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acetic anhydride
acetyl oxide

Supplier Sponsors

Name:acetyl acetate
CAS Number: 108-24-7Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:203-564-8
Nikkaji Web:J2.417A
Beilstein Number:0385737
XlogP3-AA:-0.10 (est)
Molecular Weight:102.08942000
Formula:C4 H6 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:food starch-modified
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
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Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
DG SANTE Food Contact Materials:acetic anhydride
FDA Mainterm (SATF):108-24-7 ; ACETIC ANHYDRIDE
FDA Regulation:
Subpart I--Multipurpose Additives
Sec. 172.892 Food starch-modified.
Physical Properties:
Appearance:colorless clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: -73.00 °C. @ 760.00 mm Hg
Boiling Point: 137.00 to 140.00 °C. @ 760.00 mm Hg
Boiling Point: 66.00 to 67.00 °C. @ 50.00 mm Hg
Vapor Pressure:5.100000 mmHg @ 25.00 °C.
Vapor Density:3.5 ( Air = 1 )
Flash Point: 120.00 °F. TCC ( 48.89 °C. )
logP (o/w): -0.480
Shelf Life: 6.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
 moisture Sensitive.
Soluble in:
 water, 120000 mg/L @ 20 °C (exp)
Organoleptic Properties:
Odor Type: acidic
Odor Strength:high ,
recommend smelling in a 1.00 % solution or less
Odor Description:at 1.00 % in dipropylene glycol. sharp vinegar
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
None found
Augustus Oils
Acetic Anhydride
Eastman Chemical
Acetic Anhydride, Kosher
99.5 wt % min.
Odor: characteristic
Use: Acetic anhydride ((CH3CO)2O) is manufactured by Eastman as a kosher product that may be used in foods as a reactant only. All kosher products produced by Eastman are manufactured under rabbinical supervision in full accordance with Jewish dietary laws.
EMD Millipore
For experimental / research use only.
Acetic Anhydride
Penta International
Penta International
For experimental / research use only.
Acetic Anhydride 99.5%
For experimental / research use only.
Acetic Anhydride (ca. 1mol/L in Dichloromethane)
Universal Preserv-A-Chem Inc.
Odor: characteristic
Use: Acetic anhydride is used as an intermediate to produce a variety of acylated products. Its major use is in the manufacture of cellulose acetates; other uses include the manufacture of analgesics (aspirin, acetaminophen), triacetin and a variety of other products.
WEN International
Safety Information:
European information :
Most important hazard(s):
C - Corrosive.
R 10 - Flammable.
R 20/22 - Harmful by inhalation and if swallowed.
R 34 - Causes burns.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 23 - Do not breath vapour.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 1780 mg/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 4, Pg. 119, 1951.

Dermal Toxicity:
skin-rabbit LD50 4.0 ml/kg
Union Carbide Data Sheet. Vol. 8/7/1963

Inhalation Toxicity:
inhalation-rat LC50 1000 ppm/4H
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 607, 1969.

Safety in Use Information:
Category: food starch-modified
Recommendation for acetic anhydride usage levels up to:
 not for fragrance use.
Recommendation for acetic anhydride flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):108-24-7
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :7918
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
acetyl acetate
EPA/NOAA CAMEO:hazardous materials
 acetyl acetate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:108-24-7
Pubchem (cid):7918
Pubchem (sid):134972899
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):HMDB31646
Export Tariff Code:2915.24.0000
FDA Listing of Food Additive Status:View
RSC Learn Chemistry:View
grades: cp, technnical (75, 85, 90-95%) usually assayed at 99% purity; technical grade-97%
Potential Blenders and core components note
None Found
Potential Uses:
None Found
Occurrence (nature, food, other):note
 not found in nature
 acetic acid acetyl ester
 acetic acid anhydride
 acetic acid, anhydride
 acetic anhydride (ca. 1mol/l in dichloromethane)
 acetic anhydride natural
 acetic oxide
 acetyl acetate
 acetyl anhydride
 acetyl oxide
 anhydride acetique
 ethanoic anhydride
 ethanoyl ethanoate
Esterification agent for use in prepn. of modified food starch and for acetylation of monoglycerides Acetic anhydride is a versatile reagent for acetylations, the introduction of acetyl groups to organic substrates. In these conversions, acetic anhydride is viewed as a source of CH3CO+. Alcohols and amines are readily acetylated. For example, the reaction of acetic anhydride with ethanol is:; Acetic anhydride is an irritant and flammable. Because of its reactivity toward water, alcohol foam or carbon dioxide are preferred for fire suppression. The vapour of acetic anhydride is harmful.; Acetic anhydride is the chemical compound with the formula (CH3CO)2O. Commonly abbreviated Ac2O, it is one of the simplest acid anhydrides and is a widely used reagent in organic synthesis. It is a colorless liquid that smells strongly of acetic acid, which is formed by its reaction with the moisture in the air.; As indicated by its organic chemistry, Ac2O is mainly used for acetylations leading to commercially significant materials. Its largest application is for the conversion of cellulose to cellulose acetate, which is a component of photographic film and other coated materials. Similarly it is used in the production of aspirin, acetyl salicylic acid, which is prepared by the acetylation of salicylic acid. It is also used as a wood preservative via autoclave impregnation to make a longer lasting timber. Because of its use for the synthesis of heroin by the diacetylation of morphine, acetic anhydride (known as 'AA' in clandestine chemistry circles) is listed as a U.S. DEA List II Precursor, and restricted in many other countries. The largest markets for diverted acetic anhydride continue to be heroin laboratories in Afghanistan.
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