EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

thrombin
tropostasin

Supplier Sponsors

CAS Number: 9002-04-4
Other(deleted CASRN):105881-84-3
FDA UNII: 6K15ABL77G
MDL:MFCD00166053
Category:enzyme preparations and microorganisms
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
Thrombin 95%
Sigma-Aldrich: Sigma
For experimental / research use only.
Thrombin from bovine plasma powder, cell culture tested, ≥1,500 NIH units/mg protein (E1%/280 = 19.5)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 > 50 mL/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 329, 1984.

intravenous-mouse LD50 7771 ug/kg
KIDNEY, URETER, AND BLADDER: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 669, 1988.

intraperitoneal-rat LD50 > 40 mL/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 329, 1984.

Dermal Toxicity:
skin-mouse LD50 > 3000 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 1, Pg. 272, 1973.

subcutaneous-mouse LD50 > 50 mL/kg
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 329, 1984.

subcutaneous-rat LD50 > 40 mL/kg
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 329, 1984.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
enzyme preparations and microorganisms
Recommendation for thrombin usage levels up to:
 not for fragrance use.
 
Recommendation for thrombin flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on thrombin from cattle (bovines) and pig’s blood
View page or View pdf

ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9002-04-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
Chemidplus:0009002044
RTECS:XO8950000 for cas# 9002-04-4
 
References:
Pubchem (sid):135293440
 
Other Information:
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 thrombin
Search PMC Picture
 
Synonyms:
 blood-coagulation factor II, activated
 blood-coagulation factor IIa
 E.C. 3.4.21.5
 E.C. 3.4.4.13
 evithrom
 factor IIa
 fibrinogenase
 thrombase
bovine thrombin
 thrombin human
 thrombin II
 thrombin JMI
 thrombin-C
 thrombin, topical
 thrombin, topical (recombinant)
 thrombinar
 thrombofort
 thrombostat
 tropostasin
 

Articles:

PubMed:Anticoagulation reversal in the era of the non-vitamin K oral anticoagulants.
PubMed:Anti-thrombotic effect of rutin isolated from Dendropanax morbifera Leveille.
PubMed:Biosensors: SERS Encoded Silver Pyramids for Attomolar Detection of Multiplexed Disease Biomarkers (Adv. Mater. 10/2015).
PubMed:Minipool caprylic acid fractionation of plasma using disposable equipment: a practical method to enhance immunoglobulin supply in developing countries.
PubMed:Clinical Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Novel Factor Xa Inhibitor DY-807f in Healthy Volunteers.
PubMed:Pharmacokinetics, pharmacodynamics and food effect of LB30870, a novel direct thrombin inhibitor, after single oral doses in healthy men.
PubMed:Purification and Biochemical Characterization of a Novel Fibrinolytic Enzyme from Culture Supernatant of Cordyceps militaris.
PubMed:Identification and functional characterization of a novel fungal immunomodulatory protein from Postia placenta.
PubMed:Structural characterization and anticoagulant activity of a sulfated polysaccharide from the green alga Codium divaricatum.
PubMed:Using G-Quadruplex/Hemin To "Switch-On" the Cathodic Photocurrent of p-Type PbS Quantum Dots: Toward a Versatile Platform for Photoelectrochemical Aptasensing.
PubMed:Supplementation with a 9c,11t-rich conjugated linoleic acid blend shows no clear inhibitory effects on platelet function in healthy subjects at low and moderate cardiovascular risk: A randomized controlled trial.
PubMed:Review of the Target-Specific Oral Anticoagulants in Development for the Treatment and Prevention of Venous Thromboembolism.
PubMed:Synthetic analogues of flavonoids with improved activity against platelet activation and aggregation as novel prototypes of food supplements.
PubMed:Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation.
PubMed:Sub-nanomolar detection of thrombin activity on a microfluidic chip.
PubMed:Evaluation of dabigatran for appropriateness of use and bleeding events in a community hospital setting.
PubMed:Efficacy and safety of argatroban and bivalirudine in patients with suspected heparin-induced thrombocytopenia.
PubMed:In Vivo AAV1 Transduction With hRheb(S16H) Protects Hippocampal Neurons by BDNF Production.
PubMed:Managing bleeding and emergency reversal of newer oral anticoagulants: a review for primary care providers.
PubMed:Strategies for urgent reversal of target-specific oral anticoagulants.
PubMed:Antiplatelet and anticoagulation agents in acute coronary syndromes: what is the current status and what does the future hold?
PubMed:Incidence, mortality, and risk factors for oral anticoagulant-associated intracranial hemorrhage in patients with atrial fibrillation.
PubMed:Non-vitamin K oral anticoagulants in atrial fibrillation: Where are we now?
PubMed:Antiplatelet effects of Rhus verniciflua stokes heartwood and its active constituents--fisetin, butein, and sulfuretin--in rats.
PubMed:Cardiovascular, bleeding, and mortality risks in elderly Medicare patients treated with dabigatran or warfarin for nonvalvular atrial fibrillation.
PubMed:A simple and sensitive label-free fluorescent approach for protein detection based on a Perylene probe and aptamer.
PubMed:The current landscape of treatment options for venous thromboembolism: a focus on novel oral anticoagulants.
PubMed:One-pot synthesized DNA-templated Ag/Pt bimetallic nanoclusters as peroxidase mimics for colorimetric detection of thrombin.
PubMed:Characterization of physical properties of tissue factor-containing microvesicles and a comparison of ultracentrifuge-based recovery procedures.
PubMed:The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance.
PubMed:Determination of dabigatran, rivaroxaban and apixaban by ultra-performance liquid chromatography - tandem mass spectrometry (UPLC-MS/MS) and coagulation assays for therapy monitoring of novel direct oral anticoagulants.
PubMed:Oral anticoagulants and status of antidotes for the reversal of bleeding risk.
PubMed:Hyperbranched rolling circle amplification based electrochemiluminescence aptasensor for ultrasensitive detection of thrombin.
PubMed:Non-vitamin K antagonist oral anticoagulants (NOACs): clinical evidence and therapeutic considerations.
PubMed:Serine protease inhibitors as good predictors of meat tenderness: which are they and what are their functions?
PubMed:Race against the clock: overcoming challenges in the management of anticoagulant-associated intracerebral hemorrhage.
PubMed:New oral anticoagulants and their implications for dental patients.
PubMed:Fas-induced apoptosis increases hepatocyte tissue factor procoagulant activity in vitro and in vivo.
PubMed:Enhancement of platelet aggregation by ursolic Acid and oleanolic Acid.
PubMed:Treatment discontinuations with new oral agents for long-term anticoagulation: insights from a meta-analysis of 18 randomized trials including 101,801 patients.
PubMed:Inhibitory effect of allyl isothiocyanate on platelet aggregation.
PubMed:Dabigatran etexilate in atrial fibrillation.
PubMed:New orally active anticoagulant agents for the prevention and treatment of venous thromboembolism in cancer patients.
PubMed:Modulation of proteome expression by F-type lectin during viral hemorrhagic septicemia virus infection in fathead minnow cells.
PubMed:Impact of nonsynonymous mutations of factor X on the functions of factor X and anticoagulant activity of edoxaban.
PubMed:Effect of age on bovine subcutaneous fat proteome: molecular mechanisms of physiological variations during beef cattle growth.
PubMed:Alditols and monosaccharides from sorghum vinegar can attenuate platelet aggregation by inhibiting cyclooxygenase-1 and thromboxane-A2 synthase.
PubMed:Direct oral anticoagulants in the prevention of venous thromboembolism: evidence from major clinical trials.
PubMed:Edoxaban: a focused review of its clinical pharmacology.
PubMed:Dry-cured ham restructured with fibrin.
PubMed:Preventive effect of fermented Maillard reaction products from milk proteins in cardiovascular health.
PubMed:Development of an aptamer-based impedimetric bioassay using microfluidic system and magnetic separation for protein detection.
PubMed:Perilla oil improves blood flow through inhibition of platelet aggregation and thrombus formation.
PubMed:Thrombin inhibition by dabigatran attenuates atherosclerosis in ApoE deficient mice.
PubMed:Galla rhois exerts its antiplatelet effect by suppressing ERK1/2 and PLCβ phosphorylation.
PubMed:Gender, race and diet affect platelet function tests in normal subjects, contributing to a high rate of abnormal results.
PubMed:[New treatments for stroke and thromboembolism prevention in atrial fibrillation].
PubMed:Effect of Morinda citrifolia fruit extract and its iridoid glycosides on blood fluidity.
PubMed:Dabigatran for stroke prevention in nonvalvular atrial fibrillation: focus in the geriatric population.
PubMed:Effect of embryonic development on the chicken egg yolk plasma proteome after 12 days of incubation.
PubMed:Comparison of static and microfluidic protease assays using modified bioluminescence resonance energy transfer chemistry.
PubMed:A convenient sandwich assay of thrombin in biological media using nanoparticle-enhanced fluorescence polarization.
PubMed:Emergency department management of patients on novel oral anticoagulant agents.
PubMed:Antithrombotic alternatives for stroke prevention in atrial fibrillation: critical differences and remaining questions.
PubMed:Lupine protein hydrolysates inhibit enzymes involved in the inflammatory pathway.
PubMed:The new era of anticoagulation.
PubMed:Postprandial coagulation activation in overweight individuals after weight loss: acute and long-term effects of a high-monounsaturated fat diet and a low-fat diet.
PubMed:Phloretin suppresses thrombin-mediated leukocyte-platelet-endothelial interactions.
PubMed:Deep vein thrombosis and novel oral anticoagulants: a clinical review.
PubMed:Dabigatran Use in the Real World: A Multihospital System Experience.
PubMed:Immobilization of DNA aptamers on polyester cloth for antigen detection by dot blot immunoenzymatic assay (aptablot).
PubMed:Life-threatening epistaxis and red blood cell polyagglutination under dabigatran.
PubMed:In vitro predictability of drug-drug interaction likelihood of P-glycoprotein-mediated efflux of dabigatran etexilate based on [I]2/IC50 threshold.
PubMed:Adverse events in patients initiated on dabigatran etexilate therapy in a pharmacist-managed anticoagulation clinic.
PubMed:Dabigatran etexilate for thromboembolic prophylaxis in non-valvular atrial fibrillation: the RE-LY study and substudies with commentary.
PubMed:Practical considerations in the use of novel oral anticoagulants for stroke prevention in nonvalvular atrial fibrillation.
PubMed:Advantages and limitations of the new anticoagulants.
PubMed:Clotting factor VIII (FVIII) and thrombin generation in camel plasma: A comparative study with humans.
PubMed:Improving sensitivity of gold nanoparticle based fluorescence quenching and colorimetric aptasensor by using water resuspended gold nanoparticle.
PubMed:Effect of tomato industrial processing on phenolic profile and antiplatelet activity.
PubMed:Selected reaction monitoring method to determine the species origin of blood-based binding agents in meats: a collaborative study.
PubMed:Evaluation of the oral direct factor Xa inhibitor - betrixaban.
PubMed:Novel oral anticoagulants for thromboprophylaxis after orthopaedic surgery.
PubMed:Determining the impact of instrument variation and automated software algorithms on the TGT in hemophilia and normalized plasma.
PubMed:Enhanced antimicrobial activity of peptide-cocktails against common bacterial contaminants of ex vivo stored platelets.
PubMed:Hyperimmune globulins and same-day thrombotic adverse events as recorded in a large healthcare database during 2008-2011.
PubMed:Dabigatran and kidney disease: a bad combination.
PubMed:Correction of microplate location effects improves performance of the thrombin generation test.
PubMed:Transitions of care in anticoagulated patients.
PubMed:Preclinical safety evaluation of human platelets treated with antimicrobial peptides in severe combined immunodeficient mice.
PubMed:Assessment of immunoglobulin concentrates on thrombogenic activity by thrombin generation assay, prekallikrein activator assay, and size-exclusion chromatography.
PubMed:Anticoagulation beyond direct thrombin and factor Xa inhibitors: indications for targeting the intrinsic pathway?
PubMed:New anticoagulant and antiplatelet agents: a primer for the gastroenterologist.
PubMed:Marine-derived bioactive peptides as new anticoagulant agents: a review.
PubMed:Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience.
PubMed:New oral anticoagulants in non-valvular atrial fibrillation.
PubMed:[Direct oral thrombin inhibitor, "dabigatran"].
PubMed:Investigation of protein detection parameters using nanofunctionalized organic field-effect transistors.
PubMed:Practical use of dabigatran etexilate for stroke prevention in atrial fibrillation.
PubMed:Moving toward a more ideal anticoagulant: the oral direct thrombin and factor Xa inhibitors.
PubMed:Rivaroxaban for the treatment of acute coronary syndromes.
PubMed:Tutorial in oral antithrombotic therapy: biology and dental implications.
PubMed:Effect of quercetin-rich onion peel extracts on arterial thrombosis in rats.
PubMed:[Antithrombotic management in atrial fibrillation].
PubMed:The reply.
PubMed:Dabigatran: a nephrological way out.
PubMed:Stroke prevention in atrial fibrillation--an Asian stroke perspective.
PubMed:Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo.
PubMed:A new era of oral anticoagulation in atrial fibrillation: implications in clinical practice.
PubMed:Recent advances in antithrombotic therapy for stroke prevention in patients with atrial fibrillation.
PubMed:Novel oral anticoagulants for stroke prevention in patients with atrial fibrillation.
PubMed:Direct thrombin and factor Xa inhibition for stroke prevention in patients with atrial fibrillation.
PubMed:The discovery of dabigatran etexilate.
PubMed:Antithrombotics for stroke prevention in non-valvular atrial fibrillation: an update.
PubMed:The pharmacology and therapeutic use of dabigatran etexilate.
PubMed:Novel oral anticoagulants for stroke prevention in patients with atrial fibrillation: dawn of a new era.
PubMed:[Dabigatran as an alternative to warfarin for the prevention of thromboembolism in atrial fibrillation].
PubMed:Sulfation pattern of the fucose branch is important for the anticoagulant and antithrombotic activities of fucosylated chondroitin sulfates.
PubMed:Insect cell-based expression and characterization of a single-chain variable antibody fragment directed against blood coagulation factor VIII.
PubMed:Metal-organic framework (MOF): a novel sensing platform for biomolecules.
PubMed:New oral anticoagulants: comparative pharmacology with vitamin K antagonists.
PubMed:Better hemostatic profiles of never-frozen liquid plasma compared with thawed fresh frozen plasma.
PubMed:Novel amperometric aptasensor based on analyte-induced suppression of enzyme catalysis in polymeric bionanocomposites.
PubMed:Recurring extracorporeal circuit clotting during continuous renal replacement therapy in fungal sepsis: successful treatment with argatroban.
PubMed:The efficacy and safety of platelet-rich plasma and adipose-derived stem cells: an update.
PubMed:Dabigatran: a cause of hematologic emergency.
PubMed:Antithrombotic and profibrinolytic activities of isorhamnetin-3-O-galactoside and hyperoside.
PubMed:Positive outcome after intentional overdose of dabigatran.
PubMed:Contemporary Anticoagulation Reversal: Focus on Direct Thrombin Inhibitors and Factor Xa Inhibitors.
PubMed:An update on antithrombotic therapy in atrial fibrillation: the role of newer and emergent drugs.
PubMed:Flavan-3-ol-enriched dark chocolate and white chocolate improve acute measures of platelet function in a gender-specific way--a randomized-controlled human intervention trial.
PubMed:Antithrombotic effect of chikusetsusaponin IVa isolated from Ilex paraguariensis (Maté).
PubMed:Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: a consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011.
PubMed:Dabigatran compared with warfarin for stroke prevention with atrial fibrillation: experience in Hong Kong.
PubMed:The new oral anticoagulants: a challenge for hospital formularies.
PubMed:Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury.
PubMed:Stroke prevention in atrial fibrillation: impact of novel oral anticoagulants.
PubMed:Chemical characteristic of an anticoagulant-active sulfated polysaccharide from Enteromorpha clathrata.
PubMed:Comparative effectiveness of warfarin and new oral anticoagulants for the management of atrial fibrillation and venous thromboembolism: a systematic review.
PubMed:Phenolic fractions from Trifolium pallidum and Trifolium scabrum aerial parts in human plasma protect against changes induced by hyperhomocysteinemia in vitro.
PubMed:Coagulation profile of liquid-state plasma.
PubMed:Enantioselective analysis of melagatran via an LSPR biosensor integrated with a microfluidic chip.
PubMed:Prediction of drug concentration-time profiles of therapeutic proteins in humans from animals.
PubMed:Emerging anticoagulant therapies for atrial fibrillation: new options, new challenges.
PubMed:An evidence-based review of apixaban and its potential in the prevention of stroke in patients with atrial fibrillation.
PubMed:Antithrombotic therapy for secondary stroke prevention.
PubMed:Efficacy and safety of fibrin sealant for tissue adherence in facial rhytidectomy.
PubMed:Hemopericardium and cardiac tamponade associated with dabigatran use.
PubMed:Exploration of the antiplatelet activity profile of betulinic acid on human platelets.
PubMed:Acute ischemic stroke treated with intravenous tissue plasminogen activator in a patient taking dabigatran with radiographic evidence of recanalization.
PubMed:Mammary gland carcinoma in a dog with peripheral blood and bone marrow involvement associated with disseminated intravascular coagulation.
PubMed:New oral anticoagulants: will they replace warfarin?
PubMed:General colorimetric detection of proteins and small molecules based on cyclic enzymatic signal amplification and hairpin aptamer probe.
PubMed:Novel oral anticoagulants: focus on the direct factor Xa inhibitor darexaban.
PubMed:An aptamer-based fluorescence biosensor for multiplex detection using unmodified gold nanoparticles.
PubMed:Hemostats, sealants, and adhesives III: a new update as well as cost and regulatory considerations for components of the surgical toolbox.
PubMed:The Food and Drug Administration decision not to approve the 110 mg dose of dabigatran: give us a way out.
PubMed:A guidance pathway for the selection of novel anticoagulants in the treatment of atrial fibrillation.
PubMed:Novel direct factor IIa and Xa inhibitors: mechanisms of action and preclinical studies.
PubMed:Oral IIa and Xa inhibitors for prevention of stroke in atrial fibrillation: clinical studies and regulatory considerations.
PubMed:Unifying the mechanism of recombinant FVIIa action: dose dependence is regulated differently by tissue factor and phospholipids.
PubMed:Enzyme-free fluorescence aptasensor for amplification detection of human thrombin via target-catalyzed hairpin assembly.
PubMed:[Prevention and treatment of venous thromboembolism: the place of new oral anticoagulants].
PubMed:[Old and new oral anticoagulants. Pharmacological perspective].
PubMed:New anticoagulants in ischemic heart disease.
PubMed:Hemopericardium in a patient treated with dabigatran etexilate.
PubMed:Dabigatran: a new chapter in anticoagulation.
PubMed:Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors.
PubMed:Preparation, structure and anticoagulant activity of a low molecular weight fraction produced by mild acid hydrolysis of sulfated rhamnan from Monostroma latissimum.
PubMed:New oral anticoagulant agents after ACS.
PubMed:Use of direct thrombin inhibitor for treatment of cerebral venous thrombosis.
PubMed:Sequence determination and anticoagulant and antithrombotic activities of a novel sulfated fucan isolated from the sea cucumber Isostichopus badionotus.
PubMed:Dabigatran etexilate: an oral direct thrombin inhibitor for the management of thromboembolic disorders.
PubMed:Dabigatran: comparison to warfarin, pathway to approval, and practical guidelines for use.
PubMed:Comparison of enhanced bioluminescence energy transfer donors for protease biosensors.
PubMed:Aptamers as a sensitive tool to detect subtle modifications in therapeutic proteins.
PubMed:Newer anticoagulants in cardiovascular disease: a systematic review of the literature.
PubMed:Hierarchical dendritic gold microstructure-based aptasensor for ultrasensitive electrochemical detection of thrombin using functionalized mesoporous silica nanospheres as signal tags.
PubMed:New frontiers for stroke prevention in atrial fibrillation.
PubMed:Concerns regarding the use of dabigatran for stroke prevention in atrial fibrillation.
PubMed:Dabigatran use in a postoperative coronary artery bypass surgery patient with nonvalvular atrial fibrillation and heparin-PF4 antibodies.
PubMed:Spontaneous splenic hemorrhage after initiation of dabigatran (Pradaxa) for atrial fibrillation.
PubMed:Pharmacological basis and clinical evidence of dabigatran therapy.
PubMed:Advances in antiplatelet therapy.
PubMed:Dabigatran etexilate: what do hospitalists need to know?
PubMed:Dabigatran etexilate in clinical practice: confronting challenges to improve safety and effectiveness.
PubMed:Nicking enzyme based homogeneous aptasensors for amplification detection of protein.
PubMed:[Anticoagulant therapy for chronic cardiac diseases. Atrial fibrillation, valvular heart disease, congestive heart failure].
PubMed:Anti-platelet effects of yuzu extract and its component.
PubMed:Polyphenol fatty acid esters as serine protease inhibitors: a quantum-chemical QSAR analysis.
PubMed:Interaction between resveratrol and thrombin and its biological implication.
PubMed:A novel glycosaminoglycan-like polysaccharide from abalone Haliotis discus hannai Ino: purification, structure identification and anticoagulant activity.
PubMed:Dabigatran etexilate in atrial fibrillation patients with severe renal impairment: dose identification using pharmacokinetic modeling and simulation.
PubMed:In vitro anti-platelet effects of simple plant-derived phenolic compounds are only found at high, non-physiological concentrations.
PubMed:Dabigatran: review of pharmacology and management of bleeding complications of this novel oral anticoagulant.
PubMed:New anticoagulants for the prevention of stroke in atrial fibrillation.
PubMed:Hospital-based clinical implications of the novel oral anticoagulant, dabigatran etexilate, in daily practice.
PubMed:Bivalirudin dosing adjustments for reduced renal function with or without hemodialysis in the management of heparin-induced thrombocytopenia.
PubMed:Metabolomics-driven nutraceutical evaluation of diverse green tea cultivars.
PubMed:Activated protein C inhibits high mobility group box 1 signaling in endothelial cells.
PubMed:Anticoagulant management in the cardiovascular setting.
PubMed:Recurrent venous thrombosis despite 'optimal anticoagulation therapy' for antiphospholipid syndrome--could new oral anticoagulants solve the problem?
PubMed:Waldenström's macroglobulinemia in a dog with a bleeding diathesis.
PubMed:Antithrombotic medication for cardioembolic stroke prevention.
PubMed:Old versus new oral anticoagulants: focus on pharmacology.
PubMed:Dabigatran etexilate: A novel oral direct thrombin inhibitor.
PubMed:Update on anti-coagulation in atrial fibrillation.
PubMed:Recent progress in anticoagulant therapy: oral direct inhibitors of thrombin and factor Xa.
PubMed:Edoxaban: pharmacological principles, preclinical and early-phase clinical testing.
PubMed:The use of dabigatran in elderly patients.
PubMed:A review of the use of bromelain in cardiovascular diseases.
PubMed:Anticoagulant drugs: what is new?
PubMed:Role of emerging antithrombotic therapy in the prevention of cardioembolic complications in patients with atrial fibrillation.
PubMed:Dabigatran in atrial fibrillation: pharmacology and clinical trials.
PubMed:New anticoagulants for prevention of stroke in patients with atrial fibrillation.
PubMed:Stroke management.
PubMed:[New oral anticoagulants for treatment of venous thromboembolism].
PubMed:Spotlight on dabigatran etexilate in the prevention of stroke and systemic embolism in patients with atrial fibrillation.
PubMed:Dabigatran etexilate: a novel oral thrombin inhibitor for thromboembolic disease.
PubMed:New options for stroke prevention in atrial fibrillation.
PubMed:Antithrombotic and profibrinolytic activities of phloroglucinol.
PubMed:A graphene oxide platform for energy transfer-based detection of protease activity.
PubMed:Novel oral anticoagulants: focus on stroke prevention and treatment of venous thrombo-embolism.
PubMed:Drug and dietary interactions of warfarin and novel oral anticoagulants: an update.
PubMed:Dabigatran etexilate: a review of its use in the prevention of stroke and systemic embolism in patients with atrial fibrillation.
PubMed:Novel oral factor Xa and thrombin inhibitors in the management of thromboembolism.
PubMed:The potential role of new oral anticoagulants in the prevention and treatment of thromboembolism.
PubMed:Effects of peach palm oil on performance, serum lipoproteins and haemostasis in broilers.
PubMed:A signal-on electrochemiluminescence aptamer biosensor for the detection of ultratrace thrombin based on junction-probe.
PubMed:[Fusion expression of fibrinolytic enzyme gene PPFE-I from endophytic Paenibacillus polymyxa in Escherichia coli and activity analysis].
PubMed:A randomized, open-label pilot study comparing desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis: PREVENT-HIT Study.
PubMed:Absorption and tissue distribution of a novel carboxymethyldextran after oral administration.
PubMed:A comparative study of antioxidative activity of calcium-D-glucarate, sodium-D-gluconate and D-glucono-1,4-lactone in a human blood platelet model.
PubMed:Platelet anti-aggregation activities of compounds from Cinnamomum cassia.
PubMed:Cutting through the statistical fog: understanding and evaluating non-inferiority trials.
PubMed:Novel oral anticoagulants: implications in the perioperative setting.
PubMed:Dabigatran: an oral novel potent reversible nonpeptide inhibitor of thrombin.
PubMed:Oral IIa inhibitors.
PubMed:[Antiplatelet therapy in coronary heart disease. Some problems and achivements].
PubMed:Antioxidant and antiatherogenic activities of pentacyclic triterpenic diols and acids.
PubMed:Topical recombinant human thrombin in surgical hemostasis.
PubMed:The influence of platelet-rich plasma on the healing of extraction sockets: an explorative randomised clinical trial.
PubMed:Novel anticoagulant therapy: principle and practice.
PubMed:Signal-on electrochemiluminescence biosensor for thrombin based on target-induced conjunction of split aptamer fragments.
PubMed:[Evaluating thrombolytic efficacy and thrombus targetability of RGDS-liposomes encapsulating subtilisin FS33 in vivo].
PubMed:Dabigatran etexilate, a new oral direct thrombin inhibitor, for stroke prevention in patients with atrial fibrillation.
PubMed:Rationale and design of the PREVENT-HIT study: a randomized, open-label pilot study to compare desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis.
PubMed:Granzyme A and thrombin differentially promote the release of interleukin-8 from alveolar epithelial A549 cells.
PubMed:Performance of cold-set binding agents in re-formed beef steaks.
PubMed:New direct thrombin inhibitor becomes available.
PubMed:Antiviral activity of selected antimicrobial peptides against vaccinia virus.
PubMed:New approaches to atrial fibrillation management: treat the patient, not the ECG.
PubMed:Venous thromboembolism: a clinical review.
PubMed:Update on fondaparinux: role in management of thromboembolic and acute coronary events.
PubMed:Expression of Acc-Royalisin gene from royal jelly of Chinese honeybee in Escherichia coli and its antibacterial activity.
PubMed:Dabigatran etexilate in venous thromboembolism.
PubMed:Thrombin use in surgery: an evidence-based review of its clinical use.
PubMed:Non ST-elevation acute coronary syndrome.
PubMed:Topical bovine thrombin: a 21-year review of topical bovine thrombin spontaneous case safety reports submitted to FDA's Adverse Event Reporting System.
PubMed:Graph-theoretical comparison of protein surfaces reveals potential determinants of cross-reactivity and the molecular mimicry.
PubMed:[Dabigatran (Pradaxa): efficacy and safety].
PubMed:European community and US-FDA approval of recombinant human antithrombin produced in genetically altered goats.
PubMed:Newer anticoagulants in 2009.
PubMed:Fibrin sealant: past, present, and future: a brief review.
PubMed:New anticoagulants in atrial fibrillation.
PubMed:Antithrombotic and fibrinolytic activities of methanolic extract of aged sorghum vinegar.
PubMed:Safety of topical thrombins: the ongoing debate.
PubMed:Pharmacology, pharmacokinetics, and pharmacodynamics of dabigatran etexilate, an oral direct thrombin inhibitor.
PubMed:Advanced glycation end products strongly activate platelets.
PubMed:Topical thrombins: benefits and risks.
PubMed:Oral anticoagulation with factor Xa and thrombin inhibitors: on the threshold of change.
PubMed:Minimum stable structure of the receptor for advanced glycation end product possesses multi ligand binding ability.
PubMed:Acute coronary syndrome (unstable angina and non-ST elevation MI).
PubMed:Aflatoxin B1 misregulates the activity of serine proteases: possible implications in the toxicity of some mycotoxin.
PubMed:The role of the hemostatic system in murine liver injury induced by coexposure to lipopolysaccharide and trovafloxacin, a drug with idiosyncratic liability.
PubMed:Fresh from the biologic pipeline.
PubMed:Novel oral anticoagulants and diet: the potential for interaction.
PubMed:A review of three stand-alone topical thrombins for surgical hemostasis.
PubMed:Novel oral anticoagulants.
PubMed:Functions of coenzyme Q10 in inflammation and gene expression.
PubMed:Direct comparison of bioluminescence-based resonance energy transfer methods for monitoring of proteolytic cleavage.
PubMed:Chemical characteristic and anticoagulant activity of the sulfated polysaccharide isolated from Monostroma latissimum (Chlorophyta).
PubMed:Dabigatran etexilate: an oral direct thrombin inhibitor for prophylaxis and treatment of thromboembolic diseases.
PubMed:Identification and characterization of a serine protease inhibitor of Paragonimus westermani.
PubMed:Techniques for quantifying effects of dietary antioxidants on transcription factor translocation and nitric oxide production in cultured cells.
PubMed:Brave new world: the current and future use of novel anticoagulants.
PubMed:Direct comparison of fluorescence- and bioluminescence-based resonance energy transfer methods for real-time monitoring of thrombin-catalysed proteolytic cleavage.
PubMed:Rivaroxaban: an oral direct inhibitor of factor Xa.
PubMed:Chemical composition of Greek avgotaracho prepared from mullet (Mugil cephalus): nutritional and health benefits.
PubMed:Changing trends in anti-coagulant therapies. Are heparins and oral anti-coagulants challenged?
PubMed:Estimating the pathogen safety of manufactured human plasma products: application to fibrin sealants and to thrombin.
PubMed:A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers.
PubMed:Enteral immuno-enhanced diets with arginine are safe and beneficial for patients early after esophageal cancer surgery.
PubMed:Advancement in antithrombotics for stroke prevention in atrial fibrillation.
PubMed:Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate.
PubMed:Survival of heparins, oral anticoagulants, and aspirin after the year 2010.
PubMed:Evaluation of biomolecular interactions of sulfated polysaccharide isolated from Grateloupia filicina on blood coagulation factors.
PubMed:Effect of platelet-rich plasma on cell adhesion, cell migration, and myofibroblastic differentiation in human gingival fibroblasts.
PubMed:First plasma-free thrombin product approved by FDA.
PubMed:Antiplatelet aggregation coumarins from the leaves of Murraya omphalocarpa.
PubMed:Recent developments in antithrombotic therapy: will sodium warfarin be a drug of the past?
PubMed:Stroke management.
PubMed:Purification and characterization of a new fibrinolytic enzyme of Bacillus licheniformis KJ-31, isolated from Korean traditional Jeot-gal.
PubMed:Expression and intein-mediated purification of novel staphylokinase SakSTAR with reduced immunogenicity and antiplatelet and antithrombin activation.
PubMed:Magnetic resonance imaging, rheological properties, and physicochemical characteristics of meat systems with fibrinogen and thrombin.
PubMed:The new anticoagulants.
PubMed:Use of newer anticoagulants in patients with chronic kidney disease.
PubMed:FDA licenses human thrombin product.
PubMed:Functional connections and pathways of coenzyme Q10-inducible genes: an in-silico study.
PubMed:Inhibition by soya isoflavones of human polymorphonuclear leukocyte function: possible relevance for the beneficial effects of soya intake.
PubMed:Clopidogrel: an updated and comprehensive review.
PubMed:Screening method for the addition of bovine blood-based binding agents to food using liquid chromatography triple quadrupole mass spectrometry.
PubMed:Role of the coagulation system in acetaminophen-induced hepatotoxicity in mice.
PubMed:Percutaneous coronary intervention: the story so far.
PubMed:Fondaparinux as a treatment option for heparin-induced thrombocytopenia.
PubMed:No influence of food on the pharmacokinetics, pharmacodynamics or tolerability of the 24mg and 36mg oral tablet formulations of ximelagatran.
PubMed:Neutrophil interaction with the hemostatic system contributes to liver injury in rats cotreated with lipopolysaccharide and ranitidine.
PubMed:Anti-hypertensive effect of the Dongchunghacho, Isaria sinclairii, in the spontaneously hypertensive rats.
PubMed:In vitro reconstitution of antimicrobial pathogen activity by expressed recombinant bovine lactoferrin N-terminal peptide in Escherichia coli.
PubMed:Aptamers-based assays for diagnostics, environmental and food analysis.
PubMed:Low-density lipoprotein, collagen, and thrombin models reveal that Rosemarinus officinalis L. exhibits potent antiglycative effects.
PubMed:Evaluation and management of atrial fibrillation.
PubMed:Investigational treatments of venous thromboembolism.
PubMed:Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: an ESR study.
PubMed:Lead-induced procoagulant activation of erythrocytes through phosphatidylserine exposure may lead to thrombotic diseases.
PubMed:New antithrombotic agents.
PubMed:Antithrombotic effects of odorless garlic powder both in vitro and in vivo.
PubMed:Effect of diallyl trisulfide-rich garlic oil on blood coagulation and plasma activity of anticoagulation factors in rats.
PubMed:Effect of traditional Greek Mediterranean meals on platelet aggregation in normal subjects and in patients with type 2 diabetes mellitus.
PubMed:Plasma glycoprotein V levels in the general population: normal distribution, associated parameters and implications for clinical studies.
PubMed:Novel method of expression and purification of hirudin based on pBAD TOPO, pTYB12 vectors and gene synthesis.
PubMed:A prospective, randomized, controlled trial of autologous platelet-rich plasma gel for the treatment of diabetic foot ulcers.
PubMed:The challenges of new drugs benefits and risks analysis: lessons from the ximelagatran FDA Cardiovascular Advisory Committee.
PubMed:Argatroban: a direct thrombin inhibitor with reliable and predictable anticoagulant actions.
PubMed:The clinical use and immunologic impact of thrombin in surgery.
PubMed:Purification and characterization of a fibrinolytic enzyme of Bacillus subtilis DC33, isolated from Chinese traditional Douchi.
PubMed:Evaluation of treatment with direct thrombin inhibitors in patients with heparin-induced thrombocytopenia.
PubMed:Treatment of heparin-induced thrombocytopenia: is there a role for bivalirudin?
PubMed:Pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor ximelagatran in young healthy Japanese men.
PubMed:Antiplatelet and antithrombotic activities of methanol extract of Usnea longissima.
PubMed:Trials and tribulations of non-inferiority: the ximelagatran experience.
PubMed:Characteristics of a cheese-like food produced by fermentation of the mushroom Schizophyllum commune.
PubMed:Development of mushrooms for thrombosis prevention by protoplast fusion.
PubMed:Review and application of serine protease inhibition in coronary artery bypass graft surgery.
PubMed:Microbial fibrinolytic enzymes: an overview of source, production, properties, and thrombolytic activity in vivo.
PubMed:Vibrio vulnificus secretes a broad-specificity metalloprotease capable of interfering with blood homeostasis through prothrombin activation and fibrinolysis.
PubMed:Low potential for interactions between melagatran/ximelagatran and other drugs, food, or alcohol.
PubMed:Evolving management strategies for heparin-induced thrombocytopenia.
PubMed:Ximelagatran: a clinical perspective.
PubMed:PorA protein of Campylobacter jejuni is not a cytotoxin mediating inflammatory diarrhoea.
PubMed:Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement.
PubMed:Preventing stroke in atrial fibrillation: the SPORTIF programme.
PubMed:Current issues in anticoagulation.
PubMed:Ximelagatran--a promising new drug in thromboembolic disorders.
PubMed:Inhibition of blood platelet adhesion and secretion by different phenolics from Yucca schidigera Roezl. bark.
PubMed:Oral anticoagulation: challenges in the case-management setting.
PubMed:The role of oral direct thrombin inhibitors in atrial fibrillation.
PubMed:New possibilities in anticoagulant management of atrial fibrillation.
PubMed:Changing the guard in long-term anticoagulation: clinical and economic implications.
PubMed:The potential for changing prescribing patterns from warfarin to oral direct thrombin inhibitors: clinical scenarios.
PubMed:Treatment of venous thromboembolism and long-term prevention of recurrence: present treatment options and ximelagatran.
PubMed:[New perspectives for anticoagulation in non-rheumatic atrial fibrillation: oral antithrombins].
PubMed:Ximelagatran in prevention of cardiovascular events.
PubMed:Role of hepatic fibrin in idiosyncrasy-like liver injury from lipopolysaccharide-ranitidine coexposure in rats.
PubMed:New blood thinner offers first potential alternative in 50 years: ximelagatran.
PubMed:Ximelagatran: an oral direct thrombin inhibitor.
PubMed:Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on the oxidizability and thrombogenicity of low-density lipoprotein.
PubMed:Sample displacement chromatography of Atlantic Salmon (Salmo salar) thrombin.
PubMed:[Biological effects of vitamin K and concentration of vitamin K in Norwegian food].
PubMed:Orally active direct thrombin inhibitors.
PubMed:Purification and characterization of Atlantic salmon (Salmo salar) fibrinogen.
PubMed:Ximelagatran: a new oral anticoagulant.
PubMed:Lepirudin: a bivalent direct thrombin inhibitor for anticoagulation therapy.
PubMed:[Cervical esophagogastrostomy dehiscence after gastric pull-up for type I esophageal atresia. Case report of a patient successfully treated with fibrin glue and a review of the literature].
PubMed:Ximelagatran: the first oral direct thrombin inhibitor.
PubMed:Chinese yam (Dioscorea alata cv. Tainung No. 2) feeding exhibited antioxidative effects in hyperhomocysteinemia rats.
PubMed:Novel fibrinolytic enzyme in fermented shrimp paste, a traditional asian fermented seasoning.
PubMed:Influence of the lactokinin Ala-Leu-Pro-Met-His-Ile-Arg (ALPMHIR) on the release of endothelin-1 by endothelial cells.
PubMed:Will direct thrombin inhibitors replace warfarin for preventing embolic events in atrial fibrillation?
PubMed:Overview of heparin-induced thrombocytopenia.
PubMed:Searching for preventive measures of cardiovascular events in aged Japanese taxi drivers--the daily rhythm of cardiovascular risk factors during a night duty day.
PubMed:Recent advances in the discovery and development of direct coagulation factor Xa inhibitors.
PubMed:Oral direct thrombin inhibitors in clinical development.
PubMed:The pharmacodynamics and pharmacokinetics of the oral direct thrombin inhibitor ximelagatran and its active metabolite melagatran: a mini-review.
PubMed:Current anticoagulant therapy--unmet clinical needs.
PubMed:Pharmacokinetics and pharmacodynamics of ximelagatran, a novel oral direct thrombin inhibitor, in young healthy male subjects.
PubMed:Ximelagatran versus warfarin for stroke prevention in patients with nonvalvular atrial fibrillation. SPORTIF II: a dose-guiding, tolerability, and safety study.
PubMed:Influence of age on the pharmacokinetics and pharmacodynamics of ximelagatran, an oral direct thrombin inhibitor.
PubMed:Antioxidative and antiplatelet effects of aqueous inflorescence Piper betle extract.
PubMed:Anti-platelet fraction from Galega officinalis L. inhibits platelet aggregation.
PubMed:[Change of natural antibody levels in patients with cardiovascular diseases by the use of anti-atherogenic diets with processed soy product foods].
PubMed:Purification and characterization of a fibrinolytic enzyme produced by Bacillus amyloliquefaciens DC-4 screened from douchi, a traditional Chinese soybean food.
PubMed:Hyperhomocysteinemia and endothelial function in young subjects: effects of vitamin supplementation.
PubMed:Enhancement of allyl alcohol hepatotoxicity by endotoxin requires extrahepatic factors.
PubMed:Jojoba seed meal proteins associated with proteolytic and protease inhibitory activities.
PubMed:[Future potential indications for an oral thrombin inhibitor].
PubMed:Effect of homocysteine reduction by B-vitamin supplementation on markers of clotting activation.
PubMed:Human platelet aggregation inhibitors from thyme (Thymus vulgaris L.).
PubMed:Optimizing prophylaxis of venous thromboembolism.
PubMed:Selective inhibition of coagulation factors: advances in antithrombotic therapy.
PubMed:Release of annexin V-binding membrane microparticles from cultured human umbilical vein endothelial cells after treatment with camptothecin.
PubMed:Acid and heat stability of the anticoagulative activity of an onion extract.
PubMed:Biologically active lipids with antiatherogenic properties from white wine and must.
PubMed:Comparative efficacy of fibrinogen and platelet supplementation on the in vitro reversibility of competitive glycoprotein IIb/IIIa receptor-directed platelet inhibition.
PubMed:Impaired platelet aggregation in melanoma patients treated with interferon-alpha-2b adjuvant therapy.
PubMed:Bivalirudin: a direct thrombin inhibitor.
PubMed:Current status of the anticoagulant hirudin: its biotechnological production and clinical practice.
PubMed:Cardiovascular drug highlight: hirudin.
PubMed:Use of recombinant hirudin in heparin-induced thrombocytopenia and thrombosis (HITT) and renal failure--a case report.
PubMed:Fibrin sealants in surgical practice: An overview.
PubMed:Characteristics of wine produced by mushroom fermentation.
PubMed:Comparative efficacy of fibrinogen and platelet supplementation on the in vitro reversibility of competitive glycoprotein IIb/IIIa (alphaIIb/beta3) receptor-directed platelet inhibition.
PubMed:A multicenter, prospective, randomized trial evaluating a new hemostatic agent for spinal surgery.
PubMed:Postprandial triglycerides and blood coagulation.
PubMed:Characterization of simple and reproducible vascular stenosis model in hypercholesterolemic hamsters.
PubMed:Recombinant expression of biologically active rat leptin in Escherichia coli.
PubMed:IgE binding properties of the recombinant ovomucoid third domain expressed in Escherichia coli.
PubMed:Fibrin sealant: clinical use and the development of the University of Virginia Tissue Adhesive Center.
PubMed:Biological action of nitric oxide donor compounds on platelets from patients with sickle cell disease.
PubMed:Pernin: a novel, self-aggregating haemolymph protein from the New Zealand green-lipped mussel, Perna canaliculus (Bivalvia: Mytilidae).
PubMed:The scientific basis for combined platelet and thrombin-directed pharmacotherapy in acute coronary syndromes.
PubMed:A cooperative interaction between soy protein and its isoflavone-enriched fraction lowers hepatic lipids in male obese Zucker rats and reduces blood platelet sensitivity in male Sprague-Dawley rats.
PubMed:Separation of biologically active lipids from red wine.
PubMed:The link between high-fat meals and postprandial activation of blood coagulation factor VII possibly involves kallikrein.
PubMed:Antiplatelet activity of soy sauce as functional seasoning.
PubMed:[Dynamics of the natural antibody level as affected by the biologically active food supplement "Vitol" in patients with hypertensive disease and obesity].
PubMed:Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets.
PubMed:Plasticity-related serine proteases in the brain (review).
PubMed:Expression of recombinant Lym-1 single-chain Fv in Escherichia coli.
PubMed:Haemostatic profile of the San (Bushmen) relocated to Schmidtsdrif.
PubMed:Fumaric acid, anti-thrombin substance from Rhizopus javanicus.
PubMed:Calorie restriction decreases platelet-derived growth factor (PDGF)-A and thrombin receptor mRNA expression in autoimmune murine lupus nephritis.
PubMed:In vitro and in vivo effects of selenium and selenium with vitamin E on platelet functions in diabetic rats relationship to platelet sorbitol and fatty acid distribution.
PubMed:Selective induction of a glycoprotein IIIa ligand-induced binding site by fibrinogen and von Willebrand factor.
PubMed:Amphotericin B induced abnormalities in human platelets.
PubMed:Modulation of human platelet function by food flavonoids.
PubMed:Fibrin sealant in the United States: clinical use at the University of Virginia.
PubMed:Separation of r-hirudin from similar substances by capillary electrophoresis.
PubMed:Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors.
PubMed:The hemostatic effect of fibrin glue on graft donor sites.
PubMed:Vinculin is a major platelet protein that undergoes Ca(2+)-dependent tyrosine phosphorylation.
PubMed:High casein-lactalbumin diet accelerates blood coagulation in rats.
PubMed:Penicillin-induced dysfunction of platelet membrane glycoproteins.
PubMed:Penicillin inhibits agonist-induced expression of platelet surface membrane glycoproteins.
PubMed:Thromboxane production in copper-deficient and marginal platelets: influence of superoxide dismutase and lipid hydroperoxides.
PubMed:Copper-marginal and copper-deficient diets decrease aortic prostacyclin production and copper-dependent superoxide dismutase activity, and increase aortic lipid peroxidation in rats.
PubMed:Anticoagulant properties of a fucoïdan fraction.
PubMed:Studies of women eating diets with different fatty acid composition. III. Fatty acids and prostaglandin synthesis by platelets and cultured human endothelial cells.
PubMed:Inhibition by albumin of merocyanine 540-mediated photosensitization of platelets and viruses.
PubMed:The relationship between thromboxane and cytosolic calcium modifiers in rat platelets.
PubMed:Thrombin attenuates the stimulatory effect of histamine on Ca2+ entry in confluent human umbilical vein endothelial cell cultures.
PubMed:The effect of a salmon diet on blood clotting, platelet aggregation and fatty acids in normal adult men.
PubMed:A potent thromboxane formation inhibitor in green tea leaves.
PubMed:Influence of Bay k 8644 on aequorin-loaded human platelets.
PubMed:Caseins of various origins and biologically active casein peptides and oligosaccharides: structural and physiological aspects.
PubMed:A technique for spot application of fibrin glue during open heart operations.
PubMed:Dihydropyridine-sensitive and insensitive Ca2+ channels in human platelets.
PubMed:Application of single-donor fibrin glue to burns.
PubMed:Esophageal atresia--a rabbit model to study anastomotic healing and the use of tissue adhesive fibrin sealant.
PubMed:Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels.
PubMed:Butter-enriched diets reduce arterial prostacyclin production in rats.
PubMed:The use of fibrin glue in repair of peripheral nerves.
PubMed:Influence of vitamin E administration on platelet functions in hormonal contraceptive users.
PubMed:Fibrin glue from stored human plasma. An inexpensive and efficient method for local blood bank preparation.
PubMed:Barium-impregnated fibrin glue: application to a bleeding duodenal sinus.
PubMed:Nutrients, platelet function and composition in nine groups of French and British farmers.
PubMed:Influence of long-term diet modification on platelet function and composition in Moselle farmers.
PubMed:[Diagnostic aspects and results of drug therapy in pulmonary thromboembolism].
PubMed:[Thrombolytic therapy with urokinase in 8 patients with massive pulmonary thromboembolism].
PubMed:Reduced aggregation capacity of washed platelets and dysfibrinogenaemia in rats given butylated hydroxytoluene.
PubMed:Zinc deficiency and impaired platelet aggregation in guinea pigs.
PubMed:An evaluation of the arachidonate pathway of platelets from companion and food-producing animals, mink, and man.
PubMed:In vitro releasability of histamine and serotonin: studies of atopic patients.
PubMed:Platelet aggregation in rats in relation to hyperuricaemia induced by dietary single-cell protein and to protein deficiency.
 
Notes:
an enzyme formed from prothrombin that converts fibrinogen to fibrin.
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