None found
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1-(4-chlorophenyl)-3-[4-chloro-3-(trifluoromethyl)phenyl]urea (Click)
CAS Number: 369-77-7Picture of molecule
ECHA EINECS - REACH Pre-Reg: 206-724-5
Nikkaji Web: J5.706A
XlogP3: 5.30 (est)
Molecular Weight: 349.13813960
Formula: C14 H9 Cl2 F3 N2 O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antimicrobial agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 214.50 °C. @ 760.00 mm Hg
Boiling Point: 328.80 °C. @ 760.00 mm Hg (est)
Flash Point: 307.00 °F. TCC ( 152.70 °C. ) (est)
logP (o/w): 6.330 (est)
Soluble in:
 water, 0.2183 mg/L @ 25 °C (est)
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Organoleptic Properties:
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
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 None found
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antimicrobial agents
Recommendation for cloflucarban usage levels up to:
 not for fragrance use.
Recommendation for cloflucarban flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 369-77-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 9719
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0000369777
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NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 9719
Pubchem (sid): 134974319
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
KEGG (GenomeNet): D03548
HMDB (The Human Metabolome Database): Search
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
None Found
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Potential Uses:
 antimicrobial agents 
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Occurrence (nature, food, other): note
 not found in nature
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 irgasan CF3
 urea, N-(4-chlorophenyl)-N'-(4-chloro-3-(trifluoromethyl)phenyl)-
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PubMed: Inhibition of light emission from the bioluminescent bacterium Vibrio fischeri after exposure to triclosan and related hygiene care products.
PubMed: Modification of the bile salts-Irgasan-brilliant green agar for enumeration of Aeromonas species from food.
PubMed: Irgasan DP 300 (5-chloro-2-(2,4-dichlorophenoxy)-phenol) induces cytochrome P450s and inhibits haem biosynthesis in rat hepatocytes cultured on Matrigel.
PubMed: Characterization of mucoid Pseudomonas aeruginosa strains isolated from technical water systems.
PubMed: Short-comings of irgasan ticarcillin chlorate broth for the enrichment of Yersinia enterocolitica biotype 2, serotype 9 from meat.
PubMed: Evaluation of different antimicrobial agents used as selective supplements for isolation and recovery of Yersinia enterocolitica.
PubMed: Disinfectant effects of "Taisalite" and "Taifresh Ace" containing Irgasan DP300 against MRSA and HIV.
PubMed: [Efficacy of cefsulodin -irgasan-novobiocin agar media in the isolation of Aeromonas mesophiles from feces].
PubMed: Experimental pathology of intravenous polyurethane cannulae containing disinfectant.
PubMed: Elution of disinfectant from polyurethane cannula tubing.
PubMed: Disposition and excretion of Irgasan DP300 and its chlorinated derivatives in mice.
PubMed: Chemical changes of organic compounds in chlorinated water. XIII. Gas chromatographic-mass spectrometric studies of the reactions of Irgasan DP 300 [5-chloro-2-(2,4-dichlorophenoxy)phenol] with chlorine in dilute aqueous solution.
PubMed: Self-disinfecting plastics for intravenous catheters and prosthetic inserts.
PubMed: Differentiation of Kluyvera cryocrescens from Kluyvera ascorbata by irgasan susceptibility testing.
PubMed: Inhibition of Pseudomonas aeruginosa from cystic fibrosis by selective media.
PubMed: Growth of Aeromonas spp. on cefsulodin-Irgasan-novobiocin agar selective for Yersinia enterocolitica.
PubMed: Divalent cation dependent resistance in E. coli LMR-26 to the broad spectrum antimicrobial agent irgasan.
PubMed: An abbreviated scheme for identification of Yersinia enterocolitica isolated from food enrichments on CIN (cefsulodin-irgasan-novobiocin) agar.
PubMed: Effect of irgasan on bacterial growth and its adsorption into the cell wall.
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