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tetracaine HCl
benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester, hydrochloride (1:1)

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Name:2-(dimethylamino)ethyl 4-(butylamino)benzoate;hydrochloride
CAS Number: 136-47-0Picture of molecule3D/inchi
Other(deleted CASRN):2706-41-4
ECHA EINECS - REACH Pre-Reg:205-248-5
FDA UNII: 5NF5D4OPCI
Beilstein Number:2216051
MDL:MFCD00038912
Molecular Weight:300.82865000
Formula:C15 H25 Cl N2 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:pharmaceuticals / chemical synthisis
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
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PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 147.00 °C. @ 760.00 mm Hg
Boiling Point: 389.40 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.000003 mmHg @ 25.00 °C. (est)
Flash Point: 373.00 °F. TCC ( 189.30 °C. ) (est)
logP (o/w): 3.649 (est)
Soluble in:
 water, 8.41e+004 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
American International Chemical, LLC.
TETRACAINE HYDROCHLORIDE USP
BASF
Seluris®
BOC Sciences
For experimental / research use only.
Tetracaine HCl >98%
Odor: characteristic
Use: Tetracaine hydrochlorideis a hydrochloride salt form of tetracaine which is a potent local anaesthetic and a channel function allosteric inhibitor.
Glentham Life Sciences
Tetracaine hydrochloride
Penta International
TETRACAINE HCL
Santa Cruz Biotechnology
For experimental / research use only.
Tetracaine hydrochloride
Sigma-Aldrich: Sigma
For experimental / research use only.
Tetracaine hydrochloride ≥99%
TCI AMERICA
For experimental / research use only.
Tetracaine Hydrochloride >98.0%(HPLC)(T)
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-guinea pig LD50 4 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 739, 1957.

intraperitoneal-mouse LD50 23 mg/kg
Archiv der Pharmazie Vol. 321, Pg. 115, 1988.

intravenous-mouse LD50 6400 ug/kg
Drugs in Japan Vol. -, Pg. 815, 1995.

oral-mouse LD50 160 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: MUSCLE WEAKNESS
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 413, 1975.

intratracheal-rabbit LD50 4400 ug/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Pharmacology and Experimental Therapeutics. Vol. 132, Pg. 87, 1961.

intravenous-rabbit LD50 2150 ug/kg
Drugs in Japan Vol. 6, Pg. 490, 1982.

intraperitoneal-rat LD50 23500 ug/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 413, 1975.

intravenous-rat LD50 4500 ug/kg
BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 413, 1975.

Dermal Toxicity:
subcutaneous-guinea pig LD50 19500 ug/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 20, Pg. 380, 1947.

subcutaneous-mouse LD50 25 mg/kg
Pharmacology and Toxicology. English translation of FATOAO. Vol. 22, Pg. 138, 1959.

subcutaneous-rabbit LD50 15 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 93, Pg. 388, 1948.

subcutaneous-rat LD50 24 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 413, 1975.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
pharmaceuticals / chemical synthisis
Recommendation for tetracaine HCl usage levels up to:
 not for fragrance use.
 
Recommendation for tetracaine HCl flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA GENetic TOXicology:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :8695
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2-(dimethylamino)ethyl 4-(butylamino)benzoate;hydrochloride
Chemidplus:0000136470
RTECS:DG4900000 for cas# 136-47-0
 
References:
 2-(dimethylamino)ethyl 4-(butylamino)benzoate;hydrochloride
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:136-47-0
Pubchem (cid):8695
Pubchem (sid):134973210
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D00741
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2922.49.3700
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 amethocaine hydrochloride
 amethocaine monohydrochloride
 anacel
 anethain
 benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester, hydrochloride (1:1)
 benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride
 benzoic acid, p-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride
 butethanol
4-(butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride
p-(butylamino)benzoic acid, 2-(dimethylamino)ethyl ester, hydrochloride
4-butylaminobenzoic acid dimethylaminoethyl ester hydrochloride
p-butylaminobenzoyl-2-dimethylaminoethanol hydrochloride
 butylocaine
 curtacain
 decicain
 dessicain
 dicain
2-(dimethylamino)ethyl 4-(butylamino)benzoate hydrochloride
2-(dimethylamino)ethyl 4-(butylamino)benzoate;hydrochloride
2-(dimethylamino)ethyl p-(butylamino)benzoate hydrochloride
2-(dimethylamino)ethyl p-(butylamino)benzoate monohydrochloride
2-dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride
 gingicain M
 intercaine
 leocaine
 menonasal
 niphanoid
 protocaine hydrochloride
 tetocaine
 tetracaine hydrochloride
 tetracaine monohydrochloride
 tetracainehydrochloride
 tonexol
 
 
Notes:
a potent local anesthetic of the ester type used for surface and spinal anesthesia.
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