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lacto-N-neotetraose
lacto-N-tetraose

Supplier Sponsors

CAS Number: 13007-32-4Picture of molecule3D/inchi
FDA UNII: BY63N40B1L
Nikkaji Web:J1.099.713E
MDL:MFCD00467190
XlogP3-AA:-8.80 (est)
Molecular Weight:707.63485000
Formula:C26 H45 N O21
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:food additive
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 547 Lacto-N-neotetraose View - notice PDF
GRN 659 Lacto-N-neotetraose View - notice PDF
GRN 895 Lacto-N-neotetraose View - notice PDF
GRN 919 Lacto-N-neotetraose View - notice PDF
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Lacto-N-neotetraose
Carbosynth
For experimental / research use only.
Lacto-N-neotetraose
Santa Cruz Biotechnology
For experimental / research use only.
Lacto-N-neo-tetraose
Sigma-Aldrich: Sigma
For experimental / research use only.
Lacto-N-neo-tetraose synthetic, ≥85% (HPLC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
food additive
Recommendation for lacto-N-neotetraose usage levels up to:
 not for fragrance use.
 
Recommendation for lacto-N-neotetraose flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Safety of lacto-N-neotetraose as a novel food ingredient pursuant to Regulation (EC) No 258/97
View page or View pdf

Statement on the safety of lacto-N-neotetraose and 2'-O-fucosyllactose as novel food ingredients in food supplements for children
View page or View pdf

Safety of lacto-N-tetraose (LNT) as a novel food pursuant to Regulation (EU) 2015/2283
View page or View pdf

EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :121853
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
N-[(2S,3R,4R,5S,6R)-2-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide
Chemidplus:0013007324
 
References:
 N-[(2S,3R,4R,5S,6R)-2-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):121853
Pubchem (sid):135077814
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
HMDB (The Human Metabolome Database):HMDB06567
FooDB:FDB010844
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 milk
Search PMC Picture
 
Synonyms:
N-[(2S,3R,4R,5S,6R)-2-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3S,4R,5R)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]acetamide
D-glucose, O-beta-D-galactopyranosyl-(1-4)-O-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-4)-
 lacto-N-tetraose
 

Articles:

Google Patents:Nutritional formulations containing lacto-N-neotetraose
PubMed:Structural characterisation of human galectin-4 C-terminal domain -elucidating the molecular basis for recognition of glycosphingolipids, sulfated saccharides and blood group antigens.
PubMed:Infant Maturity at Birth Reveals Minor Differences in the Maternal Milk Metabolome in the First Month of Lactation.
PubMed:Sequential one-pot multienzyme (OPME) synthesis of lacto-N-neotetraose and its sialyl and fucosyl derivatives.
PubMed:In vitro impact of human milk oligosaccharides on enterobacteriaceae growth.
PubMed:Intact reducing glycan promotes the specific immune response to lacto-N-neotetraose-BSA neoglycoconjugates.
PubMed:Fecal microbiota composition of breast-fed infants is correlated with human milk oligosaccharides consumed.
PubMed:α-2,3-sialyltransferase expression level impacts the kinetics of lipooligosaccharide sialylation, complement resistance, and the ability of Neisseria gonorrhoeae to colonize the murine genital tract.
PubMed:4-O-Acetyl-sialic acid (Neu4,5Ac2) in acidic milk oligosaccharides of the platypus (Ornithorhynchus anatinus) and its evolutionary significance.
PubMed:The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.
PubMed:Synthesis of the human milk oligosaccharide lacto-N-tetraose in metabolically engineered, plasmid-free E. coli.
PubMed:Direct evidence for the presence of human milk oligosaccharides in the circulation of breastfed infants.
PubMed:Fecal metabolomics of healthy breast-fed versus formula-fed infants before and during in vitro batch culture fermentation.
PubMed:Human milk oligosaccharides influence maturation of human intestinal Caco-2Bbe and HT-29 cell lines.
PubMed:Galectin-3 interactions with glycosphingolipids.
PubMed:Enzyme catalysed production of sialylated human milk oligosaccharides and galactooligosaccharides by Trypanosoma cruzi trans-sialidase.
PubMed:Human milk oligosaccharide composition differs between donor milk and mother's own milk in the NICU.
PubMed:Ultra high performance liquid chromatography-tandem mass spectrometry method for the determination of soluble milk glycans in rat serum.
PubMed:Pre-clinical safety evaluation of the synthetic human milk, nature-identical, oligosaccharide 2'-O-Fucosyllactose (2'FL).
PubMed:Fucosylated but not sialylated milk oligosaccharides diminish colon motor contractions.
PubMed:Pre-clinical safety assessment of the synthetic human milk, nature-identical, oligosaccharide Lacto-N-neotetraose (LNnT).
PubMed:Variation in consumption of human milk oligosaccharides by infant gut-associated strains of Bifidobacterium breve.
PubMed:Neutral and acidic milk oligosaccharides of the striped skunk (Mephitidae: Mephitis mephitis).
PubMed:Understanding the specificity of human Galectin-8C domain interactions with its glycan ligands based on molecular dynamics simulations.
PubMed:Human milk oligosaccharides inhibit rotavirus infectivity in vitro and in acutely infected piglets.
PubMed:In vitro fermentation characteristics of select nondigestible oligosaccharides by infant fecal inocula.
PubMed:Synthesis of α-galactosyl epitopes by metabolically engineered Escherichia coli.
PubMed:Nutritional factors influencing intestinal health of the neonate.
PubMed:Lacto-N-tetraose, fucosylation, and secretor status are highly variable in human milk oligosaccharides from women delivering preterm.
PubMed:Human milk oligosaccharide concentration and risk of postnatal transmission of HIV through breastfeeding.
PubMed:Release and utilization of N-acetyl-D-glucosamine from human milk oligosaccharides by Bifidobacterium longum subsp. infantis.
PubMed:Microbial composition and in vitro fermentation patterns of human milk oligosaccharides and prebiotics differ between formula-fed and sow-reared piglets.
PubMed:Chemical characterization of milk oligosaccharides of the island flying fox (Pteropus hypomelanus) (Chiroptera: Pteropodidae).
PubMed:Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways.
PubMed:Human lipooligosaccharide IGG that prevents endemic meningococcal disease recognizes an internal lacto-N-neotetraose structure.
PubMed:Bifidobacterium longum subsp. infantis uses two different β-galactosidases for selectively degrading type-1 and type-2 human milk oligosaccharides.
PubMed:Urinary excretion of in vivo ¹³C-labelled milk oligosaccharides in breastfed infants.
PubMed:Importance of antibodies to lipopolysaccharide in natural and vaccine-induced serum bactericidal activity against Neisseria meningitidis group B.
PubMed:An infant-associated bacterial commensal utilizes breast milk sialyloligosaccharides.
PubMed:Lipooligosaccharide of Campylobacter jejuni: similarity with multiple types of mammalian glycans beyond gangliosides.
PubMed:Synthesis of 6-PEtN-α-D-GalpNAc-(1->6)-β-D-Galp-(1->4)-β-D-GlcpNAc-(1->3)-β-D-Galp-(1->4)-β-D-Glcp, a Haemophilus influenzae lipopolysacharide structure, and biotin and protein conjugates thereof.
PubMed:The meningococcal vaccine candidate neisserial surface protein A (NspA) binds to factor H and enhances meningococcal resistance to complement.
PubMed:Crystallographic structure of porcine adenovirus type 4 fiber head and galectin domains.
PubMed:Involvement of ST6Gal I in the biosynthesis of a unique human colon cancer biomarker candidate, alpha2,6-sialylated blood group type 2H (ST2H) antigen.
PubMed:Cooperation of β-galactosidase and β-N-acetylhexosaminidase from bifidobacteria in assimilation of human milk oligosaccharides with type 2 structure.
PubMed:Characterization and synthetic application of a novel beta1,3-galactosyltransferase from Escherichia coli O55:H7.
PubMed:Molecular design of spacer-N-linked sialoglycopolypeptide as polymeric inhibitors against influenza virus infection.
PubMed:Genetically modified L3,7 and L2 lipooligosaccharides from Neisseria meningitidis serogroup B confer a broad cross-bactericidal response.
PubMed:Improved determination of milk oligosaccharides using a single derivatization with anthranilic acid and separation by reversed-phase high-performance liquid chromatography.
PubMed:The fine structure of Neisseria meningitidis lipooligosaccharide from the M986 strain and three of its variants.
PubMed:Functional characterization of an eosinophil-specific galectin, ovine galectin-14.
PubMed:Caenorhabditis elegans galectins LEC-1-LEC-11: structural features and sugar-binding properties.
PubMed:Characterization of intact lipopolysaccharides from the Haemophilus influenzae strain RM 118 using electrophoresis-assisted open-tubular liquid chromatography-mass spectrometry.
PubMed:Chemo-enzymatic supported synthesis of the 3-sulfated Lewis a pentasaccharide on a multimeric polyethylene glycol.
PubMed:Variation of major neutral oligosaccharides levels in human colostrum.
PubMed:Factor H binding and function in sialylated pathogenic neisseriae is influenced by gonococcal, but not meningococcal, porin.
PubMed:Structural characterization of sialylated glycoforms of H. influenzae by electrospray mass spectrometry: fragmentation of protonated and sodiated O-deacylated lipopolysaccharides.
PubMed:Affinity-purified human immunoglobulin G that binds a lacto-N-neotetraose-dependent lipooligosaccharide structure is bactericidal for serogroup B Neisseria meningitidis.
PubMed:Structural determination of the oligosaccharides in the milk of an Asian elephant (Elephas maximus).
PubMed:Conformational analysis of a tetrasaccharide based on NMR spectroscopy and molecular dynamics simulations.
PubMed:Neisseria meningitidis expressing lgtB lipopolysaccharide targets DC-SIGN and modulates dendritic cell function.
PubMed:Syntheses of a series of lacto-N-neotetraose clusters using a carbosilane dendrimer scaffold.
PubMed:Capillary affinity electrophoresis using lectins for the analysis of milk oligosaccharide structure and its application to bovine colostrum oligosaccharides.
PubMed:Recognition factors of Ricinus communis agglutinin 1 (RCA(1)).
PubMed:Multiple co-transfection and co-expression of human beta-1,3-N-acetylglucosaminyltransferase with human calreticulin chaperone cDNA in a single step in insect cells.
PubMed:Enhanced factor H binding to sialylated Gonococci is restricted to the sialylated lacto-N-neotetraose lipooligosaccharide species: implications for serum resistance and evidence for a bifunctional lipooligosaccharide sialyltransferase in Gonococci.
PubMed:Identification of sialyltransferases of Streptococcus agalactiae.
PubMed:Carbohydrate recognition factors of the lectin domains present in the Ricinus communis toxic protein (ricin).
PubMed:Characterization of a novel galactose beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8): the complex formation of beta3Gn-T2 and beta3Gn-T8 enhances enzymatic activity.
PubMed:Recombinant probiotics for treatment and prevention of enterotoxigenic Escherichia coli diarrhea.
PubMed:An unusual anti-H lectin inhibited by milk from individuals with the Bombay phenotype.
PubMed:Assessment of the two Helicobacter pylori alpha-1,3-fucosyltransferase ortholog genes for the large-scale synthesis of LewisX human milk oligosaccharides by metabolically engineered Escherichia coli.
PubMed:Enzymatic supported synthesis of lacto-N-neotetraose using dendrimeric polyethylene glycol.
PubMed:Molecular mimicry of host structures by lipooligosaccharides of Neisseria meningitidis: characterization of sialylated and nonsialylated lacto-N-neotetraose (Galbeta1-4GlcNAcbeta1-3Galbeta1-4Glc) structures in lipooligosaccharides using monoclonal antibodies and specific lectins.
PubMed:Neisserial lipooligosaccharide is a target for complement component C4b. Inner core phosphoethanolamine residues define C4b linkage specificity.
PubMed:Molecular cloning, expression, and characterization of novel hemolytic lectins from the mushroom Laetiporus sulphureus, which show homology to bacterial toxins.
PubMed:Chemical characterization of the oligosaccharides in milk of high Arctic harbour seal (Phoca vitulina vitulina).
PubMed:Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected.
PubMed:Identification and structural characterization of a sialylated lacto-N-neotetraose structure in the lipopolysaccharide of Haemophilus influenzae.
PubMed:Chemical characterization of the oligosaccharides in beluga (Delphinapterus leucas) and Minke whale (Balaenoptera acutorostrata) milk.
PubMed:In vivo fucosylation of lacto-N-neotetraose and lacto-N-neohexaose by heterologous expression of Helicobacter pylori alpha-1,3 fucosyltransferase in engineered Escherichia coli.
PubMed:A new fermentation process allows large-scale production of human milk oligosaccharides by metabolically engineered bacteria.
PubMed:Distinguishing of linkage isomers of lactotetra oligosaccharides by using the relative ion intensity analysis of post-source decay fragment ions in curved-field reflectron matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
PubMed:Phase variable changes in genes lgtA and lgtC within the lgtABCDE operon of Neisseria gonorrhoeae can modulate gonococcal susceptibility to normal human serum.
PubMed:Human milk oligosaccharides: a novel method provides insight into human genetics.
PubMed:Receptor-mediated endocytosis of Neisseria gonorrhoeae into primary human urethral epithelial cells: the role of the asialoglycoprotein receptor.
PubMed:Study of glycosylation with N-trichloroacetyl-D-glucosamine derivatives in the syntheses of the spacer-armed pentasaccharides sialyl lacto-N-neotetraose and sialyl lacto-N-tetraose, their fragments, and analogues.
PubMed:The schistosome oligosaccharide lacto-N-neotetraose expands Gr1(+) cells that secrete anti-inflammatory cytokines and inhibit proliferation of naive CD4(+) cells: a potential mechanism for immune polarization in helminth infections.
PubMed:A remodeling system of the 3'-sulfo-Lewis a and 3'-sulfo-Lewis x epitopes.
PubMed:Structure and properties of the exopolysaccharide produced by Streptococcus macedonicus Sc136.
PubMed:Chemical characterisation of the oligosaccharides in hooded seal (Cystophora cristata) and Australian fur seal (Arctocephalus pusillus doriferus) milk.
PubMed:Construction of LPS mutants.
PubMed:Synthesis of 3-O-sulfoglucuronyl lacto-N-neotetraose 2-aminoethyl glycoside and biotinylated neoglycoconjugates thereof.
PubMed:Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides.
PubMed:Role of lipooligosaccharide in Opa-independent invasion of Neisseria gonorrhoeae into human epithelial cells.
PubMed:Variability of human milk neutral oligosaccharides in a diverse population.
PubMed:Characterization of chimeric lipopolysaccharides from Escherichia coli strain JM109 transformed with lipooligosaccharide synthesis genes (lsg) from Haemophilus influenzae.
PubMed:Facile enzymatic conversion of lactose into lacto-N-tetraose and lacto-N-neotetraose.
PubMed:The genetic basis of the phase variation repertoire of lipopolysaccharide immunotypes in Neisseria meningitidis.
PubMed:Enzymatic glycosylation of reducing oligosaccharides linked to a solid phase or a lipid via a cleavable squarate linker.
PubMed:Synthesis of lacto-N-neotetraose and lacto-N-tetraose using the dimethylmaleoyl group as amino protective group.
PubMed:Cloning, expression, and characterization of a novel UDP-galactose:beta-N-acetylglucosamine beta1,3-galactosyltransferase (beta3Gal-T5) responsible for synthesis of type 1 chain in colorectal and pancreatic epithelia and tumor cells derived therefrom.
PubMed:Detailed acceptor specificities of human alpha1,3-fucosyltransferases, Fuc-TVII and Fuc-TVI.
PubMed:Molecular cloning and characterization of two zebrafish alpha(1,3)fucosyltransferase genes developmentally regulated in embryogenesis.
PubMed:Effect of lacto-N-neotetraose, asialoganglioside-GM1 and neuraminidase on adherence of otitis media-associated serotypes of Streptococcus pneumoniae to chinchilla tracheal epithelium.
PubMed:In vitro alpha1-3 or alpha1-4 fucosylation of type I and II oligosaccharides with secreted forms of recombinant human fucosyltransferases III and VI.
PubMed:Characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae strain F62: instability of transposon Tn1545 delta3 in gonococci and evidence that multiple genetic loci are essential for lipooligosaccharide sialylation.
PubMed:Neisseria gonorrhoeae that infect men have lipooligosaccharides with terminal N-acetyllactosamine repeats.
PubMed:The ruminant parasite Haemonchus contortus expresses an alpha1,3-fucosyltransferase capable of synthesizing the Lewis x and sialyl Lewis x antigens.
PubMed:The (alpha2-->8)-linked polysialic acid capsule and lipooligosaccharide structure both contribute to the ability of serogroup B Neisseria meningitidis to resist the bactericidal activity of normal human serum.
PubMed:Glycosyltransferase and sulfotransferase activities in chick corneal stromal cells before and after in vitro culture.
PubMed:Purification and characterization of UDP-GlcNAc:Galbeta1-4GlcNAcbeta1-3*Galbeta1-4Glc(NAc)-R(GlcNAc to *Gal) beta1,6N-acetylglucosaminyltransferase from hog small intestine.
PubMed:Expression cloning and characterization of a novel murine alpha1, 3-fucosyltransferase, mFuc-TIX, that synthesizes the Lewis x (CD15) epitope in brain and kidney.
PubMed:The lipooligosaccharide (LOS) of Neisseria meningitidis serogroup B strain NMB contains L2, L3, and novel oligosaccharides, and lacks the lipid-A 4'-phosphate substituent.
PubMed:Characterization of terminal NeuNAcalpha2-3Galbeta1-4GlcNAc sequence in lipooligosaccharides of Neisseria meningitidis.
PubMed:Nonopsonic phagocytosis of group C Neisseria meningitidis by human neutrophils.
PubMed:Enzymatic characterization of human alpha1,3-fucosyltransferase Fuc-TVII synthesized in a B cell lymphoma cell line.
PubMed:Functional characterization of an isogenic meningococcal alpha-2,3-sialyltransferase mutant: the role of lipooligosaccharide sialylation for serum resistance in serogroup B meningococci.
PubMed:Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae.
PubMed:Sialylation of Neisseria meningitidis lipooligosaccharide inhibits serum bactericidal activity by masking lacto-N-neotetraose.
PubMed:Oligosaccharides interfere with the establishment and progression of experimental pneumococcal pneumonia.
PubMed:Outer membrane vesicle vaccines made from short-chain lipopolysaccharide mutants of serogroup B Neisseria meningitidis: effect of the carbohydrate chain length on the immune response.
PubMed:Structural basis of the Neisseria meningitidis immunotypes including the L4 and L7 immunotypes.
PubMed:Characterization of lactoferrin-binding proteins of human macrophage membrane: multiple species of lactoferrin-binding proteins with polylactosamine-binding ability.
PubMed:Analysis of the icsBA locus required for biosynthesis of the inner core region from Neisseria meningitidis lipopolysaccharide.
PubMed:Two glycosyltransferase genes, lgtF and rfaK, constitute the lipooligosaccharide ice (inner core extension) biosynthesis operon of Neisseria meningitidis.
PubMed:Functional relationships of the genetic locus encoding the glycosyltransferase enzymes involved in expression of the lacto-N-neotetraose terminal lipopolysaccharide structure in Neisseria meningitidis.
PubMed:Lacto-N-fucopentaose III (Lewis x), a target of the antibody response in mice vaccinated with irradiated cercariae of Schistosoma mansoni.
PubMed:Inner core biosynthesis of lipooligosaccharide (LOS) in Neisseria meningitidis serogroup B: identification and role in LOS assembly of the alpha1,2 N-acetylglucosamine transferase (RfaK).
PubMed:Binding characteristics of human lactoferrin to the human monocytic leukemia cell line THP-1 differentiated into macrophages.
PubMed:Schistosoma mansoni: characterization of an alpha 1-3 fucosyltransferase in adult parasites.
PubMed:Molecular analysis of a locus for the biosynthesis and phase-variable expression of the lacto-N-neotetraose terminal lipopolysaccharide structure in Neisseria meningitidis.
PubMed:Monoclonal antibodies against Haemophilus lipopolysaccharides: clone DP8 specific for Haemophilus ducreyi and clone DH24 binding to lacto-N-neotetraose.
PubMed:A lipooligosaccharide-binding site on HepG2 cells similar to the gonococcal opacity-associated surface protein Opa.
PubMed:Acceptor specificity of different length constructs of human recombinant alpha 1,3/4-fucosyltransferases. Replacement of the stem region and the transmembrane domain of fucosyltransferase V by protein A results in an enzyme with GDP-fucose hydrolyzing activity.
PubMed:Construction of Neisseria meningitidis strains carrying multiple chromosomal copies of the porA gene for use in the production of a multivalent outer membrane vesicle vaccine.
PubMed:Determination of GDP-Fuc:Gal beta 1-4GlcNAc-R (Fuc to GlcNAc) alpha 1,3 fucosyltransferase activity by a solid-phase method.
PubMed:Tn916-generated, lipooligosaccharide mutants of Neisseria meningitidis and Neisseria gonorrhoeae.
PubMed:The adhesive specificity of the soluble human lectin, IgE-binding protein, toward lipid-linked oligosaccharides. Presence of the blood group A, B, B-like, and H monosaccharides confers a binding activity to tetrasaccharide (lacto-N-tetraose and lacto-N-neotetraose) backbones.
PubMed:Anti-j: human cold agglutinins recognizing linear (i) and branched (I) type 2 chains.
PubMed:Structure of the sialylated L3 lipopolysaccharide of Neisseria meningitidis.
PubMed:Kinetic study of human beta-1,4-galactosyltransferase expressed in E. coli.
PubMed:Preparation, characterization, and immunogenicity of meningococcal lipooligosaccharide-derived oligosaccharide-protein conjugates.
PubMed:Lactotetraose series ganglioside 3',6'-isoLD1 in tumors of central nervous and other systems in vitro and in vivo.
PubMed:Differences in the binding specificities of Pseudomonas aeruginosa M35 and Escherichia coli C600 for lipid-linked oligosaccharides with lactose-related core regions.
PubMed:An enzyme releasing lacto-N-biose from oligosaccharides.
PubMed:Biosynthesis of blood group I and i antigens in rat tissues. Identification of a novel beta 1-6-N-acetylglucosaminyltransferase.
PubMed:Structure of the L2 lipopolysaccharide core oligosaccharides of Neisseria meningitidis.
PubMed:Characterization of I/F1 glycoprotein as a receptor for Mycoplasma pneumoniae.
PubMed:The structural basis for pyocin resistance in Neisseria gonorrhoeae lipooligosaccharides.
PubMed:Eight lipooligosaccharides of Neisseria meningitidis react with a monoclonal antibody which binds lacto-N-neotetraose (Gal beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc).
PubMed:Identification of carbohydrate structures as receptors for localised adherent enteropathogenic Escherichia coli.
PubMed:Chemical structures of three neutral oligosaccharides obtained from horse (thoroughbred) colostrum.
PubMed:Lacto- and ganglio-series glycolipids are adhesion receptors for Neisseria gonorrhoeae.
PubMed:Structure of the L5 lipopolysaccharide core oligosaccharides of Neisseria meningitidis.
PubMed:Effect of lactose derivatives on metastatic potential of B16 melanoma cells.
PubMed:Liquid ion-exchange chromatography under pressure of milk oligosaccharides using a pulsed amperometric detector.
PubMed:Immunohistochemical analysis of LNT, NeuAc2----3LNT, and Lex carbohydrate antigens in human tumors and normal tissues.
PubMed:Assignment of the 1H- and 13C-NMR spectra of eight oligosaccharides of the lacto-N-tetraose and neotetraose series.
PubMed:Monoclonal IgM with unique specificity to gangliosides GM1 and GD1b and to lacto-N-tetraose associated with human motor neuron disease.
PubMed:Fractionation of human milk oligosaccharides by high-performance liquid chromatography.
PubMed:Structure and immunochemistry of meningococcal lipopolysaccharides.
PubMed:Anti-My-28, an antigranulocyte mouse monoclonal antibody, binds to a sugar sequence in lacto-N-neotetraose.
PubMed:Carbon nuclear magnetic resonance spectra of oligosaccharides isolated from human milk and ovarian cyst mucin.
PubMed:Further studies of the specificities of monoclonal anti-i and anti-I antibodies using chemically synthesized, linear oligosaccharides of the poly-N-acetyllactosamine series.
PubMed:Identification and fractionation of human milk oligosaccharides by proton-nuclear magnetic resonance spectroscopy and reverse-phase high-performance liquid chromatography.
PubMed:Preparation of lacto-N-neotetraose from human milk by high-performance liquid chromatography.
PubMed:A monoclonal IgM lambda macroglobulin with specificity for lacto-N-tetraose in a patient with bronchogenic carcinoma.
PubMed:Comparative study on ganglioside compositions of various rabbit tissues. Tissue-specificity in ganglioside molecular species of rabbit thymus.
PubMed:The reactions of antibodies to paragloboside (lacto-N-neotetraosyl ceramide) with human erythrocytes and lymphocytes.
PubMed:Quantitation of some urinary oligosaccharides during pregnancy and lactation.
PubMed:Identification of sialosylparagloboside as the erythrocyte receptor for an 'anti-p' antibody.
PubMed:A human cold agglutinin which binds lacto-N-neotetraose.
PubMed:Rosette formation between human lymphocytes and sheep erythrocytes. Inhibition of rosette formation by specific glycopeptides.
PubMed:Studies on human platelet gangliosides.
 
Notes:
binds human cold agglutinin. Isol. from human milk 10697138; 1370278; 14533820; 16239538; 16441441; 17101655; 17372007; 1910009; 2452383; 2474254; 2988366; 3926023; 6083447; 6798116; 6874813; 8193150; 8416736; 9353017); Neolactotetraose is a common oligosaccharide present in human breast milk. After lactose and lipids, human milk oligosaccharides (HMOs) are quantitatively the third largest and most diverse component of breast milk. These small mass HMOs are selectively metabolized by select bifidobacterial strains and represent a potential new class of bioactive molecules functioning as prebiotics to facilitate protective gut colonization in breast-fed newborns. The oligosaccharide composition of human milk varies among individuals. The geographical origin of the donors is one of the factors that accounts for this variability. This can be explained by genetically determined traits that are not uniformly distributed. (PMID: 10420591
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