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kathon 886
5-chloro-2-methyl-2H-isothiazol-3-one, mixture with 2-methyl-2H-4 isothiazol-3-one (3:1)

Supplier Sponsors

CAS Number: 55965-84-9Picture of molecule3D/inchi
Other(deleted CASRN):229619-22-1
FDA UNII: 15O9QS218W
MDL:MFCD01716911
Molecular Weight:264.75413000
Formula:C8 H9 Cl N2 O2 S2
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:indirect food additives: adhesives and components of coatings
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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DG SANTE Food Contact Materials:5-chloro-2-methyl-2H-isothiazol-3-one, mixture with 2-methyl-2H-4 isothiazol-3-one (3:1)
FDA Mainterm (IAUFC):55965-84-9 ; 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE MIXTURE WITH 2-METHYL-4-ISOTHIAZOLIN-3-ONE
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 5.367e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
5-Chloro-2-methyl-3(2H)-isothiazolone with 2-methyl-3(2H)-isothiazolone 95%
Connect Chemicals
Con WT
Connect Chemicals
Conncide CIT 15
Covalent Chemical
Isothiazolinones
Dow Chemical
KATHON™ for Metal Working
Jiangyin Healthway
Kathon CG (colourless)
New functional food ingredients
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 60 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Mutation Research. Vol. 118, Pg. 129, 1983.

oral-rat LD50 53 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Mutation Research. Vol. 118, Pg. 129, 1983.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
indirect food additives: adhesives and components of coatings
Recommendation for kathon 886 usage levels up to:
 not for fragrance use.
 
Recommendation for kathon 886 flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :41679
National Institute of Allergy and Infectious Diseases:Data
5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one
Chemidplus:0055965849
 
References:
 5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):41679
Pubchem (sid):135002809
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Indirect Additives used in Food Contact Substances:View
CHEMBL:View
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
5-chloro-2-methyl-1,2-thiazol-3-one;2-methyl-1,2-thiazol-3-one
5-chloro-2-methyl-2H-isothiazol-3-one, mixture with 2-methyl-2H-4 isothiazol-3-one (3:1)
 mcrocide III
 somacide RS
isothiazolinone
3(2H)-isothiazolone, 5-chloro-2-methyl-, mixt. with 2-methyl-3(2H)-isothiazolone
 

Articles:

PubMed:Fate and control of pathogenic and spoilage micro-organisms in orange blossom (Citrus aurantium) and rose flower (Rosa centifolia) hydrosols.
PubMed:Contact allergy to 1,2-benzisothiazolin-3-one.
PubMed:Octylisothiazolinone, an additional cause of allergic contact dermatitis caused by leather: case series and potential implications for the study of cross-reactivity with methylisothiazolinone.
PubMed:Cosmetic preservative labelling on the Thai market.
PubMed:The fate of two isothiazolinone biocides, 5-chloro-2-methylisothiazol-3(2H)-one (CMI) and 2-methylisothiazol-3(2H)-one (MI), in liquid air fresheners and assessment of inhalation exposure.
PubMed:Methylisothiazolinone in selected consumer products in Belgium: Adding fuel to the fire?
PubMed:Human Cumulative Irritation Tests of Common Preservatives Used in Personal Care Products: A Retrospective Analysis of Over 45 000 Subjects.
PubMed:Photoaggravated contact dermatitis to Kathon CG (methylchloroisothiazolinone/methylisothiazolinone): a novel pattern of involvement in a growing epidemic?
PubMed:Determination of methylisothiazolinone and methylchloroisothiazolinone in cosmetic products by ultra high performance liquid chromatography with tandem mass spectrometry.
PubMed:[Determination of three isothiazolinone biocides in water-borne adhesives by high performance liquid chromatography].
PubMed:Occupational contact dermatitis caused by N-butyl-1,2-benzisothiazolin-3-one in a cutting fluid.
PubMed:Isothiazolinones: sensitizers not to miss in children.
PubMed:Analysis of isothiazolinone preservatives in polyvinyl alcohol cooling towels used in Japan.
PubMed:Emission of isothiazolinones from water-based paints.
PubMed:Increased sensitization to Kathon CG (methylchloroisothiazolinone plus methylisothiazolinone) in the south of Gran Canaria, Spain.
PubMed:Patch testing with methylchloroisothiazolinone/methylisothiazolinone 200 ppm aq. detects significantly more contact allergy than 100 ppm. A multicentre study within the European Environmental and Contact Dermatitis Research Group.
PubMed:Methylisothiazolinone: second 'epidemic' of isothiazolinone sensitization.
PubMed:Tissue accumulation and toxicity of isothiazolinone in Ctenopharyngodon idellus (grass carp): association with P-glycoprotein expression and location within tissues.
PubMed:Methylisothiazolinone allergy in the paediatric population: the epidemic begins?
PubMed:Contact allergic dermatitis due to Kathon CG contained in ultrasound gel.
PubMed:Three-phase hollow-fiber liquid-phase microextraction combined with HPLC-UV for the determination of isothiazolinone biocides in adhesives used for food packaging materials.
PubMed:Involvement of outer membrane proteins and peroxide-sensor genes in Burkholderia cepacia resistance to isothiazolone.
PubMed:A tuneable switch for controlling environmental degradation of bioplastics: addition of isothiazolinone to polyhydroxyalkanoates.
PubMed:Methylisothiazolinone contact allergy--growing epidemic.
PubMed:Effects of a 28-day oral exposure to a 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one biocide formulation in Sprague-Dawley rats.
PubMed:A case of eyelid contact dermatitis by "ipoallergic" eye-cleansing.
PubMed:Effects of chemical agent injections on genotoxicity of wastewater in a microfiltration-reverse osmosis membrane process for wastewater reuse.
PubMed:Allergic contact dermatitis to methylisothiazolinone: exposure from baby wipes causing hand dermatitis.
PubMed:Methylchloroisothiazolinone and methylisothiazolinone allergic contact dermatitis and the effect of patch test concentration.
PubMed:Results of a cosmetovigilance survey in The Netherlands.
PubMed:Determination of isothiazolinone preservatives in cosmetics and household products by matrix solid-phase dispersion followed by high-performance liquid chromatography-tandem mass spectrometry.
PubMed:Determination of biocides in different environmental matrices by use of ultra-high-performance liquid chromatography-tandem mass spectrometry.
PubMed:Effects of parabens and isothiazolinone on the microbiological quality of baby shampoo: the challenge test.
PubMed:A patient's drawing helped the physician to make the correct diagnosis: occupational contact allergy to isothiazolinone.
PubMed:Contact dermatitis due to methylchloroisothiazolinone/methylisothiazolinone (Kathon CG) as a contaminant in the manufacturing process of a cream.
PubMed:Contact dermatitis in a child from methlychloroisothiazolinone and methylisothiazolinone in moist wipes.
PubMed:[Determination of 3 isothiazolinone preservatives in toys using liquid chromatography-tandem mass spectrometry].
PubMed:Activated soil filters for removal of biocides from contaminated run-off and waste-waters.
PubMed:Kinetic migration of isothiazolinone biocides from paper packaging to Tenax and Porapak.
PubMed:Biocide-containing varnish for the protection of sandstone: comparison of formulations and laboratory test methods.
PubMed:Susceptibility of Mycobacterium immunogenum and Pseudomonas fluorescens to formaldehyde and non-formaldehyde biocides in semi-synthetic metalworking fluids.
PubMed:Contact allergy to preservatives. Analysis of IVDK data 1996-2009.
PubMed:Analysis of isothiazolinone biocides in paper for food packaging by ultra-high-performance liquid chromatography-tandem mass spectrometry.
PubMed:Determination of biocides and pesticides by on-line solid phase extraction coupled with mass spectrometry and their behaviour in wastewater and surface water.
PubMed:Trace analysis of isothiazolinones in water samples by large-volume direct injection liquid chromatography tandem mass spectrometry.
PubMed:Consumer exposure to biocides--identification of relevant sources and evaluation of possible health effects.
PubMed:The epidemiology of contact allergy. Allergen exposure and recent trends.
PubMed:A critical cysteine residue in monoacylglycerol lipase is targeted by a new class of isothiazolinone-based enzyme inhibitors.
PubMed:The efficacy of biocides and other chemical additives in cooling water systems in the control of amoebae.
PubMed:Inhibition of the PCAF histone acetyl transferase and cell proliferation by isothiazolones.
PubMed:Differential effects of allergens and irritants on early differentiating monocyte-derived dendritic cells.
PubMed:Differential biocide susceptibility of the multiple genotypes of Mycobacterium immunogenum.
PubMed:Treatment of water-based metalworking fluids to prevent hypersensitivity pneumonitis associated with Mycobacterium spp.
PubMed:Analysis of isothiazolinones in environmental waters by gas chromatography-mass spectrometry.
PubMed:Contact sensitivity to preservatives in the UK, 2004-2005: results of multicentre study.
PubMed:20 Years of standard patch testing in an eczema population with focus on patients with multiple contact allergies.
PubMed:Comparison of reactivity to allergens using the TRUE Test and IQ chamber system.
PubMed:European Standard Series patch test results from a contact dermatitis clinic in Israel during the 7-year period from 1998 to 2004.
PubMed:Allergic contact dermatitis to preservatives.
PubMed:A sensitive radioimmunoassay of insulin autoantibody: reduction of non-specific binding of [125I]insulin.
PubMed:The relative cytotoxicity of personal care preservative systems in Balb/C 3T3 clone A31 embryonic mouse cells and the effect of selected preservative systems upon the toxicity of a standard rinse-off formulation.
PubMed:Improved detection of allergen-specific T-cell responses in allergic contact dermatitis through the addition of 'cytokine cocktails'.
PubMed:Occupational dermatitis in a milk industry worker due to Kathon CG.
PubMed:Biocidal activity of formaldehyde and nonformaldehyde biocides toward Mycobacterium immunogenum and Pseudomonas fluorescens in pure and mixed suspensions in synthetic metalworking fluid and saline.
PubMed:Occupational dermatitis in a milk industry worker due to Kathon CG.
PubMed:From knowledge generation to knowledge archive. A general strategy using TOPS-MODE with DEREK to formulate new alerts for skin sensitization.
PubMed:Investigation of biocide efficacy by photoacoustic biofilm monitoring.
PubMed:Co-existing sensitivity to metronidazole and isothiazolinone.
PubMed:[Determination of eleven preservatives including bronopol in cosmetic by reversed-phase ion-pair chromatography].
PubMed:Binary and mixed population biofilms: time-lapse image analysis and disinfection with biocides.
PubMed:Preservation of products with MCI/MI in Switzerland.
PubMed:A study of the effect of isothiazolones on the performance and characteristics of a laboratory-scale rotating biological contactor.
PubMed:A child with "occupational" allergic contact dermatitis due to MCI/MI.
PubMed:Allergic contact dermatitis in patients with anogenital complaints.
PubMed:Methylchloro-isothiazolinone revisited.
PubMed:The outcome of an additional patch-test reading on days 6 or 7.
PubMed:Occupational induction of hypersensitivity after an accidental exposure to chloromethylisothiazolinone and methylisothiazolinone (CMI/MI) in an industrial worker.
PubMed:Allergic contact dermatitis due to Kathon CG in Hong Kong.
PubMed:Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides.
PubMed:Visual and laser Doppler perfusion scanning assessments of Kathon CG patch test reactions.
PubMed:An epidemic of isothiazolinone sensitization in a flax spinning mill.
PubMed:Can chemical burns and allergic contact dermatitis from higher concentrations of methylchloroisothiazolinone/methylisothiazolinone be prevented?
PubMed:[Contact allergy to cosmetics].
PubMed:Production of respirable vesicles containing live Legionella pneumophila cells by two Acanthamoeba spp.
PubMed:Occupational asthma in an isothiazolinone manufacturing plant.
PubMed:Occupational allergic contact dermatitis from 2,3-epoxypropyl trimethyl ammonium chloride (EPTMAC) and Kathon LX in a starch modification factory.
PubMed:1,2-Benzisothiazolin-3-one (Proxel): irritant or allergen? A clinical study and literature review.
PubMed:Three cases of contact allergy after chemical burns from methylchloroisothiazolinone/methylisothiazolinone: one with concomitant allergy to methyldibromoglutaronitrile/phenoxyethanol.
PubMed:Methylisothiazolinones. Diagnosis and prevention of allergic contact dermatitis.
PubMed:Genetic toxicity and carcinogenicity studies of Kathon.
PubMed:Outbreak of contact dermatitis related to Acticide EP paste in a paint manufacturing factory.
PubMed:Formulation effect on the dermal bioavailability of isothiazolone biocide.
PubMed:No cross-sensitization between MCI/MI, benzisothiazolinone and octylisothiazolinone.
PubMed:Occupational hypersensitivity to isothiazolinone derivatives in a radiology technician.
PubMed:Euglena gracilis as a supplementary test organism for detecting biologically active compounds.
PubMed:Mutagenicity of cosmetic products containing Kathon.
PubMed:[A new allergen dibromodicyanobutane. Report of a study in 310 patients January-December 1994].
PubMed:The guinea pig maximization test--with a multiple dose design.
PubMed:[Replacement of preservation agent Kathon CG in cosmetics by Euxyl K 400; indeed out of the frying pan into the fire].
PubMed:An unusual case of sensitization to methylchloro- and methyl-isothiazolinone (MCI/MI).
PubMed:Assessment of continuing sensitivity to MCI/MI (Kathon CG).
PubMed:Increasing incidence of contact allergy to the new preservative 1,2-dibromo-2,4-dicyanobutane (methyldibromoglutaronitrile).
PubMed:A study on expert reading of patch test reactions: inter-individual accordance.
PubMed:Comparative toxicities of selected compounds to nauplii of Balanus amphitrite amphitrite Darwin and Artemia sp.
PubMed:Tolerance to different toilet paper preparations: toxicological and allergological aspects.
PubMed:Bioluminescent strains of E. coli for the assay of biocides.
PubMed:Skin disease and contact sensitivity in house painters using water-based paints, glues and putties.
PubMed:Contact hypersensitivity to a new isothiazolinone.
PubMed:Occupationally induced allergic contact dermatitis to methylchloroisothiazolinone/methylisothiazolinone among machinists.
PubMed:Further observations on adverse reactions to a bowler's grip.
PubMed:The antimicrobial activity in vitro of chlorhexidine, a mixture of isothiazolinones ('Kathon' CG) and cetyl trimethyl ammonium bromide (CTAB).
PubMed:Occupational dermatitis from isothiazolinones in the nylon production.
PubMed:Temporary health effects from exposure to water-borne paints.
PubMed:Occupational asthma in a hairdresser caused by persulphate salts.
PubMed:Allergic contact dermatitis from the preservative 1,2-benzisothiazolin-3-one (1,2-BIT; Proxel): a case report, its prevalence in those occupationally at risk and in the general dermatological population, and its relationship to allergy to its analogue Kathon CG.
PubMed:[Replacement of Kathon CG by Euxyl K 400 in cosmetics; from the frying pan into the fire?].
PubMed:Contact allergy to isothiazolinone derivatives: unusual clinical presentations.
PubMed:Sensitization to the isothiazolinone biocide. Report of the Swiss Contact Dermatitis Research Group 1988-1990.
PubMed:Evaluation of the frequency of contact allergic reactions to Kathon CG in the Maastricht area--1987-1990.
PubMed:The 'isothiazolinone story'.
PubMed:Silicon membrane interface for the direct analysis of Kathon CG in aqueous solutions and cosmetic emulsions.
PubMed:Another isothiazolinone source.
PubMed:A case of contact allergy to Kathon CG in the United States.
PubMed:Kathon CG--can New Zealand avoid the epidemic?
PubMed:[Peri-anal allergic contact eczema with dyshidrotic eczema of the hands due to the use of Kathon CG moist toilet wipes].
PubMed:Contact allergy to moist toilet paper.
PubMed:[Contact hypersensitivity to Kathon CG. Apropos of 35 cases among 977 tested subjects].
PubMed:[How do we feel about Kathon CG].
PubMed:Kathon CG and cosmetic products.
PubMed:Pitfalls in patch testing: problems with rather than from Kathon CG.
PubMed:Kathon CG and cosmetic products.
PubMed:[Research on Kathon CG in cosmetic and personal hygiene products].
PubMed:2 cases of occupational allergy to Kathon 886.
PubMed:Lymphocyte transformation test for diagnosis of isothiazolinone allergy in man.
PubMed:Contact dermatitis due to a natural plasticine.
PubMed:Water versus petrolatum as vehicle for patch testing methylisothiazolinone + methylchloroisothiazolinone (Kathon CG).
PubMed:The frequency of contact allergy in atopic patients with dermatitis.
PubMed:Patch test sensitivity to the preservative Kathon CG in Spain.
PubMed:Methylchloroisothiazolinone-methylisothiazolinone reactions in patients screened for vehicle and preservative hypersensitivity.
PubMed:[Evaluation of humidifier units within the scope of room climate modification].
PubMed:Occupational allergic contact dermatitis due to methylisothiazolinones in a cleansing cream.
PubMed:[Kathon CG--a new contact sensitizing preservative].
PubMed:Patch test sensitivity to Kathon CG in Prague.
PubMed:Contact allergy to the preservative Kathon CG.
PubMed:Kathon CG and cosmetic products.
PubMed:Aspects of pharmaceutical and chemical standardization of patch test materials.
PubMed:Patch testing with degradation products of Kathon CG.
PubMed:Allergic contact dermatitis from Kathon CG in moist toilet paper.
PubMed:Isothiazolinone sensitivity.
PubMed:Methylchloroisothiazolinone-methylisothiazolinone (Kathon CG)
PubMed:Isothiazolinone.
PubMed:Isothiazolinone preservative: cause of a continuing epidemic of cosmetic dermatitis.
PubMed:Sensitization to Kathon CG in Geneva and Switzerland.
PubMed:Risk of sensitization to Kathon CG.
PubMed:The irritancy and allergenicity of 2-n-octyl-4-isothiazolin-3-one (Skane M-8), with recommendations for patch test concentration.
PubMed:Sensitivity to Kathon CG: findings in 365 consecutive patients.
PubMed:Kathon CG content in cosmetic products.
PubMed:Kathon CG reactivity in 1396 consecutively patch tested patients in the Copenhagen area.
PubMed:Kathon CG as a sensitizer.
PubMed:Risk of sensitization to Kathon CG.
PubMed:Milk tester's dermatitis.
PubMed:Occupational allergic contact dermatitis from Kathon WT.
PubMed:Frequency of sensitisation to the preservative Kathon CG.
PubMed:Prevalence and sources of Kathon CG sensitization in Italy.
PubMed:Kathon CG: a review.
PubMed:Kathon CG in cosmetics.
PubMed:Risk of sensitisation to Kathon.
PubMed:Measurement of risk of sensitisation and its application to Kathon.
PubMed:Contact allergy to Kathon CG.
PubMed:Isothiazolinone preservative as important contact allergen in cosmetics.
PubMed:Contact allergy to a contaminant in Kathon CG in the guinea pig.
PubMed:Kathon CG.
PubMed:[Contact allergy to Kathon CG].
PubMed:[Kathon CG: an important allergen in cosmetics].
PubMed:Contact allergy to the active ingredients of Kathon CG.
PubMed:Human safety study of body lotion containing Kathon CG.
PubMed:Positive test reactions to Kathon in patients with work-related skin disease.
PubMed:Preservatives in the European standard series for epicutaneous testing.
PubMed:[Kathon CG: an important allergen in cosmetics].
PubMed:[Toxicology of selected biocides].
PubMed:[Skin tests for hypersensitivity to Kathon CG and Germall II].
PubMed:Epicutaneous patch test with the preservative Kathon CG.
PubMed:Rapid increase in contact allergy to Kathon CG in Finland.
PubMed:Demonstration of Kathon CG in some commercial products.
PubMed:Dose-response assessments of Kathon biocide. (II). Threshold prophetic patch testing.
PubMed:Contact dermatitis to Kathon CG.
PubMed:Milk recorder dermatitis.
PubMed:Contact allergy to the preservative Kathon CG.
PubMed:Patch test sensitivity to Kathon CG.
PubMed:Contact allergy to the preservative Kathon CG.
PubMed:Absorption and disposition of 14C-labelled Kathon biocide, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one, following intravenous or dermal administration to male Sprague-Dawley rats.
PubMed:Diagnostic patch test concentration for Kathon CG.
PubMed:Chloracetamide-N-metholol: an example of an in vitro and in vivo clastogen which is non-mutagenic to Salmonella.
PubMed:Dose-response assessments of Kathon biocide (I). Diagnostic use and diagnostic threshold patch testing with sensitized humans.
PubMed:Kathon CG: cosmetic allergy and patch test sensitization.
PubMed:Biocide patch tests.
PubMed:The characterization of isothiazolinone preservatives in cosmetics.
PubMed:[Use of the kinetics of bactericidal effect of Kathon CG on known germs in order to determine its efficacy in water and in heparin hydrophilic cream].
PubMed:Assembling a battery of assays to predict carcinogenicity: a case study.
PubMed:Kathon--genotoxicity studies.
PubMed:Evaluation of some formaldehyde-release compounds and other biocides in the mouse micronucleus test.
PubMed:Kathon biocide: manifestation of delayed contact dermatitis in guinea pigs is dependent on the concentration for induction and challenge.
PubMed:Mutagenicity of two non-formaldehyde-forming antimicrobial agents.
PubMed:The genetic toxicology of Kathon biocide, a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one.
PubMed:Mutagenic activity of Kathon, an industrial biocide and cosmetics preservative containing 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one.
 
Notes:
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