EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2,5-dihydroxybenzaldehyde
gentisinaldehyde

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Name:2,5-dihydroxybenzaldehyde
CAS Number: 1194-98-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:214-789-6
FDA UNII: 0Q83HDS90W
Nikkaji Web:J7.451I
Beilstein Number:1363961
MDL:MFCD00003333
XlogP3-AA:1.20 (est)
Molecular Weight:138.12242000
Formula:C7 H6 O3
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:yellow to green crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 100.00 to 103.00 °C. @ 760.00 mm Hg
Boiling Point: 276.00 to 277.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:0.003000 mmHg @ 25.00 °C. (est)
Flash Point: 275.00 °F. TCC ( 135.10 °C. ) (est)
logP (o/w): 0.540
Soluble in:
 water, 1.38E+04 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
BOC Sciences
For experimental / research use only.
2,5-Dihydroxybenzaldehyde >98%
Odor: characteristic
Use: 2,5-Dihydroxybenzaldehyde is a is a natural phenol found in the heartwoods of Pseudolarix amabilis, it is a tyrosine kinase inhibitor.
Carbosynth
For experimental / research use only.
2,5-Dihydroxybenzaldehyde
EMD Millipore
For experimental / research use only.
2,5-Dihydroxybenzaldehyde
sds
Santa Cruz Biotechnology
For experimental / research use only.
2,5-Dihydroxybenzaldehyde
Sigma-Aldrich: Aldrich
For experimental / research use only.
2,5-Dihydroxybenzaldehyde 98%
sds
TCI AMERICA
For experimental / research use only.
2,5-Dihydroxybenzaldehyde >98.0%(GC)
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
natural substances and extractives
Recommendation for 2,5-dihydroxybenzaldehyde usage levels up to:
 not for fragrance use.
 
Recommendation for 2,5-dihydroxybenzaldehyde flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):1194-98-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :70949
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2,5-dihydroxybenzaldehyde
Chemidplus:0001194985
 
References:
 2,5-dihydroxybenzaldehyde
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):70949
Pubchem (sid):135026429
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C05585
HMDB (The Human Metabolome Database):HMDB04062
FooDB:FDB023295
Export Tariff Code:2912.49.2600
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 wine
Search Picture
 
Synonyms:
 benzaldehyde, 2,5-dihydroxy-
 gentisaldehyde
 gentisate aldehyde
 gentisinaldehyde
 

Articles:

PubMed:Effect of structure on the interactions between five natural antimicrobial compounds and phospholipids of bacterial cell membrane on model monolayers.
PubMed:Synthesis and in vitro antiproliferative activity of new phenylaminoisoquinolinequinones against cancer cell lines.
PubMed:Synthesis of benzophenonehydrazone Schiff bases and their in vitro antiglycating activities.
PubMed:Synthesis and characterization of novel nano-chitosan Schiff base and use of lead (II) sensor.
PubMed:Diffusion-free mediator based miniature biofuel cell anode fabricated on a carbon-MEMS electrode.
PubMed:Sequential C-N and C-O bond formation in a single pot: synthesis of 2H-benzo[b][1,4]oxazines from 2,5-dihydroxybenzaldehyde and amino acid precursors.
PubMed:Total extract of Beta vulgaris var. cicla seeds versus its purified phenolic components: antioxidant activities and antiproliferative effects against colon cancer cells.
PubMed:A bioanode based on MWCNT/protein-assisted co-immobilization of glucose oxidase and 2,5-dihydroxybenzaldehyde for glucose fuel cells.
PubMed:Liquid chromatographic/electrospray ionization mass spectrometric identification of the oxidation end-products of trans-resveratrol in aqueous solutions.
PubMed:Tyrosol degradation via the homogentisic acid pathway in a newly isolated Halomonas strain from olive processing effluents.
PubMed:Antibacterial activities of naturally occurring compounds against Mycobacterium avium subsp. paratuberculosis.
PubMed:Aurocitrin and related polyketide metabolites from the wood-decay fungus Hypocrea sp. BCC 14122.
PubMed:Antibacterial activities of phenolic benzaldehydes and benzoic acids against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, and Salmonella enterica.
PubMed:Effects of aminoguanidine Schiff's base on biomarkers of the oxidative stress, 4-hydroxy-2-nonenal and conjugated dienes, in the model diabetes mellitus.
PubMed:Simultaneous determination of amphetamine and one of its metabolites by HPLC with electrochemical detection.
PubMed:Analysis of aliphatic amines in air samples by HPLC with electrochemical detection.
PubMed:Measurement of 4-hydroxynonenal in small volume blood plasma samples: modification of a gas chromatographic-mass spectrometric method for clinical settings.
PubMed:Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver.
PubMed:Cytotoxicity effects of di- and tri-hydroxybenzaldehydes as a chemopreventive potential agent on tumor cells.
PubMed:The reductive half-reaction of xanthine oxidase. Reaction with aldehyde substrates and identification of the catalytically labile oxygen.
PubMed:Validation of malondialdehyde and 4-hydroxy-2-trans-nonenal measurement in plasma by NICI-GC-MS.
PubMed:Patulin biosynthesis: epoxidation of toluquinol and gentisyl alcohol by particulate preparations from Penicillium patulum.
PubMed:Substrate preference of a cytosolic aldehyde dehydrogenase inducible in rat liver by treatment with 3-methylcholanthrene.
PubMed:Identification of phyllostine as an intermediate of the patulin pathway in Penicillium urticae.
PubMed:Conidiogenesis and secondary metabolism in Penicillium urticae.
PubMed:Patulin biosynthesis: the metabolism of m-hydroxybenzyl alcohol and m-hydroxybenzaldehyde by particulate preparations from Penicillium patulum.
PubMed:The oxidation of gentisaldehyde by nicotinamide-adenine dinucleotide-specific, aromatic aldehyde dehydrogenase from rabbit liver.
 
Notes:
Gentisate aldehyde is a substrate of the enzyme aldehyde oxidase 1 [EC:1.2.3.1] in Valine, leucine and isoleucine degradation, Tyrosine metabolism, Tryptophan metabolism, Vitamin B6 metabolism and Nicotinate and nicotinamide metabolism. (KEGG) [HMDB]
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