EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

urea, N-(2,5-dioxo-4-imidazolidinyl)-

Supplier Sponsors

CAS Number: 97-59-6Picture of molecule3D/inchi
Other(deleted CASRN):37305-69-4
ECHA EINECS - REACH Pre-Reg:202-592-8
FDA UNII: 344S277G0Z
Nikkaji Web:J3.978K
Beilstein Number:102364
XlogP3-AA:-2.20 (est)
Molecular Weight:158.11742000
Formula:C4 H6 N4 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 239.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -1.523 (est)
Soluble in:
 water, 5260 mg/L @ 25 °C (exp)
 water, 1e+006 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: skin conditioning
skin protecting agents
soothing agents
Alfa Biotechnology
For experimental / research use only.
Allantoin 98%
Allan Chemical
American International Chemical, LLC.
BOC Sciences
For experimental / research use only.
Camden-Grey Essential Oils
Allantoin powder
Odor: characteristic
Use: Allantoin is used in cosmetic applications such as shaving creams, shampoos, lipsticks, suntan products, hair gels, body powder, lotions and creams. Usage recommended rate is from .5% to 2%. Make your emulsion, then add Allantoin during the cooling process (the emulsion should be below 90 deg. F). To completely mix and disperse Allantoin, very good mixing is a must.
Charkit Chemical
Charkit Chemical
Connect Chemicals
Odor: characteristic
Use: ALLANTOIN is used as an active ingredient in a lot of cosmetics with several beneficial effects including: a moisturizing and keratolytic effect, increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of dead skin cells, increasing the smoothness of the skin; promoting cell proliferation and wound healing; and a soothing, anti-irritant, and skin protectant effect by forming complexes with irritant and sensitizing agents. ALLANTOIN is frequently present in toothpaste, mouthwash, and other oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions, various cosmetic lotions and creams, and other cosmetic and pharmaceutical products.
ECSA Chemicals
Glentham Life Sciences
Kraft Chemical
Nanjing Jiancheng Chemical
Odor: characteristic
Use: Allantoin is widely used as antiseptic for its bactericidal effect. It can constrain the bacterium, yeast, mould, gram-positive bacterium and gram-negative bacterium. Allantoin can be applied in cream, dew liquid, shampoo, hair conditioner, eye cosmetics, liquid cosmetics and other cosmetics.
Norman, Fox & Co.
Penta International
Penta International
For experimental / research use only.
Allantoin ≥98.0% (N)
TRI-K Industries
Odor: characteristic
Use: An exceptional healing, soothing and moisturizing agent, Allantoin enhances the efficacy and appeal of dermatological and cosmetic formulations, leaving skin soft and supple.
Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
cosmetic agents
Recommendation for allantoin usage levels up to:
 not for fragrance use.
Recommendation for allantoin flavor usage levels up to:
 not for flavor use.
Safety References:
EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA Substance Registry Services (TSCA):97-59-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :204
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
RTECS:YT1600000 for cas# 97-59-6
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:97-59-6
Pubchem (cid):204
Pubchem (sid):134970637
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C01551
HMDB (The Human Metabolome Database):HMDB00462
YMDB (Yeast Metabolome Database):YMDB00213
Export Tariff Code:2933.21.0000
VCF-Online:VCF Volatile Compounds in Food
mederma, a topical skin gel produced by merz pharmaceuticals, llc, 4215 tudor lane greensboro, nc 27410, contains water (purified), peg-4, allium cepa (onion) bulb extraxt, xanthan gum, allantoin, fragrance, methylparaben and sorbic acid.
Potential Blenders and core components note
None Found
Potential Uses:
 oral care agents
Occurrence (nature, food, other):note
 beet root
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 borage embryo
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 borage leaf
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 borage rhizome
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 borage root
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 borage seed
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 borage sprout
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 cherry sour cherry stem
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 coffee leaf
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 corn embryo
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 lupine white lupine sprout
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 pea shoot
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 potato plant
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 rice seed
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 shea tree seed
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 soybean leaf
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 soybean seed
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 soybean shoot
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 tea plant
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 watermelon seed
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 wheat embryo
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 allantoin powder
 allantoin powder USP
 allantoin USP
 brookosome A
 cutemol emollient
 fancol TOIN
 glyoxylic diureide
4H-imidazole-2,5-diol, 4-[(hydroxyiminomethyl)amino]-
 uniderm A
 urea, (2,5-dioxo-4-imidazolidinyl)-
 urea, N-(2,5-dioxo-4-imidazolidinyl)-


PubMed:Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents.
PubMed:Antihypertensive action of allantoin in animals.
PubMed:Effects of allantoin on cognitive function and hippocampal neurogenesis.
PubMed:Biological system responses to zearalenone mycotoxin exposure by integrated metabolomic studies.
PubMed:Rapid detection of economic adulterants in fresh milk by liquid chromatography-tandem mass spectrometry.
PubMed:Diet-induced hyperinsulinemia differentially affects glucose and protein metabolism: a high-throughput metabolomic approach in rats.
PubMed:Nanoparticulate silver increases uric acid and allantoin excretion in rats, as identified by metabolomics.
PubMed:Pegloticase: a novel agent for treatment-refractory gout.
PubMed:Distribution and function of allantoin (5-ureidohydantoin) in rice grains.
PubMed:Effect of Dioscorea opposita Thunb. (yam) supplementation on physicochemical and sensory characteristics of yogurt.
PubMed:Decrease of plasma glucose by allantoin, an active principle of yam ( Dioscorea spp.), in streptozotocin-induced diabetic rats.
PubMed:Toxicometabolomics approach to urinary biomarkers for mercuric chloride (HgCl₂)-induced nephrotoxicity using proton nuclear magnetic resonance (¹H NMR) in rats.
PubMed:Intake, digestibility and rumen dynamics of neutral detergent fibre in cattle fed low-quality tropical forage and supplemented with nitrogen and/or starch.
PubMed:Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats.
PubMed:Improved high-performance liquid chromatography (HPLC) method for qualitative and quantitative analysis of allantoin in Zea mays.
PubMed:Uric acid recycling in the shield bug, Parastrachia japonensis (Hemiptera: Parastrachiidae), during diapause.
PubMed:Urinary excretion of purine derivatives as an index of microbial protein synthesis in the camel (Camelus dromedarius).
PubMed:Suppressive effect of viscous dietary fiber on elevations of uric acid in serum and urine induced by dietary RNA in rats is associated with strength of viscosity.
PubMed:Rasburicase: potential role in managing tumor lysis in patients with hematological malignancies.
PubMed:Aspects of excretion of antlion larvae (Neuroptera: myrmeleontidae) during feeding and non-feeding periods.
PubMed:Major constituents, leptin, and non-protein nitrogen compounds in mares' colostrum and milk.
PubMed:Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells.
PubMed:High versus low protein diets to mink--postprandial plasma urea and creatinine response, osmotic load and pattern of nitrogen and electrolyte excretion.
PubMed:Effectiveness of a nonrinse, alcohol-free antiseptic hand wash.
PubMed:Identification of allantoin, uric acid, and indoxyl sulfate as biochemical indicators of filth in food packaging by LC.
PubMed:Effects of corn particle size and source on performance of lactating cows fed direct-cut grass-legume forage.
PubMed:A modified HET-CAM assay approach to the assessment of anti-irritant properties of plant extracts.
PubMed:Intraruminal supplementation with increasing levels of exogenous polysaccharide-degrading enzymes: effects on nutrient digestion in cattle fed a barley grain diet.
PubMed:Biosynthesis and catabolism of caffeine in low-caffeine-containing species of Coffea.
PubMed:Xanthine degradation and related enzyme activities in leaves and fruits of two coffea species differing in caffeine catabolism.
PubMed:Synergistic operation of the CAR2 (Ornithine transaminase) promoter elements in Saccharomyces cerevisiae.
PubMed:Effect of dietary or abomasal supplementation of exogenous polysaccharide-degrading enzymes on rumen fermentation and nutrient digestibility.
PubMed:Food intake, nutrient utilization and water turnover in the lesser mouse-deer (Tragulus javanicus) given lundai (Sapium baccatum).
PubMed:Compositional and toxicological evaluation of the diazotrophic cyanobacterium, Cyanothece sp. strain ATCC 51142.
PubMed:Winter evaluation of a postmilking powdered teat dip.
PubMed:[Purine and pyrimidine metabolites for the estimation of rumen metabolism: HPLC analysis in milk and blood plasma].
PubMed:[The effect of aldioxa on the formation of gastritis induced with sodium hydroxide].
PubMed:Uricogenic potential of selected cooked foods in rats.
PubMed:Improved reagent for detection of allantoin in thin-layer chromatographic method for urine stains on foods and packaging.
PubMed:Effects of intraruminal sodium chloride infusion on rumen and renal nitrogen and electrolyte dynamics in sheep.
PubMed:[Allantoin excretion of wethers in variations of raw protein and energy administration].
PubMed:Induction of tumours in rats by feeding nitrosatable amines together with sodium nitrite.
PubMed:Extraction and thin layer chromatographic confirmation of urine residues: new plate development.
PubMed:Food additives.
PubMed:Nitrogen retention in rats fed on diets enriched with arginine and glycine. 1. Improved N retention after trauma.
PubMed:Utilization of dried microbial cells grown on methanol in a semi-purified diet for growing pigs.
PubMed:Long-term feeding study on disodium 5-ribonucleotide in dogs.
PubMed:Extraction and thin layer chromatographic confirmation of urine residues from food packaging materials.
PubMed:Thin layer chromatographic test for mammalian urine on wheat.
PubMed:Observations on the regulation of uricase activity during development of Drosophila melanogaster.
PubMed:Decomposition of nucleic acids and some of their degradation products by microorganisms.
a urea hydantoin that is found in urine and plants and is used in dermatological preparations. Allantoin is a chemical compound with formula C4H6N4O3. It is also called 5-ureidohydantoin or glyoxyldiureide. It is a diureide of glyoxylic acid. Named after the allantois, an amniote embryonic excretory organ in which it concentrates during development in most mammals except humans and higher apes, it is a product of oxidation of uric acid by purine catabolism. After birth, it is the predominant means by which nitrogenous waste is excreted in the urine of these animals. In humans and higher apes, the metabolic pathway for conversion of uric acid to allantoin is not present, so the former is excreted. Recombinant rasburicase is sometimes used as a drug to catalyze this metabolic conversion in patients. In fish, allantoin is broken down further (into ammonia) before excretion. Allantoin is a major metabolic intermediate in many other organisms including plants and bacteria.; Its chemical formula is C4H6N4O3. It is also called 5-ureidohydantoin, glyoxyldiureide, and 5-ureidohydantoin. It is a product of oxidation of uric acid. It is a diureide of glyoxylic acid. It is a product of purine metabolism in most mammals except higher apes, and it is present in their urine. Allantoin is a botanical extract of the comfrey plant and is used for its healing, soothing, and anti-irritating properties. Allantoin helps to heal wounds and skin irritations and stimulate growth of healthy tissue. This extract can be found in anti-acne products, sun care products, and clarifying lotions because of its ability to help heal minor wounds and promote healthy skin.
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