EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

chlorpheniramine maleate
carbinoxamide maleate

Supplier Sponsors

Name:(Z)-but-2-enedioicacid;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
CAS Number: 113-92-8Picture of molecule3D/inchi
Other(deleted CASRN):7054-11-7
ECHA EINECS - REACH Pre-Reg:204-037-5
FDA UNII: V1Q0O9OJ9Z
Nikkaji Web:J237.304A
MDL:MFCD00069225
Molecular Weight:390.86611000
Formula:C20 H23 Cl N2 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystalline solid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 379.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000006 mmHg @ 25.00 °C. (est)
Flash Point: 361.00 °F. TCC ( 183.00 °C. ) (est)
logP (o/w): 3.389 (est)
Soluble in:
 water, 1.41e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Alfa Biotechnology
For experimental / research use only.
Chlorpheniramine maleate 98%
American International Chemical, LLC.
Chlorpheniramine Maleate
BOC Sciences
For experimental / research use only.
Chlorpheniramine Maleate >98%
Odor: characteristic
Use: Chlorpheniramine inhibits the proliferation of MCF-7, MDA-MB 231, and Ehrlich cells in a dose-response manner, and significantly reduces the ornithine decarboxylase mRNA translation by 50%-70% at the 250 M.
Penta International
CHLORPHENIRAMINE MALEATE
Santa Cruz Biotechnology
For experimental / research use only.
Chlorpheniramine Maleate ≥99%
Sigma-Aldrich
For experimental / research use only.
Chlorpheniramine Maleate
European Pharmacopoeia (EP) Reference Standard
TCI AMERICA
For experimental / research use only.
Chlorpheniramine Maleate >99.0%(HPLC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-bird - wild LD50 75 mg/kg
Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.

intravenous-dog LD50 97600 ug/kg
BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.

intravenous-guinea pig LD50 68 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958.

oral-guinea pig LD50 198 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.

intraperitoneal-mouse LD50 76700 ug/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.

intravenous-mouse LD50 26100 ug/kg
Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.

oral-mouse LD50 130 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1644, 1978.

oral-rat LD50 306 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1371, 1978.

Dermal Toxicity:
subcutaneous-guinea pig LD50 101 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.

subcutaneous-mouse LD50 104 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.

subcutaneous-rat LD50 365 mg/kg
Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for chlorpheniramine maleate usage levels up to:
 not for fragrance use.
 
Recommendation for chlorpheniramine maleate flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):113-92-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :5281068
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(Z)-but-2-enedioicacid;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Chemidplus:0000113928
EPA/NOAA CAMEO:hazardous materials
RTECS:US6504000 for cas# 113-92-8
 
References:
 (Z)-but-2-enedioicacid;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:113-92-8
Pubchem (cid):5281068
Pubchem (sid):134974030
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C07780
HMDB (The Human Metabolome Database):HMDB01944
Export Tariff Code:2933.39.9100
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 allerclor
 allergin
 allergisan
 alunex
 antagonate
(Z)-but-2-enedioicacid;3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
 C-meton
 carbinoxamide maleate
 chlor-trimeton
 chlor-tripolon
 chlorcaps T.D.
 chlormene
 chloropheniramine maleate
[3-(4-chlorophenyl)-3-(2-pyridinyl)propyl]-dimethylammonium
[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]dimethylamine, (2Z)but-2-enedioic acid
[3-(4-chlorophenyl)-3-pyridin-2-yl-propyl]-dimethyl-azanium
3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine (2Z)-2-butenedioate (1:1)
3-(4-chlorophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine (2Z)-but-2-enedioate (1:1)
3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine
3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-aminium (2Z)-3-carboxyprop-2-enoate
 chloroprophenpyridamine maleate
 chlorphenamine hydrogen maleate
 chlorphenamine maleate
(±)-chlorpheniramine maleate
 chlorpheniramine maleate USP
 chlorpheniramine maleate USP 325 mesh
 chlorpheniramine maleate USP 80 mesh
 chlorprophenpyridamine maleate
 chlortrimeton
 cloropiril M.P.
 dehist
1-(N,N-dimethylamino)-3-(p-chlorophenyl-3-a-pyridyl)propane maleate
 histadur
(Z)-4-hydroxy-4-oxo-2-butenoate
 ibioton
 kloromin
 lorphen
 neorestamin
(Z)-4-oxidanyl-4-oxidanylidene-but-2-enoate
 phenetron
 piriex
 piriton
 puermin
 pyridamal 100
 pyridamal-100
 pyridine, 2-(p-chloro-a-(2-(dimethylamino)ethyl)benzyl)-, maleate (1:1)
2-pyridinepropanamine, g-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1)
2-pyridinepropanamine, g-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
 synistamin
 teldrin
 

Articles:

PubMed:Evaluating the efficiency of spectral resolution of univariate methods manipulating ratio spectra and comparing to multivariate methods: An application to ternary mixture in common cold preparation.
PubMed:Potential use of a megamolecular polysaccharide sacran as a hydrogel-based sustained release system.
PubMed:Preparation of Chlorpheniramine Maleate-loaded Alginate/Chitosan Particulate Systems by the Ionic Gelation Method for Taste Masking.
PubMed:A case of levocetirizine-induced fixed drug eruption and cross-reaction with piperazine derivatives.
PubMed:Resolution of five-component mixture using mean centering ratio and inverse least squares chemometrics.
PubMed:Drug release-modulating mechanism of hydrophilic hydroxypropylmethylcellulose matrix tablets: distribution of atoms and carrier and texture analysis.
PubMed:A prediction model for monitoring ribbed roller compacted ribbons.
PubMed:Combined use of ionic liquid and hydroxypropyl-β-cyclodextrin for the enantioseparation of ten drugs by capillary electrophoresis.
PubMed:Herb-drug pharmacokinetic interaction of artificial calculus bovis with diclofenac sodium and chlorpheniramine maleate in rats.
PubMed:Report: Simultaneous determination of naphazoline hydrochloride, chlorpheniramine maleate and methylene blue in their ternary mixture.
PubMed:Evaluation of Chlorpheniramine Maleate microparticles in orally disintegrating film and orally disintegrating tablet for pediatrics.
PubMed:Mechanism of synergistic interactions and its influence on drug release from extended release matrices manufactured using binary mixtures of polyethylene oxide and sodium carboxymethylcellulose.
PubMed:Development and validation of RP-HPLC method for simultaneous estimation of nimesulide, phenylephrine hydrochloride, chlorpheniramine maleate and caffeine anhydrous in pharmaceutical dosage form.
PubMed:Evaluation of different combined regimens in the treatment of cholinergic urticaria.
PubMed:Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget's Disease to Trastuzumab Monotherapy.
PubMed:Low-viscosity hydroxypropylcellulose (HPC) grades SL and SSL: versatile pharmaceutical polymers for dissolution enhancement, controlled release, and pharmaceutical processing.
PubMed:Application of near-infrared spectroscopy in real-time monitoring of product attributes of ribbed roller compacted flakes.
PubMed:Isolation and characterization of jackfruit mucilage and its comparative evaluation as a mucoadhesive and controlled release component in buccal tablets.
PubMed:Operator care and eco-concerned development of a fast, facile and economical assay for basic nitrogenous drugs based on simplified ion-pair mini-scale extraction using safer solvent combined with drop-based spectrophotometry.
PubMed:Design and synthesis of novel 3-(4-chlorophenyl)-2-(3-substituted propyl thio) quinazolin-4-(3H)-ones as a new class of H1-antihistaminic agents.
PubMed:Analysis of liquid medication dose errors made by patients and caregivers using alternative measuring devices.
PubMed:Characterization of soy polysaccharide and its in vitro and in vivo evaluation for application in colon drug delivery.
PubMed:Health outcome and safety assessment of a fixed dose combination of Amantadine, Paracetamol, Chlorpheniramine maleate, and Phenylephrine introduction in India: A prescription event monitoring study.
PubMed:Comparison of the determination of a low-concentration active ingredient in pharmaceutical tablets by backscatter and transmission Raman spectrometry.
PubMed:Applicability of total reflection X-ray fluorescence (TXRF) as a screening platform for pharmaceutical inorganic impurity analysis.
PubMed:Synthesis and antihistaminic activity of 3H-benzo [4,5] thieno [2,3-d][1,2,3] triazin-4-ones.
PubMed:Design and synthesis of novel 2-(3-substituted propyl)-3-(2-methyl phenyl) quinazolin-4-(3H)-ones as a new class of H1-antihistaminic agents.
PubMed:Formulation and development of taste masked fast-disintegrating tablets (FDTs) of Chlorpheniramine maleate using ion-exchange resins.
PubMed:Antihistaminic activity of aqueous extract of stem bark of Ailanthus excelsa Roxb.
PubMed:Gastrin-releasing peptide induces itch-related responses through mast cell degranulation in mice.
PubMed:[Protective effects of d-chlorpheniramine maleate pre-treatment against acute side effects of Irinotecan(CPT- 11)].
PubMed:Antihistaminic and antiviral activities of steroids of Turbinaria conoides.
PubMed:Development of potential novel cushioning agents for the compaction of coated multi-particulates by co-processing micronized lactose with polymers.
PubMed:Baboon syndrome induced by oral antitussive-decongestant agent in a child.
PubMed:A case of chlorpheniramine maleate-induced hypersensitivity with aspirin intolerance.
PubMed:Antihistaminic activity of Clitoria ternatea L. roots.
PubMed:A porous graphitized carbon column HPLC method for the quantification of paracetamol, pseudoephedrine, and chlorpheniramine in a pharmaceutical formulation.
PubMed:Modified release from hydroxypropyl methylcellulose compression-coated tablets.
PubMed:Enhancement of on chip chemiluminescence signal intensity of tris(1,10-phenanthroline)-ruthenium(II) peroxydisulphate system for analysis of chlorpheniramine maleate in pharmaceutical formulations.
PubMed:Improved drug delivery to the lower intestinal tract with tablets compression-coated with enteric/nonenteric polymer powder blends.
PubMed:Formulation and stability study of chlorpheniramine maleate nasal gel.
PubMed:Multivariate optimization and validation of a capillary electrophoresis method for the simultaneous determination of dextromethorphan hydrobromur, phenylephrine hydrochloride, paracetamol and chlorpheniramine maleate in a pharmaceutical preparation using response surface methodology.
PubMed:Preparation and in vitro release of dual-drug resinate complexes containing codeine and chlorpheniramine.
PubMed:[Simultaneous determination of ibuprofen and pseudoephedrin hydrochloride and chlorpheniramine maleate in the compound buluoweimanamin tablets by HPLC].
PubMed:In-line quantification of micronized drug and excipients in tablets by near infrared (NIR) spectroscopy: Real time monitoring of tabletting process.
PubMed:Prescription writing trends of antihistamines at the university health centre.
PubMed:Calibration sampling paradox in near infrared spectroscopy: a case study of multi-component powder blend.
PubMed:Treatment of allergic conjunctivitis: results of a 1-month, single-masked randomized study.
PubMed:Normal-phase LC method for simultaneous analysis of pseudophedrine hydrochloride, dextromethorphan hydrobromide, chlorpheniramine maleate, and paracetamol in tablet formulations.
PubMed:Quantification of chlorpheniramine maleate enantiomers by ultraviolet spectroscopy and chemometric methods.
PubMed:Simultaneous determination of paracetamol, phenylephrine hydrochloride and chlorpheniramine maleate in pharmaceutical preparations using multivariate calibration 1.
PubMed:Optimised process and formulation conditions for extended release dry polymer powder-coated pellets.
PubMed:In-line quantification of drug and excipients in cohesive powder blends by near infrared spectroscopy.
PubMed:Allergic contact dermatitis from dibucaine hydrochloride, chlorpheniramine maleate, and naphazoline hydrochloride in an over-the-counter topical antiseptic.
PubMed:Nicolau syndrome: an iatrogenic cutaneous necrosis.
PubMed:Rapid simultaneous determination of paracetamol, amantadine hydrochloride, caffeine and chlorpheniramine maleate in human plasma by liquid chromatography/tandem mass spectrometry.
PubMed:Synthesis and pharmacological investigation of novel 4-(3-ethylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a] quinazolin-5-ones as a new class of H1-antihistaminic agents.
PubMed:Safety and robustness of coated pellets: self-healing film properties and storage stability.
PubMed:4-(3-Methoxyphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones: new class of H1-antihistaminic agents.
PubMed:Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts.
PubMed:Modulating pH-independent release from coated pellets: effect of coating composition on solubilization processes and drug release.
PubMed:Hypersensitivity to intravenous ondansetron: a case report.
PubMed:[Evaluation of short-time premedication with d-chlorpheniramine maleate injection for paclitaxel-induced hypersensitivity reaction].
PubMed:Effect of drying processes and curing time of chitosan-lysine semi-IPN beads on chlorpheniramine maleate delivery.
PubMed:Development and evaluation of oral controlled release chlorpheniramine-ion exchange resinate suspension.
PubMed:Simultaneous determination of phenylephrine hydrochloride, guaifenesin, and chlorpheniramine maleate in cough syrup by gradient liquid chromatography.
PubMed:New insight into modified release pellets - Internal structure and drug release mechanism.
PubMed:Transbuccal delivery of chlorpheniramine maleate from mucoadhesive buccal patches.
PubMed:Case of allergic contact dermatitis due to a topical agent containing chlorpheniramine maleate, with a false-negative patch test.
PubMed:Synthesis and pharmacological investigation of novel 4-(2-methylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H(1)-antihistaminic agents.
PubMed:Sodium lauryl sulfate impedes drug release from zinc-crosslinked alginate beads: switching from enteric coating release into biphasic profiles.
PubMed:Synthesis of 4-butyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H(1)-antihistaminic agents.
PubMed:Development and validation of chemometrics-assisted spectrophotometry and liquid chromatography methods for the simultaneous determination of the active ingredients in two multicomponent mixtures containing chlorpheniramine maleate and phenylpropanolamine hydrochloride.
PubMed:4-Cyclohexyl-1-substituted-4H-[1,2,4]triazolo [4,3-a] quinazolin-5-ones: novel class of H1-antihistaminic agents.
PubMed:Preparation of codeine-resinate and chlorpheniramine-resinate sustained-release suspension and its pharmacokinetic evaluation in beagle dogs.
PubMed:Synthesis and pharmacological investigation of novel 4-benzyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H1-antihistaminic agents.
PubMed:Influence of processing parameters and formulation factors on the drug release from tablets powder-coated with Eudragit L 100-55.
PubMed:Distribution to the skin of epinastine hydrochloride in atopic dermatitis patients.
PubMed:Synthesis and pharmacological investigation of novel 1-alkyl-4-(4-substituted aryl/heteroaryl)-1,2,4-triazolo [4,3- a] quinazolin-5 (4H)-ones as a new class of H1-antihistaminic agents.
PubMed:Major degradation product identified in several pharmaceutical formulations against the common cold.
PubMed:Drugs acting as plasticizers in polymeric systems: a quantitative treatment.
PubMed:Characterization of hydroxypropylmethylcellulose films using microwave non-destructive testing technique.
PubMed:Floating hot-melt extruded tablets for gastroretentive controlled drug release system.
PubMed:Synthesis and pharmacological investigation of novel 1-substituted-4-(4-substituted phenyl)-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as a new class of H1-antihistamine agents.
PubMed:Influence of plasticizer level on the drug release from sustained release film coated and hot-melt extruded dosage forms.
PubMed:The interaction and compatibility between a soft contact lens and an ophthalmic drug.
PubMed:Extruded and spheronized beads containing Carbopol 974P to deliver nonelectrolytes and salts of weakly basic drugs.
PubMed:[Simultaneous determination of ephedrine and chlorpheniramine in human plasma by a highly sensitive liquid chromatography-tandem mass spectrometric method].
PubMed:Simultaneous determination of chlorpheniramine maleate and dexamethasone in a tablet dosage form by liquid chromatography.
PubMed:Determination of phenylephrine hydrochloride, chlorpheniramine maleate, and methscopolamine nitrate in tablets or capsules by liquid chromatography with two UV absorbance detectors in series.
PubMed:Properties of sustained release hot-melt extruded tablets containing chitosan and xanthan gum.
PubMed:Simultaneous quantitation of five active principles in a pharmaceutical preparation: development and validation of a near infrared spectroscopic method.
PubMed:Short-term tolerability of etoricoxib in patients with cutaneous hypersensitivity reactions to nonsteroidal anti-inflammatory drugs.
PubMed:In vitro evaluation of drug release from self micro-emulsifying drug delivery systems using a biodegradable homolipid from Capra hircus.
PubMed:Simultaneous determination of some active ingredients in cough and cold preparations by gas chromatography, and method validation.
PubMed:Liquid chromatography and chemometric-assisted spectrophotometric methods for the analysis of two multicomponent mixtures containing cough suppressant drugs.
PubMed:Adolescent abuse of dextromethorphan.
PubMed:Systematic comparison of different functionality columns for a classical pharmaceutical problem.
PubMed:Synthesis and H1-antihistaminic activity of some novel 1-substituted-4-(3-methylphenyl)-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones.
PubMed:Apoptosis in rat jejunal mucosa is regulated partly through the central nervous system, which controls feeding behavior.
PubMed:Content uniformity and dissolution tests of triplicate mixtures by a double divisor-ratio spectra derivative method.
PubMed:Simultaneous determination of methylephedrine and noscapine in human plasma by liquid chromatography-tandem mass spectrometry.
PubMed:Asymmetric membrane capsules for delivery of poorly water-soluble drugs by osmotic effects.
PubMed:Preincisional dextromethorphan combined with thoracic epidural anesthesia and analgesia improves postoperative pain and bowel function in patients undergoing colonic surgery.
PubMed:Sorbitan monopalmitate-based proniosomes for transdermal delivery of chlorpheniramine maleate.
PubMed:Airway closure after antigen challenge in cynomolgus monkeys: effect of the histamine H1 receptor antagonist, chlorpheniramine maleate.
PubMed:Synthesis and pharmacological investigation of novel 1-substituted-4-phenyl-1,2,4-triazolo[4,3-a]quinazolin-5(4H)-ones as a new class of H1-antihistaminic agents.
PubMed:New approaches with two cyano columns to the separation of acetaminophen, phenylephrine, chlorpheniramine and related compounds.
PubMed:Rapid identification and quantification of chlorpheniramine maleate or pheniramine maleate in pharmaceutical preparations by thin-layer chromatography-densitometry.
PubMed:The interaction effect of perioperative cotreatment with dextromethorphan and intravenous lidocaine on pain relief and recovery of bowel function after laparoscopic cholecystectomy.
PubMed:Major degradation product identified in several pharmaceutical formulations against the common cold.
PubMed:The role of histamine in estradiol-induced conditioned consumption reductions.
PubMed:To evaluate and compare the effects of first generation anti-histamine (chlorpheniramine maleate) and second generation anti-histamine (loratadine) on isolated trachea of rabbit.
PubMed:Degranulation of uterine mast cell modifies contractility of isolated myometrium from pregnant women.
PubMed:Synthesis and pharmacological investigation of some novel 2-methyl-3-(substituted methylamino)-(3H)-quinazolin-4-ones as histamine H1-receptor blockers.
PubMed:The influence of excipients on drug release from hydroxypropyl methylcellulose matrices.
PubMed:LC/MS for the degradation profiling of cough-cold products under forced conditions.
PubMed:Analgesic effects of preincisional administration of dextromethorphan and tenoxicam following laparoscopic cholecystectomy.
PubMed:In vitro and ex vivo permeation studies of chlorpheniramine maleate gels prepared by carbomer derivatives.
PubMed:Evaluation of antipruritic effects of several agents on scratching behavior by NC/Nga mice.
PubMed:Simultaneous determination of chlorpheniramine and pseudoephedrine in human plasma by liquid chromatography-tandem mass spectrometry.
PubMed:Chlorpheniramine maleate as an alternative to antiemetic cyclizine.
PubMed:Influences of osmotic agents in diffusion layer on drug release from multilayer coated pellets.
PubMed:Effect of drug solubility and different excipients on floating behaviour and release from glyceryl monooleate matrices.
PubMed:Angioedema of the lips and tongue induced by angiotensin-converting enzyme inhibitor. A report of two cases.
PubMed:The influence of polymeric subcoats and pellet formulation on the release of chlorpheniramine maleate from enteric coated pellets.
PubMed:Simultaneous determination of paracetamol and chlorpheniramine maleate by micellar electrokinetic chromatography.
PubMed:A randomized, placebo-controlled trial of the effect of antihistamine or corticosteroid treatment in acute otitis media.
PubMed:Determination of chlorpheniramine maleate and tincture ipecac in dosage form by liquid chromatography with ultraviolet detection.
PubMed:Multiple unit gastroretentive drug delivery systems: a new preparation method for low density microparticles.
PubMed:In vitro release studies of chlorpheniramine maleate from gels prepared by different cellulose derivatives.
PubMed:Proteinase-activated receptor-2 activation induces uterine contractility in term pregnant rats that is not dependent on mast cell activation and cyclo-oxygenase products.
PubMed:Postoperative intramuscular dextromethorphan injection provides pain relief and decreases opioid requirement after modified radical mastectomy.
PubMed:Effect of histamine on phasic and tonic contractions of isolated uterine tissue from pregnant women.
PubMed:Middle ear fluid histamine and leukotriene B4 in acute otitis media: effect of antihistamine or corticosteroid treatment.
PubMed:[Weekly administration of paclitaxel and pirarubicine for recurrent breast cancer].
PubMed:[Weekly administration of paclitaxel with a short course of premedication for advanced or recurrent gastric cancer].
PubMed:[Simultaneous determination of 5-component contents in Kuaian anticold solution by high performance liquid chromatography].
PubMed:Influence of thermal processing on the properties of chlorpheniramine maleate tablets containing an acrylic polymer.
PubMed:A chromatographic method for rapid and simultaneous analysis of codeine phosphate, ephedrine HCl and chlorpheniramine maleate in cough-cold syrup formulation.
PubMed:The diagnosis of lichen-planus-like contact dermatitis to chlorpheniramine maleate.
PubMed:Single-patient drug trial methodology for allergic rhinitis.
PubMed:Simple and sensitive method for the determination of chlorpheniramine maleate in human plasma using liquid chromatography-mass spectrometry.
PubMed:Comparative evaluation of rate of hydration and matrix erosion of HEC and HPC and study of drug release from their matrices.
PubMed:Solid-state plasticization of an acrylic polymer with chlorpheniramine maleate and triethyl citrate.
PubMed:Synthesis and pharmacological investigation of some novel 2-phenyl-3-(substituted methyl amino) quinazolin-4(3H)-ones as H1-receptor blockers.
PubMed:A possible trend suggesting increased abuse from Coricidin exposures reported to the Texas Poison Network: comparing 1998 to 1999.
PubMed:[Sensitivity of cationic polymer Eudragit RL to electrolytes and its effect on drug release from Eudragit RL matrix].
PubMed:Understanding and predicting drug delivery from hydrophilic matrix tablets using the "sequential layer" model.
PubMed:Simultaneous high-performance liquid chromatographic determination of paracetamol, phenylephrine HCl, and chlorpheniramine maleate in pharmaceutical dosage forms.
PubMed:Influence of plasticization time, curing conditions, storage time, and core properties on the drug release from Aquacoat-coated pellets.
PubMed:Influence of chlorpheniramine maleate on topical hydroxypropylcellulose films produced by hot-melt extrusion.
PubMed:Separation of cold medicine ingredients by capillary electrophoresis.
PubMed:Allergic contact dermatitis due to both chlorpheniramine maleate and dibucaine hydrochloride in an over-the-counter medicament.
PubMed:Hydrophilic matrices for controlled drug delivery: an improved mathematical model to predict the resulting drug release kinetics (the "sequential layer" model).
PubMed:Quantitative analysis of chlorpheniramine maleate and phenylephrine hydrochloride in nasal drops by differential-derivative spectrophotometric, zero-crossing first derivative UV spectrophotometric and absorbance ratio methods.
PubMed:Synthesis of iron-crosslinked hydroxamated alginic acid and its in vitro evaluation as a potential matrix material for oral sustained-release beads.
PubMed:Evidence for the degradation of maleate moiety in chlorpheniramine maleate solution using a stability-indicating HPLC method.
PubMed:Drug release from film-coated chlorpheniramine maleate nonpareil beads: effect of water-soluble polymer, coating level, and soluble core material.
PubMed:Formulation and evaluation of Methocel K15M bioadhesive matrix tablets.
PubMed:Calculation of the required size and shape of hydroxypropyl methylcellulose matrices to achieve desired drug release profiles.
PubMed:Histaminergic effect on apoptosis of rat small intestinal mucosa after ischemia-reperfusion.
PubMed:Efficacy of potential chemopreventive agents on rat colon aberrant crypt formation and progression.
PubMed:Formulation and process considerations for beads containing Carbopol 974P, NF resin made by extrusion-spheronization.
PubMed:Premedication with dextromethorphan provides posthemorrhoidectomy pain relief.
PubMed:Preincisional dextromethorphan treatment for postoperative pain management after upper abdominal surgery.
PubMed:Full and fractionated experimental designs for robustness testing in the high-performance liquid chromatographic analysis of codeine phosphate, pseudoephedrine hydrochloride and chlorpheniramine maleate in a pharmaceutical preparation.
PubMed:Time dependent pharmacokinetic interaction between phenylpropanolamine and chlorpheniramine maleate in human subjects.
PubMed:Multimechanism oral dosage forms fabricated by three dimensional printing.
PubMed:Atomic emission spectrometric determination of ephedrine, cinchonine, chlorpheniramine, atropine and diphenhydramine based on formation of ion associates with ammonium reineckate.
PubMed:Preincisional dextromethorphan decreases postoperative pain and opioid requirement after modified radical mastectomy.
PubMed:Drug release from film-coated chlorpheniramine maleate nonpareil beads: water influx and development of a new drug release model.
PubMed:Transmucosal sustained-delivery of chlorpheniramine maleate in rabbits using a novel, natural mucoadhesive gum as an excipient in buccal tablets.
PubMed:Design and evaluation of a new transdermal formulation containing chlorpheniramine maleate.
PubMed:Evidence that mast cell degranulation, histamine and tumour necrosis factor alpha release occur in LPS-induced plasma leakage in rat skin.
PubMed:Development of a multifunctional matrix drug delivery system surrounded by an impermeable cylinder.
PubMed:[Effect of beta-glycyrrhizinate on eye mucosa absorption of drugs].
PubMed:Evaluation of the gum from Hakea gibbosa as a sustained-release and mucoadhesive component in buccal tablets.
PubMed:Preincisional dextromethorphan treatment decreases postoperative pain and opioid requirement after laparoscopic cholecystectomy.
PubMed:Drug release from beads coated with an aqueous colloidal ethylcellulose dispersion, Aquacoat, or an organic ethylcellulose solution.
PubMed:Properties of sustained-release tablets prepared by hot-melt extrusion.
PubMed:Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropylcellulose films prepared by hot melt extrusion.
PubMed:Non-traditional plasticization of polymeric films.
PubMed:Dapsone versus corticosteroids in lichen planus.
PubMed:Microencapsulation of chlorpheniramine maleate-resin particles with crosslinked chitosan for sustained release.
PubMed:Prolonged release of drug from O/w emulsion and residence in rat nasal cavity.
PubMed:A partial involvement of histamine in ultrasonically nebulized distilled water-induced bronchoconstriction in guinea-pigs.
PubMed:On the employment of lambda carrageenan in a matrix system. III. Optimization of a lambda carrageenan-HPMC hydrophilic matrix.
PubMed:Nonprescription chlorpheniramine maleate and submaximal exercise responses.
PubMed:Optimization of sustained-release tablet formulations: a four-component mixture experiment.
PubMed:Evaluation of extended-release applications for solid dispersion hot-melt fluid bed coatings utilizing hydrophobic coating agents.
PubMed:Mechanisms of chlorpheniramine maleate release from hydrophilic swellable polymer systems.
PubMed:In vitro characterization of a controlled-release chlorpheniramine maleate delivery system prepared by the air-suspension technique.
PubMed:Development of a novel controlled-release system for gastric retention.
PubMed:Swelling of and drug release from monoglyceride-based drug delivery systems.
PubMed:Rapid and accurate determination of chlorpheniramine maleate, noscapine hydrochloride and guaiphenesin in binary mixtures by derivative spectrophotometry.
PubMed:[Determination of multicomponent contents in anticold solution by high performance liquid chromatography].
PubMed:Near-infrared spectroscopy as a nondestructive alternative to conventional tablet hardness testing.
PubMed:H1-receptor-mediated excitation and facilitation of the heat response by histamine in canine visceral polymodal receptors studied in vitro.
PubMed:New formulation of aqueous flunisolide nasal spray in the treatment of allergic rhinitis: comparative assessment of safety, tolerability, and efficacy.
PubMed:[Quantitative analysis of chlorpheniramine maleate in cough and cold drugs by ion-pair high-performance liquid chromatography for the simultaneous determination of chlorpheniramine and maleate].
PubMed:Safety and efficacy of azelastine nasal spray (Astelin NS) for seasonal allergic rhinitis: a 4-week comparative multicenter trial.
PubMed:Design and evaluation of transdermal chlorpheniramine maleate drug delivery system.
PubMed:Histaminergic control of mucosal repair in the small intestine.
PubMed:Simultaneous assay of phenylpropanolamine hydrochloride, caffeine, paracetamol, glycerylguaiacolate and chlorpheniramine maleate in Silabat tablet using HPLC with diode array detection.
PubMed:Modified release matrix prepared by compaction of spheres containing waxy material.
PubMed:A case of iatrogenic growth retardation induced by a corticosteroid-containing anti-allergic drug.
PubMed:A novel psychophysical procedure for bitter taste assessment in rats.
PubMed:A comparative study of various therapeutic regimens in urticaria.
PubMed:Properties of multiphase microspheres of poly(D,L-lactic-co-glycolic acid) prepared by a potentiometric dispersion technique.
PubMed:The combination of antihistamine (chlorpheniramine) and an omega-3/omega-6 fatty acid-containing product for the management of pruritic cats: results of an open clinical trial.
PubMed:In vitro adsorption of phenobarbital, chlorpheniramine maleate, and theophylline by four commercially available activated charcoal suspensions.
PubMed:Allergic conjunctivitis and uveitis models: reappraisal with some marketed drugs.
PubMed:A dose-ranging study of the efficacy and safety of azelastine nasal spray in the treatment of seasonal allergic rhinitis with an acute model.
PubMed:Sensitive high-performance liquid chromatographic determination of chlorpheniramine in human serum using column switching.
PubMed:Role of histamine receptors in intestinal repair after ischemia-reperfusion in rats.
PubMed:Mechanical properties of dry and wet cellulosic and acrylic films prepared from aqueous colloidal polymer dispersions used in the coating of solid dosage forms.
PubMed:[Effect of gastrin and H2-receptor antagonist on electrical control activity following canine intestinal transection].
PubMed:Cough variant asthma: a case study with antigen, histamine and methacholine inhalation challenge tests.
PubMed:Azelastine nasal spray in the management of seasonal allergic rhinitis.
PubMed:Mixed ion pair liquid chromatography method for the simultaneous assay of ascorbic acid, caffeine, chlorpheniramine maleate, dextromethorphan HBr monohydrate and paracetamol in Frenadol sachets.
PubMed:Estimation of the molecular weight of an interacting chlorpheniramine maleate-salicylamide system from dissolution rate data.
PubMed:Comparative study of SCH 434 and CTM-D in the treatment of seasonal allergic rhinitis.
PubMed:Mydriatic effect of ocular decongestants studied by pupillography.
PubMed:Comparison of azelastine and chlorpheniramine in the treatment of mastocytosis.
PubMed:Determination of chlorpheniramine maleate in tablets and injections by 1H-NMR spectroscopy.
PubMed:Dissolution, stability, and morphological properties of conventional and multiphase poly(DL-lactic-co-glycolic acid) microspheres containing water-soluble compounds.
PubMed:Over-the-counter cold medications. A critical review of clinical trials between 1950 and 1991.
PubMed:Automated drug dissolution monitor that uses a UV-visible diode array spectrophotometer.
PubMed:Effects of FR 113680 and FK 224, novel tachykinin receptor antagonists, on cigarette smoke-induced rat tracheal plasma extravasation.
PubMed:Relationship of film properties to drug release from monolithic films containing adjuvants.
PubMed:Correlation of in vitro release rate and in vivo absorption characteristics of four chlorpheniramine maleate extended-release formulations.
PubMed:Formulation optimization of sustained-release tablet of chlorpheniramine maleate by means of extreme vertices design and simultaneous optimization technique.
PubMed:Effect of physical and chemical properties on drug release from selected thermosoftening vehicles.
PubMed:Response of plasma membrane to applied hydrostatic pressure in chondrocytes and fibroblasts.
PubMed:Spectrophotometric determination of ephedrine HCl, cinchonine HCl, chlorpheniramine maleate, atropine sulphate and diphenhydramine HCl by solvent extraction of reineckate complexes.
PubMed:The optical resolution of racemic chlorpheniramine and its stereoselective pharmacokinetics in rat plasma.
PubMed:Drug-induced acute pulmonary edema--sequential changes in CT images.
PubMed:Comparative effect of dimethindene maleate and chlorpheniramine maleate on histamine-induced weal and flare.
PubMed:In vitro and in vivo correlation for controlled-release formulation of d-chlorpheniramine maleate.
PubMed:N(+)-glucuronidation of aliphatic tertiary amines, a general phenomenon in the metabolism of H1-antihistamines in humans.
PubMed:Acute poisoning from hair dye.
PubMed:Release of chlorpheniramine maleate from fatty acid ester matrix disks prepared by melt-extrusion.
PubMed:Development of a new controlled-release formulation of chlorpheniramine maleate using in vitro/in vivo correlations.
PubMed:Extraction-frequencymetric method. A new measurement technique for determination of micro amounts of chlorpheniramine.
PubMed:Responses of the L5178Y mouse Lymphoma cell forward mutation assay. V: 27 coded chemicals.
PubMed:Cimetidine does not change the effect of Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2) on the opiate form of footshock-induced analgesia.
PubMed:Solubilization of salicylamide and acetaminophen by antihistamines in aqueous solution.
PubMed:[The role of eosinophils, neutrophils and lymphocytes for the development of bronchial hyperresponsiveness in a guinea pig model of asthma].
PubMed:Physical and chemical factors influencing the release of drugs from acrylic resin films.
PubMed:Efficacy of chlorpheniramine maleate for management of pruritus in cats.
PubMed:Determination of chlorpheniramine maleate, dihydrocodeine bitartrate and ephedrine hydrochloride in cough mixture by derivative and differential spectrometry.
PubMed:[Inhibitory effect of FK-506 on the development of late asthmatic response and on the increased bronchial responsiveness].
PubMed:Allergic rhinitis model with Brown Norway rat and evaluation of antiallergic drugs.
PubMed:[Inhibition of antigen-induced late asthmatic response and bronchial hyperresponsiveness by cyclosporin A].
PubMed:Changes in adrenal neuropeptides content [peptide 7B2, neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP)] induced by pharmacological and hormonal manipulations.
PubMed:Responsiveness of chloroquine-induced pruritus to antihistamine therapy--a clinical survey.
PubMed:Drug release from laminated polymeric films prepared from aqueous latexes.
PubMed:Contact dermatitis due to chlorpheniramine maleate in eyedrops.
PubMed:A possible case of drug-induced familial pemphigus.
PubMed:The pathophysiology of rhinitis. III. The control of IgG secretion.
PubMed:Quantitation of cutaneous inflammation induced by reactive species generated by UV-visible irradiation of rose bengal.
PubMed:Differential cognitive effects of terfenadine and chlorpheniramine.
PubMed:Prevention of adverse reactions following milbemycin D administration to microfilaremic dogs infected with Dirofilaria immitis.
PubMed:Determination of chlorpheniramine maleate in tablets by second-derivative absorption spectrophotometry.
PubMed:[Behavior of chlorpheniramine in vivo after administration of d- and l-chlorpheniramine maleate].
PubMed:Multicenter, double-blind, multiple-dose, parallel-groups efficacy and safety trial of azelastine, chlorpheniramine, and placebo in the treatment of spring allergic rhinitis.
PubMed:Simultaneous determination of pseudoephedrine hydrochloride, chlorpheniramine maleate, and dextromethorphan hydrobromide by second-derivative photodiode array spectroscopy.
PubMed:[Antiemetic protocol in oncohematologic polychemotherapy].
PubMed:Management of ovarian hyperstimulation syndrome with chlorpheniramine maleate, mannitol, and invasive hemodynamic monitoring.
PubMed:Skin permeation of chlorpheniramine maleate and detection of demethylated metabolites by high-performance liquid chromatography.
PubMed:The role of mediators in the response of the canine peripheral lung to 1 ppm ozone.
PubMed:Simultaneous analysis of acetaminophen, pseudoephedrine hydrochloride and chlorpheniramine maleate in a cold tablet using an isocratic, mixed micellar high-performance liquid chromatographic mobile phase.
PubMed:Intranasally and orally administered antihistamine treatment of experimental rhinovirus colds.
PubMed:Hypocapnia-induced constriction of the canine peripheral airways exhibits tachyphylaxis.
PubMed:Hay fever treatments--which should be tried first?
PubMed:A comparison of budesonide and beclomethasone dipropionate nasal aerosols in ragweed-induced rhinitis.
PubMed:Effects of H1 antihistamines on canine nasal vascular and airway resistances.
PubMed:Gastric rupture and death caused by ipecac syrup.
PubMed:Efficacy of an H1 antagonist, astemizole, for chronic allergic rhinitis.
PubMed:Analysis of multicomponent formulations containing pseudoephedrine HCl and chlorpheniramine maleate using first-derivative spectroscopy on a diode-array spectrophotometer.
PubMed:Effect of histamine and antihistamines on interleukin-1 production by human monocytes.
PubMed:Effect of diethylcarbamazine citrate and anti-inflammatory drugs on experimental onchocercal punctate keratitis.
PubMed:Suppression of histamine-induced wheal response by loratadine (SCH 29851) over 28 days in man.
PubMed:Simultaneous determination of codeine and chlorpheniramine in human plasma by capillary column gas chromatography.
PubMed:NTP Toxicology and Carcinogenesis Studies of Chlorpheniramine Maleate (CAS No. 113-92-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
PubMed:Nonprescription drug screening. Chlorpheniramine maleate.
PubMed:Derivative spectrophotometric determination of some corticosteroids in combinations with other drugs.
PubMed:Synthesis of 2-(4-substituted-1-piperazinyl)benzimidazoles as H1-antihistaminic agents.
PubMed:Gas chromatographic determination of histapyrrodine hydrochloride in pharmaceutical preparations.
PubMed:Taste preference for cough syrups: a comparative study of three codeine-containing medications.
PubMed:Pharmacologic evaluation of loratadine (SCH 29851), chlorpheniramine and placebo.
PubMed:High-performance liquid chromatography of antipyretics on chemically modified porous glass.
PubMed:Liquid chromatographic determination of organic nitrogenous bases in dosage forms: a progress report.
PubMed:Unusual effects of histamine antagonists on canine nasal blood vessels.
PubMed:The effect of an aerosolized antihistamine, chlorpheniramine maleate, on exercise-induced bronchospasm.
PubMed:Quantitation of acetaminophen, chlorpheniramine maleate, dextromethorphan hydrobromide, and phenylpropanolamine hydrochloride in combination using high-performance liquid chromatography.
PubMed:Inhibitory effects of various drugs on phorbol myristate acetate and n-formyl methionyl leucyl phenylalanine induced O2- production in polymorphonuclear leukocytes.
PubMed:Bare silica as a reverse-phase stationary phase: liquid chromatographic separation of antihistamines with buffered aqueous organic mobile phases.
PubMed:In vitro dissolution profile and in vivo absorption study of sustained-release tablets containing chlorpheniramine maleate with water-insoluble glucan.
PubMed:Subnanogram quantitation of chlorpheniramine in plasma by a new radioimmunoassay and comparison with a liquid chromatographic method.
PubMed:Enhanced skin reactivity to platelet-derived permeability factor (PDPF) and exogenous histamine in an acute phase rabbit model.
PubMed:Sustained-release dosage forms containing chlorpheniramine maleate with water-insoluble glucan.
PubMed:Liquid chromatographic determination of acetaminophen in multicomponent analgesic tablets.
PubMed:Clinical, endocrinologic, and intraovarian prostaglandin F responses to H-1 receptor blockade in the ovarian hyperstimulation syndrome: studies in the rabbit model.
PubMed:The effect of an H1 blocker, chlorpheniramine maleate, on total menstrual loss.
PubMed:Studies on the efficacy of some post-service intrauterine infusions on the conception rate of repeat breeding cattle.
PubMed:The protective effect of inhaled chlorpheniramine and atropine on bronchoconstriction stimulated by airway cooling.
PubMed:Multi-center, double-blind, placebo-controlled trial of fluocortin butyl in perennial rhinitis.
PubMed:Inhibition of histamine-induced nasal symptoms by the H1 antihistamine chlorpheniramine maleate: demonstration of topical effect.
PubMed:Lack of efficacy of a decongestant-antihistamine combination for otitis media with effusion ("secretory" otitis media) in children. Results of a double-blind, randomized trial.
PubMed:Significance of H1 and H2 receptors in the human nose: rationale for topical use of combined antihistamine preparations.
PubMed:Controlled trial of terfenadine and chlorpheniramine maleate in perennial rhinitis.
PubMed:Simultaneous spectrophotometric determination of dibucaine and chlorpheniramine maleate in pharmaceuticals using thermochromism of ion associates.
PubMed:Effect of the H1 antihistamine chlorpheniramine maleate on histamine-induced symptoms in the human conjunctiva. Indirect evidence for nervous H1 receptors.
PubMed:Blockade of carcinoid flush with cimetidine and clonidine.
PubMed:Clinical studies of terfenadine in seasonal allergic rhinitis.
PubMed:[Pharmacological study of mequitazine (LM-209) (II). Anti-allergic action (author's transl)].
PubMed:[Pharmacological study of mequitazine (LM-209) (I). Antagonistic actions of chemical mediators (author's transl)].
PubMed:High pressure liquid chromatographic determination of antihistamine-adrenergic combination products: collaborative study.
PubMed:The effects upon vigilance and reaction speed of the addition of ephedrine hydrochloride to chlorpheniramine maleate.
PubMed:The effectiveness of antihistamines in the common cold.
PubMed:IR and X-ray diffraction study of chlorpheniramine maleate-montmorillonite interaction.
PubMed:High-performance liquid chromatographic assay of codeine in acetaminophen with codeine dosage forms.
PubMed:Evaluation of sustained-action chlorpheniramine-pseudoephedrine dosage form in humans.
PubMed:Simultaneous GLC analysis of salicylamide, phenylpropanolamine hydrochloride, caffeine, chlorpheniramine maleate, phenylephrine hydrochloride, and pyrilamine maleate in capsule preparations.
PubMed:Effect of decongestant with or without antihistamine on eustachian tube function.
PubMed:Spectrophotometric method for determination of chlorpheniramine maleate in pharmaceutical preparations in the presence of codeine phosphate and ephedrine hydrochloride.
PubMed:Clinical investigation of terfenadine, a non-sedating antihistamine.
PubMed:High pressure liquid chromatographic determination of antihistamine-adrenergic combination products.
PubMed:Isolation and identification of the polar metabolites of chlorpheniramine in the dog.
PubMed:Effectiveness of antihistamines in the symptomatic management of the common cold.
PubMed:Semautomated method for the analysis of chlorpheniramine maleate tablets: collaborative study.
PubMed:Urinary excretion of chlorpheniramine and pseudoephedrine in humans.
PubMed:[High performance liquid chromatographic analysis of drugs. I. Simultaneous determination of dexamethasone and chlorpheniramine maleate in ointment (author's transl)].
PubMed:Semiautomated method for the analysis of formulations of chlorpheniramine maleate and brompheniramine maleate.
PubMed:Histamine-induced ACTH secretion and inhibitory effect of antihistaminic drugs.
PubMed:Applications of paired ion high-pressure liquid chromatography: quantitative determination of potassium guaiacolsulfonate and other ingredients in cough syrups.
PubMed:Ultrastructural observations on mast cell degranulation and its prevention.
PubMed:Bronchial hyperreactivity to histamine and methacholine in asthmatic children after inhalation of SCH 1000 and chlorpheniramine maleate.
PubMed:Studies on antihistaminic action. II: In vitro and in vivo effect of chlorpheniramine and its analogs on the uptake and retention of 5-hydroxytryptamine by rabbit blood platelets.
PubMed:Systemic reactions with total dose infusion of iron dextran complex in obstetric patients.
PubMed:Evaluation of the local antihistaminic activity of dimetindene maleate by a quantitative method.
PubMed:A repeated dose comparison of the side effects of five antihistamines on objective assessments of psychomotor performance, central nervous system arousal and subjective appraisals of sleep and early morning behaviour.
PubMed:Primary acquired cold urticaria. Double-blind comparative study of treatment with cyproheptadine, chlorpheniramine, and placebo.
PubMed:Uptake and release of 5-hydroxytryptamine by rabbit platelets. II. Kinetic analysis of inhibition by chlorpheniramine maleate.
PubMed:Quantitative determination of four antihistamines in combination by high-pressure liquid chromatography.
PubMed:Determination of nanogram amounts of aromatic compounds by spectrophotometry on thin-layer chromatograms.
PubMed:Aggregation of antihistamines in aqueous solution: effect of counterions on self-association of pyridine derivatives.
PubMed:Simultaneous quantitative GLC determination of chlorpheniramine maleate and phenylpropanolamine hydrochloride in a cold tablet preparation.
PubMed:Stress incontinence: conservative therapy with sympathomimetic drugs.
PubMed:Infrared identification of maleic acid in pharmaceutical maleate salts.
PubMed:A comparative study of clemastine ('Tavegil') and chlorpheniramine maleate in the treatment of hay fever.
PubMed:Colorimetric determinations of chlorpheniramine maleate, ephedrine hydrochloride, and guaiacolsulfonate potassium in a cough syrup.
PubMed:Role of histamine in the hypoxic vascular response of the lung.
PubMed:Inhibition of the primary lesion of adjuvant. induced polyarthritis in rats (18-hour arthritis test) for specific detection of clinically effective anti-arthritic drugs.
PubMed:Polarographic determination of chlorpheniramine maleate in pharmaceuticals.
PubMed:Studies on antihistaminic action. I. Effect of chlorpheniramine maleate on blood levels of 5-hydroxytryptamine and histamine in the rabbit.
PubMed:The metabolism of chlorpheniramine maleate in the dog and rat.
PubMed:Metabolism of chlorpheniramine maleate in man.
PubMed:A new long-acting formulation of chlorpheniramine maleate in hay fever.
PubMed:[Studies on analysis of mixed anti-cold pharmaceutical preparations. 8. Colorimetric determination of chlorpheniramine maleate and tripelennamine hydrochloride with cobaltothiocyanate].
PubMed:[Effect of a new antihistamine 8599RP on chronic urticaria, with special reference to its comparison with d-chlorpheniramine maleate].
PubMed:[Colorimetric determination of chlorpheniramine maleate with chlorocyan and 1-phenyl-3-methyl-5-pyrazolone].
PubMed:[Considerations on the use of dextro-chlorpheniramine maleate cream in some cases of allergic dermatitis].
PubMed:Chlorpheniramine maleate tablets.
PubMed:COLORIMETRIC DETERMINATION OF CHLORPHENIRAMINE MALEATE.
PubMed:Vascular effects of chlorpheniramine maleate (Chlor-Trimeton).
PubMed:[Colorimetric determination of chlorpheniramine maleate in antipyretic preparations].
PubMed:Chlorpheniramine maleate in prophylaxis of pyrexial reactions during blood-transfusions.
PubMed:Treatment of pruritic dermatoses with chlorpheniramine maleate and prednisone in combination (metreton).
 
Notes:
a histamine h1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. it has also been used in veterinary applications. one of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
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