magnesium hydroxide
magnesium(2+) hydroxide
 
Notes:
an inorganic compound that occurs in nature as the mineral brucite. it acts as an antacid with cathartic effects. Used in foods as a dietary supplement, pH control agent and processing aid Magnesium hydroxide is an inorganic compound with the chemical formula Mg(OH)2. As a suspension in water, it may be referred to as Milk of Magnesia. The solid mineral form of magnesium hydroxide is known as brucite.
  • Charkit Chemical
    • Charkit Chemical Corporation
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      MAGNESIUM HYDROXIDE POWDER USP FCC
       
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      Magnesium Hydroxide
       
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    • Penta International Corporation
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      13-00900 MAGNESIUM HYDROXIDE USP
       
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magnesium dihydroxide (Click)
CAS Number: 1309-42-8Picture of molecule
ECHA EINECS - REACH Pre-Reg: 215-170-3
FDA UNII: NBZ3QY004S
MDL: MFCD00011104
Molecular Weight: 58.31934000
Formula: Mg H2 O2
NMR Predictor: Predict (works with chrome or firefox)
Category: nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Google Scholar: with word "flavor"Search
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Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
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Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1428 Magnesium hydroxide View-review
JECFA Food Additive: Magnesium Hydroxide
GSFA Codex: Magnesium hydroxide (528)
DG SANTE Food Additives: magnesium hydroxide
DG SANTE Food Contact Materials: magnesium hydroxide
FDA Mainterm: MAGNESIUM HYDROXIDE
FDA Regulation:
FDA PART 155 -- CANNED VEGETABLES
Subpart B--Requirements for Specific Standardized Canned Vegetables
Sec. 155.170 Canned peas.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.180 Components of paper and paperboard in contact with dry food.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.210 Defoaming agents used in the manufacture of paper and paperboard.


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1428 Magnesium hydroxide.
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Physical Properties:
Appearance: white powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 100.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 24.500000 mm/Hg @ 25.00 °C. (est)
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -1.380 (est)
Soluble in:
 water, 7.605e+005 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
 water
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Organoleptic Properties:
Odor Description:
at 100.00 %. 
odorless
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: absorbents
buffering agents
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Suppliers:
Allan Chemical
Magnesium Hydroxide Powder
American Elements
Magnesium Hydroxide 99%
Odor: characteristic
Use: Magnesium Hydroxide is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. Hydroxide, the OH- anion composed of an oxygen atom bonded to a hydrogen atom, is commonly present in nature and is one of the most widely studied molecules in physical chemistry. Hydroxide compounds have diverse properties and uses, from base catalysis to detection of carbon dioxide. In a watershed 2013 experiment, scientists at JILA (the Joint Institute for Laboratory Astrophysics) achieved evaporative cooling of compounds for the first time using hydroxide molecules, a discovery that may lead to new methods of controlling chemical reactions and could impact a range of disciplines, including atmospheric science and energy production technologies. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia)and follows applicable ASTM testing standards.
American International Chemical
Magnesium Hydroxide
Charkit Chemical
MAGNESIUM HYDROXIDE POWDER USP FCC
ECSA Chemicals
Magnesium Hydroxide
Company Profile
HallStar
MARINCO H (RX-14073)
Odor: characteristic
Use: MARINCO H (RX-14073) is a high activity magnesium hydroxide that is used as an acid acceptor, buffer and as a chemical thickener for SMC.
Penta International
MAGNESIUM HYDROXIDE USP
Sigma-Aldrich
For experimental / research use only.
Magnesium Hydroxide reagent grade, 95%
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  8500 mg/kg
Drugs in Japan Vol. -, Pg. 1131, 1990.

intraperitoneal-rat LD50  2780 mg/kg
Drugs in Japan Vol. -, Pg. 1131, 1990.

oral-mouse LD50  8500 mg/kg
Drugs in Japan Vol. -, Pg. 1131, 1990.

intraperitoneal-mouse LD50  815 mg/kg
Drugs in Japan Vol. -, Pg. 1131, 1990.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: nutrient supplements
Recommendation for magnesium hydroxide usage levels up to:
 not for fragrance use.
 
Recommendation for magnesium hydroxide flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 1309-42-8
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 14791
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: nwg
 magnesium dihydroxide
Chemidplus: 0001309428
RTECS: OM3570000 for cas# 1309-42-8
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References:
 magnesium dihydroxide
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 1309-42-8
Pubchem (cid): 14791
Pubchem (sid): 134979979
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEMBL: View
KEGG (GenomeNet): D00731
HMDB (The Human Metabolome Database): HMDB32435
FooDB: FDB013291
Export Tariff Code: 2816.10.0000
Haz-Map: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
•milk of magnesia usp, is an aqueous suspension of magnesium hydroxide containing 7.0-8.5% of mg(oh)2. each milliliter is capable of neutralizing approx 2.7 meq of acid. ...magnesium hydroxide is also avail as magnesia tablets...generally contain 325 mg each, which can neutralize 11.2 meq of acid. •usp; 250 ml & 500 ml bottles with aluminum hydroxide gel; 250 ml, 375 ml, 500 ml & 1 l bottles. •suspension of 30% magnesium hydroxide in water: hydro-magma. •magnesium hydroxide drug available generically: powder; tablets 300 & 600 mg. •vet: primarily in laxative mixtures for suspension in large quantities of water, occasionally in bolus, & occasionally as milk of magnesia; magma magnesii, cream of magnesia, mixture of magnesium hydroxide, & mistura magnesii hydroxidi (approx an 8% aqueous solution). •magnesium hydroxide is usually marketed in combination with other antacids. •grades: technical, nf, fcc. •vet: magnalox boluses, each bolus contains: magnesium hydroxide 27 g; ginger 200 mg, & capsicum 50 mg. •a mixture of salts, available as maalox, mylanta, gelusil, and aludrox, contains magnesium hydroxide, mg(oh)2, and variable amounts of aluminum oxide in the form of aluminum hydroxide and hydrated aluminum oxide, ie, 2.9-4.2% magnesium hydroxide and 2.0-2.4% aluminum oxide, al2o3, for a mixture of 4.9-6.6% combined magnesium hydroxide and aluminum oxide. this mixture may contain a flavoring and antimicrobial agents in a total amount not to exceed 0.5% .
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 absorbents 
 buffering agents 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 magmesia hydrate
 magnesiamaito
 magnesium dihydroxide
 magnesium hydroxide powder USP
 magnesium hydroxide USP
 magnesium hydroxide USP FCC powder
 magnesium(2+) hydroxide
 magnesium(II) hydroxide
 magox
 marinco H (RX-14073)
 milk of magnesia
 milmag
 nemalite
 phillips magnesia tablets
 reachim
 versamag
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Articles:
PubMed: Mechanisms of mineral membrane fouling growth modulated by pulsed modes of current during electrodialysis: evidences of water splitting implications in the appearance of the amorphous phases of magnesium hydroxide and calcium carbonate.
PubMed: Posaconazole tablet pharmacokinetics: lack of effect of concomitant medications altering gastric pH and gastric motility in healthy subjects.
PubMed: Characteristics of selective fluoride adsorption by biocarbon-Mg/Al layered double hydroxides composites from protein solutions: kinetics and equilibrium isotherms study.
PubMed: Magnesium degradation products: effects on tissue and human metabolism.
PubMed: Nutraceutically inspired pectin-Mg(OH)â‚‚ nanocomposites for bioactive packaging applications.
PubMed: How pulse modes affect proton-barriers and anion-exchange membrane mineral fouling during consecutive electrodialysis treatments.
PubMed: Modified hydrotalcite-like compounds as active fillers of biodegradable polymers for drug release and food packaging applications.
PubMed: Multistep mineral fouling growth on a cation-exchange membrane ruled by gradual sieving effects of magnesium and carbonate ions and its delay by pulsed modes of electrodialysis.
PubMed: Layered double hydroxide nanoparticles as target-specific delivery carriers: uptake mechanism and toxicity.
PubMed: Design of a multifunctional nanohybrid system of the phytohormone gibberellic acid using an inorganic layered double-hydroxide material.
PubMed: Randomized clinical trial of laxatives and oral nutritional supplements within an enhanced recovery after surgery protocol following liver resection.
PubMed: Determination of tetracyclines in surface water and milk by the magnesium hydroxide coprecipitation method.
PubMed: First identification of O,S-diethyl Thiocarbonate in Indian Cress absolute and odor evaluation of its synthesized homologues by GC-sniffing.
PubMed: Microscopic approach for the identification of cationic membrane fouling during cheddar cheese whey electroacidification.
PubMed: Clinical pharmacokinetics and gastrointestinal tolerability of a novel extended-release microsphere formulation of azithromycin.
PubMed: Separation and speciation of selenium in food and water samples by the combination of magnesium hydroxide coprecipitation-graphite furnace atomic absorption spectrometric determination.
PubMed: Synthesis and properties of cordycepin intercalates of Mg-Al-nitrate layered double hydroxides.
PubMed: Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects.
PubMed: Magnesium therapy for nephrolithiasis.
PubMed: Different Mg to Fe ratios in the mixed metal MgFe hydroxy-carbonate compounds and the effect on phosphate binding compared with established phosphate binders.
PubMed: Bioavailability of the oral selective phosphodiesterase 4 inhibitor cilomilast.
PubMed: Grayanotoxin poisoning in three goats.
PubMed: [Kinetics of aluminum absorption and serum concentration in chronic renal insufficiency].
PubMed: Clopidogrel bioavailability: absence of influence of food or antacids.
PubMed: Effects of food, antacid, and dosage form on the pharmacokinetics and relative bioavailability of sertindole in healthy volunteers.
PubMed: Effects of food and antacid on the pharmacokinetics of single doses of mycophenolate mofetil in rheumatoid arthritis patients.
PubMed: Effect of aluminum hydroxide/magnesium hydroxide antacid and bismuth subsalicylate on gastric pH in horses.
PubMed: Pharmacokinetics of tenidap sodium administered with food or antacid in healthy volunteers.
PubMed: Ondansetron absorption in adults: effect of dosage form, food, and antacids.
PubMed: Orange juice enhances aluminium absorption from antacid preparation.
PubMed: Diagnosis of magnesium-induced diarrhea.
PubMed: The effect of food and antacids on lansoprazole absorption and disposition.
PubMed: The effect of an antacid and food on the absorption of cimetidine and ranitidine.
PubMed: Ketorolac tromethamine pharmacokinetics and metabolism after intravenous, intramuscular, and oral administration in humans and animals.
PubMed: [The effect of almagel, gastrotsepin and food on the acidity and protease activity of the stomach and duodenum in peptic ulcer].
PubMed: Influence of food and antacid administration on fluoride bioavailability from enteric-coated sodium fluoride tablets.
PubMed: Absorption studies of the H2-blocker nizatidine.
PubMed: Effect of food and various antacids on the absorption of tenoxicam.
PubMed: Antacid and formula effects on gastric acidity in infants with gastroesophageal reflux.
PubMed: Interaction of nutrients with antacids: a complication during enteral tube feeding.
PubMed: [Histo-autoradiographic study of the synthesis of gastric mucus in the rat stomach. Chronology of stimulation of mucus synthesis following ingestion of water, food and a combination of montmorillonite beidellite and an antacid].
PubMed: In vivo and in vitro evaluation of magnesium-aluminum hydroxide antacid tablets and liquid.
PubMed: In vitro tests overestimate in vivo neutralizing capacity of antacids in presence of food.
PubMed: [Histo-autoradiographic study of the secretion of gastric mucus in the rat stomach. II. Role of feeding and its combination with an antacid].
PubMed: Response of milking cows fed a high concentrate, low roughage diet plus sodium bicarbonate, magnesium oxide, or magnesium hydroxide.
PubMed: Absolute bioavailability and effect of food and antacid on diazepam absorption from a slow-release preparation.
PubMed: Antacids and anticholinergics in the treatment of duodenal ulcer.
PubMed: [Determination of neutralization capacity of antacids in gastric juice].
PubMed: The GI drug column. The ACG committee on FDA related matters.
PubMed: Effect of food on antacid neutralizing capacity in man.
PubMed: Reduction of exogenous oxalate in urine of rats by binding with aluminium-oxyhydrate (Andursil) and an anion-exchanger (Colestid) in the intestinal tract.
PubMed: The role of a defined formula diet in the prevention of stress-induced gastric mucosal injury in the rat.
PubMed: Effect of antacids on the bioavailability of diflunisal in the fasting and postprandial states.
PubMed: The effect of oral local anaesthetic and alkali on basal and food-stimulated serum gastrin levels in patients with duodenal ulcer.
PubMed: Effect of chronic antacid ingestion on serum gastrin and gastric secretion.
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