cetyl pyridinium chloride anhydrous
1-hexadecylpyridinium chloride
None found
  • American International Chemical, LLC.
    • American International Chemical, Inc.
      Consistent sources
      North American supplier for globally sourced ingredients.
      AIC is a Framingham, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of 30 Sales Representatives, along with our 19 strategically located warehouses are ready to supply product when and where you need it.
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      CPCUIP Cetylpyridinium Chloride
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1-hexadecylpyridin-1-ium chloride (Click)
CAS Number: 123-03-5Picture of molecule
Other: 136499-13-3
ECHA EINECS - REACH Pre-Reg: 204-593-9
Beilstein Number: 3578606
MDL: MFCD00011731
Molecular Weight: 339.99286000
Formula: C21 H38 Cl N
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: antimicrobial agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
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US Patents: Search
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Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 31 Cetylpyridinium chloride View-notice PDF
GRN 38 Cetylpyridinium chloride View-notice PDF
FDA Mainterm: Cetylpyridinium chloride
FDA Regulation:
Subpart D--Specific Usage Additives
Sec. 173.375 Cetylpyridinium chloride.
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Physical Properties:
Appearance: white powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 77.00 to  83.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): 1.710
Soluble in:
 water, 246.6 mg/L @ 25 °C (est)
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Organoleptic Properties:
Odor Strength: high
Odor Description:
at 100.00 %. 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antimicrobial agents
antistatic agents
emulsifying agents
hair conditioning
oral care agents
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American International Chemical, LLC.
Cetylpyridinium Chloride
BOC Sciences
For experimental / research use only.
Cetylpyridinium Chloride >98%
Odor: characteristic
Use: Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic.
George Uhe Company
Cetylpyridinium Chloride
Sigma-Aldrich: Aldrich
For experimental / research use only.
1-Hexadecyl-pyridinium, Chloride
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Safety Information:
Preferred SDS: View
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  200 mg/kg
Yakkyoku. Pharmacy. Vol. 31, Pg. 471, 1980.

intraperitoneal-rat LD50  6 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 35, Pg. 89, 1946.

oral-rabbit LD50  400 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 208, 1966.

intravenous-rabbit LD50  36 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 208, 1966.

oral-mouse LD50  108 mg/kg
Proceedings of the Society for Experimental Biology and Medicine. Vol. 120, Pg. 511, 1965.

intravenous-mouse LD50  10 mg/kg
Journal of Biological Standardization. Vol. 1, Pg. 87, 1973.

intraperitoneal-mouse LD50  7 mg/kg
Journal of Pharmaceutical Sciences. Vol. 59, Pg. 188, 1970.

oral-cat LD  > 500 mg/kg
Journal of Pharmaceutical Sciences. Vol. 59, Pg. 188, 1970.

oral-dog LD  > 500 mg/kg
Journal of Pharmaceutical Sciences. Vol. 59, Pg. 188, 1970.

Dermal Toxicity:
subcutaneous-rat LD50 250 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 35, Pg. 89, 1946.

skin-rabbit LDLo 2000 mg/kg
Journal of Pharmaceutical Sciences. Vol. 59, Pg. 188, 1970.

subcutaneous-rabbit LD50 300 mg/kg
Drugs in Japan Vol. -, Pg. 544, 1990.

Inhalation Toxicity:
inhalation-rat LC50 90mg/m3/4H Food and Chemical Toxicology. Vol. 29, Pg. 851, 1991.

inhalation-rat LC50 90 mg/m3/4H
Food and Chemical Toxicology. Vol. 29, Pg. 851, 1991.

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Safety in Use Information:
Category: antimicrobial agents
Recommendation for cetyl pyridinium chloride anhydrous usage levels up to:
 not for fragrance use.
Recommendation for cetyl pyridinium chloride anhydrous flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the evaluation of the safety and efficacy of CecureŽ for the removal of microbial surface contamination of raw poultry products
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 123-03-5
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 31239
National Institute of Allergy and Infectious Diseases: Data
SCCNFP: opinion
WGK Germany: 3
 1-hexadecylpyridin-1-ium chloride
Chemidplus: 0000123035
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 1-hexadecylpyridin-1-ium chloride
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 123-03-5
Pubchem (cid): 31239
Pubchem (sid): 134974210
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): Search
Haz-Map: View
Household Products: Search
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
•cepacaine soln (benzocaine, combination, cetylpyridinium chloride, dibucaine). •cetylpridinium chloride lozenges, 0.067% with benzyl alc (cepacol). lozenges, 0.067% with neomycin sulfate 2.5 mg tyrothricin 1 mg, methylparaben 4 mg, propylparaben 1 mg, ethyl aminobenzoate 5 mg (cepacol antibiotic troches). soln, 0.025% with alc 14% & phosphate buffers; 150 & 420 ml bottles (cepacol). •available as aqueous or alcohol solutions (eg, tincture) in concn of 10% or less. •grades: technical; nf •lozenges, 0.07%. mouthwash, 0.05%.
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Potential Blenders and core components note
None Found
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Potential Uses:
 antimicrobial agents 
 antistatic agents 
 emulsifying agents 
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Occurrence (nature, food, other): note
 not found in nature
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 acetoquat CPC
 ceepryn chloride
 cepacol chloride
1-cetylpyridinium chloride
N-cetylpyridinium chloride
 cetylpyridinium chloride anhydrous
 cetylpyridinium chloride USP
 hexadecyl pyridinium chloride anhydrous
1-hexadecylpyridin-1-ium chloride anhydrous
 hexadecylpyridinium chloride
1-hexadecylpyridinium chloride
N-hexadecylpyridinium chloride
1-palmitylpyridinium chloride
 pionin B
 pyridinium, 1-hexadecyl-, chloride
 pyridinium, 1-hexadecyl-, chloride (1:1)
 pyridinium, hexadecyl-, chloride
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PubMed: Selective removal and inactivation of bacteria by nanoparticle composites prepared by surface modification of montmorillonite with quaternary ammonium compounds.
PubMed: Development of antimicrobial resistance in Campylobacter jejuni and Campylobacter coli adapted to biocides.
PubMed: Effects of efflux-pump inducers and genetic variation of the multidrug transporter cmeB in biocide resistance of Campylobacter jejuni and Campylobacter coli.
PubMed: Involvement of efflux mechanisms in biocide resistance of Campylobacter jejuni and Campylobacter coli.
PubMed: Microbiological quality of water immersion-chilled and air-chilled broilers.
PubMed: Survival of Escherichia coli O157:H7 in meat product brines containing antimicrobials.
PubMed: Thin-layer chromatographic plates with monolithic layer of silica: Production, physical-chemical characteristics, separation capabilities.
PubMed: Physiological and transcriptional characterization of persistent and nonpersistent Listeria monocytogenes isolates.
PubMed: A novel method for quantitative determination of tea polysaccharide by resonance light scattering.
PubMed: Thermal inactivation of acid, cold, heat, starvation, and desiccation stress-adapted Escherichia coli O157:H7 in moisture-enhanced nonintact beef.
PubMed: Evaluation of brining ingredients and antimicrobials for effects on thermal destruction of Escherichia coli O157:H7 in a meat model system.
PubMed: Effect of Hofmeister anions on micellization and micellar growth of the surfactant cetylpyridinium chloride.
PubMed: Chemical decontamination of Campylobacter jejuni on chicken skin and meat.
PubMed: Linear-to-branched micelles transition: a rheometry and diffusing wave spectroscopy (DWS) study.
PubMed: Ultrasound velocimetry in a shear-thickening wormlike micellar solution: evidence for the coexistence of radial and vorticity shear bands.
PubMed: [Sorption characteristics of surfactant onto bentonite using microwave irradiation].
PubMed: A significant role for Sigma B in the detergent stress response of Listeria monocytogenes.
PubMed: Food as a vehicle for transmission of Shiga toxin-producing Escherichia coli.
PubMed: Multistate outbreak of Burkholderia cenocepacia colonization and infection associated with the use of intrinsically contaminated alcohol-free mouthwash.
PubMed: Anticalculus effect of a cetylpyridinium chloride/zinc gluconate mucoadhesive gel: results of a randomized, double-blind, controlled clinical trial.
PubMed: Spectrophotometric study of anionic azo-dye light yellow (X6G) interaction with surfactants and its micellar solubilization in cationic surfactant micelles.
PubMed: Inhibition of Escherichia coli O157:H7, Listeria monocytogenes and Staphylococcus aureus on sliced roast beef by cetylpyridinium chloride and acidified sodium chlorite.
PubMed: Effects of acidified sodium chlorite, cetylpyridinium chloride and hot water on populations of Listeria monocytogenes and Staphylococcus aureus on beef.
PubMed: Differential killing activity of cetylpyridinium chloride with or without bacto neutralizing buffer quench against firmly adhered Salmonella gaminara and Shigella sonnei on cut lettuce stored at 4 degrees C.
PubMed: Fast determination of anions on a short coated column.
PubMed: Efficacy of cetylpyridinium chloride against Listeria monocytogenes and its influence on color and texture of cooked roast beef.
PubMed: 3D-QSAR, synthesis, and antimicrobial activity of 1-alkylpyridinium compounds as potential agents to improve food safety.
PubMed: Antimicrobial activity of cetylpyridinium chloride against Listeria monocytogenes on frankfurters and subsequent effect on quality attributest.
PubMed: Cetylpyridinium chloride treatment of ready-to-eat Polish sausages: effects on Listeria monocytogenes populations and quality attributes.
PubMed: Effect of simulated spray chilling with chemical solutions on acid-habituated and non-acid-habituated Escherichia coli O157:H7 cells attached to beef carcass tissue.
PubMed: Effect of chemical decontamination and refrigerated storage on the isolation of Mycobacterium avium subsp. paratuberculosis from heat-treated milk.
PubMed: Prevalence of Escherichia coli O157 and levels of aerobic bacteria and Enterobacteriaceae are reduced when hides are washed and treated with cetylpyridinium chloride at a commercial beef processing plant.
PubMed: Sensitivity of Escherichia coli O157:H7 to commercially available alkaline cleaners and subsequent resistance to heat and sanitizers.
PubMed: Effects of cetylpyridinium chloride, acidified sodium chlorite, and potassium sorbate on populations of Escherichia coli O157:H7, Listeria monocytogenes, and Staphylococcus aureus on fresh beef.
PubMed: Protocol for evaluating the efficacy of cetylpyridinium chloride as a beef hide intervention.
PubMed: Comparative evaluation of the MGIT and BACTEC culture systems for the recovery of Mycobacterium avium subsp. paratuberculosis from milk.
PubMed: Reduction of poliovirus 1, bacteriophages, Salmonella montevideo, and Escherichia coli O157:H7 on strawberries by physical and disinfectant washes.
PubMed: Incidence of Mycobacterium paratuberculosis in bulk raw and commercially pasteurized cows' milk from approved dairy processing establishments in the United Kingdom.
PubMed: Survival of Listeria monocytogenes in commercial food-processing equipment cleaning solutions and subsequent sensitivity to sanitizers and heat.
PubMed: Effect of commercial-scale high-temperature, short-time pasteurization on the viability of Mycobacterium paratuberculosis in naturally infected cows' milk.
PubMed: Efficacy of cetylpyridinium chloride in immersion treatment for reducing populations of pathogenic bacteria on fresh-cut vegetables.
PubMed: Antimicrobial activity of cetylpyridinium chloride washes against pathogenic bacteria on beef surfaces.
PubMed: The effects of antimicrobial mouthrinses on oral malodor and their status relative to US Food and Drug Administration regulations.
PubMed: Recovery of thuringiensin with cetylpyridinium chloride using micellar-enhanced ultrafiltration process
PubMed: Spraying chicken skin with selected chemicals to reduce attached Salmonella typhimurium.
PubMed: Use of antimicrobial spray applied with an inside-outside birdwasher to reduce bacterial contamination on prechilled chicken carcasses.
PubMed: Cetylpyridinium chloride (CPC) treatment on poultry skin to reduce attached Salmonella.
PubMed: Ocular and dermal irritation studies of some quaternary ammonium compounds.
PubMed: Dietary staining in vitro by mouthrinses as a comparative measure of antiseptic activity and predictor of staining in vivo.
PubMed: Acute inhalation toxicity of cetylpyridinium chloride.
PubMed: Binding of dyes to hydroxyapatite treated with cetylpyridinium chloride or cetrimonium bromide.
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