EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

laevo-selenomethionine
butanoic acid, 2-amino-4-(methylseleno)-, (2S)-

Supplier Sponsors

CAS Number: 3211-76-5Picture of molecule3D/inchi
FDA UNII: 964MRK2PEL
Nikkaji Web:J114.178C
MDL:MFCD00037210
Molecular Weight:196.10807000
Formula:C5 H11 N O2 Se
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
FR DOC # 2012-1692 Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental Study of Consumer Response to Health Claims and Disclaimers About the Relationship Between Selenium and Risk of Various Cancers View - notice PDF
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 320.00 to 321.00 °C. @ 760.00 mm Hg (est)
Flash Point: 298.00 °F. TCC ( 147.80 °C. ) (est)
logP (o/w): 0.152 (est)
Soluble in:
 water, 1.445e+005 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
AIDP
L-Selenomethionine 0.5%0.5% min.
American International Chemical, LLC.
L-Selenomethionine
BOC Sciences
For experimental / research use only.
L-Selenomethionine 95%
Odor: characteristic
Use: L-Selenomethionine is the predominant food-form of selenium with antioxidant activity. L-Selenomethionine has been shown to increase the activity of glutathione peroxidase in endothelial cells.
Glentham Life Sciences
L-(+)-Selenomethionine
Indis NV
For experimental / research use only.
L-Selenomethionine
Santa Cruz Biotechnology
For experimental / research use only.
L-Selenomethionine
Sigma-Aldrich: Sigma
For experimental / research use only.
Seleno-L-methionine ≥98% (TLC), powder
sds
TCI AMERICA
For experimental / research use only.
L-Selenomethionine >98.0%(HPLC)(T)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements
Recommendation for laevo-selenomethionine usage levels up to:
 not for fragrance use.
 
Recommendation for laevo-selenomethionine flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

L-selenomethionine as a source of selenium added for nutritional purposes to food supplements
View page or View pdf

Scientific Opinion on the safety and efficacy of L-selenomethionine as feed additive for all animal species
View page or View pdf

Assessment of the application for renewal of authorisation of selenomethionine produced by Saccharomyces cerevisiae CNCM I-3060 (selenised yeast inactivated) for all animal species
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :105024
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
(2S)-2-amino-4-methylselanylbutanoic acid
Chemidplus:0003211765
RTECS:EK7713840 for cas# 3211-76-5
 
References:
 (2S)-2-amino-4-methylselanylbutanoic acid
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):105024
Pubchem (sid):135060924
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C05335
HMDB (The Human Metabolome Database):HMDB03966
FooDB:FDB012156
Export Tariff Code:2931.90.9050
FDA Listing of Food Additive Status:View
MedlinePlusSupp:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
(S)-2-amino-4-(methyl seleno) butanoic acid
(2S)-2-amino-4-(methylselanyl)butanoic acid
(2S)-2-amino-4-(methylseleno)butanoic acid
(S)-2-amino-4-(methylseleno)butanoic acid
(S)-2-amino-4-(methylseleno)butyric acid
(2S)-2-amino-4-methylselanylbutanoic acid
 butanoic acid, 2-amino-4-(methylseleno)-, (2S)-
 butanoic acid, 2-amino-4-(methylseleno)-, (S)-
 butyric acid, 2-amino-4-(methylselenyl)-, L-
 megavite RX
 selenium-L-methionine
 selenium-laevo-methionine
 seleno-L-methionine
 seleno-laevo-methionine
L-selenomethionine
L-(+)-selenomethionine
L-selenomethionine 0.5 blend
L-selenomethionine 0.5%0.5% min.
L-selenomethioninum
 

Articles:

PubMed:Preparation and Characterization of a Laboratory Scale Selenomethionine-Enriched Bread. Selenium Bioaccessibility.
PubMed:Characterization of selenium-enriched mycelia of Catathelasma ventricosum and their antihyperglycemic and antioxidant properties.
PubMed:Preliminary crystallographic analysis of Xyn52B2, a GH52 β-D-xylosidase from Geobacillus stearothermophilus T6.
PubMed:Dietary selenomethionine influences the accumulation and depuration of dietary methylmercury in zebrafish (Danio rerio).
PubMed:Differential protein expression of Caco-2 cells treated with selenium nanoparticles compared with sodium selenite and selenomethionine.
PubMed:Effective selenium detoxification in the seed proteins of a hyperaccumulator plant: the analysis of selenium-containing proteins of monkeypot nut (Lecythis minor) seeds.
PubMed:Selenium-enriched foods are more effective at increasing glutathione peroxidase (GPx) activity compared with selenomethionine: a meta-analysis.
PubMed:Cloning, purification and preliminary crystallographic analysis of Ara127N, a GH127 β-L-arabinofuranosidase from Geobacillus stearothermophilus T6.
PubMed:Integrative assessment of selenium speciation, biogeochemistry, and distribution in a northern coldwater ecosystem.
PubMed:Cytoplasmic and nuclear toxicity of 3,5-dimethylaminophenol and potential protection by selenocompounds.
PubMed:Dietary selenomethionine exposure alters swimming performance, metabolic capacity and energy homeostasis in juvenile fathead minnow.
PubMed:Hepatic metabolite profiles in mice with a suboptimal selenium status.
PubMed:Preconcentration of seleno-amino acids on a XAD resin and determination in regional olive oils by SPE UPLC-ESI-MS/MS.
PubMed:In ovo exposure to selenomethionine via maternal transfer increases developmental toxicities and impairs swim performance in F1 generation zebrafish (Danio rerio).
PubMed:Effect of selenate on viability and selenomethionine accumulation of Chlorella sorokiniana grown in batch culture.
PubMed:Glyphosate, pathways to modern diseases II: Celiac sprue and gluten intolerance.
PubMed:A unique octameric structure of Axe2, an intracellular acetyl-xylooligosaccharide esterase from Geobacillus stearothermophilus.
PubMed:Fish toxicity testing with selenomethionine spiked feed--what's the real question being asked?
PubMed:Effect of selenomethionine supplementation in food on the excretion and toxicity of arsenic exposure in female mice.
PubMed:Agronomic selenium biofortification in Triticum durum under Mediterranean conditions: from grain to cooked pasta.
PubMed:The relationship of selenium tolerance and speciation in Lecythidaceae species.
PubMed:Evaluation of selenium species in selenium-enriched pakchoi (Brassica chinensis Jusl var parachinensis (Bailey) Tsen & Lee) using mixed ion-pair reversed phase HPLC-ICP-MS.
PubMed:Nonchromatographic speciation of selenium in edible oils using dispersive liquid-liquid microextraction and electrothermal atomic absorption spectrometry.
PubMed:An in situ assessment of selenium bioaccumulation from water-, sediment-, and dietary-exposure pathways using caged Chironomus dilutus larvae.
PubMed:Study of selenocompounds from selenium-enriched culture of edible sprouts.
PubMed:Chemical characterisation and speciation of organic selenium in cultivated selenium-enriched Agaricus bisporus.
PubMed:Selenium accumulation and speciation in biofortified chickpea (Cicer arietinum L.) under Mediterranean conditions.
PubMed:Generation of selenium-enriched rice with enhanced grain yield, selenium content and bioavailability through fertilisation with selenite.
PubMed:Molecular mechanisms involved in the protective effect of selenocystine against methylmercury-induced cell death in human HepG2 cells.
PubMed:In situ speciation and distribution of toxic selenium in hydrated roots of cowpea.
PubMed:SCO4008, a putative TetR transcriptional repressor from Streptomyces coelicolor A3(2), regulates transcription of sco4007 by multidrug recognition.
PubMed:Selenium biotransformations in an engineered aquatic ecosystem for bioremediation of agricultural wastewater via brine shrimp production.
PubMed:Selenium bioaccessibility and speciation in biofortified Pleurotus mushrooms grown on selenium-rich agricultural residues.
PubMed:In vitro bioavailability of total selenium and selenium species from seafood.
PubMed:Selenomethionine protects against neuronal degeneration by methylmercury in the developing rat cerebrum.
PubMed:Organoselenium compounds modulate extracellular redox by induction of extracellular cysteine and cell surface thioredoxin reductase.
PubMed:Dietary selenomethionine exposure induces physical malformations and decreases growth and survival to metamorphosis in an amphibian (Hyla chrysoscelis).
PubMed:Composition and distribution of the main active components in selenium-enriched fruit bodies of Cordyceps militaris link.
PubMed:Selenium and zinc internalized by Lactobacillus buchneri Lb26 (DSM 16341) and Bifidobacterium lactis Bb1 (DSM 17850): improved bioavailability using a new biological approach.
PubMed:Selenate-enriched urea granules are a highly effective fertilizer for selenium biofortification of paddy rice grain.
PubMed:Selenium speciation and localization in chironomids from lakes receiving treated metal mine effluent.
PubMed:Selenium toxicity to honey bee (Apis mellifera L.) pollinators: effects on behaviors and survival.
PubMed:Forms of selenium affect its transport, uptake and glutathione peroxidase activity in the Caco-2 cell model.
PubMed:Selenium status in adult cats and dogs fed high levels of dietary inorganic and organic selenium.
PubMed:Selenoglucosinolates and their metabolites produced in Brassica spp. fertilised with sodium selenate.
PubMed:Effects of sodium selenite and germination on the sprouting of chickpeas (Cicer arietinum L.) and its content of selenium, formononetin and biochanin A in the sprouts.
PubMed:Attenuation of the cortisol response to stress in female rainbow trout chronically exposed to dietary selenomethionine.
PubMed:Method development and optimization for the determination of selenium in bean and soil samples using hydride generation electrothermal atomic absorption spectrometry.
PubMed:Chronic exposure to dietary selenomethionine increases gonadal steroidogenesis in female rainbow trout.
PubMed:Evaluating the trophic transfer of selenium in aquatic ecosystems using caged fish, X-ray absorption spectroscopy and stable isotope analysis.
PubMed:Selenium concentration and speciation in biofortified flour and bread: Retention of selenium during grain biofortification, processing and production of Se-enriched food.
PubMed:[Determination of selenium species in food by high performance liquid chromatography with inductively coupled plasma mass spectrometry].
PubMed:The suppression of prostate LNCaP cancer cells growth by Selenium nanoparticles through Akt/Mdm2/AR controlled apoptosis.
PubMed:A novel cystine based antioxidant attenuates oxidative stress and hepatic steatosis in diet-induced obese mice.
PubMed:Selenium bioavailability from naturally produced high-selenium peas and oats in selenium-deficient rats.
PubMed:Quantitative determination of small selenium species in human serum by HPLC/ICPMS following a protein-removal, pre-concentration procedure.
PubMed:Induction of ROS, p53, p21 in DEHP- and MEHP-exposed LNCaP cells-protection by selenium compounds.
PubMed:Speciation analysis of selenium in rice samples by using capillary electrophoresis-inductively coupled plasma mass spectrometry.
PubMed:Evaluation of genotypic variation of broccoli (Brassica oleracea var. italic) in response to selenium treatment.
PubMed:Dietary selenomethionine exposure in adult zebrafish alters swimming performance, energetics and the physiological stress response.
PubMed:Selenium accumulation, distribution, and speciation in spineless prickly pear cactus: a drought- and salt-tolerant, selenium-enriched nutraceutical fruit crop for biofortified foods.
PubMed:Selenium speciation in soil and rice: influence of water management and Se fertilization.
PubMed:Selenium accumulation in coturnix quail fed seleno-L-methionine.
PubMed:Distribution and in vitro availability of selenium in selenium-containing storage protein from selenium-enriched rice utilizing optimized extraction.
PubMed:Effects of vitamin E and organic selenium on oxidative stability of omega-3 enriched dark chicken meat during cooking.
PubMed:Dietary supplementation of selenium in inorganic and organic forms differentially and commonly alters blood and liver selenium concentrations and liver gene expression profiles of growing beef heifers.
PubMed:Selenium bioavailability: current knowledge and future research requirements.
PubMed:Selenomethionine and alpha-tocopherol do not inhibit prostate carcinogenesis in the testosterone plus estradiol-treated NBL rat model.
PubMed:Changes in selenium speciation associated with increasing tissue concentrations of selenium in wheat grain.
PubMed:Selenium bioavailability from soy protein isolate and tofu in rats fed a torula yeast-based diet.
PubMed:Competition between selenomethionine and methionine absorption in the intestinal tract of green sturgeon (Acipenser medirostris).
PubMed:Effects of dietary selenomethionine supplementation on growth performance, meat quality and antioxidant property in yellow broilers.
PubMed:Developmental selenomethionine and methylmercury exposures affect zebrafish learning.
PubMed:Protective effects of selenomethionine against ionizing radiation under the modulation of p53 tumor suppressor.
PubMed:Enhancement of methyl methanesulfonate-induced base excision repair in the presence of selenomethionine on p53-dependent pathway.
PubMed:Biodynamics, subcellular partitioning, and ultrastructural effects of organic selenium in a freshwater bivalve.
PubMed:Simultaneous extraction of arsenic and selenium species from rice products by microwave-assisted enzymatic extraction and analysis by ion chromatography-inductively coupled plasma-mass spectrometry.
PubMed:Simultaneous determination of arsenic and selenium species in fish tissues using microwave-assisted enzymatic extraction and ion chromatography-inductively coupled plasma mass spectrometry.
PubMed:Study of the effect of sample preparation and cooking on the selenium speciation of selenized potatoes by HPLC with ICP-MS and electrospray ionization MS/MS.
PubMed:Selenium-enriched garlic and cabbage as a dietary selenium source for broilers.
PubMed:Production and characterization of fully selenomethionine-labeled Saccharomyces cerevisiae.
PubMed:Selenium supplementation of lactating dairy cows: effects on milk production and total selenium content and speciation in blood, milk and cheese.
PubMed:High potential for selenium biofortification of lentils ( Lens culinaris L.).
PubMed:Characteristics of transport of selenoamino acids by epithelial amino acid transporters.
PubMed:How to use the world's scarce selenium resources efficiently to increase the selenium concentration in food.
PubMed:Chemical forms of mercury and selenium in fish following digestion with simulated gastric fluid.
PubMed:Selenium species in selenium-enriched and drought-exposed potatoes.
PubMed:Selenium in edible mushrooms.
PubMed:Comparison of biotransformation of inorganic selenium by Lactobacillus and Saccharomyces in lactic fermentation process of yogurt and kefir.
PubMed:Mechanisms of selenium chemoprevention and therapy in prostate cancer.
PubMed:Analysis of Saccharomyces cerevisiae null allele strains identifies a larger role for DNA damage versus oxidative stress pathways in growth inhibition by selenium.
PubMed:A selenium-deficient Caco-2 cell model for assessing differential incorporation of chemical or food selenium into glutathione peroxidase.
PubMed:Brazil nuts: an effective way to improve selenium status.
PubMed:Selenium speciation and bioavailability in biofortified products using species-unspecific isotope dilution and reverse phase ion pairing-inductively coupled plasma-mass spectrometry.
PubMed:Anticlastogenic and antigenotoxic effects of selenomethionine on doxorubicin-induced damage in vitro in human lymphocytes.
PubMed:Crystal structure of glycoside hydrolase family 78 alpha-L-Rhamnosidase from Bacillus sp. GL1.
PubMed:Selenium.
PubMed:Crystallization and preliminary crystallographic analysis of an esterase with a novel domain from the hyperthermophile Thermotoga maritima.
PubMed:The effect of consumption of selenium enriched rye/wheat sourdough bread on the body's selenium status.
PubMed:Gender-dependent effects of selenite on the perfused rat heart: a toxicological study.
PubMed:Chemical form of selenium in naturally selenium-rich lentils (Lens culinaris L.) from Saskatchewan.
PubMed:Selenium transformation studies during broccoli (Brassica oleracea) growing process by liquid chromatography-inductively coupled plasma mass spectrometry (LC-ICP-MS).
PubMed:Selenomethionine biotransformation and incorporation into proteins along a simulated terrestrial food chain.
PubMed:Non-optimal levels of dietary selenomethionine alter splenocyte response and modify oxidative stress markers in female mice.
PubMed:Determination of selenium bioavailability from wheat mill fractions in rats by using the slope-ratio assay and a modified torula yeast-based diet.
PubMed:Updated estimates of the selenomethionine content of NIST wheat reference materials by GC-IDMS.
PubMed:Crystallization and preliminary crystallographic analysis of the family GH78 alpha-L-rhamnosidase RhaB from Bacillus sp. GL1.
PubMed:Uptake and speciation of selenium in garlic cultivated in soil amended with symbiotic fungi (mycorrhiza) and selenate.
PubMed:Selenium long-term administration and its effect on mercury toxicity.
PubMed:Comparative toxicosis of sodium selenite and selenomethionine in lambs.
PubMed:Selenium species bioaccessibility in enriched radish (Raphanus sativus): a potential dietary source of selenium.
PubMed:Primary hair growth in dogs depends on dietary selenium concentrations.
PubMed:Application of isotope dilution analysis for the evaluation of extraction conditions in the determination of total selenium and selenomethionine in yeast-based nutritional supplements.
PubMed:Cystathionine gamma-lyase contributes to selenomethionine detoxification and cytosolic glutathione peroxidase biosynthesis in mouse liver.
PubMed:Selenium content and distribution in cow's milk supplemented with two dietary selenium sources.
PubMed:Selenium bioavailability from buckwheat bran in rats fed a modified AIN-93G torula yeast-based diet.
PubMed:Selenium in Australia: selenium status and biofortification of wheat for better health.
PubMed:Composition of chemical species of selenium contained in selenium-enriched shiitake mushroom and vegetables determined by high performance liquid chromatography with inductively coupled plasma mass spectrometry.
PubMed:Effects of dietary selenomethionine on larval rainbow trout (Oncorhynchus mykiss).
PubMed:Changes in the chemical form of selenium observed during the manufacture of a selenium-enriched sourdough bread for use in a human nutrition study.
PubMed:Effectiveness of selenium supplements in a low-selenium area of China.
PubMed:Selenium distribution in wheat grain, and the effect of postharvest processing on wheat selenium content.
PubMed:[Studies on comparing the toxicity between sodium selenite and selenomethionine in rats].
PubMed:Quantification and speciation of mercury and selenium in fish samples of high consumption in Spain and Portugal.
PubMed:Susceptibility to hypoxia/reoxygenation of aged rat cardiomyocytes and its modulation by selenium supplementation.
PubMed:Study of the lipophilicity of selenium species.
PubMed:The use of high-selenium yeast to raise selenium status: how does it measure up?
PubMed:Interaction of selenium compounds with zinc finger proteins involved in DNA repair.
PubMed:Study of selenium distribution in the protein fractions of the Brazil nut, Bertholletia excelsa.
PubMed:Identification and synthesis of a novel selenium-sulfur amino acid found in selenized yeast: Rapid indirect detection NMR methods for characterizing low-level organoselenium compounds in complex matrices.
PubMed:Influences of different selenium species on the uptake and assimilation of Hg(II) and methylmercury by diatoms and green mussels.
PubMed:Speciation and bioavailability of selenium in yeast-based intervention agents used in cancer chemoprevention studies.
PubMed:Methioninase and selenomethionine but not Se-methylselenocysteine generate methylselenol and superoxide in an in vitro chemiluminescent assay: implications for the nutritional carcinostatic activity of selenoamino acids.
PubMed:Establishment of selenium uptake and species distribution in lupine, Indian mustard, and sunflower plants.
PubMed:Preparation of selenium-enriched sprouts and identification of their selenium species by high-performance liquid chromatography-inductively coupled plasma mass spectrometry.
PubMed:Selenomethionine contents of NIST wheat reference materials.
PubMed:The nutritional significance, metabolism and toxicology of selenomethionine.
PubMed:Absorption, distribution and excretion of selenium from beef and rice in healthy North American men.
PubMed:Purification, crystallization and preliminary crystallographic analysis of phosphoglucose isomerase from the hyperthermophilic archaeon Pyrococcus furiosus.
PubMed:Speciation of selenium compounds from high selenium broccoli is affected by the extracting solution.
PubMed:Preparation, homogeneity and stability studies of a candidate LRM for Se speciation.
PubMed:Digestibility and chemical species of selenium contained in high-selenium yeast.
PubMed:Selenium supplementation can protect cultured rat cardiomyocytes from hypoxia/reoxygenation damage.
PubMed:Crystallization and preliminary X-ray crystallographic analysis of SP1, a novel chaperone-like protein.
PubMed:Selenium for prevention: eating your way to better DNA repair?
PubMed:Growth characteristics and selenium status changes of yeast cells with inorganic and organic selenium supplementation: selenium, a chemopreventive agent.
PubMed:Metabolic pathway for selenium in the body: speciation by HPLC-ICP MS with enriched Se.
PubMed:Methylseleno-amino acid content of food materials by stable isotope dilution mass spectrometry.
PubMed:Characterization of selenium species in Brazil nuts by HPLC-ICP-MS and ES-MS.
PubMed:Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability.
PubMed:Assessment of selenium bioavailability from high-selenium spirulina subfractions in selenium-deficient rats.
PubMed:Bioavailability of selenium from raw or cured selenomethionine-enriched fillets of Atlantic salmon (Salmo salar) assessed in selenium-deficient rats.
PubMed:Development of aquatic life criteria for selenium: a regulatory perspective on critical issues and research needs.
PubMed:Selenium biotransformations into proteinaceous forms by foodweb organisms of selenium-laden drainage waters in California.
PubMed:Selenium toxicity: cause and effects in aquatic birds.
PubMed:Capillary gas chromatography inductively coupled plasma mass spectrometry (CGC-ICPMS) for the enantiomeric analysis of D,L-selenomethionine in food supplements and urine.
PubMed:Selenium (Se) from high-selenium broccoli is utilized differently than selenite, selenate and selenomethionine, but is more effective in inhibiting colon carcinogenesis.
PubMed:Selenomethionine content of candidate reference materials.
PubMed:Interactions of selenium compounds with other antioxidants in DNA damage and apoptosis in human normal keratinocytes.
PubMed:[Effect of methionine supplementation on the selenium bioavailability in rats fed on grains from Keshan disease endemic area].
PubMed:Bioavailability and possible benefits of wheat intake naturally enriched with selenium and its products.
PubMed:Chemical speciation influences comparative activity of selenium-enriched garlic and yeast in mammary cancer prevention.
PubMed:Selenomethionine: a review of its nutritional significance, metabolism and toxicity.
PubMed:Increase in dopamine metabolites in murine striatum after oral exposure to inorganic but not organic form of selenium.
PubMed:Overproduction and characterization of seleno-methionine xylanase T-6.
PubMed:Selenium.
PubMed:Distribution of free seleno-amino acids in plant tissue of Melilotus indica L. grown in selenium-laden soils.
PubMed:Long-term supplementation with selenate and selenomethionine: urinary excretion by New Zealand women.
PubMed:[Determination of the selenomethionine content in grain and human blood].
PubMed:Effects of selenium on colonic fermentation in the rat.
PubMed:[Method of cyanogen bromide-fluorimetry determination of trace amount of selenomethionine in grain and blood].
PubMed:In vitro and in vivo effects of selenium and selenium with vitamin E on platelet functions in diabetic rats relationship to platelet sorbitol and fatty acid distribution.
PubMed:Utilization of chromatographic and spectroscopic techniques to study the oxidation kinetics of selenomethionine.
PubMed:Selenium metabolism and bioavailability.
PubMed:A selenium supplement associated or not with vitamin E delays early renal lesions in experimental diabetes in rats.
PubMed:Human selenium supplementation as assessed by changes in blood selenium concentration and glutathione peroxidase activity.
PubMed:Oral intake of selenium has no effect on the serum concentrations of growth hormone, insulin-like growth factor-1, insulin-like growth factor-binding proteins 1 and 3 in healthy women.
PubMed:Effects of supplementation of fertilizers on human selenium status in Finland.
PubMed:Inhibition of colony formation of Hela cells by naturally occurring and synthetic agents.
PubMed:Optimization of an Escherichia coli formate dehydrogenase assay for selenium compounds.
PubMed:Effect of dietary phytate on growth and selenium status of chicks fed selenite or selenomethionine.
PubMed:Enrichment of selenium in allium vegetables for cancer prevention.
PubMed:Characterization of tissue selenium profiles and anticarcinogenic responses in rats fed natural sources of selenium-rich products.
PubMed:Selenium status of infants is influenced by supplementation of formula or maternal diets.
PubMed:The bioavailability of various selenium compounds to a marine wading bird.
PubMed:Generation of reactive oxygen species from the reaction of selenium compounds with thiols and mammary tumor cells.
PubMed:Absorption, distribution and elimination of selenium as L-selenomethionine in non-human primates.
PubMed:Interactive effects of selenium, methionine, and dietary protein on survival, growth, and physiology in mallard ducklings.
PubMed:Utilization of two different chemical forms of selenium during lactation using stable isotope tracers: an example of speciation in nutrition.
PubMed:The effects of topical and oral L-selenomethionine on pigmentation and skin cancer induced by ultraviolet irradiation.
PubMed:Interactive effects of arsenate, selenium, and dietary protein on survival, growth, and physiology in mallard ducklings.
PubMed:The necessity of dietary vitamin B6 to selenium biopotency for tissue selenium and glutathione peroxidase in rats.
PubMed:Effect of selenium compounds and thiols on human mammary tumor cells.
PubMed:Interactive effects of boron, selenium, and dietary protein on survival, growth, and physiology in mallard ducklings.
PubMed:Effects of dietary zinc and cadmium on tissue selenium concentration and glutathione peroxidase activity in rats fed DL-selenomethionine or sodium selenite.
PubMed:Selenium utilization during human lactation by use of stable-isotope tracers.
PubMed:Radiolabeling of infective third-stage larvae of Strongyloides stercoralis by feeding [75 Se]selenomethionine-labeled Escherichia coli to first- and second-stage larvae.
PubMed:Selenium-containing proteins of rat kidney.
PubMed:Effect of dietary methionine on tissue selenium and glutathione peroxidase (EC 1.11.1.9) activity in rats given selenomethionine.
PubMed:Selenium supplementation in healthy Belgian adults: response in platelet glutathione peroxidase activity and other blood indices.
PubMed:Effect of dietary methionine on utilization of tissue selenium from dietary selenomethionine for glutathione peroxidase in the rat.
PubMed:Enhancement of BOP-induced pancreatic carcinogenesis in selenium-fed Syrian golden hamsters under specific dietary conditions.
PubMed:Selenium as a sulfhydryl redox catalyst and survey of potential selenium-dependent enzymes.
PubMed:Comparative studies of selenium-75 (selenite and selenomethionine) absorption from various milk diets in suckling rats.
PubMed:A comparison of selenomethionine and sodium selenite as a supplement in chicken feeds.
PubMed:Bioavailability of selenium to residents in a low-selenium area of China.
PubMed:Urinary excretion of selenium by New Zealand and North American human subjects on differing intakes.
PubMed:Effects of riboflavin supplementation and selenium source on selenium metabolism in the young pig.
PubMed:Differences in the effects of selenite and biological selenium on the chemical form and distribution of mercury after the simultaneous administration of HgCl2 and selenium to rats.
PubMed:The nutritional biochemistry of selenium.
PubMed:Considerations in the design of selenium bioavailability studies.
PubMed:Toxic effects of dietary selenium in the Syrian hamster.
PubMed:Selenium bioavailability with reference to human nutrition.
PubMed:Oscillations in tissue uptake of 75Se-L-selenomethionine in rats and mice adapted to controlled feeding schedules.
PubMed:Quantitative selenium metabolism in normal New Zealand women.
PubMed:On supplementing the selenium intake of New Zealanders. 1. Short experiments with large doses of selenite or selenomethionine.
PubMed:On supplementing the selenium intake of New Zealanders. 2. Prolonged metabolic experiments with daily supplements of selenomethionine, selenite and fish.
PubMed:Bioavailability of food iron-(59Fe), vitamin B12-(60Co) and protein bound selenomethionine-(75Se) in pancreatic exocrine insufficiency due to cystic fibrosis.
PubMed:An evaluation of angiography, 75Se-methionine scintigraphy and the Lundh test in the diagnosis of pancreatic disease.
PubMed:Chemical examination of seleniferous cabbage Brassica oleracea capitata.
 
Notes:
diagnostic aid in pancreas function determination. Found in onion, cabbage, coco de mono (Lecythis elliptica), Brazil nuts (Bertholletia excelsa), wheat grains and other plants. Dietary supplement for avoidance of Se deficiency in humans and ruminants It has been suggested that selenomethionine, which is an organic form of selenium, is easier for the human body to absorb than selenite, which is an inorganic form. It was determined in a clinical trial that selenomethionine is absorbed 19% better than selenite.; Selenomethionine is an amino acid containing selenium that cannot be synthesized by higher animals, but can be obtained from plant material. Selenomethionine is the major seleno-compound in cereal grains (wheat grain, maize and rice), soybeans and enriched yeast. Seleno-compounds present in plants may have a profound effect upon the health of animals and human subjects. It is now known that the total Se content cannot be used as an indication of its efficacy, but knowledge of individual selenocompounds is necessary to fully assess the significance. Thus, speciation of the seleno-compounds has moved to the forefront. Since animals and man are dependent upon plants for their nutritional requirements, this makes the types of seleno-compounds in plants even more critical. Se enters the food chain through incorporation into plant proteins, mostly as selenocysteine and selenomethionine at normal Se levels. There are two possible pathways for the catabolism of selenomethionine. One is the transsulfuration pathway via selenocystathionine to produce selenocysteine, which in turn is degraded to H2Se by the enzyme b-lyase. The other pathway is the transamination-decarboxylation pathway. It was estimated that 90% of methionine is metabolized through this pathway and thus could be also the major route for selenomethionine catabolism. (PMID: 14748935, Br J Nutr. 2004 Jan;91(1):11-28.); Selenomethionine is an amino acid containing selenium. The L-isomer of selenomethionine, known as Se-met and Sem, is a common natural food source of selenium. In vivo, selenomethionine is randomly incorporated instead of methionine and is readily oxidized. Its antioxidant activity arises from its ability to deplete reactive species. Selenium and sulfur are chalcogen elements that share many chemical properties and the substitution of methionine to selenomethionine may have no effect on protein structure and function. However, the incorporation of selenomethionine into tissue proteins and keratin in horses causes alkali disease. Alkali disease is characterized by emaciation, loss of hair, deformation and shedding of hooves, loss of vitality and erosion of the joints of long bones.
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