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(+)-taxodione
podocarpa-7,9(11),13-triene-6,12-dione, 11-hydroxy-13-isopropyl- (8CI)

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Name:(4bS,8aS)-4-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a-tetrahydrophenanthrene-3,9-dione
CAS Number: 19026-31-4Picture of molecule3D/inchi
FDA UNII: W96G420HJX
Nikkaji Web:J245.694J
XlogP3-AA:4.10 (est)
Molecular Weight:314.42482000
Formula:C20 H26 O3
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in:
 water, 2.367 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
(4bS,8aS)-4-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a-tetrahydrophenanthrene-3,9-dione 95%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for (+)-taxodione usage levels up to:
 not for fragrance use.
 
Recommendation for (+)-taxodione flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :73588
National Institute of Allergy and Infectious Diseases:Data
(4bS,8aS)-4-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a-tetrahydrophenanthrene-3,9-dione
Chemidplus:0019026314
 
References:
 (4bS,8aS)-4-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a-tetrahydrophenanthrene-3,9-dione
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):73588
Pubchem (sid):135031458
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C09194
HMDB (The Human Metabolome Database):Search
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 salvia austriaca root
Search Trop Picture
 
Synonyms:
(4bS,8aS)-4-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a-tetrahydrophenanthrene-3,9-dione
3,9-phenanthrenedione, 4b,5,6,7,8,8a-hexahydro-4-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS-trans)- (9CI)
 podocarpa-7,9(11),13-triene-6,12-dione, 11-hydroxy-13-isopropyl- (8CI)
 

Articles:

PubMed:The production and antiprotozoal activity of abietane diterpenes in Salvia austriaca hairy roots grown in shake-flasks and bioreactor.
PubMed:Taxodione and Extracts from Salvia austriaca Roots as Human Cholinesterase Inhibitors.
PubMed:Antimicrobial and Antileishmanial Activities of Diterpenoids Isolated from the Roots of Salvia deserta.
PubMed:A bioguided identification of the active compounds that contribute to the antiproliferative/cytotoxic effects of rosemary extract on colon cancer cells.
PubMed:Anti-apoptotic effect of taxodione on serum/glucose deprivation-induced PC12 cells death.
PubMed:Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site.
PubMed:In vitro antiprotozoal activity of abietane diterpenoids isolated from Plectranthus barbatus Andr.
PubMed:Antiproliferative activity of abietane diterpenoids against human tumor cells.
PubMed:Cytotoxic and apoptogenic properties of three isolated diterpenoids from Salvia chorassanica through bioassay-guided fractionation.
PubMed:Antimicrobial and anti-biofilm properties of new taxodione derivative from hairy roots of Salvia austriaca.
PubMed:An unusual taxodione derivative from hairy roots of Salvia austriaca.
PubMed:Genetic transformation of Salvia austriaca by Agrobacterium rhizogenes and diterpenoid isolation.
PubMed:A new highly hydroxylated triterpene from Salvia atropatana Bunge.
PubMed:A new triterpene from Salvia xanthocheila Boiss.
PubMed:Antifungal abietane-type diterpenes from the cones of Taxodium distichum Rich.
PubMed:Syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons against methicillin-resistant Staphylococcus aureus and Propionibacterium acnes.
PubMed:Antitermitic activities of abietane-type diterpenes from Taxodium distichum cones.
PubMed:Antioxidant diterpenoids from the roots of Salvia barrelieri.
PubMed:Taxodione, a DNA-binding compound from Taxodium distichum L. (Rich.).
PubMed:Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.
PubMed:Structural and spectral assignment by two-dimensional NMR of two new derivatives of the abietane diterpenoid taxodione.
PubMed:Studies on di- and triterpenoids from Salvia staminea with cytotoxic activity.
PubMed:Synthesis of variously oxidized abietane diterpenes and their antibacterial activities against MRSA and VRE.
PubMed:Constituents of the roots of Salvia prionitis.
PubMed:Effects of plant diterpenes on the neuronal GABAA receptor-operated chloride current.
PubMed:Diterpenoid total synthesis. 13. Taxodione, a quinone methide tumor inhibitor.
PubMed:Inhibition of phosphofructokinase by quinone methide and alpha-methylene lactone tumor inhibitors.
PubMed:Tumor inhibitors. 48. Taxodione and taxodone, two novel diterpenoid quinone methide tumor inhibitors from Taxodium distichum.
PubMed:Taxodione and taxodone, two novel diterpenoid quinone methide tumor inhibitors from Taxodium distichum.
 
Notes:
None found
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