calcium citrate
1,2,3-propanetricarboxylic acid, 2-hydroxy-, calcium salt
 
Notes:
Emulsifier in foods, dietary supplement Calcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate.
  • American International Chemical, LLC.
    • American International Chemical, Inc.
      Consistent sources
      North American supplier for globally sourced ingredients.
      AIC is a Framingham, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of 30 Sales Representatives, along with our 19 strategically located warehouses are ready to supply product when and where you need it.
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      Product(s):
      CACGIG Calcium Citrate
      C15GIP CALCIUM 15
      Dietary supplement in beverages/ gel packs, liquid shots and syrups
       
       
Synonyms   Articles   Notes   Search
tricalcium 2-hydroxypropane-1,2,3-tricarboxylate (Click)
CAS Number: 813-94-5Picture of molecule
Other: 12405-04-8
ECHA EINECS - REACH Pre-Reg: 212-391-7
FDA UNII: 86117BWO7P
Beilstein Number: 3924520
MDL: MFCD00150786
Molecular Weight: 498.43450000
Formula: C12 H10 Ca3 O14
NMR Predictor: Predict (works with chrome or firefox)
Category: sequestrant, buffer, firming agent
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Google Scholar: with word "volatile"Search
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Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1195 Calcium citrate View-review
EU SANCO Calcium citrates View-review
EU SANCO Calcium citrates View-review
JECFA Food Additive: Calcium Citrate
GSFA Codex: Tricalcium citrate (333(iii))
DG SANTE Food Additives: calcium citrate
FDA Mainterm: CALCIUM CITRATE
FDA Regulation:
FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.169 Pasteurized process cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.173 Pasteurized process cheese food.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.179 Pasteurized process cheese spread.


FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.141 Artificially sweetened fruit jelly.


FDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Fruit Butters, Jellies, Preserves, and Related Products
Sec. 150.161 Artificially sweetened fruit preserves and jams.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1195 Calcium citrate.
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Physical Properties:
Appearance: white fine powder (est)
Assay: 97.50 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 309.00 to  310.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.000057 mm/Hg @ 25.00 °C. (est)
Flash Point: 311.00 °F. TCC ( 155.00 °C. )
logP (o/w): -1.721 (est)
Soluble in:
 water, very slightly
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
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Organoleptic Properties:
Odor Description:
at 100.00 %. 
odorless
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: buffering agents
Synonyms   Articles   Notes   Search   Top
Suppliers:
Aceto
Calcium Citrate USP
American International Chemical, LLC.
CALCIUM 15
Odor: characterisitc
Use: Dietary supplement in beverages/ gel packs, liquid shots and syrups
American International Chemical, LLC.
Calcium Citrate
BOC Sciences
For experimental / research use only.
Calcium citrate PURIFIED
Graham Chemical
Calcium Citrate
Jungbunzlauer Suisse
Tricalcium Citrate
Flavor: characteristic
The most commonly used calcium salt of citric acid is tricalcium dicitrate tetrahydrate, hereinafter referred to as tricalcium citrate. In some countries such as USA, tricalcium citrate is simply denominated calcium citrate. It is produced by complete neutralization of citric acid with a high purity calcium source such as calcium hydroxide or calcium carbonate. With its high calcium content of 21%, tricalcium citrate is the most economic calcium salt among the commonly used organic calcium salts.
Kraft Chemical
Calcium Citrate
Lianyungang Yunbo Chemical
TRICALCIUM CITRATE
Prinova
Calcium Citrate
Qingdao Dacon Trading
Calcium Citrate
Sigma-Aldrich: Sigma
For experimental / research use only.
Calcium citrate tribasic tetrahydrate BioUltra, ≥98.0% (calc. on dry substance, KT)
Silver Fern Chemical
Calcium Citrate
Odor: characteristic
Use: Calcium Citrate is mainly used as a food additive as a preserver, flavor enhancer, or firming agent. It can also be used in dietary supplements, as a chemical buffer, water softener, and a sequestrating agent.
Tate & Lyle
Calcium Citrate
Universal Preserv-A-Chem Inc.
CALCIUM CITRATE POWDER FOOD GRADE
Odor: characteristic
Use: Calcium Citrate is white powder, used as chelant, buffer, coagulant, calcareous intensified agent. It can be used in soy products. Meanwhile, its usage and limitation are low powered concentrated milk, sweet condensed milk, cream. It can be used in flour, cookie, etc.
Zhong Ya Chemical
Calcium Citrate
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: sequestrant, buffer, firming agent
Recommendation for calcium citrate usage levels up to:
 not for fragrance use.
 
Recommendation for calcium citrate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 813-94-5
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 13136
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 tricalcium 2-hydroxypropane-1,2,3-tricarboxylate
Chemidplus: 0000813945
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References:
 tricalcium 2-hydroxypropane-1,2,3-tricarboxylate
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 813-94-5
Pubchem (cid): 13136
Pubchem (sid): 134977003
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEMBL: View
HMDB (The Human Metabolome Database): Search
FooDB: FDB013368
Haz-Map: View
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
grades: reagent; technical; fcc. tetrahydrate
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 acicontral
 calcium 15
 calcium citrate granular USP FCC
 calcium citrate USP
 calcium dicitrate
 calciumcitrate
2-hydroxy-1,2,3-propanetricarboxylic acid calcium salt
1,2,3-propanetricarboxylic acid, 2-hydroxy-, calcium salt
 tricalcium 2-hydroxypropane-1,2,3-tricarboxylate
 tricalcium citrate
 tricalcium dicitrate
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Articles:
PubMed: Calcium and vitamin D supplementation: state of the art for daily practice.
PubMed: Safety Assessment of Citric Acid, Inorganic Citrate Salts, and Alkyl Citrate Esters as Used in Cosmetics.
PubMed: A comparative study of calcium absorption following a single serving administration of calcium carbonate powder versus calcium citrate tablets in healthy premenopausal women.
PubMed: Vitamin D Supplementation Efficacy: Sleeve Gastrectomy Versus Gastric Bypass Surgery.
PubMed: Effects of a typical acute oral calcium load on arterial properties and endothelial function in healthy subjects.
PubMed: Assessment the levels of tartrate-resistant acid phosphatase (TRAP) on mice fed with eggshell calcium citrate malate.
PubMed: The steady-state serum concentration of genistein aglycone is affected by formulation: a bioequivalence study of bone products.
PubMed: The effect of vitamin D on calcium absorption in older women.
PubMed: Prenatal effects of natural calcium supplement on Wistar rats during organogenesis period of pregnancy.
PubMed: Hormone replacement after thyroid and parathyroid surgery.
PubMed: Prevention and treatment of peripheral neuropathy after bariatric surgery.
PubMed: Controlling the bleeding of carmine colorant in crabstick.
PubMed: [Nutrition and bone health. Food for specified health use (FOSHU) and bone health].
PubMed: Comparison of the absorption of calcium carbonate and calcium citrate after Roux-en-Y gastric bypass.
PubMed: The health benefits of calcium citrate malate: a review of the supporting science.
PubMed: [Polyhydramnios, prematurity, dystrophy, polyuria, constipation, nephrocalcinosis and renal tumor: presentation of a classic tubulopathy].
PubMed: Determination of calcium salt solubility with changes in pH and P(CO(2)), simulating varying gastrointestinal environments.
PubMed: Calcium supplementation in clinical practice: a review of forms, doses, and indications.
PubMed: Fortification of all-purpose wheat-flour tortillas with calcium lactate, calcium carbonate, or calcium citrate is acceptable.
PubMed: Calcium retention in adolescent boys on a range of controlled calcium intakes.
PubMed: The acute effects of different sources of dietary calcium on postprandial energy metabolism.
PubMed: Calcium fortification systems differ in bioavailability.
PubMed: Influence of components of infant formulas on in vitro iron, zinc, and calcium availability.
PubMed: Relative bioavailability of calcium-rich dietary sources in the elderly.
PubMed: Dietary citrate treatment of polycystic kidney disease in rats.
PubMed: Selenium intakes, absorption, retention, and status in adolescent girls.
PubMed: Absorption of calcium fumarate salts is equivalent to other calcium salts when measured in the rat model.
PubMed: Calcium intake influences the association of protein intake with rates of bone loss in elderly men and women.
PubMed: Fate of salmonellae in calcium-supplemented orange juice at refrigeration temperature.
PubMed: Survival of salmonellae in pasteurized, refrigerated calcium-fortified orange juice.
PubMed: Acute effects of calcium sodium citrate supplementation of a test meal on mineral homeostasis, oxalate, and calcium oxalate crystallization in the urine of healthy humans--preliminary results in patients with idiopathic calcium urolithiasis.
PubMed: Absorption of calcium as the carbonate and citrate salts, with some observations on method.
PubMed: Iron status, menarche, and calcium supplementation in adolescent girls.
PubMed: Comparison of erosion of dental enamel by four drinks using an intra-oral applicance.
PubMed: Acute oral calcium-sodium citrate load in healthy males. Effects on acid-base and mineral metabolism, oxalate and other risk factors of stone formation in urine.
PubMed: Calcium absorption from apple and orange juice fortified with calcium citrate malate (CCM).
PubMed: Lessening dental erosive potential by product modification.
PubMed: Effect of calcium supplementation on blood pressure in children.
PubMed: Aluminum and lead absorption from dietary sources in women ingesting calcium citrate.
PubMed: Supplementation trials with calcium citrate malate: evidence in favor of increasing the calcium RDA during childhood and adolescence.
PubMed: Effect of age, calcium source, and radiolabeling method on whole body 47Ca retention in the rat.
PubMed: Effects of meal on the pharmacokinetics of fluoride from oral monofluorophosphate.
PubMed: Calcium citrate without aluminum antacids does not cause aluminum retention in patients with functioning kidneys.
PubMed: Modification by food of the calcium absorbability and physicochemical effects of calcium citrate.
PubMed: Lactose, calcium source and age affect calcium bioavailability in rats.
PubMed: Calcium supplementation: effect on iron absorption.
PubMed: Fluoride bioavailability from slow-release sodium fluoride given with calcium citrate.
PubMed: Effects of different calcium sources on iron absorption in postmenopausal women.
PubMed: Calcium absorption from a new calcium delivery system (CCM).
PubMed: Gastrointestinal absorption of calcium from milk and calcium salts.
PubMed: An evaluation of the importance of gastric acid secretion in the absorption of dietary calcium.
PubMed: Agar medium for differential enumeration of lactic streptococci.
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