EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

octacosanol
cluytyl alcohol

Supplier Sponsors

Name:octacosan-1-ol
CAS Number: 557-61-9Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:209-181-2
FDA UNII: 81I2215OVK
Nikkaji Web:J10.708E
Beilstein Number:1786879
MDL:MFCD00044770
XlogP3:13.80 (est)
Molecular Weight:410.76946000
Formula:C28 H58 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 83.30 °C. @ 760.00 mm Hg
Boiling Point: 428.14 °C. @ 760.00 mm Hg (est)
Flash Point: 276.00 °F. TCC ( 135.30 °C. ) (est)
logP (o/w): 13.066 (est)
Soluble in:
 water, 1.398e-007 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
AIDP
Octacosanol 10%10%
AIDP
Octacosanol 50%50%
Alfa Biotechnology
For experimental / research use only.
Octacosanol 95%
BOC Sciences
For experimental / research use only.
Octacosanol >98%
Odor: characteristic
Use: 1-Octacosanol is a 28-carbon primary fatty alcohol commonly found in the epicuticular waxes of plants. It has shown protective effects against parkonsonism and due to its excellent tolerability and non-toxicity,
Charkit Chemical
SPINACH OCTACOSANOL
Jiangyin Healthway
Octacosanol 30.0% -- 90.0%
New functional food ingredients
Santa Cruz Biotechnology
For experimental / research use only.
1-Octacosanol
Sigma-Aldrich: Sigma
For experimental / research use only.
1-Octacosanol ≥99% (GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
special dietary and nutritional additives
Recommendation for octacosanol usage levels up to:
 not for fragrance use.
 
Recommendation for octacosanol flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):557-61-9
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :68406
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
octacosan-1-ol
Chemidplus:0000557619
EPA/NOAA CAMEO:hazardous materials
 
References:
 octacosan-1-ol
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):68406
Pubchem (sid):135025350
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C08387
HMDB (The Human Metabolome Database):HMDB34380
FooDB:FDB012759
FDA Listing of Food Additive Status:View
MedlinePlusSupp:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 apple plant
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 beet
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 beet root
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 brussel sprout leaf
Search Trop Picture
 chive leaf
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 chive plant
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 cotton plant
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 elder black elder flower
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 ginkgo biloba leaf
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 not found in nature
 poppy opium poppy fruit
Search Trop Picture
 potato leaf
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 watermelon fruit
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 wheat
Search Trop Picture
 
Synonyms:
 cluytyl alcohol
 montanyl alcohol
 octacosan-1-ol
1-octacosanol
N-octacosanol
 octacosyl alcohol
 

Articles:

PubMed:Evaluation of anthelmintic activity and in silico PASS assisted prediction of Cordia dichotoma (Forst.) root extract.
PubMed:Octacosanol Enhances the Proliferation and Migration of Human Umbilical Vein Endothelial Cells via Activation of the PI3K/Akt and MAPK/Erk Pathways.
PubMed:The variation of root exudates from the hyperaccumulator Sedum alfredii under cadmium stress: metabonomics analysis.
PubMed:Triacylglycerols and aliphatic alcohols from fruits of three Tunisian Pistacia lentiscus populations.
PubMed:High-Performance Thin-Layer Chromatography for Quantification of 1-Octacosanol in Antarctic Krill (Euphausia superba Dana).
PubMed:Lipophilic profile of the edible halophyte Salicornia ramosissima.
PubMed:Holoptelea integrifolia (Roxb.) Planch: a review of its ethnobotany, pharmacology, and phytochemistry.
PubMed:Vitiquinolone--a quinolone alkaloid from Hibiscus vitifolius Linn.
PubMed:Interaction of organic solvents with the epicuticular wax layer of wheat leaves.
PubMed:[Chemical constituents from leaves of Nelumbo nucifera].
PubMed:The influence of molecular structure and aerosol phase on the heterogeneous oxidation of normal and branched alkanes by OH.
PubMed:Evaluation of γ-oryzanol content and composition from the grains of pigmented rice-germplasms by LC-DAD-ESI/MS.
PubMed:A new guaianolide from Artemisia roxburghiana.
PubMed:One new pyrroline compound from Callistemon viminalis (Sol. Ex Gaertner) G.Don Ex Loudon.
PubMed:Antimicrobial and antioxidant activities of the extracts and compounds from the leaves of Psorospermum aurantiacum Engl. and Hypericum lanceolatum Lam.
PubMed:Effects of ozone therapy on haemostatic and oxidative stress index in coronary artery disease.
PubMed:Anti-parkinsonian effects of octacosanol in 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-treated mice.
PubMed:A gas chromatography-tandem quadrupole mass spectrometric analysis of policosanols in commercial vegetable oils.
PubMed:Antinociceptive and anti-inflammatory effects of octacosanol from the leaves of Sabicea grisea var. grisea in mice.
PubMed:A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--Part 27.
PubMed:Protective effects of octacosanol on 6-hydroxydopamine-induced Parkinsonism in rats via regulation of ProNGF and NGF signaling.
PubMed:Synthesis of 1-octacosanol and GC-C-IRMS discrimination of samples from different origin.
PubMed:Trace quantification of 1-octacosanol and 1-triacontanol and their main metabolites in plasma by liquid-liquid extraction coupled with gas chromatography-mass spectrometry.
PubMed:Regulation of HMGCoA reductase activity by policosanol and octacosadienol, a new synthetic analogue of octacosanol.
PubMed:Nutritional bioactive components of wheat straw as affected by genotype and environment.
PubMed:Policosanol, alpha-tocopherol, and moisture content as a function of timing of harvest of Switchgrass (Panicum virgatum L.).
PubMed:Antiatherosclerotic function of Kokuto, Okinawan noncentrifugal cane sugar.
PubMed:Three novel compounds from the leaves of Smallanthus sonchifolius.
PubMed:Long-chain fatty alcohols from pomace olive oil modulate the release of proinflammatory mediators.
PubMed:Octacosanol isolated from Tinospora cordifolia downregulates VEGF gene expression by inhibiting nuclear translocation of NF-<kappa>B and its DNA binding activity.
PubMed:[Effect of octacostyl alcohol preparation on blood free radical metabolism and cardiac endocrine function of rats].
PubMed:Octacosanol attenuates disrupted hepatic reactive oxygen species metabolism associated with acute liver injury progression in rats intoxicated with carbon tetrachloride.
PubMed:In silico toxicological screening of natural products.
PubMed:Effects of emulsified policosanols with different chain lengths on cholesterol metabolism in heterozygous LDL receptor-deficient mice.
PubMed:Octacosanol administration to humans decreases neutral sterol and bile acid concentration in feces.
PubMed:Comparison of various extraction methods for policosanol from rice bran wax and establishment of chromatographic fingerprint of policosanol.
PubMed:[Study on the active components of Nardostachys chinensis].
PubMed:Quantification of sterols and aliphatic alcohols in Mediterranean stone pine (Pinus pinea L.) populations.
PubMed:Comparison of composition and absorption of sugarcane policosanols.
PubMed:["Natural" treatments of hypercholesterolemia].
PubMed:Lack of effect of sugar cane policosanol on plasma cholesterol in Golden Syrian hamsters.
PubMed:Policosanol content and composition in perilla seeds.
PubMed:Policosanol inhibits cholesterol synthesis in hepatoma cells by activation of AMP-kinase.
PubMed:Antihyperlipidaemic effect of a Monascus purpureus brand dietary supplement on a large sample of subjects at low risk for cardiovascular disease: a pilot study.
PubMed:Structural analysis of wheat wax (Triticum aestivum, c.v. 'Naturastar' L.): from the molecular level to three dimensional crystals.
PubMed:What do microbes encounter at the plant surface? Chemical composition of pea leaf cuticular waxes.
PubMed:Policosanol has no antioxidant activity in human low-density lipoprotein but increases excretion of bile acids in hamsters.
PubMed:Quantitative determination of sterols and other alcohols in overland flow from grazing land and possible source materials.
PubMed:Policosanol contents and compositions of wheat varieties.
PubMed:Antibacterial potential from Indian Suregada angustifolia.
PubMed:In vitro and in vivo study of octacosanol metabolism.
PubMed:Cuticular wax profiles of leaves of some traditionally used African Bignoniaceae.
PubMed:Wheat germ policosanol failed to lower plasma cholesterol in subjects with normal to mildly elevated cholesterol concentrations.
PubMed:Nutritional significance and metabolism of very long chain fatty alcohols and acids from dietary waxes.
PubMed:Octacosanol supplementation increases running endurance time and improves biochemical parameters after exhaustion in trained rats.
PubMed:[Studies on chemical constituents of Choerospondias axillaris].
PubMed:[A new chromone glycoside from Cassia siamea lam].
PubMed:Octacosanol in human health.
PubMed:Study of the interaction between policosanol and excipients.
PubMed:Inhibition of rat lipoprotein lipid peroxidation by the oral administration of D003, a mixture of very long-chain saturated fatty acids.
PubMed:Policosanol: clinical pharmacology and therapeutic significance of a new lipid-lowering agent.
PubMed:[Determination of triacontanol and octacosanol in fenglasu and fenglasu capsules by capillary gas chromatography].
PubMed:Trace determination of 1-octacosanol in rat plasma by solid-phase extraction with Tenax GC and capillary gas chromatography.
PubMed:[Effects of octacosanol in food physiological parameters in tail-suspended rats].
PubMed:[Results of the multicenter controlled study of the hypolipidemic drug polycosanol in Russia].
PubMed:Policosanol, reaction time and event-related potentials.
PubMed:Lipid composition of the extracellular matrix of Botrytis cinerea germlings.
PubMed:Effect of policosanol on cerebral ischemia in Mongolian gerbils.
PubMed:Long-term therapy with policosanol improves treadmill exercise-ECG testing performance of coronary heart disease patients.
PubMed:Chlorogenic acid, an antioxidant principle from the aerial parts ofArtemisia iwayomogi that acts on 1,1-diphenyl-2-picrylhydrazyl radical.
PubMed:[Active constituents lowering blood-lipid in beeswax].
PubMed:Analytical procedure for the determination of 1-octacosanol in plasma by solvent extraction and capillary gas chromatography.
PubMed:Aromatase inhibitors from Urtica dioica roots.
PubMed:Octacosanol affects lipid metabolism in rats fed on a high-fat diet.
PubMed:Tissue distribution of (8-14C)-octacosanol in liver and muscle of rats after serial administration.
PubMed:Effect of policosanol on isoprenaline-induced myocardial necrosis in rats.
PubMed:Cholesterol-lowering effects of policosanol in rabbits.
PubMed:Distribution of radioactive octacosanol in response to exercise in rats.
PubMed:Efficacy of nutritional supplements used by athletes.
PubMed:Effect of policosanol on cerebral ischemia in Mongolian gerbils: role of prostacyclin and thromboxane A2.
PubMed:Effects of Policosanol on platelet aggregation in rats.
PubMed:Biodistribution and metabolism of orally administered octacosanol in rats.
PubMed:[Chemical constituents of Eupolyphaga sinensis Walker].
PubMed:Rapid elicitation of second messengers by nanomolar doses of triacontanol and octacosanol.
PubMed:Nutritional supplements in amyotrophic lateral sclerosis.
PubMed:Trial of octacosanol in amyotrophic lateral sclerosis.
PubMed:Effect of Triacontanol on Chlamydomonas: I. Stimulation of Growth and Photosynthetic CO(2) Assimilation.
PubMed:Octacosanol in parkinsonism.
PubMed:Specificity of 1-triacontanol as a plant growth stimulator and inhibition of its effect by other long-chain compounds.
PubMed:EFFECT OF OCTACOSANOL, WHEAT GERM OIL, AND VITAMIN E ON PERFORMANCE OF SWIMMING RATS.
PubMed:Physiological and biochemical evaluation of potential antifatigue drugs. III. The effect of octacosanol, wheat germ oil and vitamin E on the performance of swimming rats.
PubMed:Effects of octacosanol on chick comb growth.
PubMed:The isolation of n-octacosanol from wheat wax.
 
Notes:
1-Octacosanol (also known as n-octacosanol, octacosyl alcohol, cluytyl alcohol, montanyl alcohol) is a straight-chain aliphatic 28-carbon primary fatty alcohol that is common in the epicuticular waxes of plants, including the leaves of many species of Eucalyptus, of most forage and cereal grasses, of Acacia, Trifolium, Pisum and many other legume genera among many others, sometimes as the major wax constituent. Octacosanol also occurs in wheat germ. Octacosanol is insoluble in water but freely soluble in low molecular-weight alkanes and in chloroform (CHCl3).
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