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Category:natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 540.64 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 403.00 °F. TCC ( 206.20 °C. ) (est)
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| logP (o/w): | 2.300 (est) |
| Soluble in: |
| | water, 166.3 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | natural substances and extractives |
| Recommendation for phyllodulcin usage levels up to: | | | not for fragrance use.
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| Recommendation for phyllodulcin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydroisochromen-1-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 164615 |
| Pubchem (sid): | 135120754 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 3,4- | dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl) 1H-2-benzopyran-1-one | | 3,4- | dihydro-8-hydroxy-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one | | 8- | hydroxy-3-(3-hydroxy-4-methoxyphenyl)-3,4-dihydroisochromen-1-one | | (±)- | phyllodulcin |
Articles:
| PubMed:[New facts about the molecular background of isovanilline-type sweeteners]. |
| PubMed:Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals. |
| PubMed:New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). |
| PubMed:Inhibitory effects of thunberginols A, B, and F on degranulations and releases of TNF-alpha and IL-4 in RBL-2H3 cells. |
| PubMed:Metabolic fate of orally administered phyllodulcin in rats. |
| PubMed:Phyllodulcin, a constituent of "Amacha", inhibits phosphodiesterase in bovine adrenocortical cells. |
| PubMed:Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats. |
| PubMed:Structure-requirements of isocoumarins, phthalides, and stilbenes from Hydrangeae Dulcis Folium for inhibitory activity on histamine release from rat peritoneal mast cells. |
| PubMed:Effect of cytokinin 4PU30 on organ differentiation and dihydroisocoumarin production in amacha callus cultures. |
| PubMed:Development of bioactive functions in Hydrangeae dulcis folium. VI. Syntheses of thunberginols A and F and their 3'-deoxy-derivatives using regiospecific lactonization of stilbene carboxylic acid: structures and inhibitory activity on histamine release of hydramacrophyllols A and B. |
| PubMed:Structure-taste correlations in sweet dihydrochalcone, sweet dihydroisocoumarin, and bitter flavone compounds. |
| PubMed:Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. |
| PubMed:Development of bioactive functions in hydrangeae dulcis folium. III. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (1). Thunberginols A, B, and F. |
| PubMed:[Development of bioactive functions in hydrangeae dulcis folium. II. Antiulcer, antiallergy, and cholagoic effects of the extract from hydrangeae dulcis folium]. |
| PubMed:[Quantitative analysis of dihydroisocoumarin constituents of Hydrangeae Dulcis Folium by means of high performance liquid chromatography. Chemical characterization of the processing, distribution in plant, and seasonal fluctuation]. |
| PubMed:Thunberginols A, B, and F, new antiallergic and antimicrobial principles from hydrangeae dulcis folium. |
| PubMed:[Study on the development of biological-active compounds after the model of natural products]. |
| PubMed:Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced induction in Epstein-Barr virus early antigen in Raji cells. |
| PubMed:Antifungal activity of oosponol, oospolactone, phyllodulcin, hydrangenol, and some other related compounds. |
| PubMed:[High-speed liquid chromatographic analysis of drugs. IV. Speration analysis of phyllodulcin and hydrangenol in sweet hydrangea (author's transl)]. |
| PubMed:[The quantitative analysis of phyllodulcin in "Amacha" (sweet hydrangea) by means of thin-layer chromatography (author's transl)]. |
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3D/inchi