| PubMed:Specific incorporation of an artificial nucleotide opposite a mutagenic DNA adduct by a DNA polymerase. |
| PubMed:Inhibition of human aldehyde oxidase activity by diet-derived constituents: structural influence, enzyme-ligand interactions, and clinical relevance. |
| PubMed:O6-alkylguanine postlesion DNA synthesis is correct with the right complement of hydrogen bonding. |
| PubMed:Redox-responsive magnetic nanoparticle for targeted convection-enhanced delivery of O6-benzylguanine to brain tumors. |
| PubMed:Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients. |
| PubMed:Novel MSH6 mutations in treatment-naïve glioblastoma and anaplastic oligodendroglioma contribute to temozolomide resistance independently of MGMT promoter methylation. |
| PubMed:Exo1 independent DNA mismatch repair involves multiple compensatory nucleases. |
| PubMed:NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. |
| PubMed:In vivo enrichment of genetically manipulated platelets corrects the murine hemophilic phenotype and induces immune tolerance even using a low multiplicity of infection. |
| PubMed:Investigations on the effect of O(6)-benzylguanine on the formation of dG-dC interstrand cross-links induced by chloroethylnitrosoureas in human glioma cells using stable isotope dilution high-performance liquid chromatography electrospray ionization tandem mass spectrometry. |
| PubMed:Lentiviral MGMT(P140K)-mediated in vivo selection employing a ubiquitous chromatin opening element (A2UCOE) linked to a cellular promoter. |
| PubMed:Visualization of phagosomal hydrogen peroxide production by a novel fluorescent probe that is localized via SNAP-tag labeling. |
| PubMed:Aldehyde oxidase activity in donor-matched fresh and cryopreserved human hepatocytes and assessment of variability in 75 donors. |
| PubMed:Cell-permeant and photocleavable chemical inducer of dimerization. |
| PubMed:Site-specific protein labeling with SNAP-tags. |
| PubMed:Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. |
| PubMed:In vivo roles of conjugation with glutathione and O6-alkylguanine DNA-alkyltransferase in the mutagenicity of the bis-electrophiles 1,2-dibromoethane and 1,2,3,4-diepoxybutane in mice. |
| PubMed:Cationic core-shell nanoparticles with carmustine contained within O⁶-benzylguanine shell for glioma therapy. |
| PubMed:Expression of O (6)-Methylguanine-DNA Methyltransferase Examined by Alkyl-Transfer Assays, Methylation-Specific PCR and Western Blots in Tumors and Matched Normal Tissue. |
| PubMed:Hydrogen bonding or stacking interactions in differentiating duplex stability in oligonucleotides containing synthetic nucleoside probes for alkylated DNA. |
| PubMed:Targeted delivery of dendritic polyglycerol-doxorubicin conjugates by scFv-SNAP fusion protein suppresses EGFR+ cancer cell growth. |
| PubMed:Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase. |
| PubMed:MGMT repletion after treatment of glioblastoma cells with temozolomide and O6-benzylguanine implicates NFκB and mutant p53. |
| PubMed:Tolerance of base pair size and shape in postlesion DNA synthesis. |
| PubMed:Temozolomide-mediated DNA methylation in human myeloid precursor cells: differential involvement of intrinsic and extrinsic apoptotic pathways. |
| PubMed:Efficacy of protracted temozolomide dosing is limited in MGMT unmethylated GBM xenograft models. |
| PubMed:The role of SNAP-tag in technical approaches. |
| PubMed:Hypoxia-selective O6-alkylguanine-DNA alkyltransferase inhibitors: design, synthesis, and evaluation of 6-(benzyloxy)-2-(aryldiazenyl)-9H-purines as prodrugs of O6-benzylguanine. |
| PubMed:Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality. |
| PubMed:F2A sequence linking MGMT(P140K) and MDR1 in a bicistronic lentiviral vector enables efficient chemoprotection of haematopoietic stem cells. |
| PubMed:Mismatch repair deficiency: a temozolomide resistance factor in medulloblastoma cell lines that is uncommon in primary medulloblastoma tumours. |
| PubMed:Design of a hypoxia-activated prodrug inhibitor of O6-alkylguanine-DNA alkyltransferase. |
| PubMed:Formation and repair of pyridyloxobutyl DNA adducts and their relationship to tumor yield in A/J mice. |
| PubMed:In vivo selection of autologous MGMT gene-modified cells following reduced-intensity conditioning with BCNU and temozolomide in the dog model. |
| PubMed:Progress in high-throughput assays of MGMT and APE1 activities in cell extracts. |
| PubMed:A strategy for selective O(6)-alkylguanine-DNA alkyltransferase depletion under hypoxic conditions. |
| PubMed:MGMT inhibition restores ERα functional sensitivity to antiestrogen therapy. |
| PubMed:SNAP-tag based proteomics approach for the study of the retrograde route. |
| PubMed:Phase I clinical trial of O6-benzylguanine and topical carmustine in the treatment of cutaneous T-cell lymphoma, mycosis fungoides type. |
| PubMed:Releasable SNAP-tag probes for studying endocytosis and recycling. |
| PubMed:Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes. |
| PubMed:SNAP-tag technology mediates site specific conjugation of antibody fragments with a photosensitizer and improves target specific phototoxicity in tumor cells. |
| PubMed:A phase II study of O6-benzylguanine and temozolomide in pediatric patients with recurrent or progressive high-grade gliomas and brainstem gliomas: a Pediatric Brain Tumor Consortium study. |
| PubMed:4-nitrobenzyloxycarbonyl derivatives of O(6)-benzylguanine as hypoxia-activated prodrug inhibitors of O(6)-alkylguanine-DNA alkyltransferase (AGT), which produces resistance to agents targeting the O-6 position of DNA guanine. |
| PubMed:Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity. |
| PubMed:Multifaceted roles of alkyltransferase and related proteins in DNA repair, DNA damage, resistance to chemotherapy, and research tools. |
| PubMed:Labelling cell structures and tracking cell lineage in zebrafish using SNAP-tag. |
| PubMed:Radioiodinated O(6)-Benzylguanine derivatives containing an azido function. |
| PubMed:Influence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells. |
| PubMed:Activity of irinotecan and temozolomide in the presence of O6-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models. |
| PubMed:Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition. |
| PubMed:Quenched substrates for live-cell labeling of SNAP-tagged fusion proteins with improved fluorescent background. |
| PubMed:Targeting O⁶-methylguanine-DNA methyltransferase with specific inhibitors as a strategy in cancer therapy. |
| PubMed:O6-methylguanine induces altered proteins at the level of transcription in human cells. |
| PubMed:Localizable and highly sensitive calcium indicator based on a BODIPY fluorophore. |
| PubMed:Thin layer chromatography-based assay of O6-methylguanine-DNA methyltransferase activity in tissue. |
| PubMed:Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates. |
| PubMed:Gateways to clinical trials. |
| PubMed:Development of SNAP-tag-mediated live cell labeling as an alternative to GFP in Porphyromonas gingivalis. |
| PubMed:In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase. |
| PubMed:MGMT modulates glioblastoma angiogenesis and response to the tyrosine kinase inhibitor sunitinib. |
| PubMed:The cyclin-dependent kinase inhibitor PHA-848125 suppresses the in vitro growth of human melanomas sensitive or resistant to temozolomide, and shows synergistic effects in combination with this triazene compound. |
| PubMed:Chemoprotection of human hematopoietic stem cells by simultaneous lentiviral overexpression of multidrug resistance 1 and O(6)-methylguanine-DNA methyltransferase(P140K). |
| PubMed:Effect of O6-chloroethylguanine DNA lesions on the kinetics and mechanism of micronucleus induction in vivo. |
| PubMed:Blockade of MGMT expression by O6 benzyl guanine leads to inhibition of pancreatic cancer growth and induction of apoptosis. |
| PubMed:Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity. |
| PubMed:Protein conjugates of SH3-domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases. |
| PubMed:In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene. |
| PubMed:Pharmacokinetics of temozolomide administered in combination with O6-benzylguanine in children and adolescents with refractory solid tumors. |
| PubMed:Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle. |
| PubMed:Phase 1 trial of temozolomide plus irinotecan plus O6-benzylguanine in adults with recurrent malignant glioma. |
| PubMed:Site-specific, covalent labeling of recombinant antibody fragments via fusion to an engineered version of 6-O-alkylguanine DNA alkyltransferase. |
| PubMed:Phase I trial of temozolomide plus O6-benzylguanine 5-day regimen with recurrent malignant glioma. |
| PubMed:The alkyltransferase-like ybaZ gene product enhances nucleotide excision repair of O(6)-alkylguanine adducts in E. coli. |
| PubMed:Phase II trial of temozolomide plus o6-benzylguanine in adults with recurrent, temozolomide-resistant malignant glioma. |
| PubMed:Indo-1 derivatives for local calcium sensing. |
| PubMed:Phase II trial of Gliadel plus O6-benzylguanine in adults with recurrent glioblastoma multiforme. |
| PubMed:Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53. |
| PubMed:Degradation of BRCA2 in alkyltransferase-mediated DNA repair and its clinical implications. |
| PubMed:Role of copper transporters in resistance to platinating agents. |
| PubMed:Substitution of aminomethyl at the meta-position enhances the inactivation of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine. |
| PubMed:The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity. |
| PubMed:Development of an O(6)-alkylguanine-DNA alkyltransferase assay based on covalent transfer of the benzyl moiety from [benzene-3H]O(6)-benzylguanine to the protein. |
| PubMed:Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. |
| PubMed:Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells. |
| PubMed:Enhancement of cisplatin [cis-diammine dichloroplatinum (II)] cytotoxicity by O6-benzylguanine involves endoplasmic reticulum stress. |
| PubMed:Heterogeneity of human glioblastoma: glutathione-S-transferase and methylguanine-methyltransferase. |
| PubMed:Carmustine-resistant cancer cells are sensitized to temozolomide as a result of enhanced mismatch repair during the development of carmustine resistance. |
| PubMed:Bone marrow-derived cells exhibiting lung epithelial cell characteristics are enriched in vivo using methylguanine DNA methyltransferase-mediated drug resistance. |
| PubMed:Co-expression of MGMT(P140K) and alpha-L-iduronidase in primary hepatocytes from mucopolysaccharidosis type I mice enables efficient selection with metabolic correction. |
| PubMed:Caged substrates for protein labeling and immobilization. |
| PubMed:Phase I trial of single-dose temozolomide and continuous administration of o6-benzylguanine in children with brain tumors: a pediatric brain tumor consortium report. |
| PubMed:Differential inactivation of polymorphic variants of human O6-alkylguanine-DNA alkyltransferase. |
| PubMed:Phase 1 trial of O6-benzylguanine and BCNU in children with CNS tumors: a Children's Oncology Group study. |
| PubMed:O6-methylguanine-DNA-methyltransferase promoter demethylation is involved in basic fibroblast growth factor induced resistance against temozolomide in human melanoma cells. |
| PubMed:The therapeutic potential of O6-alkylguanine DNA alkyltransferase inhibitors. |
| PubMed:Triazene compounds: mechanism of action and related DNA repair systems. |
| PubMed:Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma. |
| PubMed:Novel mechanism whereby nuclear factor kappaB mediates DNA damage repair through regulation of O(6)-methylguanine-DNA-methyltransferase. |
| PubMed:A concise synthesis of the Pennsylvania Green fluorophore and labeling of intracellular targets with O6-benzylguanine derivatives. |
| PubMed:In vivo selection and chemoprotection after drug resistance gene therapy in a nonmyeloablative allogeneic transplantation setting in dogs. |
| PubMed:Methylation damage response in hematopoietic progenitor cells. |
| PubMed:Stable differentiation and clonality of murine long-term hematopoiesis after extended reduced-intensity selection for MGMT P140K transgene expression. |
| PubMed:Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines. |
| PubMed:Vector design for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells. |
| PubMed:O6-benzylguanine and BCNU in multiple myeloma: a phase II trial. |
| PubMed:Molecular basis of selectivity of nucleoside triphosphate incorporation opposite O6-benzylguanine by sulfolobus solfataricus DNA polymerase Dpo4: steady-state and pre-steady-state kinetics and x-ray crystallography of correct and incorrect pairing. |
| PubMed:O (4)-benzylfolic acid inactivates O (6)-alkylguanine-DNA alkyltransferase in brain tumor cell lines. |
| PubMed:S-alkylthiolation of O6-methylguanine-DNA-methyltransferase (MGMT) to sensitize cancer cells to anticancer therapy. |
| PubMed:Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial. |
| PubMed:The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents. |
| PubMed:Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents. |
| PubMed:Role of O6-methylguanine-DNA methyltransferase in protecting from alkylating agent-induced toxicity and mutations in mice. |
| PubMed:Local intracerebral administration of O(6)-benzylguanine combined with systemic chemotherapy with temozolomide of a patient suffering from a recurrent glioblastoma. |
| PubMed:A single cycle of treatment with temozolomide, alone or combined with O(6)-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro: role of O(6)-methylguanine-DNA methyltransferase and the mismatch repair system. |
| PubMed:Fluorophores for live cell imaging of AGT fusion proteins across the visible spectrum. |
| PubMed:Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms. |
| PubMed:In vivo selection of transduced hematopoietic stem cells and little evidence of their conversion into hepatocytes in vivo. |
| PubMed:Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. |
| PubMed:Exploiting the role of O6-methylguanine-DNA-methyltransferase (MGMT) in cancer therapy. |
| PubMed:Inactivation of O6-alkylguanine DNA alkyltransferase as a means to enhance chemotherapy. |
| PubMed:Emerging cancer therapeutic opportunities target DNA-repair systems. |
| PubMed:Directed evolution of O6-alkylguanine-DNA alkyltransferase for applications in protein labeling. |
| PubMed:Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine. |
| PubMed:A phase II trial of O6-benzylguanine and carmustine in patients with advanced soft tissue sarcoma. |
| PubMed:Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. |
| PubMed:The antineoplastic efficacy of the prodrug Cloretazine is produced by the synergistic interaction of carbamoylating and alkylating products of its activation. |
| PubMed:[O6-benzylguanine stimulates regulatory functions of the Ada protein in Escherichia coli]. |
| PubMed:Role of GADD34 in modulation of cisplatin cytotoxicity. |
| PubMed:Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma. |
| PubMed:Phase I study of O6-benzylguanine and temozolomide administered daily for 5 days to pediatric patients with solid tumors. |
| PubMed:518A2 melanoma cells are protected by G3139 and other antineoplastic agents against the cytotoxic effects of DTIC. |
| PubMed:Phase I trial of temozolomide plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. |
| PubMed:The P140K mutant of human O(6)-methylguanine-DNA-methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O(6)-(4-bromothenyl)guanine. |
| PubMed:Role of O6-methylguanine-DNA methyltransferase and effect of O6-benzylguanine on the anti-tumor activity of cis-diaminedichloroplatinum(II) in oral cancer cell lines. |
| PubMed:O6-3-[125I]iodobenzyl-2'-deoxyguanosine ([125I]IBdG): synthesis and evaluation of its usefulness as an agent for quantification of alkylguanine-DNA alkyltransferase (AGT). |
| PubMed:Protein-functionalized polymer brushes. |
| PubMed:Mitochondrial targeting of human O6-methylguanine DNA methyltransferase protects against cell killing by chemotherapeutic alkylating agents. |
| PubMed:O6-methylguanine-DNA methyltransferase, O6-benzylguanine, and resistance to clinical alkylators in pediatric primary brain tumor cell lines. |
| PubMed:Inactivated MGMT by O6-benzylguanine is associated with prolonged G2/M arrest in cancer cells treated with BCNU. |
| PubMed:Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine. |
| PubMed:Lipophilicity coefficients of potential tumor imaging agents, positron-labeled O(6)-benzylguanine derivatives. |
| PubMed:Beta-glucuronidase-cleavable prodrugs of O6-benzylguanine and O6-benzyl-2'-deoxyguanosine. |
| PubMed:Synthesis and antitumor activity of methyltriazene prodrugs simultaneously releasing DNA-methylating agents and the antiresistance drug O(6)-benzylguanine. |
| PubMed:Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy. |
| PubMed:Brain tumor cell lines resistant to O6-benzylguanine/1,3-bis(2-chloroethyl)-1-nitrosourea chemotherapy have O6-alkylguanine-DNA alkyltransferase mutations. |
| PubMed:Nuclear-localizing O6-benzylguanine-resistant GFP-MGMT fusion protein as a novel in vivo selection marker. |
| PubMed:Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity. |
| PubMed:Pharmacokinetics of O(6)-benzylguanine in pediatric patients with central nervous system tumors: a pediatric oncology group study. |
| PubMed:Hematopoietic stem cell gene therapy of murine protoporphyria by methylguanine-DNA-methyltransferase-mediated in vivo drug selection. |
| PubMed:Inhibition of O6-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors: comparison with nonconjugated inhibitors and effect on fotemustine and temozolomide-induced cell death. |
| PubMed:Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment. |
| PubMed:Interstitial infusion of carmustine in the rat brain stem with systemic administration of O6-benzylguanine. |
| PubMed:Cloning and expression of canine O6-methylguanine-DNA methyltransferase in target cells, using gammaretroviral and lentiviral vectors. |
| PubMed:Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide. |
| PubMed:O6-3-[131I]iodobenzylguanine: improved synthesis and further evaluation of a potential agent for imaging of alkylguanine-DNA alkyltransferase. |
| PubMed:Labeling of fusion proteins of O6-alkylguanine-DNA alkyltransferase with small molecules in vivo and in vitro. |
| PubMed:O6-benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomas. |
| PubMed:In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication. |
| PubMed:Hammerhead ribozyme-mediated sensitization of human tumor cells after treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea. |
| PubMed:Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1. |
| PubMed:Recent advances in brain tumor therapy: local intracerebral drug delivery by polymers. |
| PubMed:Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea. |
| PubMed:Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide. |
| PubMed:In vivo selection of human hematopoietic cells in a xenograft model using combined pharmacologic and genetic manipulations. |
| PubMed:Induced protein dimerization in vivo through covalent labeling. |
| PubMed:In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning. |
| PubMed:Blockage of abasic site repair enhances antitumor efficacy of 1,3-bis-(2-chloroethyl)-1-nitrosourea in colon tumor xenografts. |
| PubMed:Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine. |
| PubMed:Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression. |
| PubMed:Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients. |
| PubMed:A bicistronic SIN-lentiviral vector containing G156A MGMT allows selection and metabolic correction of hematopoietic protoporphyric cell lines. |
| PubMed:Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide. |
| PubMed:Alkylation damage repair protein O6-alkylguanine-DNA alkyltransferase from the hyperthermophiles Aquifex aeolicus and Archaeoglobus fulgidus. |
| PubMed:Enhancement of platinum-induced cytotoxicity by O6-benzylguanine. |
| PubMed:SarCNU mediates selection of P140K methylguanine-DNA-methyltransferase transduced human CD34(+) cells in vitro. |
| PubMed:Selective enhancement of ifosfamide-induced toxicity in Chinese hamster ovary cells. |
| PubMed:Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients. |
| PubMed:Covalent and selective immobilization of fusion proteins. |
| PubMed:Synthesis and preliminary biological evaluation of radiolabeled O6-benzylguanine derivatives, new potential PET imaging agents for the DNA repair protein O6-alkylguanine-DNA alkyltransferase in breast cancer. |
| PubMed:Directed evolution of O6-alkylguanine-DNA alkyltransferase for efficient labeling of fusion proteins with small molecules in vivo. |
| PubMed:Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells. |
| PubMed:Delayed repletion of O6-methylguanine-DNA methyltransferase resulting in failure to protect the human glioblastoma cell line SF767 from temozolomide-induced cytotoxicity. |
| PubMed:Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyl]guanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT. |
| PubMed:Effects of zinc occupancy on human O6-alkylguanine-DNA alkyltransferase. |
| PubMed:The effect of O6-alkylguanine-DNA alkyltransferase and mismatch repair activities on the sensitivity of human melanoma cells to temozolomide, 1,3-bis(2-chloroethyl)1-nitrosourea, and cisplatin. |
| PubMed:Hypersensitivity of DNA polymerase beta null mouse fibroblasts reflects accumulation of cytotoxic repair intermediates from site-specific alkyl DNA lesions. |
| PubMed:The combi-targeting concept: a novel 3,3-disubstituted nitrosourea with EGFR tyrosine kinase inhibitory properties. |
| PubMed:O6-benzylguanine-mediated enhancement of chemotherapy. |
| PubMed:Effect of O6-benzylguanine on nitrogen mustard-induced toxicity, apoptosis, and mutagenicity in Chinese hamster ovary cells. |
| PubMed:Toxicity of intracranial and intraperitoneal O6-benzyl guanine in combination with BCNU delivered locally in a mouse model. |
| PubMed:Base excision repair as a therapeutic target in colon cancer. |
| PubMed:Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMT(P140K) into hematopoietic stem cells. |
| PubMed:[The increasing mutagenic effect of nitrosoguanidine under the influence of modified bases during inhibition of repair AGT enzyme in mammalian somatic cells in vitro]. |
| PubMed:Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically resectable tumors. |
| PubMed:Repair of oligodeoxyribonucleotides by O(6)-alkylguanine-DNA alkyltransferase. |
| PubMed:Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer. |
| PubMed:Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase. |
| PubMed:Comparative cytotoxicity of carmustine (BCNU), nimustine (ACNU) and elmustine (HeCNU) after depletion of O6-alkylguanine-DNA alkyltransferase (O6-AGT). |
| PubMed:Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine. |
| PubMed:Clinical relevance of MGMT in the treatment of cancer. |
| PubMed:Phase II trial of carmustine plus O(6)-benzylguanine for patients with nitrosourea-resistant recurrent or progressive malignant glioma. |
| PubMed:Biochemical changes associated with a multidrug-resistant phenotype of a human glioma cell line with temozolomide-acquired resistance. |
| PubMed:Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro. |
| PubMed:Mutagenesis by O(6)-[4-oxo-4-(3-pyridyl)butyl]guanine in Escherichia coli and human cells. |
| PubMed:O(6)-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives. |
| PubMed:Misincorporation and stalling at O(6)-methylguanine and O(6)-benzylguanine: evidence for inactive polymerase complexes. |
| PubMed:Effect of the O6 substituent on misincorporation kinetics catalyzed by DNA polymerases at O(6)-methylguanine and O(6)-benzylguanine. |
| PubMed:[Mutation of human O6-alkylguanine-DNA alkyltransferase confers resistance to O6-benzylguanine]. |
| PubMed:Role of cytochrome P450 isoenzymes in metabolism of O(6)-benzylguanine: implications for dacarbazine activation. |
| PubMed:Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships. |
| PubMed:G156A MGMT-transduced human mesenchymal stem cells can be selectively enriched by O6-benzylguanine and BCNU. |
| PubMed:Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation. |
| PubMed:Repair of O(6)-methylguanine is not affected by thymine base pairing and the presence of MMR proteins. |
| PubMed:Covalent capture of a human O(6)-alkylguanine alkyltransferase-DNA complex using N(1),O(6)-ethanoxanthosine, a mechanism-based crosslinker. |
| PubMed:The effectiveness of the O(6)-alkylguanine-DNA alkyltransferase encoded by the ogt(ST) gene from S. typhimurium in protection against alkylating drugs, resistance to O(6)-benzylguanine and sensitisation to dibromoalkane genotoxicity. |
| PubMed:Differential degradation rates of inactivated alkyltransferase in blood mononuclear cells and tumors of patients after treatment with O(6)-benzylguanine. |
| PubMed:Interactions between methylating and pyridyloxobutylating agents in A/J mouse lungs: implications for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis. |
| PubMed:Mutagenesis by O(6)-methyl-, O(6)-ethyl-, and O(6)-benzylguanine and O(4)-methylthymine in human cells: effects of O(6)-alkylguanine-DNA alkyltransferase and mismatch repair. |
| PubMed:Inactivation of O(6)-methylguanine-DNA methyltransferase by glucose-conjugated inhibitors. |
| PubMed:O6-Benzylguanine potentiates BCNU but not busulfan toxicity in hematopoietic stem cells. |
| PubMed:Enforced expression of wild-type p53 curtails the transcription of the O(6)-methylguanine-DNA methyltransferase gene in human tumor cells and enhances their sensitivity to alkylating agents. |
| PubMed:Comparison of single- versus double-bolus treatments of O(6)-benzylguanine for depletion of O(6)-methylguanine DNA methyltransferase (MGMT) activity in vivo: development of a novel fluorometric oligonucleotide assay for measurement of MGMT activity. |
| PubMed:Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells. |
| PubMed:Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT. |
| PubMed:Debenzylation of O(6)-benzyl-8-oxoguanine in human liver: implications for O(6)-benzylguanine metabolism. |
| PubMed:Purification and characterization of West Nile virus nucleoside triphosphatase (NTPase)/helicase: evidence for dissociation of the NTPase and helicase activities of the enzyme. |
| PubMed:Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide. |
| PubMed:Inactivation of human O(6)-alkylguanine-DNA alkyltransferase by modified oligodeoxyribonucleotides containing O(6)-benzylguanine. |
| PubMed:Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector. |
| PubMed:O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma. |
| PubMed:Radiolabeled guanine derivatives for the in vivo mapping of O(6)-alkylguanine-DNA alkyltransferase: 6-(4-[(18)F]Fluoro-benzyloxy)-9H-purin-2-ylamine and 6-(3-[(131)I]Iodo-benzyloxy)-9H-purin-2-ylamine. |
| PubMed:Resistance-modifying agents. 8. Inhibition of O(6)-alkylguanine-DNA alkyltransferase by O(6)-alkenyl-, O(6)-cycloalkenyl-, and O(6)-(2-oxoalkyl)guanines and potentiation of temozolomide cytotoxicity in vitro by O(6)-(1-cyclopentenylmethyl)guanine. |
| PubMed:Effect of O6-benzylguanine on alkylating agent-induced toxicity and mutagenicity. In Chinese hamster ovary cells expressing wild-type and mutant O6-alkylguanine-DNA alkyltransferases. |
| PubMed:Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. |
| PubMed:Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells. |
| PubMed:Plasma and cerebrospinal fluid pharmacokinetics of O6-benzylguanine and analogues in nonhuman primates. |
| PubMed:Pharmacokinetics of oral O6-benzylguanine and evidence of interaction with oral ketoconazole in the rat. |
| PubMed:Phase I clinical and pharmacological study of O6-benzylguanine followed by carmustine in patients with advanced cancer. |
| PubMed:Can O6-alkylguanine-DNA alkyltransferase depletion enhance alkylator activity in the clinic? |
| PubMed:Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents. |
| PubMed:Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase. |
| PubMed:Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl-N-nitrosourea: evidence of elimination of p53 by homologous recombination. |
| PubMed:Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase. |
| PubMed:Genetic modification of haematopoietic cells for combined resistance to podophyllotoxins, other agents covered by MDR1-mediated efflux activity and nitrosoureas. |
| PubMed:Potentiation of BCNU anticancer activity by O6-benzylguanine: a study in vitro and in vivo. |
| PubMed:The role of human O(6)-alkylguanine-DNA alkyltransferase in promoting 1,2-dibromoethane-induced genotoxicity in Escherichia coli. |
| PubMed:Enhanced in vivo repair of O(4)-methylthymine by a mutant human DNA alkyltransferase. |
| PubMed:Role of O6-alkylguanine-DNA alkyltransferase in the resistance of mouse spermatogenic cells to O6-alkylating agents. |
| PubMed:O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials. |
| PubMed:Limiting numbers of G156A O(6)-methylguanine-DNA methyltransferase-transduced marrow progenitors repopulate nonmyeloablated mice after drug selection. |
| PubMed:Differential modulation of chemosensitivity to alkylating agents and platinum compounds by DNA repair modulators in human lung cancer cell lines. |
| PubMed:Repair of O(6)-alkylguanine by alkyltransferases. |
| PubMed:In vivo administration of O(6)-benzylguanine does not influence apoptosis or mutation frequency following DNA damage in the murine intestine, but does inhibit P450-dependent activation of dacarbazine. |
| PubMed:Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine. |
| PubMed:Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine. |
| PubMed:Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism. |
| PubMed:O(6)-(4-bromothenyl)guanine improves the therapeutic index of temozolomide against A375M melanoma xenografts. |
| PubMed:O(6)-methylguanine-DNA methyltransferase activity, p53 gene status and BCNU resistance in mouse astrocytes. |
| PubMed:Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats. |
| PubMed:Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy. |
| PubMed:O(6)-benzylguanine enhances the in vitro immunotoxic activity of temozolomide on natural or antigen-dependent immunity. |
| PubMed:Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo. |
| PubMed:Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells - implications for chemoprotective gene therapy. |
| PubMed:Human O(6)-alkylguanine-DNA alkyltransferase: protection against alkylating agents and sensitization to dibromoalkanes. |
| PubMed:Redesigning the substrate specificity of human O(6)-alkylguanine-DNA alkyltransferase. Mutants with enhanced repair of O(4)-methylthymine. |
| PubMed:Role of codon 160 in the sensitivity of human O6-alkylguanine-DNA alkyltransferase to O6-benzylguanine. |
| PubMed:Retroviral-mediated expression of the P140A, but not P140A/G156A, mutant form of O6-methylguanine DNA methyltransferase protects hematopoietic cells against O6-benzylguanine sensitization to chloroethylnitrosourea treatment. |
| PubMed:Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer. |
| PubMed:Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine. |
| PubMed:Human long-term culture initiating cells are sensitive to benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and protected after mutant (G156A) methylguanine methyltransferase gene transfer. |
| PubMed:O6-benzylguanine-resistant mutant MGMT genes improve hematopoietic cell tolerance to alkylating agents. |
| PubMed:O6-benzylguanine: a clinical trial establishing the biochemical modulatory dose in tumor tissue for alkyltransferase-directed DNA repair. |
| PubMed:DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts. |
| PubMed:Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine. |
| PubMed:Influence of O6-benzylguanine on the anti-tumour activity and normal tissue toxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea and molecular combinations of 5-fluorouracil and 2-chloroethyl-1-nitrosourea in mice. |
| PubMed:Identification and characterisation of the Drosophila melanogaster O6-alkylguanine-DNA alkyltransferase cDNA. |
| PubMed:Leukocyte O6-alkylguanine-DNA alkyltransferase from human donors is uniformly sensitive to O6-benzylguanine. |
| PubMed:Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine. |
| PubMed:Mismatch repair and differential sensitivity of mouse and human cells to methylating agents. |
| PubMed:Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer. |
| PubMed:Simultaneous protection of G156A methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and sensitization of tumor cells using O6-benzylguanine and temozolomide. |
| PubMed:Increasing DNA repair capacity in bone marrow by gene transfer as a prospective tool in cancer therapy. |
| PubMed:Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain. |
| PubMed:Pharmacokinetics of O6-benzylguanine and its active metabolite 8-oxo-O6-benzylguanine in plasma and cerebrospinal fluid after intrathecal administration of O6-benzylguanine in the nonhuman primate. |
| PubMed:Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma. |
| PubMed:Chemoprotective gene transfer I: transduction of human haemopoietic progenitors with O6-benzylguanine-resistant O6-alkylguanine-DNA alkyltransferase attenuates the toxic effects of O6-alkylating agents in vitro. |
| PubMed:Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase. |
| PubMed:Effects of O6-benzylguanine on growth and differentiation of P19 embryonic carcinoma cells treated with alkylating agents. |
| PubMed:Modulation of O6-alkylating agent induced clastogenicity by enhanced DNA repair capacity of bone marrow cells. |
| PubMed:O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases. |
| PubMed:Reaction of O6-benzylguanine-resistant mutants of human O6-alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides. |
| PubMed:O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings. |
| PubMed:Isolation of human O6-alkylguanine-DNA alkyltransferase mutants highly resistant to inactivation by O6-benzylguanine. |
| PubMed:Role of wild-type p53 on the antineoplastic activity of temozolomide alone or combined with inhibitors of poly(ADP-ribose) polymerase. |
| PubMed:Heterogeneity of O6-alkylguanine-DNA-alkyltransferase measured by flow cytometric analysis in blood and bone marrow mononuclear cells. |
| PubMed:Simultaneous determination of O6-benzylguanine and 8-oxo-O6-benzylguanine in human plasma by reversed-phase high-performance liquid chromatography. |
| PubMed:Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. |
| PubMed:N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea sensitivity in mismatch repair-defective human cells. |
| PubMed:Substrate specificity of human O6-methylguanine-DNA methyltransferase for O6-benzylguanine derivatives in oligodeoxynucleotides. |
| PubMed:Selection for G156A O6-methylguanine DNA methyltransferase gene-transduced hematopoietic progenitors and protection from lethality in mice treated with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea. |
| PubMed:The potential role of glycine-160 of human O6-alkylguanine-DNA alkyltransferase in reaction with O6-benzylguanine as determined by site-directed mutagenesis and molecular modelling comparisons. |
| PubMed:O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU. |
| PubMed:Inhibition of DNA repair as a means of increasing the antitumor activity of DNA reactive agents. |
| PubMed:O6-benzylguanine and its role in chemotherapy. |
| PubMed:[Study on potentiation of nitrosourea-cytotoxicity by DNA repair enzyme inhibitors in human brain tumor cells]. |
| PubMed:Effect of DNA on the inactivation of O6-alkylguanine-DNA alkyltransferase by 9-substituted O6-benzylguanine derivatives. |
| PubMed:Creation of human alkyltransferases resistant to O6-benzylguanine. |
| PubMed:Repair of O6-benzylguanine by the Escherichia coli Ada and Ogt and the human O6-alkylguanine-DNA alkyltransferases. |
| PubMed:Role of O6-methylguanine-DNA methyltransferase, glutathione transferase M3-3 and glutathione in resistance to carmustine in a human non-small cell lung cancer cell line. |
| PubMed:O6-benzylguanine potentiates the in vivo toxicity and clastogenicity of temozolomide and BCNU in mouse bone marrow. |
| PubMed:Mismatch repair provokes chromosome aberrations in hamster cells treated with methylating agents or 6-thioguanine, but not with ethylating agents. |
| PubMed:Retroviral transfer of a bacterial alkyltransferase gene (ada) into human bone marrow cells protects against O6-benzylguanine plus 1, 3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity. |
| PubMed:Effect of single and multiple administration of an O6-benzylguanine/temozolomide combination: an evaluation in a human melanoma xenograft model. |
| PubMed:Intraarterial O6-benzylguanine enables the specific therapy of nitrosourea-resistant intracranial human glioma xenografts in athymic rats with 1,3-bis(2-chloroethyl)-1-nitrosourea. |
| PubMed:Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine. |
| PubMed:Mismatch repair mutations override alkyltransferase in conferring resistance to temozolomide but not to 1,3-bis(2-chloroethyl)nitrosourea. |
| PubMed:Retroviral transduction of a mutant methylguanine DNA methyltransferase gene into human CD34 cells confers resistance to O6-benzylguanine plus 1,3-bis(2-chloroethyl)-1-nitrosourea. |
| PubMed:Protection of mammalian cells against chloroethylating agent toxicity by an O6-benzylguanine-resistant mutant of human O6-alkylguanine-DNA alkyltransferase. |
| PubMed:O6-methylguanine induces intrachromosomal homologous recombination in human cells. |
| PubMed:In vitro inactivation of human O6-alkylguanine DNA alkyltransferase by antitumor triazene compounds. |
| PubMed:3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity. |
| PubMed:Conformational change in human DNA repair enzyme O6-methylguanine-DNA methyltransferase upon alkylation of its active site by SN1 (indirect-acting) and SN2 (direct-acting) alkylating agents: breaking a "salt-link". |
| PubMed:Human CD34+ hematopoietic progenitors have low, cytokine-unresponsive O6-alkylguanine-DNA alkyltransferase and are sensitive to O6-benzylguanine plus BCNU. |
| PubMed:Cytotoxicity of fluoroethylating agents is potentiated by O6-benzylguanine. |
| PubMed:Determination of O6-benzylguanine in human plasma by reversed-phase high-performance liquid chromatography. |
| PubMed:O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU. |
| PubMed:Differential sensitivity of human and mouse alkyltransferase to O6-benzylguanine using a transgenic model. |
| PubMed:Role of O6-methylguanine-DNA methyltransferase in resistance of human brain tumor cell lines to the clinically relevant methylating agents temozolomide and streptozotocin. |
| PubMed:O6-ethylguanine and O6-benzylguanine incorporated site-specifically in codon 12 of the rat H-ras gene induce semi-targeted as well as targeted mutations in Rat4 cells. |
| PubMed:Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea. |
| PubMed:Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro. |
| PubMed:Ubiquitination-dependent proteolysis of O6-methylguanine-DNA methyltransferase in human and murine tumor cells following inactivation with O6-benzylguanine or 1,3-bis(2-chloroethyl)-1-nitrosourea. |
| PubMed:Thymidine kinase deficient cells with decreased TTP pools are hypersensitive to DNA alkylating agents. |
| PubMed:Potentiation of testicular cytotoxicity by the alkyltransferase inhibitor O6 benzylguanine and the 5-fluorouracil/N-(2-chloroethyl)-N-nitrosourea molecular combination, B.4152. |
| PubMed:Role of DNA repair in resistance to drugs that alkylate O6 of guanine. |
| PubMed:Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta. |
| PubMed:Intracellular Localization and intercellular heterogeneity of the human DNA repair protein O(6)-methylguanine-DNA methyltransferase. |
| PubMed:Pharmacokinetics of O6-benzylguanine in rats and its metabolism by rat liver microsomes. |
| PubMed:Retroviral transfer of a bacterial alkyltransferase gene into murine bone marrow protects against chloroethylnitrosourea cytotoxicity. |
| PubMed:Human liver oxidative metabolism of O6-benzylguanine. |
| PubMed:Plasma and cerebrospinal fluid pharmacokinetics of O6-benzylguanine and time course of peripheral blood mononuclear cell O6-methylguanine-DNA methyltransferase inhibition in the nonhuman primate. |
| PubMed:Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea. |
| PubMed:Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine. |
| PubMed:Activity of temozolomide in the treatment of central nervous system tumor xenografts. |
| PubMed:Modulation of nitrosourea toxicity in rodent embryonic cells by O6-benzylguanine, a depletor of O6-methylguanine-DNA methyltransferase. |
| PubMed:Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine. |
| PubMed:O6-alkylguanine-DNA alkyltransferase. A target for the modulation of drug resistance. |
| PubMed:O6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide. |
| PubMed:Inhibition of O6-alkylguanine-DNA alkyltransferase in animal and human ovarian tumor cell lines by O6-benzylguanine and sensitization to BCNU. |
| PubMed:Sensitization of human colon tumour cell lines to carmustine by depletion of O6-alkylguanine-DNA alkyltransferase. |
| PubMed:Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine. |
| PubMed:Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo. |
| PubMed:Metabolism of O6-benzylguanine, an inactivator of O6-alkylguanine-DNA alkyltransferase. |
| PubMed:Enhancing effect of O6-alkylguanine derivatives on chloroethylnitrosourea cytotoxicity toward tumor cells. |
| PubMed:Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity. |
| PubMed:Response of repair-competent and repair-deficient Escherichia coli to three O6-substituted guanines and involvement of methyl-directed mismatch repair in the processing of O6-methylguanine residues. |
| PubMed:Combined depletion of O6-alkylguanine-DNA alkyltransferase and glutathione to modulate nitrosourea resistance in breast cancer. |
| PubMed:Activation of human O6-alkylguanine-DNA alkyltransferase by DNA. |
| PubMed:Degradation of O6-benzylguanine in aqueous polyethylene glycol 400 (PEG 400) solutions: concerns with formaldehyde in PEG 400. |
| PubMed:Effects of inhibition of O6-alkylguanine-DNA alkyltransferase in rats on carcinogenesis by methylnitrosourea and ethylnitrosourea. |
| PubMed:Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine. |
| PubMed:Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase. |
| PubMed:Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL. |
| PubMed:Potential of O6-methylguanine or O6-benzylguanine in the enhancement of chloroethylnitrosourea cytotoxicity on brain tumours. |
| PubMed:Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine. |
| PubMed:Chemosensitisation of alkylating agents by pentoxifylline, O6-benzylguanine and ethacrynic acid in haematological malignancies. |
| PubMed:A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine. |
| PubMed:Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro. |
| PubMed:Repair of O6-methylguanine and O4-methylthymidine in F344 rat liver following treatment with 1,2-dimethylhydrazine and O6-benzylguanine. |
| PubMed:Effect of O6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). |
| PubMed:Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells. |
| PubMed:Depletion of O6-methylguanine-DNA methyltransferase and potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea antitumor activity by O6-benzylguanine in vitro. |
| PubMed:Modulation of O6-methylguanine-DNA methyltransferase-mediated 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea resistance by O6-benzylguanine in vitro and in vivo. |
| PubMed:The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene. |
| PubMed:Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone. |
| PubMed:Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer. |
| PubMed:The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells. |
| PubMed:Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea. |
| PubMed:Chemical characteristics of complexes of O6,9-dimethylguanine with cis-platin and debenzylation rates of O6-benzylguanines. |
| PubMed:Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. |
| PubMed:Depletion of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine in three-dimensional collagen cultures of normal human breast epithelial cells. |
| PubMed:Modulation of ethylnitrosourea-induced toxicity and mutagenicity in human cells by O6-benzylguanine. |
| PubMed:Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation. |
| PubMed:O6-alkylguanine DNA-alkyltransferase is not a major determinant of sensitivity to 1,3-bis(2-chloroethyl)-1-nitrosourea in four medulloblastoma cell lines. |
| PubMed:Comparison of the inactivation of mammalian and bacterial O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine and O6-methylguanine. |
| PubMed:Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts. |
| PubMed:Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine. |
| PubMed:Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents. |
| PubMed:Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. |
| PubMed:Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea. |
3D/inchi