monocrotaline N-oxide, 35337-98-5

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CODE108004 CODE108004
Product(s):
35337-98-5 Monocrotaline N-Oxide 98%
Monocrotaline N-Oxide is an alkaloid isolated from Crotalaria pallida Ait leading to DNA adduct formation in vivo.

CAS Number:	35337-98-5	3D/inchi
FDA UNII:	2LCP0RBK6G
XlogP3-AA:	-1.30 (est)
Molecular Weight:	341.36071000
Formula:	C16 H23 N O7
NMR Predictor:	Predict (works with chrome, Edge or firefox)

Category:natural substances and extractives

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

Google Scholar:	Search
Google Books:	Search
Google Scholar: with word "volatile"	Search
Google Scholar: with word "flavor"	Search
Google Scholar: with word "odor"	Search
Google Patents:	Search
US Patents:	Search
EU Patents:	Search
Pubchem Patents:	Search
PubMed:	Search
NCBI:	Search

Physical Properties:

Assay:	95.00 to 100.00
Food Chemicals Codex Listed:	No
Soluble in:
	water, 3.215e+005 mg/L @ 25 °C (est)

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

None found

Suppliers:

BOC Sciences

For experimental / research use only.

Monocrotaline N-Oxide 98%

Odor: characteristic

Use: Monocrotaline N-Oxide is an alkaloid isolated from Crotalaria pallida Ait leading to DNA adduct formation in vivo.

Santa Cruz Biotechnology

For experimental / research use only.

Monocrotaline N-oxide

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LDLo 25 mg/kg Journal of Pathology and Bacteriology. Vol. 78, Pg. 471, 1959.
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
natural substances and extractives
Recommendation for monocrotaline N-oxide usage levels up to:
	not for fragrance use.

Recommendation for monocrotaline N-oxide flavor usage levels up to:
	not for flavor use.

Safety References:

European Food Safety Authority (EFSA) reference(s):

Dietary exposure assessment to pyrrolizidine alkaloids in the European population
View page or View pdf

EPI System: View

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA GENetic TOXicology:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

Laboratory Chemical Safety Summary :197173

National Institute of Allergy and Infectious Diseases:Data

Chemidplus:0035337985

References:

NIST Chemistry WebBook:	Search Inchi
Pubchem (cid):	197173
Pubchem (sid):	135175234
Pherobase:	View

Other Information:

(IUPAC):	Atomic Weights of the Elements 2011 (pdf)
Videos:	The Periodic Table of Videos
tgsc:	Atomic Weights use for this web site
(IUPAC):	Periodic Table of the Elements
CHEMBL:	View
HMDB (The Human Metabolome Database):	Search
VCF-Online:	VCF Volatile Compounds in Food
ChemSpider:	View

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

found in nature

Synonyms:

14,19-	dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione 4-oxide (13-alpha,14-alpha)-
2H-[1,6]	dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, 11-oxide
	monocrotaline oxide
20-	norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, 4-oxide, (13-alpha,14-alpha)-

Articles:

PubMed:If you've got it, flaunt it: ingested alkaloids affect corematal display behavior in the salt marsh moth, Estigmene acrea.

PubMed:Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo.

PubMed:Dietary alkaloids and the development of androconial organs in Estigmene acrea.

Notes:

None found

monocrotaline N-oxide 20-norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, 4-oxide, (13-alpha,14-alpha)-

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Articles:

monocrotaline N-oxide
20-norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, 4-oxide, (13-alpha,14-alpha)-