EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

vinpocetine
eburnamenine-14-carboxylic acid, ethyl ester, (3a,16a)-

Supplier Sponsors

CAS Number: 42971-09-5Picture of molecule3D/inchi
Other(deleted CASRN):115986-87-3
ECHA EINECS - REACH Pre-Reg:256-028-0
FDA UNII: 543512OBTC
Nikkaji Web:J3.510F
Beilstein Number:0900803
XlogP3-AA:4.10 (est)
Molecular Weight:350.46162000
Formula:C22 H26 N2 O2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:special dietary and nutritional additives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
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Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 419.50 °C. @ 760.00 mm Hg (est)
Flash Point: 406.00 °F. TCC ( 207.50 °C. ) (est)
logP (o/w): 5.137 (est)
Soluble in:
 water, 5.924 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
AIDP
Vinpocetine 99.5% min.
BOC Sciences
For experimental / research use only.
Vinpocetine >98%
Odor: characteristic
Use: Vinpocetine, isolated from the lesser periwinkle plant, is a derivative of the vinca alkaloid vincamine with an effect of cerebral blood-flow enhancing and neuroprotection.
Glentham Life Sciences
Vinpocetine
Santa Cruz Biotechnology
For experimental / research use only.
Vinpocetine 98%
Sigma-Aldrich: Sigma
For experimental / research use only.
Vinpocetine ≥98%, solid
sds
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 117 mg/kg
Yakkyoku. Pharmacy. Vol. 35, Pg. 1919, 1984.

intravenous-mouse LD50 45 mg/kg
Yakkyoku. Pharmacy. Vol. 35, Pg. 1919, 1984.

oral-mouse LD50 534 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1938, 1976.

intraperitoneal-rat LD50 119 mg/kg
Yakkyoku. Pharmacy. Vol. 35, Pg. 1919, 1984.

intravenous-rat LD50 32 mg/kg
Yakkyoku. Pharmacy. Vol. 35, Pg. 1919, 1984.

oral-rat LD50 503 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1938, 1976.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
special dietary and nutritional additives
Recommendation for vinpocetine usage levels up to:
 not for fragrance use.
 
Recommendation for vinpocetine flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :443955
National Institute of Allergy and Infectious Diseases:Data
Chemidplus:0042971095
 
References:
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):443955
Pubchem (sid):135000873
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D01371
HMDB (The Human Metabolome Database):Search
FDA Listing of Food Additive Status:View
ChemSpider:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 apovincaminic acid ethyl ester
(+)-apovincaminic acid ethyl ester
(+)-cis-apovincaminic acid ethyl ester
3-a,16-a-apovincaminic acid ethyl ester
3a,16a-apovincaminic acid ethyl ester
cis-apovincaminic acid ethyl ester
(3S,16S)-apovincaminic acid ethylester
 bravinton
 ceractin
(3a,16a)-eburnamenine-14-carboxylic acid ethyl ester
 eburnamenine-14-carboxylic acid, ethyl ester, (3a,16a)-
 ethyl (+)-apovincaminate
 ethyl (+)-cis-apovincaminate
 ethyl (3a,16a)-eburnamenine-14-carboxylate
(11aS,11bS)-11a-ethyl-2,3,4,5,11a,11b-hexahydro-1H-3a,9b-diaza-benzo[cd]fluoranthene-10-carboxylic acid ethyl ester
 vinpocetine 98% min.
 vinpocetine 99.5% min.
 vinpocetinum
 

Articles:

PubMed:Identification and quantification of vinpocetine and picamilon in dietary supplements sold in the United States.
PubMed:Omeprazole does not change the oral bioavailability or pharmacokinetics of vinpocetine in rats.
PubMed:Preventive effect of piracetam and vinpocetine on hypoxia-reoxygenation induced injury in primary hippocampal culture.
PubMed:Comparison of self-microemulsifying drug delivery system versus solid dispersion technology used in the improvement of dissolution rate and bioavailability of vinpocetine.
PubMed:Herbal medicine in the treatment of Alzheimer's disease.
PubMed:Bioavailability of vinpocetine and interference of the time of application with food intake.
 
Notes:
None found
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