EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

sucrose acetate isobutyrate
2-methylpropanoic acid [(2R,3R,4S,5S)-5-(acetyloxymethyl)-5-[[(2R,3R,4S,5R,6R)-6-(acetyloxymethyl)-3,4,5-tris(2-methyl-1-oxopropoxy)-2-oxanyl]oxy]-3,4-bis(2-methy

Supplier Sponsors

Name:[(2S,3S,4R,5R)-2-(acetyloxymethyl)-2-[(2R,3R,4S,5R,6R)-6-(acetyloxymethyl)-3,4,5-tris(2-methylpropanoyloxy)oxan-2-yl]oxy-4-(2-methylpropanoyloxy)-5-(2-methylpropanoyloxymethyl)ox
CAS Number: 126-13-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:204-771-6
FDA UNII:H5KI1C3YTV
MDL:MFCD00041859
XlogP3-AA:5.30 (est)
Molecular Weight:846.91894000
Formula:C40 H62 O19
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
CAS Number: 137204-24-1Picture of molecule3D/inchi
XlogP3-AA:-2.50 (est)
Molecular Weight:454.42670000
Formula:C18 H30 O13
NMR Predictor:Predict (works with chrome or firefox)
CAS Number: 27216-37-1Picture of molecule3D/inchi
XlogP3-AA:5.30 (est)
Molecular Weight:846.91894000
Formula:C40 H62 O19
NMR Predictor:Predict (works with chrome or firefox)
Category:stabilizers of emulsions of flavoring oils in nonalcoholic beverages
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 104 Sucrose acetate isobutyrate View-notice PDF
EU SANCO Sucrose acetate isobutyrate View-review
JECFA Food Additive: Sucrose Acetate Isobutyrate
GSFA Codex: Sucrose acetate isobutyrate (444)
DG SANTE Food Additives:sucrose acetate isobutyrate
DG SANTE Food Contact Materials:sucrose acetate isobutyrate
FDA Mainterm (SATF):126-13-6 ; SUCROSE ACETATE ISOBUTYRATE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I--Multipurpose Additives
Sec. 172.833 Sucrose acetate isobutyrate (SAIB).


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.10000 @ 25.00 °C.
Refractive Index:1.44600 @ 20.00 °C.
Boiling Point: 105.00 °C. @ 760.00 mm Hg
Acid Value: 0.20 max. KOH/g
Saponification Value:524.00 to 540.00
Flash Point: 61.00 °F. TCC ( 16.11 °C. )
logP (o/w): 6.619 (est)
Soluble in:
 organic solvents
 water, 0.0001831 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: film formers
plasticisers
 
Suppliers:
Beijing Lys Chemicals
Sucrose acetate isobutyrate
Berjé
Sucrose Acetate iso Butyrate
Happening at Berje
BOC Sciences
For experimental / research use only.
Sucrose acetate isobutyrate 95%
Carbosynth
For experimental / research use only.
Sucrose acetoisobutyrate
Eastman Chemical
Sustane SAIB MCT (Sucrose Acetate Isobutyrate) Food Grade, Kosher
Odor: characteristic
Use: Eastman™ SAIB-100 (sucrose acetate isobutyrate) is an odorless and tasteless, thermally stable, viscous liquid. It has very light color (less than 1, Gardner color scale). It is produced by the controlled esterification of sucrose, a natural sugar, with acetic and isobutyric anhydrides. The electrical properties of Eastman™ SAIB are equal to or better than those of many widely-used plasticizers and it possesses an especially high volume resistivity. It also has good thermal hydrolytic stability making it useful in surface coatings and electrical insulation.
Penta International
SUCROSE ACETATE ISOBUTYRATE 90% IN ETHYL ACETATE, Kosher
Penta International
SUCROSE ACETATE ISOBUTYRATE 90% IN ETHYL ALCOHOL, Kosher
Penta International
SUCROSE ACETATE ISOBUTYRATE FOOD GRADE KOSHER
Santa Cruz Biotechnology
For experimental / research use only.
Sucrose acetate isobutyrate solution
Sigma-Aldrich
Sucrose acetate isobutyrate, FG
Certified Food Grade Products
 
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LDLo 25600 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: MUSCLE WEAKNESS SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Journal of Agricultural and Food Chemistry. Vol. 21, Pg. 473, 1973.

oral-mouse LDLo > 25600 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: FOOD INTAKE (ANIMAL) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Journal of Agricultural and Food Chemistry. Vol. 21, Pg. 473, 1973.

intraperitoneal-rat LDLo 25600 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: MUSCLE WEAKNESS SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Journal of Agricultural and Food Chemistry. Vol. 21, Pg. 473, 1973.

oral-rat LDLo 25600 mg/kg
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: MUSCLE WEAKNESS SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Journal of Agricultural and Food Chemistry. Vol. 21, Pg. 473, 1973.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: stabilizers of emulsions of flavoring oils in nonalcoholic beverages
Recommendation for sucrose acetate isobutyrate usage levels up to:
 not for fragrance use.
 
Recommendation for sucrose acetate isobutyrate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Re-evaluation of sucrose acetate isobutyrate (E 444) as a food additive
View page or View pdf

EPI System: View
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
Env. Mutagen Info. Center:Search
EPA Substance Registry Services (TSCA):126-13-6
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :31339
National Institute of Allergy and Infectious Diseases:Data
WISER:UN 1170
WGK Germany:nwg
[(2S,3S,4R,5R)-2-(acetyloxymethyl)-2-[(2R,3R,4S,5R,6R)-6-(acetyloxymethyl)-3,4,5-tris(2-methylpropanoyloxy)oxan-2-yl]oxy-4-(2-methylpropanoyloxy)-5-(2-methylpropanoyloxymethyl)ox
Chemidplus:0000126136
Chemidplus:0137204241
Chemidplus:0000126136
 
References:
 [(2S,3S,4R,5R)-2-(acetyloxymethyl)-2-[(2R,3R,4S,5R,6R)-6-(acetyloxymethyl)-3,4,5-tris(2-methylpropanoyloxy)oxan-2-yl]oxy-4-(2-methylpropanoyloxy)-5-(2-methylpropanoyloxymethyl)ox
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:126-13-6
Pubchem (cid):31339
Pubchem (sid):134973376
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:137204-24-1
Pubchem (cid):44149120
Pubchem (sid):135271633
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:27216-37-1
Pubchem (cid):31339
Pubchem (sid):134973376
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):HMDB37136
FooDB:FDB016131
Export Tariff Code:2915.60.0000
FDA Listing of Food Additive Status:View
Haz-Map:View
Household Products:Search
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
EFSA Update of results on the monitoring of furan levels in food:Read Report
EFSA Previous report: Results on the monitoring of furan levels in food:Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food:Read Report
Formulations/Preparations:
•clear sucrose derivative available either as semi-solid (100%), or as a 90% soln in ethyl alc. •a nail polish comprises a mixt of sucrose benzoate, sucrose acetate isobutyrate, & if desired, a plasticizer (org phthalate, adipate, or phosphate) which replaces the toluenesulfonamide-formaldehyde resin generally used for adhesion of the polish to finger- or toenail.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 film formers
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
6-O-acetyl-1,3,4-tris-O-(2-methyl-1-oxopropyl)-beta-D-fructofuranosyl alpha-D-glucopyranoside 6-acetate 2,3,4-tris(2-methylpropanoate)
6-O-acetyl-1,3,4-tris-O-(2-methyl-1-oxopropyl)-β-D-fructofuranosyl a-D-glucopyranoside 6-acetate 2,3,4-tris(2-methylpropanoate)
1-O-acetyl-3,4,6-tri-O-isobutyryl-b-D-fructofuranosyl 6-O-acetyl-2,3,4-tri-O-isobutyryl-a-D-glucopyranoside
[(2S,3S,4R,5R)-2-(acetyloxymethyl)-2-[(2R,3R,4S,5R,6R)-6-(acetyloxymethyl)-3,4,5-tris(2-methylpropanoyloxy)oxan-2-yl]oxy-4-(2-methylpropanoyloxy)-5-(2-methylpropanoyloxymethyl)ox
isobutyric acid hexaester with sucrose diacetate
isobutyric acid, hexaester with sucrose diacetate
a-D-glucopyranoside, 1-O-acetyl-3,4,6-tris-O-(2-methyl-1-oxopropyl)-β-D-fructofuranosyl, 6-acetate 2,3,4-tris(2-methylpropanoate)
2-methylpropanoic acid [(2R,3R,4S,5S)-5-(acetyloxymethyl)-5-[[(2R,3R,4S,5R,6R)-6-(acetyloxymethyl)-3,4,5-tris(2-methyl-1-oxopropoxy)-2-oxanyl]oxy]-3,4-bis(2-methy
 saccharose acetate isobutyrate
 SAIB
 sucrose 6,6'-acetate hexaisobutyrate
 sucrose acetate iso butyrate
 sucrose acetate isobutyrate 90% in ethyl acetate
 sucrose acetate isobutyrate 90% in ethyl alcohol
 sucrose acetate isobutyrate food grade
 sucrose acetate isobutyrate solution
 sucrose acetoisobutyrate
 sucrose di(acetate) hexaisobutyrate
 sucrose diacetate hexaisobutyrate
 sucrose, diacetate hexaisobutyrate
 sustane SAIB MCT (sucrose acetate isobutyrate) food grade
 

Articles:

Info:EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
PubMed:Injectable Colloidal Gold in a Sucrose Acetate Isobutyrate Gelating Matrix with Potential Use in Radiation Therapy.
PubMed:Local delivery of recombinant human bone morphogenetic proteins and bisphosphonate via sucrose acetate isobutyrate can prevent femoral head collapse in Legg-Calve-Perthes disease: a pilot study in pigs.
PubMed:Sucrose acetate isobutyrate as an in situ forming system for sustained risperidone release.
PubMed:[Rheological properties of sucrose acetate isobutyrate in situ gel].
PubMed:Intracranial drug-delivery scaffolds: biocompatibility evaluation of sucrose acetate isobutyrate gels.
PubMed:Sucrose acetate isobutyrate (SAIB): three-generation reproduction study in the rat and teratology studies in the rat and rabbit.
PubMed:4-week range-finding and 1-year oral toxicity studies of sucrose acetate isobutyrate (SAIB) in the cynomolgus monkey.
PubMed:Subchronic toxicity studies of sucrose acetate isobutyrate (SAIB) in the rat and dog.
PubMed:Sucrose acetate isobutyrate (SAIB): historical aspects of its use in beverages and a review of toxicity studies prior to 1988.
PubMed:A sugar-based phase-transitioning delivery system for bone tissue engineering.
PubMed:In vitro study of lysozyme in poly(lactide-co-glycolide) microspheres with sucrose acetate isobutyrate.
PubMed:Induction of mucosal and systemic antibody specific for SeMF3 of Streptococcus equi by intranasal vaccination using a sucrose acetate isobutyrate based delivery system.
PubMed:Effect of sucrose acetate isobutyrate (SAIB) ingestion on the hepatobiliary function of normal human male and female volunteers.
PubMed:Lack of genotoxic effects of sucrose acetate isobutyrate (SAIB).
PubMed:Oral toxicity and carcinogenicity studies of sucrose acetate isobutyrate (SAIB) in the Fischer 344 rat and B6C3F1 mouse.
PubMed:Metabolism and pharmacokinetics of sucrose acetate isobutyrate (SAIB) and sucrose octaisobutyrate (SOIB) in rats, dogs, monkeys or humans: a review.
PubMed:Studies on the metabolism of sucrose acetate isobutyrate in the rat and in man.
PubMed:Biochemical effects of sucrose acetate isobutyrate (SAIB) on the liver.
PubMed:Biological effects of sucrose acetate isobutyrate in rodents and dogs.
PubMed:A novel risperidone-loaded SAIB-PLGA mixture matrix depot with a reduced burst release: effects of solvents and PLGA on drug release behaviors in vitro/in vivo.
PubMed:Biodegradable Nanoparticles for Protein Delivery: Analysis of Preparation Conditions on Particle Morphology and Protein Loading, Activity and Sustained Release Properties.
PubMed:Study of a pingyangmycin delivery system: Zein/Zein-SAIB in situ gels.
PubMed:Collagen-chondroitin sulfate-based PLLA-SAIB-coated rhBMP-2 delivery system for bone repair.
PubMed:A comparison of two controlled-release delivery systems for the delivery of amiloride to control angiogenesis.
PubMed:Disposition of sucrose octa-isobutyrate in rats, dogs and monkeys.
PubMed:Impact of weighting agents and sucrose on gravitational separation of beverage emulsions.
PubMed:In vivo evaluation of risperidone-SAIB in situ system as a sustained release delivery system in rats.
PubMed:Sustained delivery of human growth hormone from a novel gel system: SABER.
PubMed:Application of microdialysis to study the in vivo release of pingyangmycin from in situ gels in rabbits.
PubMed:Injectable controlled release formulations incorporating protein crystals.
PubMed:Sustained-release injectables formed in situ and their potential use for veterinary products.
PubMed:[Determination of dimethylformamide in food additive sucrose esters of fatty acids using solid-phase extraction].
PubMed:Determination of sucrose esters of fatty acids in food additive premixes by gas chromatography and confirmation of identity by gas chromatography/mass spectrometry.
PubMed:Evaluation of certain food additives and contaminants. Forty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives.
 
Notes:
flavor-suspending agent for soft drinks. Clouding agent, stabiliser and specific gravity control agent for beverages, esp. fruit drinks Sucrose acetoisobutyrate (SAIB) is a emulsifier and has E Number E444.
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