti.
PubMed:Importance of calcium in the actions of some drugs that stimulate the isolated hypodynamic frog heart.
PubMed:Cytological and physiological effects of sodium caprylate on Candida albicans.
PubMed:[Prevention of thermal denaturation of serum albumin by sodium caprylate].
PubMed:A method for minimizing the fungistatic activity of sodium caprylate in sterility testing.
PubMed:Four new fungicides for Coccidioides immitis: 1. Sodium caprylate. 2. Ethyl vanillate 3. Fradicin. 4. Thiolutin.
PubMed:[Protective action of sodium caprylate on protein denaturation].
PubMed:Sodium caprylate treatment for thrusii.
PubMed:Cardiovascular effects of sodium caprylate in the cat.
PubMed:Effect of sodium caprylate on the thermal stability of the respiratory system in rat brain.
PubMed:The effect of sodium caprylate on the cardiac output of the isolated frog heart.
PubMed:Sodium caprylate; a new and effective treatment for moniliasis of the skin and mucous membranes.
PubMed:Sodium caprylate; a new and effective treatment for dermatomycosis of the feet.
 
Notes:
Used in foods as a binder, emulsifier and anticaking agent
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