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potassium orotate
4-pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, potassium salt (1:1)

Supplier Sponsors

CAS Number: 24598-73-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:246-341-0
FDA UNII: 6ZDN9W1C9W
MDL:MFCD00039118
Molecular Weight:195.19590000
Formula:C5 H4 N2 O4.K
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nutrient supplements, EFSA concludes: use is of safety concern.
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -0.928 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American International Chemical, LLC.
Potassium Orotate Anhydrous
BOC Sciences
For experimental / research use only.
Potassium 2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
Global Calcium
Potassium Orotate
Penta International
POTASSIUM OROTATE
Sigma-Aldrich: Sigma
For experimental / research use only.
Orotic acid potassium salt ≥99%
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 10900 mg/kg
Russian Pharmacology and Toxicology Vol. 51, Pg. 100, 1988.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements, EFSA concludes: use is of safety concern.
Recommendation for potassium orotate usage levels up to:
 not for fragrance use.
 
Recommendation for potassium orotate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Orotic acid salts as sources of orotic acid and various minerals added for nutritional purposes to food supplements
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):24598-73-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :23665705
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
potassium 2,4-dioxo-1H-pyrimidine-6-carboxylate
Chemidplus:0024598730
RTECS:RM3201500 for cas# 24598-73-0
 
References:
 potassium 2,4-dioxo-1H-pyrimidine-6-carboxylate
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):23665705
Pubchem (sid):135046017
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
2,6-dioxo-1,3-dihydropyrimidine-4-carboxylic acid, potassium salt
 etrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid monopotassium salt, 1,2,3,6-t
 orotic acid potassium salt
 orotic acid, monopotassium salt
 potassium 1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylate
 potassium 2,4-dioxo-1H-pyrimidine-6-carboxylate
 potassium 2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylate
 potassium 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate
 potassium orotate anhydrous
 potassiumorotate
4-pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, monopotassium salt
4-pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, potassium salt (1:1)
1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid monopotassium salt
 

Articles:

PubMed:[New derivatives of triazino- and imidazoindole with hepatoprotective activity].
PubMed:[Psychophysiological effects of combined administration of pantogam and potassium orotate in patients with neurotic disorders].
PubMed:[Effectiveness of treating periodontitis in patients with thyroid dysfunction].
PubMed:[Effects of bemethyl, ethomersol, and yakton on the liver regeneration after partial hepatectomy].
PubMed:[Effect of potassium orotate on the reversibility of cirrhotic changes and regeneration of the rat liver].
PubMed:[Content of components of the renin-angiotensin-aldosterone system and prostaglandins series E, F in various organs after suturing of peripheral nerves during treatment with dehydrating agents].
PubMed:Metabolic effect of orotic acid in calves.
PubMed:[The carbohydrate-resistant mechanism of the action of caries-prophylactic agents on the oral fluid in children].
PubMed:[The treatment results in patients with gouty nephropathy].
PubMed:[Structure of the liver after correction of experimental chronic hepatitis with benzonal and potassium orotate].
PubMed:[Mud treatment of patients with rheumatoid arthritis with an immunologic deficiency].
PubMed:[The glycolytic status of peripheral blood phagocytes and its therapeutic correction in patients with foot mycoses].
PubMed:[Effect of quinazopyrine on the process of reparative regeneration].
PubMed:[Mechanism of the action of potassium orotate on sodium excretion from the body].
PubMed:[Use of neurotropic drugs and potassium orotate in the complex treatment of patients with chronic salpingo-oophoritis with marked pain syndrome].
PubMed:[Pharmacological correction of central nervous system function in exposure to Coriolis acceleration].
PubMed:[Quantitative evaluation of the anxiolytic and nootropic effects of potassium orotate in a wide range of doses].
PubMed:[Effect of pyridoxine, riboflavin, potassium orotate, folic and glutamic acids on the recovery of work capacity in sexually immature rats].
PubMed:[Comparative study of the indices of the antidepressive activity of potassium orotate and piracetam].
PubMed:[The action of potassium orotate in prophylactic and therapeutic administration to irradiated rats].
PubMed:[Reparative regeneration of the liver as a model for the preclinical study of the hepatotropism of anti-alcohol agents].
PubMed:[Various principles of therapeutic tactics in epilepsy patients during pregnancy].
PubMed:[Electron-radioautographic study of the effect of potassium orotate on RNA and protein synthesis in fibroblasts during experimental wound healing].
PubMed:[Anxiolytic effect of potassium orotate].
PubMed:[Effect of potassium orotate on the metabolism of various vitamins in patients with long bone fractures].
PubMed:The enzymatic status of circulating lymphocytes as an index of the regenerative process in the lungs under stimulation with pyrimidine and purine derivatives. A clinical experimental study.
PubMed:The status of the lymphoid system under conditions of lung regeneration stimulation.
PubMed:[Potassium orotate and polyvitamins in the treatment of fractures].
PubMed:[Effect of potassium orotate and the sodium salt of uridine monophosphate on the development of experimental adrenaline myocardial dystrophy].
PubMed:[Morphologic and biochemical study of stimulated collagenogenesis].
PubMed:[Oxidative phosphorylation in cardiac muscle mitochondria during combined treatment of experimental myocardial infarct with potassium orotate and hyperbaric oxygenation].
PubMed:[Therapeutic effect of indomethacin and potassium orotate in experimental nephritis in rats].
PubMed:[Dependence of calcium absorption in the chicken small intestine on its Ca2+-binding protein content and the effect of exogenous nucleotide precursors on this process].
PubMed:[Effect of anabolic substances on the state of the individual components of the glutathione-ascorbic acid system].
PubMed:[Comparative evaluation of the effectiveness of 2 drug combinations (strophanthin and potassium orotate, strophanthin and methyluracil) in circulatory insufficiency].
PubMed:[Action of potassium orotate, hyperbaric oxygenation and their combination on the course of experimental microfocal myocardial infarct].
PubMed:[Autoradiographic analysis of the effect of potassium orotate on the intensity of uridine-5 3H and proline-3H incorporation into wound fibroblasts].
PubMed:[Effect of potassium orotate and guanine on calcium uptake in small intestine of chickens with different amounts of vitamin D3].
PubMed:[Autoradiographic study of stimulation of RNA synthesis in fibroblasts].
PubMed:[Effect of potassium orotate on metabolism in chickens under different provision with vitamin D3].
PubMed:[DNA synthesis by granulation tissue fibroblasts under conditions of stimulation of the wound process].
PubMed:[Differential spectrophotometric method of determining potassium orotate].
PubMed:[Strophanthin sensitivity in disorders of cardiac blood supply, altered immunologic reactivity and under the influence of several pharmacologic agents].
PubMed:[Effect of complex treatment using potassium orotate on the non-specific immunologic reactivity of children with viral hepatitis].
PubMed:[Autoradiographic study of the rate of collagen synthesis under conditions of stimulation of the wound process].
PubMed:[An autoradiographic and electron microscopic study of fibroblasts under conditions of stimulation of the wound process].
PubMed:[Changes in hemodynamics in acute myocardial infarct following administration of potassium orotate].
PubMed:[Stimulation of fibrillogenesis in granulation tissue].
PubMed:[Effect of potassium orotate on the clinical laboratory indices of viral hepatitis in children].
PubMed:[Effect of potassium orotate on compensatory hypertrophy of the remaining lung after left-side pneumonectomy].
PubMed:[Mechanisms of the effect of orotic acid on the growth and development of young rats].
PubMed:[Effect of potassium orotate on the contractile function of the myocardium in patients with coronary aterosclerosis].
PubMed:[Effect of potassium orotate on the indicators of rheohepatogram in patients with coronary arteriosclerosis].
PubMed:[Effect of potassium orotate and nerobol on the nucleic acid metabolism in patients with pulmonary tuberculosis].
PubMed:Effect of potassium orotate on the transport of organic substances in the kidneys.
PubMed:[Prevention of experimental adrenaline damage to the myocardium with potassium orotate].
PubMed:[The effect of potassium orotate on the ultrastructure of cardiac muscle cells in experimental myocardial infarct].
PubMed:[Some results of treatment of chronic hepatitis with potassium orotate (first preliminary report)].
PubMed:[Effect of potassium orotate on the bile-secretion function of the liver in normal state and in experimental hepatitis].
PubMed:[Use of potassium orotate in patients with diabetes mellitus].
PubMed:[Effect of potassium orotate on the course of myocardial infarct].
PubMed:[Therapeutic use of potassium orotate].
PubMed:[Experiences with potassium orotate in hyperuricemic subjects].
PubMed:[Behavior of bloodketones in chronic decompensated liver diseases, in the course of treatment with potassium orotate and alpha-tocopherol].
PubMed:[Influence of potassium orotate on hydrosaline metabolism in patients of liver disease].
PubMed:[Orotic acid (Potassium orotate): Its use in dermatology (Preliminary communication)].
PubMed:[Effects of potassium orotate on various pentose fractions in the blood of normal individuals].
PubMed:[First experience with potassium orotate therapy of chronic liver diseases].
PubMed:[Notes on a case of edematigenous complex deficiency syndrome in a gastrectomized subject; combined potassium orotate and vitamin E therapy].
PubMed:[Behavior of blood ketones in chronic decompensated liver diseases during treatment with potassium orotate & alpha-tocopherol].
 
Notes:
None found
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