biotin
5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid
 
Notes:
A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. a water-soluble, enzyme co-factor present in minute amounts in every living cell. it occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. Present in many foods; particularly rich sources include yeast, eggs, liver, certain fish (e.g. mackerel, salmon, sardines), soybeans, cauliflower and cow peas. Dietary supplement. Isol. from various higher plant sources, e.g. sweet corn seedlings and radish leaves Biotin D(+) is a cofactor responsible for carbon dioxide transfer in several carboxylase enzymes:; Biotin binds very tightly to the tetrameric protein avidin (also streptavidin and neutravidin), with a dissociation constant Kd in the order of 10?15 mol/L which is one of the strongest known protein-ligand interactions, approaching the covalent bond in strength. This is often used in different biotechnological applications. Until 2005, very harsh conditions were required to break the biotin-streptavidin bond.; Biotin is a water-soluble B-complex vitamin which is composed of an ureido ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is used in cell growth, the production of fatty acids, metabolism of fats, and amino acids. It plays a role in the Kreb cycle, which is the process in which energy is released from food. Biotin not only assists in various metabolic chemical conversions, but also helps with the transfer of carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengthening hair and nails. Consequenty, it is found in many cosmetic and health products for the hair and skin. Biotin deficiency is a rare nutritional disorder caused by a deficiency of biotin. Initial symptoms of biotin deficiency include: Dry skin, Seborrheic dermatitis, Fungal infections, rashes including erythematous periorofacial macular rash, fine and brittle hair, and hair loss or total alopecia. If left untreated, neurological symptoms can develop, including mild depression, which may progress to profound lassitude and, eventually, to somnolence; Biotin is an enzyme co-factor present in minute amounts in every living cell. Biotin is also known as vitamin H or B7 or coenzyme R. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. Biotin has been recognized as an essential nutrient. Our biotin requirement is fulfilled in part through diet, through endogenous reutilization of biotin and perhaps through capture of biotin generated in the intestinal flora. The utilization of biotin for covalent attachment to carboxylases and its reutilization through the release of carboxylase biotin after proteolytic degradation constitutes the 'biotin cycle'. Biotin deficiency is associated with neurological manifestations, skin rash, hair loss and metabolic disturbances that are thought to relate to the various carboxylase deficiencies (metabolic ketoacidosis with lactic acidosis). It has also been suggested that biotin deficiency is associated with protein malnutrition, and that marginal biotin deficiency in pregnant women may be teratogenic. Biotin acts as a carboxyl carrier in carboxylation reactions. There are four biotin-dependent carboxylases in mammals: those of propionyl-CoA (PCC), 3-methylcrotonyl-CoA (MCC), pyruvate (PC) and acetyl-CoA carboxylases (isoforms ACC-1 and ACC-2). All but ACC-2 are mitochondrial enzymes. The biotin moiety is covalently bound to the epsilon amino group of a Lysine residue in each of these carboxylases in a domain 60-80 amino acids long. The domain is structurally similar among carboxylases from bacteria to mammals. There are four biotin-dependent carboxylases in mammals: those of propionyl-CoA (PCC), 3-methylcrotonyl-CoA (MCC), pyruvate (PC) and acetyl-CoA carboxylases (isoforms ACC-1 and ACC-2). All but ACC-2 are mitochondrial enzymes. The biotin moiety is covalently bound to the epsilon amino group of a Lys residue in each of these carboxylases in a domain 60-80 amino acids long. The domain is structurally similar among carboxylases from bacteria to mammals. Evidence is emerging that biotin participates in processes other than classical carboxylation reactions. Specifically, novel roles for biotin in cell signaling, gene expression, and chromatin structure have been identified in recent years. Human cells accumulate biotin by using both the sodium-dependent multivitamin transporter and monocarboxylate transporter 1. These transporters and other biotin-binding proteins partition biotin to compartments involved in biotin signaling: cytoplasm, mitochondria, and nuclei. The activity of cell signals such as biotinyl-AMP, Sp1 and Sp3, nuclear factor (NF)-kappaB, and receptor tyrosine kinases depends on biotin supply. Consistent with a role for biotin and its catabolites in modulating these cell signals, greater than 2000 biotin-dependent genes have been identified in various human tissues. Many biotin-dependent gene products play roles in signal transduction and localize to the cell nucleus, consistent with a role for biotin in cell signaling. Posttranscriptional events related to ribosomal activity and protein folding may further contribute to effects of biotin on gene expression. Finally, research has shown that biotinidase and holocarboxylase synthetase mediate covalent binding of biotin to histones (DNA-binding proteins), affecting chromatin structure; Biotin, also known as vitamin H or B7, is a water-soluble B-complex vitamin which is composed of an ureido (tetrahydroimidizalone) ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is a cofactor in the metabolism of fatty acids and leucine, and it plays a role in gluconeogenesis.; Signs of Biotin Deficiency: In general, appetite and growth are decreased. Dermatologic symptoms include dermatitis, alopecia (hair loss) and achromotrichia (absence or loss of pigment in the hair.) Perosis (a shortening and thickening of bones) is seen in the skeleton. Fatty Liver and Kidney Syndrome (FLKS) and hepatic steatosis also can occur. Genetic defect could also cause biotin deficiency. Holocarboxylase synthetase deficiency is a genetic mutation. It is a severe metabolic disorder. Biochemical and clinical manifestation includes: ketolactic acidosis, organic aciduria, hyperammonemia, skin rash, feeding problems, hypotonie, seizures, development delay, alopecia, and coma. This disease is lethal, however, mentioned manifestation can be reversed by pharmacologic doses of biotin (10-100 mg per day).[citation needed]; at least seven biotinylation sites have been identified in human histones. Biotinylation of histones appears to play a role in cell proliferation, gene silencing, and the cellular response to DNA repair. Roles for biotin in cell signaling and chromatin structure are consistent with the notion that biotin has a unique significance in cell biology. (PMID: 15992684, 16011464)
  • American International Chemical, LLC.
    • American International Chemical, Inc.
      Consistent sources
      North American supplier for globally sourced ingredients.
      AIC is a Framingham, MA based ISO Certified sales and marketing company serving the food, pharmaceutical, nutritional, personal care, biotech, and industrial markets of North America since 1972. Our success is a result of a company culture built on customer needs, along with partnerships with global manufacturers committed to the rigors and demands of the North American market. Our team of 30 Sales Representatives, along with our 19 strategically located warehouses are ready to supply product when and where you need it.
      Email: Info
      Voice: (800) 238-0001
      Facebook
      Twitter
      Linkedin
      Product(s):
      BTNAUP Biotin
      BT10UP BIOTIN 10% (On Mannitol)
       
  • Charkit Chemical
    • Charkit Chemical Corporation
      The Specialty Chemical Specialists
      Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.
      Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals.
      Email: Sales
      Voice: 203-299-3220
      Fax: 203-299-1355
      Facebook
      Twitter
      Linkedin
      Latest News
      Events
      Products List: View
      Product(s):
      BIOTIN, D- PURE
       
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co.
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
      Email: Info
      Email: Sales
      Voice: 86-510-86023169
      Fax: 86-510-86023170
      Mobile0086-13093133011
      Services
      Biochemical
      Natural Food Colour
      New functional food ingredients
      Product(s):
      106884 Vitamin H (D-Biotin)
       
  • OQEMA
    • OQEMA
      With a focus on providing the highest level of service
      OQEMA has established itself at the forefront of the global chemical industry.
      The guiding principles of OQEMA have always been to establish long term relationships with customers and suppliers alike to build sustainable and profitable business for all parties. Through OQEMA’s business divisions the company tailors products and services to better support and service our customers requirements. This structure also allows the company to focus its marketing campaigns more effectively to certain industries. Over the last decade OQEMA has achieved strong growth as a result of the expansion of our business model. Going forward, the company will be expanding this business model into existing and new strategic territories.
      Email: Contact Us:
      US Email: Dean Matienzo
      Email: Sales
      US Email: Dean Matienzo - Sales Manager
      Voice: +44 1993 843081
      Fax: +44 1993 841261
      US Voice: +1 973 886 3778
      US Fax: +1 973 346 1106
      Linkedin
      Website
      Global Distribution
      Product(s):
      Biotin Pure
      Biotin 2%
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Product(s):
      02-31000 D-BIOTIN FCC (VITAMIN H), Kosher
      02-31005 D-BIOTIN USP (VITAMIN H), Kosher
       
Synonyms   Articles   Notes   Search
5-[(3aR,6S,6aS)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-6-yl]pentanoic acid (Click)
CAS Number: 58-85-5Picture of molecule
Other: 15720-24-8
ECHA EINECS - REACH Pre-Reg: 200-399-3
FDA UNII: 6SO6U10H04
Nikkaji Web: J94.599D
Beilstein Number: 86838
MDL: MFCD00005541
XlogP3-AA: 0.30 (est)
Molecular Weight: 244.31412000
Formula: C10 H16 N2 O3 S
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
182.8159 Biotin View-review
FDA Mainterm: BIOTIN
FDA Regulation:
FDA PART 101 -- FOOD LABELING
Subpart A--General Provisions
Sec. 101.9 Nutrition labeling of food.


FDA PART 107 -- INFANT FORMULA
Subpart D--Nutrient Requirements
Sec. 107.100 Nutrient specifications.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart I--Nutrients
Sec. 182.8159 Biotin.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: white to off-white crystalline powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 232.00 °C. @ 760.00 mm Hg
Boiling Point: 573.58 °C. @ 760.00 mm Hg (est)
Flash Point: 573.00 °F. TCC ( 300.70 °C. ) (est)
logP (o/w): 0.861 (est)
Soluble in:
 water, 220 mg/L @ 25 °C (exp)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: antiseborrhoeic agents
hair conditioning
skin conditioning
Synonyms   Articles   Notes   Search   Top
Suppliers:
A.M.G.L.T.
Biotin
Aceto
Biotin Pure
AIDP
Biotin 1% Vitamin H 1%
AIDP
Biotin USP Vitamin H 97%-100.5%
American International Chemical, LLC.
BIOTIN 10% (On Mannitol)
American International Chemical, LLC.
Biotin
Atlantic Chemicals
Biotine (Vitamin H)
AuNutra® Industries
Biotin 1%
AuNutra® Industries
D-Biotin 1% on DCP
BBFY Industrial
Biotin
BOC Sciences
For experimental / research use only.
Biotin >98%
Odor: characteristic
Use: Biotin, also known as vitamin H or coenzyme R, is a water-soluble B-vitamin (vitamin B7).
Charkit Chemical
BIOTIN, D- PURE
Dow Chemical
D-Biotin USP/EP
Farbest-Tallman Foods
ZMC d-Biotin 1% on Maltodextrin
Flavor: bland
It is an essential nutrient used in food, beverage and dietary supplement applications including nutrient enhanced foods and beverages.
Farbest-Tallman Foods
ZMC d-Biotin 100% USP
Flavor: bland
It is an essential nutrient used in food, beverage and dietary supplement applications including nutrient enhanced foods and beverages.
Foodchem International
D-Biotin
George Uhe Company
D-Biotin (Pure And Feed Grade)
Graham Chemical
Vitamin H (
Jiangyin Healthway
Vitamin H (D-Biotin)
New functional food ingredients
Maypro Industries
Biotin min. 99% FCC
OQEMA
Biotin 2%
OQEMA
Biotin Pure
Penta International
D-BIOTIN FCC (VITAMIN H), Kosher
Penta International
D-BIOTIN USP (VITAMIN H), Kosher
Prinova
Biotin
Sigma-Aldrich
For experimental / research use only.
Biotin European Pharmacopoeia (EP) Reference Standard
Silver Fern Chemical
Vitamin H (D-Biotin) 2%
Synonyms   Articles   Notes   Search   Top
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: nutrient supplements
Recommendation for biotin usage levels up to:
 not for fragrance use.
 
Recommendation for biotin flavor usage levels up to:
 not for flavor use.
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the substantiation of a health claim related to a combination of thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, D-biotin and pumpkin seed oil and maintenance of normal hair pursuant to Article 13(5) of Regulation (EC) No 1924/2006
View page or View pdf
Scientific Opinion on the safety and efficacy of D-(+)-biotin as a feed additive for all animal species based on a dossier submitted by EUROPE-ASIA Import Export GmbH
View page or View pdf
Scientific Opinion on the safety and efficacy of biotin as a feed additive for all animal species based on a dossier submitted by VITAC EEIG
View page or View pdf
Scientific Opinion on Dietary Reference Values for biotin
View page or View pdf
Outcome of public consultations on the draft Scientific Opinions of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for biotin and pantothenic acid
View page or View pdf
Biotin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006
View page or View pdf
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 58-85-5
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 171548
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 5-[(3aR,6S,6aS)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-6-yl]pentanoic acid
Chemidplus: 0000058855
RTECS: XJ9088200 for cas# 58-85-5
Synonyms   Articles   Notes   Search   Top
References:
 5-[(3aR,6S,6aS)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-6-yl]pentanoic acid
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 58-85-5
Pubchem (cid): 171548
Pubchem (sid): 134971956
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
Metabolomics Database: Search
KEGG (GenomeNet): C00120
HMDB (The Human Metabolome Database): HMDB00030
FooDB: FDB014510
YMDB (Yeast Metabolome Database): YMDB00282
Export Tariff Code: 2936.29.5030
Household Products: Search
MedlinePlusSupp: View
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
None Found
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 biological additives 
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 apple plant
Search Trop  Picture
 avocado fruit
Search Trop  Picture
 banana fruit
Search Trop  Picture
 barley seed
Search Trop  Picture
 bean black bean root
Search Trop  Picture
 bean fava bean seed
Search Trop  Picture
 bean field bean root
Search Trop  Picture
 cacao sprout
Search Trop  Picture
 cauliflower
Search Trop  Picture
 corn cob
Search Trop  Picture
 cotton seed
Search Trop  Picture
 egg
Search  PMC Picture
 elder black elder fruit
Search Trop  Picture
 fenugreek sprout
Search Trop  Picture
 garlic bulb
Search Trop  Picture
 grape fruit
Search Trop  Picture
 lentil seed
Search Trop  Picture
 mackerel
Search  PMC Picture
 oat seed
Search Trop  Picture
 pea seed
Search Trop  Picture
 peanut seed
Search Trop  Picture
 salmon
Search  PMC Picture
 sardine
Search  PMC Picture
 sesame seed
Search Trop  Picture
 soybean seed
Search Trop  Picture
 tomato fruit
Search Trop  Picture
 walnut english walnut nut
Search Trop  Picture
 watercress plant
Search Trop  Picture
 wheat seed
Search Trop  Picture
 yeast
Search  PMC Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
 biodermatin
(+)-biotin
D-biotin
D-(+)-biotin
delta-biotin
D-biotin (pure and feed grade)
 biotin (vitamin H) USP30
 biotin 1%
ZMC D-biotin 1% on maltodextrin
 biotin 1% trituration
 biotin 1% Vitamin H 1%
 biotin 10% (on mannitol)
ZMC D-biotin 100% USP
 biotin 2%
D-biotin FCC (vitamin H)
 biotin Pure
 biotin USP
D-biotin USP (vitamin H)
 biotin USP vitamin H 97%-100.5%
 biotine
 biotine (Vitamin H)
5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid
 hexahydro-2-oxo-[3as-(3a,4β,6a)]-1H-Thieno[3,4-d]imidazole-4-pentanoic acid
 hexahydro-2-oxo-[3aS-(3aa,4b,6aa)]-1H-Thieno[3,4-d]imidazole-4-pentanoic acid
cis-hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid
(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-valeric acid
5-[(3aR,6S,6aS)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-6-yl]pentanoic acid
 injacom H
 lutavit H2
 rovimix H2
cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid
1H-thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS,4S,6aR)-
 vitamin B7
 vitamin H
Synonyms   Articles   Notes   Search   Top
Synonyms   Articles   Notes   Search   Top
Please share your Comments.
Email Address:
 
 
 
 
Top of Page Home
Copyright © 1980-2018 The Good Scents Company (tgsc) ™ Disclaimer Privacy Policy