climbazole
1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone
 
Notes:
None found
  • Symrise
    • Symrise AG
      Always Insiring More
      Symrise aroma molecules & cosmetic ingredients for unique and innovative fragrances, flavors and cosmetics.
      We are globally recognized as a leading provider of fragrances, flavors and active ingredients as well as aroma chemicals for the perfume, cosmetic, pharmaceutical, food and beverage industries. We combine our knowledge about consumers’ ever- changing needs with creativity and ground-breaking technologies. In doing so, we concentrate on the development of solutions that provide our customers with added value. We ensure sustained value creation by allowing our employees and shareholders to share our Company’s success.
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      Product(s):
      600306 Crinipan® AD Life Essentials - Actives
      Crinipan® AD is an anti-dandruff agent. It acts specifically against the main cause of dandruff, the fungus malassezia furfur.
       
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
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      Product(s):
      C2025 Climbazole >98.0%(HPLC)(T)
       
  • Vigon International
    • Vigon International, Inc.
      Passion for Simplicity
      Manufacturer and supplier of high quality flavor and fragrance ingredients.
      The growth and success of Vigon is due in large part to a unique corporate concept that Vigon has developed and established within the industry: Creative Partnerships. This partnership concept has been and continues to be the foundation and guiding principle for all of Vigon's activities.
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      Product(s):
      507268 Crinipan AD (Climbazole)
       
Synonyms   Articles   Notes   Search
1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one (Click)
CAS Number: 38083-17-9Picture of molecule
ECHA EINECS - REACH Pre-Reg: 253-775-4
FDA UNII: 9N42CW7I54
Nikkaji Web: J19.421B
Beilstein Number: 0618020
MDL: MFCD00055505
XlogP3-AA: 3.70 (est)
Molecular Weight: 292.76489000
Formula: C15 H17 Cl N2 O2
NMR Predictor: Predict (works with chrome or firefox)
Category: antimicrobial preservatives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 447.00 to  448.00 °C. @ 760.00 mm Hg (est)
Flash Point: 436.00 °F. TCC ( 224.40 °C. ) (est)
logP (o/w): 3.486 (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
preservatives
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Suppliers:
BOC Sciences
For experimental / research use only.
Climbazole >98%
Odor: characteristic
Use: Climbazole is a topical antifungal agent commonly used in the treatment of human fungal skin infections such as dandruff and eczema. Climbazole has shown a high in vitro and in vivo efficacy against Pityrosporum ovale that appears to play an important role
Santa Cruz Biotechnology
For experimental / research use only.
Climbazole
Sigma-Aldrich
For experimental / research use only.
Climbazole PESTANAL®, analytical standard
Symrise
Crinipan® AD
Life Essentials - Actives
Odor: characteristic
Use: Crinipan® AD is an anti-dandruff agent. It acts specifically against the main cause of dandruff, the fungus malassezia furfur.
TCI AMERICA
For experimental / research use only.
Climbazole >98.0%(HPLC)(T)
Vigon International
Crinipan AD (Climbazole)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn N - Harmful, Dangerous for the environment.
R 52/53 - Harmful to qauatic organisms, may cause long-term adverse effects in the aquatic environment.
S 22 - Do not breath dust.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  400 mg/kg
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 832, 1986.

Dermal Toxicity:
skin-rat LD50 > 5000 mg/kg
Farmaco. Vol. 53, Pg. 405, 1998.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: antimicrobial preservatives
Recommendation for climbazole usage levels up to:
 not for fragrance use.
 
Recommendation for climbazole flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 37907
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 3077
WGK Germany: 3
 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one
Chemidplus: 0038083179
RTECS: EL7085000 for cas# 38083-17-9
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References:
 1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 37907
Pubchem (sid): 135001046
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2933.29.4300
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 preservatives 
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 baypival
 baysan
2-butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-
2-butanone, 1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-
1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone
1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one
1-(4-chlorophenoxy)-1-(1H-imidazolyl)-3,3-dimethyl-2-butanone
1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl butanone
1-(4-chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone
1-(p-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone
1-(4-chlorophenoxy)-1-imidazolyl-3,3-dimethylbutan-2-one
1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanone
1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone
 crinipan AD (Symrise)
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Articles:
PubMed: Triclosan as a surrogate for household biocides: An investigation into biocides in aquatic environments of a highly urbanized region.
PubMed: Selective determination of antimycotic drugs in environmental water samples by mixed-mode solid-phase extraction and liquid chromatography quadrupole time-of-flight mass spectrometry.
PubMed: Sucrose ester stabilized solid lipid nanoparticles and nanostructured lipid carriers. II. Evaluation of the imidazole antifungal drug-loaded nanoparticle dispersions and their gel formulations.
PubMed: Protease activity, localization and inhibition in the human hair follicle.
PubMed: Ecotoxicity of climbazole, a fungicide contained in antidandruff shampoo.
PubMed: Ultra-high-performance liquid chromatography-tandem mass spectrometry measurement of climbazole deposition from hair care products onto artificial skin and human scalp.
PubMed: Typical azole biocides in biosolid-amended soils and plants following biosolid applications.
PubMed: Therapeutic efficacy of anti-dandruff shampoos: a randomized clinical trial comparing products based on potentiated zinc pyrithione and zinc pyrithione/climbazole.
PubMed: Occurrence and dissipation of three azole biocides climbazole, clotrimazole and miconazole in biosolid-amended soils.
PubMed: Determination of biocides in different environmental matrices by use of ultra-high-performance liquid chromatography-tandem mass spectrometry.
PubMed: Enhanced efficacy and sensory properties of an anti-dandruff shampoo containing zinc pyrithione and climbazole.
PubMed: Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff.
PubMed: Comparison of electrospray ionization and atmospheric pressure chemical ionization for multi-residue analysis of biocides, UV-filters and benzothiazoles in aqueous matrices and activated sludge by liquid chromatography-tandem mass spectrometry.
PubMed: Evaluation of the genotoxicity of the imidazole antifungal climbazole: comparison to published results for other azole compounds.
PubMed: Simultaneous determination of four anti-dandruff agents including octopirox in shampoo products by reversed-phase liquid chromatography.
PubMed: Rheology of Dead Sea shampoo containing the antidandruff climbazole.
PubMed: [Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography].
PubMed: The hair strand test - a new method for testing antifungal effects of antidandruff preparations.
PubMed: Induction and inhibition of cytochrome P450 and drug-metabolizing enzymes by climbazole.
PubMed: Climbazole is a new potent inducer of rat hepatic cytochrome P450.
PubMed: [Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema].
PubMed: [Comparison of the thermostability of natural (sulfoprolamine and sodium usnate) and synthetic (climbazole and piroctone olamine) antidandruff agents].
PubMed: In vitro activity of climbazole, clotrimazole and silver-sulphadiazine against isolates of Malassezia pachydermatis.
PubMed: In vitro susceptibility of Malassezia furfur against azole compounds.
PubMed: In vitro susceptibility of Malassezia furfur.
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