EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

calcium ascorbate
L-ascorbic acid calcium salt (2:1)

Supplier Sponsors

Name:calcium 5-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-4-oxofuran-2-olate
CAS Number: 5743-27-1Picture of molecule3D/inchi
Other(deleted CASRN):96653-51-9
ECHA EINECS - REACH Pre-Reg:227-261-5
Molecular Weight:390.31198000
Formula:C12 H14 Ca O12
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:antioxidants and preservatives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
182.3189 Calcium L-ascorbate View - review
GRN 451 Calcium ascorbate with added threonate View - notice PDF
EU SANCO Calcium ascorbate View - review
JECFA Food Additive: Calcium Ascorbate
GSFA Codex: Calcium ascorbate (302)
DG SANTE Food Additives:calcium ascorbate
FDA Mainterm (SATF):5743-27-1 ; CALCIUM ASCORBATE
FDA Regulation:
Subpart D--Chemical Preservatives
Sec. 182.3189 Calcium ascorbate.
Physical Properties:
Appearance:white to yellowish crystalline powder (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 415.00 to 416.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.000000 mmHg @ 25.00 °C. (est)
Flash Point: 356.00 °F. TCC ( 180.00 °C. )
logP (o/w): -2.653 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 alcohol, slightly
Insoluble in:
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
skin conditioning
Calcium Ascorbate 98%-101%
American International Chemical, LLC.
Calcium Ascorbate
Atlantic Chemicals
Ascorbate Calcium
ECSA Chemicals
Farbest-Tallman Foods
Calcium Ascorbate 97% DC
Flavor: bland
It is used in dietary supplement applications including hard shell capsules and tablets.
Farbest-Tallman Foods
Calcium Ascorbate USP/FCC Powder
Flavor: bland
It is used in food, beverage and dietary supplement applications as a Vitamin C source. Some applications include chewable vitamins, processed meats, nutrient enhanced beverages and foods.
Kraft Chemical
Calcium Ascorbate
Penta International
Sabinsa Corporation
Calcium Ascorbate USP
Tianjin Talent Chemical
Calcium Ascorbate DC 97SF Granule
Tianjin Talent Chemical
Calcium Ascorbate
Zhong Ya Chemical
Calcium Ascorbate (JSPC)
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
antioxidants and preservatives
Recommendation for calcium ascorbate usage levels up to:
 not for fragrance use.
Recommendation for calcium ascorbate flavor usage levels up to:
 not for flavor use.
Safety References:
European Food Safety Authority (EFSA) reference(s):

Statement of EFSA on the safety of calcium L-ascorbate with a content of threonate produced by a new manufacturing process as a source of vitamin C in food supplements
View page or View pdf

Scientific Opinion on the safety and efficacy of vitamin C (ascorbic acid, sodium ascorbate, calcium ascorbate, ascorbyl palmitate, sodium calcium ascorbyl phosphate and sodium ascorbyl phosphate) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products Ltd
View page or View pdf

Scientific Opinion on the re-evaluation of ascorbic acid (E 300), sodium ascorbate (E 301) and calcium ascorbate (E 302) as food additives
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):5743-27-1
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :54678500
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
calcium 5-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-4-oxofuran-2-olate
 calcium 5-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-4-oxofuran-2-olate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:5743-27-1
Pubchem (cid):54678500
Pubchem (sid):134988883
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
•parenteral prepn: cal-c-bate (kay): each cc of soln contains calcium gluconate 50 mg & calcium ascorbate 50 mg with benzyl alcohol 1.5% & sodium bisulfite 0.05% in 10 ml containers. •grade: fcc dihydrate •the commercial product is the natural l(+)-enantiomer monohydrate
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 ascorbate calcium
L-ascorbic acid calcium salt (2:1)
laevo-ascorbic acid calcium salt (2:1)
 calcium 5-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-4-oxofuran-2-olate
hemicalcium ascorbate
 calcium ascorbate 8.93 DC granular
 calcium ascorbate 97% DC
 calcium ascorbate 98%-101%
 calcium ascorbate dihydrate 9.4
 calcium ascorbate FCC
 calcium ascorbate with added threonate
 calcium diascorbate
 calcium L-ascorbate
 calcium laevo-ascorbate


PubMed:Effects of hot boning and moisture enhancement on the eating quality of cull cow beef.
PubMed:Combined effects of potassium lactate and calcium ascorbate as sodium chloride substitutes on the physicochemical and sensory characteristics of low-sodium frankfurter sausage.
PubMed:Reduction of sodium and increment of calcium and ω-3 polyunsaturated fatty acids in dry fermented sausages: effects on the mineral content, lipid profile and sensory quality.
PubMed:Effects of 1-methylcyclopropene and post-controlled atmosphere air storage treatments on fresh-cut Ambrosia apple slices.
PubMed:The effects of skeletal separation and moisture enhancement for improving the eating quality of cull cow beef.
PubMed:Vitamin A and C compounds permitted in supplements differ in their abilities to affect cell viability, DNA and the DNA nucleoside deoxyguanosine.
PubMed:Surface treatments and coatings to maintain fresh-cut mango quality in storage.
PubMed:Antibrowning and antimicrobial properties of sodium acid sulfate in apple slices.
PubMed:Vitamin C with metabolites: additional analysis suggests favorable changes in oxalate.
PubMed:Vitamin C with metabolites reduce oxalate levels compared to ascorbic acid: a preliminary and novel clinical urologic finding.
PubMed:Effect of tenderizers combined with organic acids on Escherichia coli O157:H7 thermal resistance in non-intact beef.
PubMed:Noninvasive in situ identification and band assignments of some pharmaceutical excipients inside USP vials with FT-near-infrared spectroscopy.
PubMed:Vitamin C-lipid metabolites: uptake and retention and effect on plasma C-reactive protein and oxidized LDL levels in healthy volunteers.
PubMed:Vitamin C metabolites, independent of smoking status, significantly enhance leukocyte, but not plasma ascorbate concentrations.
PubMed:Thermal inactivation of Escherichia coli O157:H7 in beef treated with marination and tenderization ingredients.
PubMed:Moisturizing potentials of ascorbyl palmitate and calcium ascorbate in various topical formulations.
PubMed:Effect of ionizing radiation on furan formation in fresh-cut fruits and vegetables.
PubMed:Control of browning and microbial growth on fresh-cut apples by sequential treatment of sanitizers and calcium ascorbate.
PubMed:Absorption rates and free radical scavenging values of vitamin C-lipid metabolites in human lymphoblastic cells.
PubMed:Comparing the moisturizing effects of ascorbic acid and calcium ascorbate against that of tocopherol in emulsions.
PubMed:Safety and tolerance of ester-C compared with regular ascorbic acid.
PubMed:Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics.
PubMed:Effect of pH on the survival of Listeria innocua in calcium ascorbate solutions and on quality of fresh-cut apples.
PubMed:Calcium bioavailability and kinetics of calcium ascorbate and calcium acetate in rats.
PubMed:[Reduced pain from osteoarthritis in hip joint or knee joint during treatment with calcium ascorbate. A randomized, placebo-controlled cross-over trial in general practice].
PubMed:Effects of calcium salts on beef longissimus quality.
PubMed:Effects of processing treatment and sorbate addition on the flavor characteristics of apple cider.
PubMed:Preventing the common cold with a vitamin C supplement: a double-blind, placebo-controlled survey.
PubMed:Calcium ascorbate as a potential partial substitute for NaCl in dry fermented sausages: effect on colour, texture and hygienic quality at different concentrations.
PubMed:Inhibitors of Na-K-ATPase in human urine: effects of ouabain-like factors and of vanadium-diascorbate on calcium mobilization in rat vascular smooth muscle cells: comparison with the effects of ouabain, angiotensin II, and arginine-vasopressin.
PubMed:Enhanced production of mineralized nodules and collagenous proteins in vitro by calcium ascorbate supplemented with vitamin C metabolites.
PubMed:Intestinal absorption of calcium from calcium ascorbate in rats.
PubMed:Absorption of calcium oxalate does not require dissociation in rats.
PubMed:Effects of urinary ouabain-like factors and vanadium diascorbate on calcium mobilization in porcine inner medullary collecting duct cells: comparison with the effects of ouabain and vasopressin.
PubMed:Ouabain-like factors in human urine: identification of a Na-K-ATPase inhibitor as vanadium-diascorbate adduct.
PubMed:Comparison of the anti-scorbutic activity of L-ascorbic acid and Ester C in the non-ascorbate synthesizing Osteogenic Disorder Shionogi (ODS) rat.
PubMed:Effect of ascorbate and dehydroascorbate on tissue uptake of glucose.
PubMed:An acute study on the relative gastro-intestinal absorption of a novel form of calcium ascorbate.
PubMed:Neutrophil mobility during anaesthesia in children. A trial of ascorbate premedication.
PubMed:Is calcium ascorbate preferable to sodium ascorbate?
PubMed:Characteristics of the response of dispersed guinea-pig adrenal cells to low doses (1-50 pg/ml) of alpha 1-24 adrenocorticotrophin.
PubMed:An in vitro assessment of cellular and humoral immune function in pulmonary tuberculosis: correction of defective neutrophil motility by ascorbate, levamisole, metoprolol and propranolol.
PubMed:The influence of hormones and other substances on lens regeneration in vitro.
PubMed:Effects of ascorbate on leucocytes: Part III. In vitro and in vivo stimulation of abnormal neutrophil motility by ascorbate.
PubMed:Effects of ascorbate on leucocytes: Part I. Effects of ascorbate on neutrophil motility and intracellular cyclic nucleotide levels in vitro.
PubMed:Ascorbate inhibition of 6-aminonicotinamide teratogenesis in chicken embryos.
PubMed:Winter illness and vitamin C: the effect of relatively low doses.
PubMed:[Clinical experience in the use of calcium ascorbate in otorhinolaryngology].
PubMed:The effect of calcium ascorbate on the resorption of blood clots following injury to the skull in experimental animals.
PubMed:[The effect of calcium ascorbate on therapeutic process in fracture healing; experimental research].
PubMed:Calcium ascorbate in otolaryngology.
PubMed:[Calcium and vitamin C in pulmonary tuberculosis; experiences with a new salt, calcium ascorbate].
PubMed:[Effect of the Soviet preparation of calcium ascorbate of the permeability and vitamin C metabolism].
PubMed:The influence of ascorbic acid, sodium ascorbate, calcium ascorbate and orange juice on dental enamel.
PubMed:Crystalline Dihydrate of Calcium Ascorbate.
Antioxidant Calcium ascorbate is a compound with formula CaC12H14O12. It is the calcium salt of ascorbic acid.
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