allantoin
urea, N-(2,5-dioxo-4-imidazolidinyl)-
 
Notes:
a urea hydantoin that is found in urine and plants and is used in dermatological preparations. Allantoin is a chemical compound with formula C4H6N4O3. It is also called 5-ureidohydantoin or glyoxyldiureide. It is a diureide of glyoxylic acid. Named after the allantois, an amniote embryonic excretory organ in which it concentrates during development in most mammals except humans and higher apes, it is a product of oxidation of uric acid by purine catabolism. After birth, it is the predominant means by which nitrogenous waste is excreted in the urine of these animals. In humans and higher apes, the metabolic pathway for conversion of uric acid to allantoin is not present, so the former is excreted. Recombinant rasburicase is sometimes used as a drug to catalyze this metabolic conversion in patients. In fish, allantoin is broken down further (into ammonia) before excretion. Allantoin is a major metabolic intermediate in many other organisms including plants and bacteria.; Its chemical formula is C4H6N4O3. It is also called 5-ureidohydantoin, glyoxyldiureide, and 5-ureidohydantoin. It is a product of oxidation of uric acid. It is a diureide of glyoxylic acid. It is a product of purine metabolism in most mammals except higher apes, and it is present in their urine. Allantoin is a botanical extract of the comfrey plant and is used for its healing, soothing, and anti-irritating properties. Allantoin helps to heal wounds and skin irritations and stimulate growth of healthy tissue. This extract can be found in anti-acne products, sun care products, and clarifying lotions because of its ability to help heal minor wounds and promote healthy skin.
  • Charkit Chemical
    • Charkit Chemical Corporation
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      Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.
      Since 1982, Charkit has been committed to expanding the markets we serve and our roster of products and services continues to grow with us. Personal care ingredients now include a substantial array of luxury and exotic components. Substantial inroads have been made in the nutraceutical and resins markets, with a growing roster of versatile and unique ingredients. And we continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions.
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      ALLANTOIN MEETS USP FOR COSMETIC USE
      ALLANTOIN USP
       
  • ECSA Chemicals
    • ECSA Chemicals
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      ECSA Group offers its customers in these business segments a complete 'one-stop shopping' solution.
      A hundred years on from its establishment, the Emanuele Centonze Holding SA has developed a solid presence in Switzerland and in Europe. The Group currently includes: ECSA Chemicals AG/ECSA Italia SRL Societ con Unico Socio – ECSA Maintenance AG – ECSA Energy SA – Porta Ticino Easy Stop SA. The Group operates in the distribution of chemical and petroleum products, in the international trading of commodities, and in the distribution of maintenance systems. With 285 employees, a consolidated turnover of 335 million Swiss Francs in 2015, and more than 15,000 active customers, the Group ranks among the top 500 companies in Switzerland. ECSA operates in Switzerland and the EU, and in particular has consolidated its geographical position on the main axis linking northern and southern Europe, thus creating a competitive and privileged logistical hub.
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      Allantoin
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
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      Product(s):
      01-15600 ALLANTOIN POWDER
      01-15605 ALLANTOIN POWDER USP
       
Synonyms   Articles   Notes   Search
(2,5-dioxoimidazolidin-4-yl)urea (Click)
CAS Number: 97-59-6Picture of molecule
Other: 37305-69-4
ECHA EINECS - REACH Pre-Reg: 202-592-8
FDA UNII: 344S277G0Z
Nikkaji Web: J3.978K
Beilstein Number: 102364
MDL: MFCD00005260
XlogP3-AA: -2.20 (est)
Molecular Weight: 158.11742000
Formula: C4 H6 N4 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 239.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -1.523 (est)
Soluble in:
 water, 5260 mg/L @ 25 °C (exp)
 water, 1e+006 mg/L @ 25 °C (est)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
skin protecting agents
soothing agents
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Suppliers:
Allan Chemical
Allantoin
American International Chemical
ALLANTOIN USP
Camden-Grey Essential Oils
Allantoin powder
Odor: characteristic
Use: Allantoin is used in cosmetic applications such as shaving creams, shampoos, lipsticks, suntan products, hair gels, body powder, lotions and creams. Usage recommended rate is from .5% to 2%. Make your emulsion, then add Allantoin during the cooling process (the emulsion should be below 90 deg. F). To completely mix and disperse Allantoin, very good mixing is a must.
Charkit Chemical
ALLANTOIN MEETS USP FOR COSMETIC USE
Charkit Chemical
ALLANTOIN USP
Connect Chemicals
Allantoin
Odor: characteristic
Use: ALLANTOIN is used as an active ingredient in a lot of cosmetics with several beneficial effects including: a moisturizing and keratolytic effect, increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of dead skin cells, increasing the smoothness of the skin; promoting cell proliferation and wound healing; and a soothing, anti-irritant, and skin protectant effect by forming complexes with irritant and sensitizing agents. ALLANTOIN is frequently present in toothpaste, mouthwash, and other oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions, various cosmetic lotions and creams, and other cosmetic and pharmaceutical products.
ECSA Chemicals
Allantoin
Company Profile
Kraft Chemical
Allantoin
Liberty Natural Products
ALLANTOIN USP CHINA
Nanjing Jiancheng Chemical
Allantoin
Odor: characteristic
Use: Allantoin is widely used as antiseptic for its bactericidal effect. It can constrain the bacterium, yeast, mould, gram-positive bacterium and gram-negative bacterium. Allantoin can be applied in cream, dew liquid, shampoo, hair conditioner, eye cosmetics, liquid cosmetics and other cosmetics.
Norman, Fox & Co.
ALLANTOIN
Penta International
ALLANTOIN POWDER USP
Penta International
ALLANTOIN POWDER
Sigma-Aldrich
For experimental / research use only.
Allantoin ≥98.0% (N)
TRI-K Industries
Allantoin
Odor: characteristic
Use: An exceptional healing, soothing and moisturizing agent, Allantoin enhances the efficacy and appeal of dermatological and cosmetic formulations, leaving skin soft and supple.
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for allantoin usage levels up to:
 not for fragrance use.
 
Recommendation for allantoin flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
Env. Mutagen Info. Center: Search
EPA Substance Registry Services (TSCA): 97-59-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 204
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 (2,5-dioxoimidazolidin-4-yl)urea
Chemidplus: 0000097596
RTECS: YT1600000 for cas# 97-59-6
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References:
 (2,5-dioxoimidazolidin-4-yl)urea
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 97-59-6
Pubchem (cid): 204
Pubchem (sid): 134970637
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
Metabolomics Database: Search
KEGG (GenomeNet): C01551
HMDB (The Human Metabolome Database): HMDB00462
FooDB: FDB001613
YMDB (Yeast Metabolome Database): YMDB00213
Export Tariff Code: 2933.21.0000
Haz-Map: View
Household Products: Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Formulations/Preparations:
mederma, a topical skin gel produced by merz pharmaceuticals, llc, 4215 tudor lane greensboro, nc 27410, contains water (purified), peg-4, allium cepa (onion) bulb extraxt, xanthan gum, allantoin, fragrance, methylparaben and sorbic acid.
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 oral care agents 
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Occurrence (nature, food, other): note
 beet root
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 black gram seed
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 borage embryo
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 borage leaf
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 borage rhizome
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 borage root
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 borage seed
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 borage sprout
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 butternut seed
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 cherry sour cherry stem
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 coffee leaf
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 comfrey
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 corn embryo
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 corn seed
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 lupine white lupine sprout
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 pea shoot
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 potato plant
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 rice seed
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 shea tree seed
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 soybean leaf
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 soybean seed
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 soybean shoot
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 tea plant
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 watermelon seed
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 wheat embryo
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Synonyms:
(±)-allantoin
DL-allantoin
 allantoin powder
 allantoin powder USP
 allantoin USP
 brookosome A
 cordianin
 cutemol emollient
2,5-dioxo-4-imidazolidinyl-urea
(2,5-dioxo-4-imidazolidinyl)-urea
(2,5-dioxo-4-imidazolidinyl)urea
1-(2,5-dioxo-4-imidazolidinyl)urea
N-(2,5-dioxo-4-imidazolidinyl)urea
(2,5-dioxo-imidazolidin-4-yl)-urea
(2,5-dioxoimidazolidin-4-yl)urea
1-(2,5-dioxoimidazolidin-4-yl)urea
 fancol TOIN
 glyoxyldiureid
 glyoxylic diureide
 hemocane
4H-imidazole-2,5-diol, 4-[(hydroxyiminomethyl)amino]-
 paxyl
 psoralon
 sebical
 septalan
 uniderm A
 urea, (2,5-dioxo-4-imidazolidinyl)-
 urea, N-(2,5-dioxo-4-imidazolidinyl)-
5-ureidohydantoin
5-ureidohydrantoin
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents.
PubMed: Antihypertensive action of allantoin in animals.
PubMed: Effects of allantoin on cognitive function and hippocampal neurogenesis.
PubMed: Biological system responses to zearalenone mycotoxin exposure by integrated metabolomic studies.
PubMed: Rapid detection of economic adulterants in fresh milk by liquid chromatography-tandem mass spectrometry.
PubMed: Diet-induced hyperinsulinemia differentially affects glucose and protein metabolism: a high-throughput metabolomic approach in rats.
PubMed: Nanoparticulate silver increases uric acid and allantoin excretion in rats, as identified by metabolomics.
PubMed: Pegloticase: a novel agent for treatment-refractory gout.
PubMed: Distribution and function of allantoin (5-ureidohydantoin) in rice grains.
PubMed: Effect of Dioscorea opposita Thunb. (yam) supplementation on physicochemical and sensory characteristics of yogurt.
PubMed: Decrease of plasma glucose by allantoin, an active principle of yam ( Dioscorea spp.), in streptozotocin-induced diabetic rats.
PubMed: Toxicometabolomics approach to urinary biomarkers for mercuric chloride (HgCl₂)-induced nephrotoxicity using proton nuclear magnetic resonance (¹H NMR) in rats.
PubMed: Intake, digestibility and rumen dynamics of neutral detergent fibre in cattle fed low-quality tropical forage and supplemented with nitrogen and/or starch.
PubMed: Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats.
PubMed: Improved high-performance liquid chromatography (HPLC) method for qualitative and quantitative analysis of allantoin in Zea mays.
PubMed: Uric acid recycling in the shield bug, Parastrachia japonensis (Hemiptera: Parastrachiidae), during diapause.
PubMed: Urinary excretion of purine derivatives as an index of microbial protein synthesis in the camel (Camelus dromedarius).
PubMed: Suppressive effect of viscous dietary fiber on elevations of uric acid in serum and urine induced by dietary RNA in rats is associated with strength of viscosity.
PubMed: Rasburicase: potential role in managing tumor lysis in patients with hematological malignancies.
PubMed: Aspects of excretion of antlion larvae (Neuroptera: myrmeleontidae) during feeding and non-feeding periods.
PubMed: Major constituents, leptin, and non-protein nitrogen compounds in mares' colostrum and milk.
PubMed: Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells.
PubMed: High versus low protein diets to mink--postprandial plasma urea and creatinine response, osmotic load and pattern of nitrogen and electrolyte excretion.
PubMed: Effectiveness of a nonrinse, alcohol-free antiseptic hand wash.
PubMed: Identification of allantoin, uric acid, and indoxyl sulfate as biochemical indicators of filth in food packaging by LC.
PubMed: Effects of corn particle size and source on performance of lactating cows fed direct-cut grass-legume forage.
PubMed: A modified HET-CAM assay approach to the assessment of anti-irritant properties of plant extracts.
PubMed: Intraruminal supplementation with increasing levels of exogenous polysaccharide-degrading enzymes: effects on nutrient digestion in cattle fed a barley grain diet.
PubMed: Biosynthesis and catabolism of caffeine in low-caffeine-containing species of Coffea.
PubMed: Xanthine degradation and related enzyme activities in leaves and fruits of two coffea species differing in caffeine catabolism.
PubMed: Synergistic operation of the CAR2 (Ornithine transaminase) promoter elements in Saccharomyces cerevisiae.
PubMed: Effect of dietary or abomasal supplementation of exogenous polysaccharide-degrading enzymes on rumen fermentation and nutrient digestibility.
PubMed: Food intake, nutrient utilization and water turnover in the lesser mouse-deer (Tragulus javanicus) given lundai (Sapium baccatum).
PubMed: Compositional and toxicological evaluation of the diazotrophic cyanobacterium, Cyanothece sp. strain ATCC 51142.
PubMed: Winter evaluation of a postmilking powdered teat dip.
PubMed: [Purine and pyrimidine metabolites for the estimation of rumen metabolism: HPLC analysis in milk and blood plasma].
PubMed: [The effect of aldioxa on the formation of gastritis induced with sodium hydroxide].
PubMed: Uricogenic potential of selected cooked foods in rats.
PubMed: Improved reagent for detection of allantoin in thin-layer chromatographic method for urine stains on foods and packaging.
PubMed: Effects of intraruminal sodium chloride infusion on rumen and renal nitrogen and electrolyte dynamics in sheep.
PubMed: [Allantoin excretion of wethers in variations of raw protein and energy administration].
PubMed: Induction of tumours in rats by feeding nitrosatable amines together with sodium nitrite.
PubMed: Extraction and thin layer chromatographic confirmation of urine residues: new plate development.
PubMed: Food additives.
PubMed: Nitrogen retention in rats fed on diets enriched with arginine and glycine. 1. Improved N retention after trauma.
PubMed: Utilization of dried microbial cells grown on methanol in a semi-purified diet for growing pigs.
PubMed: Long-term feeding study on disodium 5-ribonucleotide in dogs.
PubMed: Extraction and thin layer chromatographic confirmation of urine residues from food packaging materials.
PubMed: Thin layer chromatographic test for mammalian urine on wheat.
PubMed: Observations on the regulation of uricase activity during development of Drosophila melanogaster.
PubMed: Decomposition of nucleic acids and some of their degradation products by microorganisms.
PubMed: PROTEINURIA IN NEW-BORN CALVES FOLLOWING THE FEEDING OF COLOSTRUM.
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