EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

calcium propionate
propanoic acid, calcium salt (2:1)

Supplier Sponsors

Name:calcium propanoate
CAS Number: 4075-81-4Picture of molecule3D/inchi
Other(deleted CASRN):1298120-01-0
ECHA EINECS - REACH Pre-Reg:223-795-8
Nikkaji Web:J3.064C
Beilstein Number:3698682
Molecular Weight:186.22050000
Formula:C6 H10 Ca O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:preservatives, antimould and antirope agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1221 Calcium propionate View - review
GRN 157 Calcium propionate (alternative method of manufacture) View - notice PDF
EU SANCO Calcium propionate View - review
EU SANCO Calcium propionate View - review
GRN 786 Calcium propionate View - notice PDF
JECFA Food Additive: Calcium Propionate
GSFA Codex: Calcium propionate (282)
DG SANTE Food Additives:calcium propionate
FDA Mainterm (SATF):4075-81-4 ; CALCIUM PROPIONATE
FDA Regulation:
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.123 Cold-pack and club cheese.

Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.124 Cold-pack cheese food.

Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.169 Pasteurized process cheese.

Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.173 Pasteurized process cheese food.

Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.179 Pasteurized process cheese spread.

Subpart B--Requirements for Specific Standardized Bakery Products
Sec. 136.110 Bread, rolls, and buns.

Subpart B--Requirements for Specific Standardized Bakery Products
Sec. 136.115 Enriched bread, rolls, and buns.

Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.141 Artificially sweetened fruit jelly.

Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.161 Artificially sweetened fruit preserves and jams.

Subpart C--Packaging Materials for Irradiated Foods
Sec. 179.45 Packaging materials for use during the irradiation of prepackaged foods.

Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.23 Antimycotics.

Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1221 Calcium propionate.
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 98.00 to 100.00
Water Content:6% max.
Food Chemicals Codex Listed: Yes
Boiling Point: 141.70 °C. @ 760.00 mm Hg (est)
Vapor Pressure:4.230000 mmHg @ 25.00 °C. (est)
Flash Point: 136.00 °F. TCC ( 57.70 °C. ) (est)
logP (o/w): 0.246 (est)
Soluble in:
 water, 1.116e+005 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor Description:at 100.00 %. bland mild propionic acid
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: preservatives
Calcium Propionate
American International Chemical, LLC.
Anhui Haibei
Calcium Propionate
BOC Sciences
For experimental / research use only.
Calcium Propionate > 95%
Odor: characteristic
Use: Calcium Propionate is an antifungal agent.It can also be used as a food preservative
Covalent Chemical
Calcium Propionate
ECSA Chemicals
Foodchem International
Calcium Propionate
Glentham Life Sciences
Calcium propionate
Graham Chemical
Calcium Propionate
Indis NV
For experimental / research use only.
Calcium Propionate
Jarchem Industries
Jarace™ CP
Odor: characteristic
Use: Is used as a preservative in a wide variety of products, including but not limited to bread, other baked goods, processed meat, whey, and other dairy products. A mold inhibitor in bakery products at levels of 0.1 - 0.4%. In agriculture it is used to prevent milk fever in cows and as a feed supplement. Propionates prevent microbes from producing the energy they need, like benzoates do. However, unlike benzoates, propionates do not require an acidic environment.
Kraft Chemical
Calcium Propionate
Penta International
Penta International
Qingdao Dacon Trading
Calcium Propionate
Sigma-Aldrich: Aldrich
For experimental / research use only.
Calcium Propionate ≥97.0% (dry substance, NT)
Sinofi Food Ingredients
Calcium Propionate
Odor: characteristic
Use: Preservative, Cosmetics, Feed, Pharmaceutical, Antimicrobial, Mold Inhibitor, Antifungal, Antibacterial, Sauces, Baking Food, Cake Mixes, Bread, Cheese, Confections, Frostings, Gelatins, Puddings, Fillings, Jams, Jellies, Tobacco, Toothpaste, Packing Materials.
For experimental / research use only.
Propionic Acid Calcium Salt >98.0%(T)
United International
Calcium Propionate
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 2350 mg/kg
Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 27, Pg. 159, 1976.

oral-rat LD50 3920 mg/kg
Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 27, Pg. 159, 1976.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
preservatives, antimould and antirope agents
Recommendation for calcium propionate usage levels up to:
 not for fragrance use.
Recommendation for calcium propionate flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the safety and efficacy of propionic acid, sodium propionate, calcium propionate and ammonium propionate for all animal species
View page or View pdf

Scientific Opinion on the re-evaluation of propionic acid (E 280), sodium propionate (E 281), calcium propionate (E 282) and potassium propionate (E 283) as food additives
View page or View pdf

Outcome of the consultation with Member States and EFSA on the basic substance application for approval of calcium propionate to be used in plant protection as a fungicide in amenity grassland and on flower bulb and flower tuber crops
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):4075-81-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :19999
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
calcium propanoate
RTECS:UE8450000 for cas# 4075-81-4
 calcium propanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:4075-81-4
Pubchem (cid):19999
Pubchem (sid):134985066
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
KEGG (GenomeNet):C18379
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2915.50.5000
FDA Listing of Food Additive Status:View
FAO:Calcium propionate
grade: fcc
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
 calcium dipropanoate
 calcium dipropionate
 calcium propionate FCC
 calcium propanoate
 calcium propionate FCC agglomerate
 calcium propionate hydrate
 calcium propionate powder FCC
 jarace CP
 propanoic acid calcium salt
 propanoic acid, calcium salt
 propanoic acid, calcium salt (2:1)
 propionic acid calcium salt


PubMed:Water availability and calcium propionate affect fungal population and aflatoxins production in broiler finisher feed during storage.
PubMed:A proteomics study of hyperhomocysteinemia injury of the hippocampal neurons using iTRAQ.
PubMed:Framework complexes of group 2 metals organized by homochiral rods and π···π stacking forces: a breathing supramolecular MOF.
PubMed:Safety and efficacy of calcipotriol plus betamethasone dipropionate gel in the treatment of scalp psoriasis in adolescents 12-17 years of age.
PubMed:The effect of dietary alterations during rearing on feather condition in broiler breeder females.
PubMed:Inhaled corticosteroids in children: effects on bone mineral density and growth.
PubMed:Propionibacterium acidipropionici P169 and glucogenic precursors improve rumen fermentation of low-quality forage in beef cattle.
PubMed:Evaluation of β-D-glucan biopolymer as a novel mycotoxin binder for fumonisin and deoxynivalenol in soybean feed.
PubMed:Alpacas fed calcium propionate seem to moderate their energy intake.
PubMed:The effect of dietary alterations during rearing on growth, productivity, and behavior in broiler breeder females.
PubMed:Effect of calcipotriene plus betamethasone dipropionate topical suspension on the hypothalamic-pituitary-adrenal axis and calcium homeostasis in subjects with extensive psoriasis vulgaris: an open, non-controlled, 8-week trial.
PubMed:Production and partial characterisation of an inducer-dependent novel antifungal compound(s) by Pediococcus acidilactici LAB 5.
PubMed:The effectiveness of using different pulp-capping agents on the healing response of the pulp.
PubMed:DNA damage in human lymphocytes exposed to four food additives in vitro.
PubMed:Calcinosis cutis following contact with calcium chloride solution.
PubMed:Antifungal activity of Leuconostoc citreum and Weissella confusa in rice cakes.
PubMed:The use of conditioned place preference to determine broiler preferences for quantitative or qualitative dietary restriction.
PubMed:The effect of sourdough and calcium propionate on the microbial shelf-life of salt reduced bread.
PubMed:Performance and plasma metabolites of dairy calves fed starter containing sodium butyrate, calcium propionate or sodium monensin.
PubMed:Response surface methodology-based optimization of decontamination conditions for Escherichia coli O157:H7 and Salmonella Typhimurium on fresh-cut celery using thermoultrasound and calcium propionate.
PubMed:Antifungal activity of sourdough fermented wheat germ used as an ingredient for bread making.
PubMed:The Indian drawings of the poet Cesare Pascarella: non-destructive analyses and conservation treatments.
PubMed:The influence of mannan oligosaccharides, acidifiers and their combination on caecal microflora of Japanese quail (Coturnix japonica).
PubMed:The effect of increasing amount of glucogenic precursors on reproductive performance in young postpartum range cows.
PubMed:Antifungal activity of Wickerhamomyces anomalus and Lactobacillus plantarum during sourdough fermentation: identification of novel compounds and long-term effect during storage of wheat bread.
PubMed:Lactobacillus amylovorus DSM 19280 as a novel food-grade antifungal agent for bakery products.
PubMed:Gateways to clinical trials.
PubMed:In vitro antifungal effect of black cumin seed quinones against dairy spoilage yeasts at different acidity levels.
PubMed:Nutritional value of sugarcane silage enriched with corn grain, urea, and minerals as feed supplement on growth performance of beef steers grazing stargrass.
PubMed:Combination of sodium chlorite and calcium propionate reduces enzymatic browning and microbial population of fresh-cut "Granny Smith" apples.
PubMed:Effect of calcium propionate and water activity on growth and aflatoxins production by Aspergillus flavus.
PubMed:Influence of dietary peas and organic acids and probiotic supplementation on performance and caecal microbial ecology of broiler chickens.
PubMed:Chronic inhibition of nitric-oxide synthase potentiates endothelium-dependent contractions in the rat aorta by augmenting the expression of cyclooxygenase-2.
PubMed:A ready-to-use antifungal starter culture improves the shelf life of packaged bread.
PubMed:Effects of calcium propionate supplementation on lactation performance, energy balance and blood metabolites in early lactation dairy cows.
PubMed:Antibacterial interactions of monolaurin with commonly used antimicrobials and food components.
PubMed:Gateways to clinical trials.
PubMed:Application of raisin extracts as preservatives in liquid bread and bread systems.
PubMed:Antifungal activity of strains of lactic acid bacteria isolated from a semolina ecosystem against Penicillium roqueforti, Aspergillus niger and Endomyces fibuliger contaminating bakery products.
PubMed:Long-term fungal inhibitory activity of water-soluble extracts of Phaseolus vulgaris cv. Pinto and sourdough lactic acid bacteria during bread storage.
PubMed:Failure to improve energy balance or dehydration by drenching transition cows with water and electrolytes at calving.
PubMed:Effectiveness of methods for reducing acrylamide in bakery products.
PubMed:The use of sourdough fermented by antifungal LAB to reduce the amount of calcium propionate in bread.
PubMed:[Effects of long term use of beclomethasone dipropionate nasal spray on bone density with perennial allergic rhinitis].
PubMed:Production and carcase traits in broiler chickens given diets supplemented with inorganic trivalent chromium and an organic acid blend.
PubMed:Evaluation of genotoxic effects of sodium propionate, calcium propionate and potassium propionate on the root meristem cells of Allium cepa.
PubMed:Use of Lactobacillus plantarum fermentation products in bread-making to prevent Bacillus subtilis ropy spoilage.
PubMed:Combinations of antimycotics to inhibit the growth of molds capable of producing 1,3-pentadiene.
PubMed:Gateways to clinical trials.
PubMed:Physiological relationship between food preservatives, environmental factors, ochratoxin and otapksPV gene expression by Penicillium verrucosum.
PubMed:Effect of dietary calcium propionate on performance, enzyme activities and aflatoxin residues in broilers fed a diet containing low levels of aflatoxin B1.
PubMed:Gateways to clinical trials.
PubMed:Gateways to clinical trials.
PubMed:Gateways to clinical trials.
PubMed:Gateways to clinical trials.
PubMed:Extended shelf life of soy bread using modified atmosphere packaging.
PubMed:Effect of supplemental calcium propionate on insulin action to blood glucose metabolism in adult sheep.
PubMed:Effects of supplements that contain increasing amounts of metabolizable protein with or without Ca-propionate salt on postpartum interval and nutrient partitioning in young beef cows.
PubMed:Multiple outbreaks of gastrointestinal illness among school children associated with consumption of flour tortillas--Massachusetts, 2003-2004.
PubMed:Effect of dietary calcium propionate on performance, hepatic enzyme activities and aflatoxin residues in broilers fed a diet containing low levels of aflatoxin B1.
PubMed:Gateways to clinical trials.
PubMed:Gateways to clinical trials.
PubMed:Adipose tissue metabolism and production responses to calcium propionate and chromium propionate.
PubMed:Behaviour of food restricted broilers during rearing and lay--effects of an alternative feeding method.
PubMed:Study of benzoate, propionate, and sorbate salts as mould spoilage inhibitors on intermediate moisture bakery products of low pH (4.5-5.5).
PubMed:Environmental factors and weak organic acid interactions have differential effects on control of growth and ochratoxin A production by Penicillium verrucosum isolates in bread.
PubMed:Gateways to clinical trials.
PubMed:Gateways to clinical trials.
PubMed:Effects of dietary glucogenic precursors and fat on feed intake and carbohydrate status of transition dairy cows.
PubMed:Effect of weak acid preservatives on growth of bakery product spoilage fungi at different water activities and pH values.
PubMed:Effect of calcium-energy supplements on calving-related disorders, fertility and milk yield during the transition period in cows fed anionic diets.
PubMed:Diethylstilbestrol and tetrahydrochrysenes are calcium channel blockers in human platelets: relationship to the stilbene pharmacophore.
PubMed:In vitro growth response of bread-spoilage Bacillus strains to selected natural antimicrobials.
PubMed:Influence of modified atmosphere packaging on the shelf life of prebaked pizza dough with and without preservative added.
PubMed:Risk assessment of the use of sub-optimal levels of weak-acid preservatives in the control of mould growth on bakery products.
PubMed:Changes in calcium, PTH and 1,25(OH)2 vitamin D3 during tail-suspension in ovariectomized rats: effects of estrogen administration.
PubMed:Controlled trial of cumulative behavioural effects of a common bread preservative.
PubMed:Gateways to clinical trials.
PubMed:Metabolic responses of transition Holstein cows fed anionic salts and supplemented at calving with calcium and energy.
PubMed:Gateways to clinical trials.
PubMed:[The effects of BDP on calcium ion in the granular leukocytes in nasal secretions of the patients with allergic rhinitis].
PubMed:[Systemic side effects of long-term treatment with low dose inhaled corticosteroids in children with asthma].
PubMed:Effect of adrenocorticotrophic hormone on the development of oestrogen-induced changes and hyperplasia formation in the mouse uterus.
PubMed:Decreased osteocalcin levels in patients with chronic obstructive pulmonary disease using long-term inhaled beclomethasone dipropionate.
PubMed:Effect of selected natural antimicrobials on Baker's yeast activity.
PubMed:Effect of estrogen on the development of disuse atrophy of bone and muscle induced by tail-supension in rats.
PubMed:Effect of the long-term use of inhaled corticosteroids on bone mineral density in asthmatic women.
PubMed:Laboratory study on the high-temperature capture of HCl gas by dry-injection of calcium-based sorbents.
PubMed:Modeling the growth boundary of Staphylococcus aureus for risk assessment purposes.
PubMed:Effect of diethylstilbestrol (DES) on intracellular Ca(2+) levels in renal tubular cells.
PubMed:Effects of dietary inclusion of chromium propionate and calcium propionate on glucose disposal and gastrointestinal development in dairy calves.
PubMed:Effect of modified atmosphere packaging on the shelf life of sliced wheat flour bread.
PubMed:Purification and characterization of novel antifungal compounds from the sourdough Lactobacillus plantarum strain 21B.
PubMed:Effects of qualitative and quantitative food restriction treatments on feeding motivational state and general activity level of growing broiler breeders.
PubMed:Bioresorbable bone graft substitutes of different osteoconductivities: a histologic evaluation of osteointegration of poly(propylene glycol-co-fumaric acid)-based cement implants in rats.
PubMed:Decreased sodium-potassium and calcium adenosine triphosphatase activity in asthma: modulation by inhaled and oral corticosteroids.
PubMed:Effects of estradiol and calcium on gonadotrophic cells in middle-aged female rats.
PubMed:Extending storage life of fresh-cut apples using natural products and their derivatives.
PubMed:[Therapeutic potential of glucocorticoids inhalation in bronchial asthma].
PubMed:Mitogen-activated protein kinase (p38-, JNK-, ERK-) activation pattern induced by extracellular and intracellular singlet oxygen and UVA.
PubMed:Antimicrobial efficacy of preservative combinations in South African brown bread.
PubMed:A comparative study of the effectiveness of calcium propionate and calcium chloride for the prevention of parturient paresis in dairy cows.
PubMed:[Shelf-life and sensorial evaluation of corn tortillas, made with preservatives and texture conditioners].
PubMed:Effects of oral dosing with calcium propionate on total calcium and glucose concentrations in the plasma of the cow.
PubMed:The effect of supplemental propionate on insulin responsiveness to glucose and tissue responsiveness to insulin in relation to feeding in sheep.
PubMed:Immunoreactive TSH cells in the pituitary of female middle-aged rats after treatment with estradiol or calcium.
PubMed:Thyroid C cells of middle-aged rats treated with estradiol or calcium.
PubMed:Safety and efficacy of fluticasone and beclomethasone in moderate to severe asthma. Belgian Multicenter Study Group.
PubMed:Glucocorticosteroids inhibit leukotriene production.
PubMed:Field trials of an oral calcium propionate paste as an aid to prevent milk fever in periparturient dairy cows.
PubMed:Effect on cortical and trabecular bone mass of different anti-inflammatory treatments in preadolescent children with chronic asthma.
PubMed:Cross-sectional study of bone density in asthmatic children.
PubMed:IL-5 production by CD4+ T cells of asthmatic patients is suppressed by glucocorticoids and the immunosuppressants FK506 and cyclosporin A.
PubMed:Hyperglycemia and non-enzymatic glycation of serum and tissue proteins in chickens.
PubMed:The effect of Mycocurb, propionic acid, and calcium propionate on the intestinal strength of broiler chickens.
PubMed:Administration of propionate to day-old turkeys.
PubMed:Topically applied low-dose calcitriol has no calciotropic effect in patients with stable plaque psoriasis.
PubMed:Calcium salts for treating hypocalcemia: carrier effects, acid-base balance, and oral versus rectal administration.
PubMed:Role of dietary propionic acid and bile acid excretion in the hypocholesterolemic effects of oligosaccharides in rats.
PubMed:Effect of orally administered beclomethasone dipropionate on calcium absorption from the gut in normal subjects.
PubMed:Bone metabolism in children with asthma treated with inhaled beclomethasone dipropionate.
PubMed:[Inhibitory effects of organic acids and salts on selected micromycetes].
PubMed:Effect of diethylstilbestrol and related compounds on the Ca(2+)-transporting ATPase of sarcoplasmic reticulum.
PubMed:Enhanced intraspecific protoplast fusion in yeast.
PubMed:[Reduced blood flow in bones in female rats after administration of estrogen].
PubMed:Bone turnover during high dose inhaled corticosteroid treatment.
PubMed:Intestinal effects of the products of lipid digestion on gastric electrical activity in the cat. Possible involvement of vagal intestinal receptors sensitive to lipids.
PubMed:[Treatment of patients with postmenopausal osteoporosis].
PubMed:Differential effect of progesterone on the labeling of phosphatidylinositol with [3H]inositol and [32P]phosphate in the uterus of the estrogen-treated ovariectomized rat.
PubMed:Gas chromatographic determination of calcium propionate added as preservative to bread.
PubMed:Effect of early stages of fungal development on the nutritional value of diets for broiler chicks.
PubMed:Survival and growth of Bacillus cereus in bread.
PubMed:Effect of induced hypomagnesaemia on the toxicity of imidocarb in calves.
PubMed:Studies of the fungistatic activity of antifungal compounds in mash and pelleted feeds.
PubMed:Induction of vitellogenesis in Japanese quail as a sensitive indicator of the estrogen-mimetic effect of a variety of environmental contaminants.
PubMed:A note on an improved molybdate agar for the selective isolation of yeasts from tropical fruits.
PubMed:Responses in calcium and phosphorus metabolism and hepatic lipid deposition among estrogenized chicks fed various dietary ingredients.
PubMed:Isolation of Candida albicans and their sensitivity to antifungal agents.
PubMed:Bread (white and whole wheat) and nonfat dry milk as sources of bioavailable calcium for rats.
PubMed:Effect of five cycle rapid freeze-thaw treatment in conjunction with various chemicals for the reduction of Salmonella typhimurium.
PubMed:Regulation of calcium appetite in broiler chickens.
PubMed:Effect of zearalenone on female White Leghorn chickens.
PubMed:Changes in lipid composition of Escherichia coli resulting from growth with organic solvents and with food additives.
PubMed:Effect of calcium propionate on performance of laying hens.
PubMed:[Various histochemical features of the uterus and placenta of ovariectomized rats following administration of different doses of progesterone and estradiol-dipropionate].
PubMed:The effect on performance and bacterial flora of lactic acid, propionic acid, calcium propionate and calcium acrylate in the drinking water of weaned pigs.
Antimicrobial agent used as preservative in bread, cheese and other foods
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