EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

calcium gluconate
calcium di-D-gluconate monohydrate

Supplier Sponsors

Name:calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
CAS Number: 299-28-5Picture of molecule3D/inchi
Other(deleted CASRN):18016-24-5
ECHA EINECS - REACH Pre-Reg:206-075-8
Nikkaji Web:J2.984J
Molecular Weight:430.37414000
Formula:C12 H22 Ca O14
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:acidity regulators, firming agents, sequestrants, nutrient supplements, flavor enhancer
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1199 Calcium gluconate View - review
GRN 136 Calcium gluconate View - notice PDF
582.6219 Calcium gluconate View - review
EU SANCO Calcium gluconate View - review
JECFA Food Additive: Calcium Gluconate
GSFA Codex: Calcium gluconate (578)
DG SANTE Food Additives:calcium gluconate
FDA Mainterm (SATF):299-28-5 ; CALCIUM GLUCONATE
FDA Regulation:
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.141 Artificially sweetened fruit jelly.

Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.161 Artificially sweetened fruit preserves and jams.

Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1199 Calcium gluconate.
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 195.00 °C. @ 760.00 mm Hg
Boiling Point: 673.00 to 674.00 °C. @ 760.00 mm Hg
Flash Point: 707.00 °F. TCC ( 375.00 °C. )
logP (o/w): -3.175 (est)
Soluble in:
 water, 3.33E+04 mg/L @ 25 °C (exp)
Insoluble in:
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: humectants
oral care agents
skin conditioning
American Elements
Calcium D-gluconate 99%
Odor: characteristic
Use: Calcium D-Gluconate is one of numerous organo-metallic compounds sold by American Elements under the tradename AE Organo-Metallics™ for uses requiring non-aqueous solubility such as recent solar energy and water treatment applications. Calcium D-Gluconate is generally immediately available in most volumes, including bulk quantities. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
Calcium Gluconate
BOC Sciences
For experimental / research use only.
Gluconate Calcium
For experimental / research use only.
D-Gluconic acid calcium salt
Charkit Chemical
Global Calcium
Calcium Gluconate EP
Global Calcium
Calcium Gluconate for Injection EP
Global Calcium
Calcium Gluconate Hydrate JP
Global Calcium
Calcium Gluconate IP
Global Calcium
Calcium Gluconate USP ( Monohydrate )
Penta International
Penta International
Qingdao Dacon Trading
Calcium Gluconate
Sigma-Aldrich: Sigma
For experimental / research use only.
Calcium D-gluconate monohydrate ≥98%
For experimental / research use only.
Calcium Gluconate Monohydrate >98.0%(T)
Calcium Lactate Gluconate
Flavor: bland
Calcium lactate gluconate (C3H5O3)2Ca + (C6H11O7)2Ca, is a white crystalline salt made by the action of lactic acid on calcium carbonate. It is used in foods (as a baking powder) and given medicinally.Calcium lactate is often found in aged cheeses. Small crystals of it precipitate out when lactic acid is converted into a less soluble form by the bacteria active during the ripening process.
Wedor Corporation
Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LDLo 1987 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 47, Pg. 183, 1933.

intravenous-guinea pig LDLo 1810 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 191, Pg. 44, 1971.

intraperitoneal-mouse LD50 2200 mg/kg
Journal of Drug Research. Vol. 15(1-2), Pg. 121, 1984.

intravenous-mouse LD50 950 mg/kg
Toxicology and Applied Pharmacology. Vol. 4, Pg. 492, 1962.

oral-mouse LDLo 10000 mg/kg
Farmaco, Edizione Pratica. Vol. 26, Pg. 144, 1971.

intravenous-rat LD50 950 mg/kg
Drugs in Japan Vol. 6, Pg. 226, 1982.

oral-rat LDLo 10000 mg/kg
Farmaco, Edizione Pratica. Vol. 26, Pg. 144, 1971.

Dermal Toxicity:
subcutaneous-mouse LD50 2890 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 47, 1956.

Inhalation Toxicity:
Not determined
Safety in Use Information:
acidity regulators, firming agents, sequestrants, nutrient supplements, flavor enhancer
Recommendation for calcium gluconate usage levels up to:
 not for fragrance use.
Safety References:
EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):299-28-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :9290
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
RTECS:EW2100000 for cas# 299-28-5
 calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:299-28-5
Pubchem (cid):9290
Pubchem (sid):134975115
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
KEGG (GenomeNet):C08133
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2940.00.6000
FDA Listing of Food Additive Status:View
•calcium gluconate, usp contains 9% calcium available as calcium gluconate tablets, usp, containing 325, 500, 650, or 1000 mg of the salt for im and iv injection, calcium gluconate injection, usp, admin as 10% soln (0.45 meq ca++ml). •grades: technical; usp; fcc; special for ampules. •due to its limited solubility, calcium gluconate must frequently be suspended in liquid mixtures and tragacanth is useful as a suspending agent. •calcium gluconate injection:a 10% soln; 9.3 mg of ca+2ml 10-ml vial
Potential Blenders and core components note
None Found
Potential Uses:
Occurrence (nature, food, other):note
 not found in nature
 calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
 calcium bis(D-gluconate)
 calcium bis[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate]
 calcium di-D-gluconate monohydrate
 calcium di-dextro-gluconate monohydrate
 calcium di(D-gluconate)
 calcium gluconate anhydrous
 calcium gluconate anhydrous USP FCC powder
 calcium gluconate monohydrate USP FCC fine granular
 calcium gluconate monohydrate USP FCC granular
 calcium gluconate monohydrate USP FCC powder
 calcium gluconate, anhydrous USP
 calcium gluconate, monohydrate USP
 calcium hexagluconate
 gluconic acid calcium salt
D-gluconic acid calcium salt
D-gluconic acid calcium salt (2:1)
dextro-gluconic acid calcium salt (2:1)
D-gluconic acid, calcium salt (2:1)


PubMed:Aluminum Contamination in Parenteral Nutrition Admixtures for Low-Birth-Weight Preterm Infants in Mexico.
J-Stage:Evaluation of the Suppressive Effect on Bitter Taste of Gluconate
PubMed:Postprandial metabolic responses of serum calcium, parathyroid hormone and C-telopeptide of type I collagen to three doses of calcium delivered in milk.
PubMed:Spontaneous supersaturation of calcium D-gluconate during isothermal dissolution of calcium L-lactate in aqueous sodium D-gluconate.
PubMed:Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo.
PubMed:Aqueous solubility of calcium L-lactate, calcium D-gluconate, and calcium D-lactobionate: importance of complex formation for solubility increase by hydroxycarboxylate mixtures.
PubMed:Effect of calcium on the kinetics of free fatty acid release during in vitro lipid digestion in model emulsions.
PubMed:Safety and efficacy of polycalcium for improving biomarkers of bone metabolism: a 4-week open-label clinical study.
PubMed:A single-dose study of denosumab in patients with various degrees of renal impairment.
PubMed:Amlodipine fatality in an infant with postmortem blood levels.
PubMed:Feasibility of using dialysis for determining calcium ion concentration and pH in calcium-fortified soymilk at high temperature.
PubMed:Drug shortage.
PubMed:Aluminium exposure from parenteral nutrition in preterm infants and later health outcomes during childhood and adolescence.
PubMed:Hormone replacement after thyroid and parathyroid surgery.
PubMed:Calcium and phosphate compatibility in low-osmolarity parenteral nutrition admixtures intended for peripheral vein administration.
PubMed:Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse events.
PubMed:High altitude induced anorexia: effect of changes in leptin and oxidative stress levels.
PubMed:Silicate release from glass for pharmaceutical preparations.
PubMed:Primary periodic paralyses.
PubMed:[Zinc and copper content in individual components used to prepare pediatric total nutrition mixtures].
PubMed:Calcium supplementation in clinical practice: a review of forms, doses, and indications.
PubMed:The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats.
PubMed:Reaction on D-glucal by an inverting phosphorylase to synthesize derivatives of 2-deoxy-beta-D-arabino-hexopyranosyl-(1-->4)-D-glucose (2II-deoxycellobiose).
PubMed:Arsenic species in solutions for parenteral nutrition.
PubMed:[A case of intraoperative hyperkalemia induced with administration of an angiotensin II receptor antagonist (AIIA) and intake of dried persimmons].
PubMed:Incorporation of a high concentration of mineral or vitamin into chitosan-based films.
PubMed:Fluid and electrolyte therapy in ruminants.
PubMed:A fortifier comprising protein, vitamins, and calcium-glycerophosphate for preterm human milk.
PubMed:[The evaluation of the efficiency of biological prophylaxis of lead poisoning (experimental study)].
PubMed:Acute effects of calcium sodium citrate supplementation of a test meal on mineral homeostasis, oxalate, and calcium oxalate crystallization in the urine of healthy humans--preliminary results in patients with idiopathic calcium urolithiasis.
PubMed:Anything else to add?
PubMed:Parenteral calcium gluconate supplementation: efficacious or potentially disastrous?
PubMed:The study of a physiological significance of prolactin in the regulation of calcium metabolism during pregnancy and lactation in rats.
PubMed:Chromium and zinc contamination of parenteral nutrient solution components commonly used in infants and children.
PubMed:Calcium and phosphate solubility curves for parenteral nutrient solutions containing Vaminolact.
PubMed:Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification.
PubMed:Effects of meal on the pharmacokinetics of fluoride from oral monofluorophosphate.
PubMed:Influence of dietary calcium and vitamin D on colon epithelial cell proliferation and 1,2-dimethylhydrazine-induced colon carcinogenesis in rats fed high fat diets.
PubMed:Hypocalcemia and pregnancy-induced hypertension produced by maternal fasting.
PubMed:Glycero- vs glucose-phosphate in parenteral nutrition of premature infants: a comparative in vitro evaluation of calcium/phosphorus compatibility.
PubMed:Effect of dietary calcium on colon carcinogenesis induced by a single injection of 1,2-dimethylhydrazine in rats.
PubMed:Secondary copper deficiency in cattle caused by molybdenum contamination of fodder: a case history.
PubMed:Parturient paresis and hypocalcemia in ruminant livestock.
PubMed:Gastrointestinal absorption of calcium from milk and calcium salts.
PubMed:The effect of long-term enrichment of diet with selenium, vitamin E and B15 on the activity of certain enzymes in rat brain.
PubMed:Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing Aminosyn PF.
PubMed:Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing TrophAmine.
PubMed:The effect of vitamin and mineral supplements and health foods on physical endurance and performance.
PubMed:Hydrofluoric acid skin treatment not approved by FDA.
PubMed:Effect of long-term diet enrichment with selenium, vitamin E and vitamin B15 on the degree of fatty infiltration of the liver.
PubMed:Calcium and phosphorus in neonatal parenteral nutrition solutions.
PubMed:The early diagnosis of gastrinoma.
PubMed:Nutritional rickets due to food fadism.
PubMed:[Effect of methionine and vitamins B12 and B15 on the content and distribution of proteins, glycogen and lipids in the hepatic lobules of chickens].
PubMed:FDA's hands loosely tied.
PubMed:Vitamin B15--whatever it is, it won't help.
PubMed:From those wonderful people who brought you laetrile.
PubMed:[Dynamic aspects of blood gastrin after antral stimulation].
the calcium salt of gluconic acid. the compound has a variety of uses, including its use as a calcium replenisher in hypocalcemic states. Food additive: firming agent, sequestrant, stabiliser, texturiser. Anticaking agent in powdered coffee Calcium gluconate is a mineral supplement. It is the form of calcium most widely used in the treatment of hypocalcemia. Calcium gluconate contains 9.3% calcium. It is also used to counteract an overdose of magnesium sulfate, often administered to pregnant women experiencing premature labor to slow or stop contractions. Excess magnesium sulfate can cause respiratory depression, for which calcium gluconate would be the antidote.
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