osthol
2H-1-benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)-
 
Notes:
from cnidium monnieri and angelica pubescens (both apiaceae).
  • O'Laughlin Industries
    • O'Laughlin Industries Inc.
      Manufacturer of Aroma
      Leading the Flavor and Fragrance Industry since 1980.
      O'Laughlin was established in 1980 by its owner and chief executive Michael O'Laughlin, when he moved to Beijing, China and established a small office. Since then it has grown to be a world class producer of chemicals, with significant production facilities in China, and distribution and sales in all major world markets.
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      Product(s):
      774-7134 Osthole 90%
       
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7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one (Click)
CAS Number: 484-12-8Picture of molecule
FDA UNII: XH1TI1759C
Nikkaji Web: J12.542C
MDL: MFCD00076049
XlogP3-AA: 3.80 (est)
Molecular Weight: 244.29012000
Formula: C15 H16 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: cosmetic agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Appearance: white crystalline powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 82.00 to  84.00 °C. @ 760.00 mm Hg
Boiling Point: 396.00 to  397.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure: 0.000001 mm/Hg @ 25.00 °C. (est)
Flash Point: 334.00 °F. TCC ( 167.60 °C. ) (est)
logP (o/w): 3.686 (est)
Soluble in:
 alcohol
 water, 12 mg/L @ 30 °C (exp)
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Organoleptic Properties:
Odor Type: dry
Odor Strength: medium
 dry  musty  herbal  
Odor Description:
at 100.00 %. 
dry musty herbal
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
AuNutra® Industries
Osthol P.E.
BOC Sciences
For experimental / research use only.
Osthol
Changsha Organic Herb
Common Cnidium Fruit Extract
Coompo
For experimental / research use only.
Osthol from Plants ≥96%
Odor: characteristic
Use: Osthol is a calcium channel blocker. Osthol significantly enhances the osteogenic differentiation of cultured osteoblasts. Osthol also could stimulate the osteoblastic differentiation of rat calvarial osteoblast cultures by the BMP-2/p38MAPK/Runx-2/osterix pathway and that osthol may be used as an important compound in the development of new antiosteoporosis drugs. The effect of osthol on powdery mildew may be associated with the direct fungitoxic property against the pathogen. We conclude that osthol would be an attractive natural compound for practical agronomic use against powdery mildew.
ExtraSynthese
For experimental / research use only.
Osthol (HPLC) ≥99%
O'Laughlin Industries
Osthole 90%
Santa Cruz Biotechnology
For experimental / research use only.
Osthol
Sigma-Aldrich: Sigma
For experimental / research use only.
Osthol
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  2905 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Indian Journal of Medical Research. Vol. 55, Pg. 241, 1967.

intraperitoneal-rat LD50  600 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Indian Journal of Medical Research. Vol. 55, Pg. 241, 1967.

intraperitoneal-mouse LD50  190 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Indian Journal of Medical Research. Vol. 55, Pg. 241, 1967.

intravenous-dog LD  > 40 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 150, Pg. 425, 1964.

oral-guinea pig LD  > 1000 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 150, Pg. 425, 1964.

intravenous-rabbit LDLo  25 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 400, 1962.

Dermal Toxicity:
subcutaneous-mouse LD50 16 mg/kg
Pharmaceutical Chemistry Journal Vol. 11, Pg. 331, 1977.

subcutaneous-rabbit LD > 70 mg/kg
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 138, Pg. 400, 1962.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic agents
Recommendation for osthol usage levels up to:
 not for fragrance use.
 
Recommendation for osthol flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 10228
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one
Chemidplus: 0000484128
RTECS: GN7700000 for cas# 484-12-8
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References:
 7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 10228
Pubchem (sid): 134975337
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C09280
HMDB (The Human Metabolome Database): Search
FooDB: FDB002515
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 angelica root
Search Trop  Picture
 carrot plant
Search Trop  Picture
 carrot root
Search Trop  Picture
 celery leaf
Search Trop  Picture
 cnidium monnieri seed
Search Trop  Picture
 dill root
Search Trop  Picture
 fructus cnidii
Search Trop  Picture
 lemon root
Search Trop  Picture
 mandarin root
Search Trop  Picture
 masterwort
Search Trop  Picture
 orange root
Search Trop  Picture
 parsley fruit oil
Search Trop  Picture
 parsley plant
Search Trop  Picture
 parsley seed oil
Search Trop  Picture
 prangos asperula
Search Trop  Picture
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Synonyms:
2H-1-benzopyran-2-one, 7-methoxy-8-(3-methyl-2-buten-1-yl)-
2H-1-benzopyran-2-one, 7-methoxy-8-(3-methyl-2-butenyl)-
 coumarin, 7-methoxy-8- (3-methyl-2-butenyl)-
 coumarin, 7-methoxy-8-(3-methyl-2-butenyl)-
7-methoxy-8-(3-methyl butenyl-2) coumarin
7-methoxy-8-(3-methyl-2-buten-1-yl)-2H-chromen-2-one
7-methoxy-8-(3-methyl-2-butenyl) coumarin
7-methoxy-8-(3-methyl-2-butenyl)-2H-1-benzopyran-2-one
7-methoxy-8-(3-methyl-2-butenyl)-coumarin
7-methoxy-8-(3-methyl-2-butenyl)coumarin
7-methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one
7-methoxy-8-(3-methylbut-2-en-1-yl)-2H-chromen-2-one
7-methoxy-8-(3-methylbut-2-enyl)-2H-chromen-2-one
7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one
7-methoxy-8-(gamma,gamma-dimethyl allyl) coumarin
7-methoxy-8-isopentenyl coumarin
7-methoxy-8-isopentenylcoumarin
7-methoxy-8-prenylcoumarin
8-(3-methyl-2-butenyl) herniarin
8-(3-methyl-2-butenyl)herniarin
 osthenol methylether
 osthol P.E.
 osthole
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Articles:
PubMed: Click chemistry inspired synthesis and bioevaluation of novel triazolyl derivatives of osthol as potent cytotoxic agents.
PubMed: Antiviral and cytotoxic evaluation of coumarins from Prangos ferulacea.
PubMed: p53 Is a Key Regulator for Osthole-Triggered Cancer Pathogenesis.
PubMed: Osthole Attenuates Doxorubicin-Induced Apoptosis in PC12 Cells through Inhibition of Mitochondrial Dysfunction and ROS Production.
PubMed: Involvement of hepatic peroxisome proliferator-activated receptor α/γ in the therapeutic effect of osthole on high-fat and high-sucrose-induced steatohepatitis in rats.
PubMed: Cytochrome P450 isoenzymes in rat and human liver microsomes associate with the metabolism of total coumarins in Fructus Cnidii.
PubMed: N-Succinyl-chitosan nanoparticles coupled with low-density lipoprotein for targeted osthole-loaded delivery to low-density lipoprotein receptor-rich tumors.
PubMed: Protective effects of osthole on intestinal ischemia-reperfusion injury in mice.
PubMed: Chemogeography and antimicrobial activity of essential oils from Geijera parviflora and Geijera salicifolia (Rutaceae): two traditional Australian medicinal plants.
PubMed: Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated COX-2 expression and apoptosis.
PubMed: Osthole inhibits insulin-like growth factor-1-induced epithelial to mesenchymal transition via the inhibition of PI3K/Akt signaling pathway in human brain cancer cells.
PubMed: N-Hydroxycinnamide derivatives of osthole inhibit cell migration and invasion by suppressing Smad2 and Akt pathways in human colorectal adenocarcinoma cells.
PubMed: Osthole prevents intestinal ischemia-reperfusion-induced lung injury in a rodent model.
PubMed: The effects of Glycyrrhizae uralenis and its major bioactive components on pharmacokinetics of daphnetin in Cortex daphnes in rats.
PubMed: Osthole activates glucose uptake but blocks full activation in L929 fibroblast cells, and inhibits uptake in HCLE cells.
PubMed: Osthole suppresses the migratory ability of human glioblastoma multiforme cells via inhibition of focal adhesion kinase-mediated matrix metalloproteinase-13 expression.
PubMed: Preparation of osthole-polymer solid dispersions by hot-melt extrusion for dissolution and bioavailability enhancement.
PubMed: Osthole attenuates the development of carrageenan-induced lung inflammation in rats.
PubMed: Coumarin derivatives, but not coumarin itself, cause skin irritation via topical delivery.
PubMed: Osthole augments therapeutic efficiency of neural stem cells-based therapy in experimental autoimmune encephalomyelitis.
PubMed: Osthole reverses beta-amyloid peptide cytotoxicity on neural cells by enhancing cyclic AMP response element-binding protein phosphorylation.
PubMed: Osthole regulates TGF-β1 and MMP-2/9 expressions via activation of PPARα/γ in cultured mouse cardiac fibroblasts stimulated with angiotensin II.
PubMed: [Effects and mechanism of osthole on intestinal ischemia-reperfusion injury in mice].
PubMed: Osthole exhibits anti-cancer property in rat glioma cells through inhibiting PI3K/Akt and MAPK signaling pathways.
PubMed: Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: targeting vascular endothelial growth factor receptor signaling and angiogenesis.
PubMed: Simultaneous determination of 12 coumarins in bamboo leaves by HPLC.
PubMed: Osthole induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.
PubMed: [In vitro transdermal behavior of effective constituents in Chonghe gel].
PubMed: Osthole inhibits proliferation and induces apoptosis in human osteosarcoma cells.
PubMed: Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-κB/NLRP3 pathway.
PubMed: [Effect of osthole on bone metabolism in rat femoral tissues in vitro].
PubMed: Bioavailability enhancement of osthole after oral administration of Bushen Yizhi prescription extract to rats followed by Cnidium monnieri (L.) Cusson fruits extract in comparison to pure osthole at different doses.
PubMed: [Study on the chemical constituent from the dichloromethane extract of the pine needle of Cedrus deodara (II)].
PubMed: N-Hydroxycinnamide derivatives of osthole presenting genotoxicity and cytotoxicity against human colon adenocarcinoma cells in vitro and in vivo.
PubMed: Synthesis and characterization of low-toxicity N-caprinoyl-N-trimethyl chitosan as self-assembled micelles carriers for osthole.
PubMed: The effect of the coumarin-like derivative osthole on the osteogenic properties of human periodontal ligament and jaw bone marrow mesenchymal stem cell sheets.
PubMed: Antispasmodic effects of Prangos ferulacea acetone extract and its main component osthole on ileum contraction.
PubMed: Simultaneous quantification of Kirenol and ent-16β,17-dihydroxy-kauran-19-oic acid from Herba Siegesbeckiae in rat plasma by liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic studies.
PubMed: The pharmacokinetics and oral bioavailability studies of columbianetin in rats after oral and intravenous administration.
PubMed: [Effect of osthole on proliferation of neonatal rat osteoblast and the relative mechanism research].
PubMed: Osthole attenuates spinal cord ischemia-reperfusion injury through mitochondrial biogenesis-independent inhibition of mitochondrial dysfunction in rats.
PubMed: Optimal extraction and fingerprint analysis of Cnidii fructus by accelerated solvent extraction and high performance liquid chromatographic analysis with photodiode array and mass spectrometry detections.
PubMed: LC-ESI-MS/MS analysis and pharmacokinetics of jolkinolide B, a potential antitumor active component isolated from Euphorbia fischeriana, in rat plasma.
PubMed: DNA microarray gene expression profile of Mycobacterium tuberculosis when exposed to osthole.
PubMed: Pharmacokinetic study of eight coumarins of Radix Angelicae Dahuricae in rats by gas chromatography-mass spectrometry.
PubMed: Osthole attenuates hepatic injury in a rodent model of trauma-hemorrhage.
PubMed: Protective effects of osthole against myocardial ischemia/reperfusion injury in rats.
PubMed: Biotransformation of osthole by Alternaria longipes.
PubMed: Osthole improves acute lung injury in mice by up-regulating Nrf-2/thioredoxin 1.
PubMed: NBM-T-L-BMX-OS01, Semisynthesized from Osthole, Is a Novel Inhibitor of Histone Deacetylase and Enhances Learning and Memory in Rats.
PubMed: Combination treatment with platycodin D and osthole inhibits cell proliferation and invasion in mammary carcinoma cell lines.
PubMed: Protective effects of osthole, a natural derivative of coumarin, against intestinal ischemia-reperfusion injury in mice.
PubMed: Osthole ameliorates renal ischemia-reperfusion injury by inhibiting inflammatory response.
PubMed: Osthole Improves Spatial Memory Deficits in Rats via Hippocampal α 1-Adrenergic and D 1 /D 2 Receptors.
PubMed: Combined anticancer activity of osthole and cisplatin in NCI-H460 lung cancer cells in vitro.
PubMed: Osthole ameliorates renal ischemia-reperfusion injury in rats.
PubMed: Simultaneous determination of scopoletin, psoralen, bergapten, xanthotoxin, columbianetin acetate, imperatorin, osthole and isoimperatorin in rat plasma by LC-MS/MS for pharmacokinetic studies following oral administration of Radix Angelicae Pubescentis extract.
PubMed: A rapid and sensitive LC-MS/MS method for the determination of osthole in rat plasma: application to pharmacokinetic study.
PubMed: Osthole protects lipopolysaccharide-induced acute lung injury in mice by preventing down-regulation of angiotensin-converting enzyme 2.
PubMed: Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae.
PubMed: [Inhibition effect of osthole on proliferation of rat chondrocytes].
PubMed: Investigation of the biotransformation of osthole by liquid chromatography/tandem mass spectrometry.
PubMed: Osthole relaxes pulmonary arteries through endothelial phosphatidylinositol 3-kinase/Akt-eNOS-NO signaling pathway in rats.
PubMed: Antispasmodic effect of osthole and Prangos ferulacea extract on rat uterus smooth muscle motility.
PubMed: Comparative study of pharmacokinetics and tissue distribution of osthole in rats after oral administration of pure osthole and Libanotis buchtormensis supercritical extract.
PubMed: Modification of rat model of sciatica induced by lumber disc herniation and the anti-inflammatory effect of osthole given by epidural catheterization.
PubMed: Pharmacokinetics and tissue distribution study of praeruptorin d from radix peucedani in rats by high-performance liquid chromatography (HPLC).
PubMed: Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro.
PubMed: Reduction of rat cardiac hypertrophy by osthol is related to regulation of cardiac oxidative stress and lipid metabolism.
PubMed: Osthole attenuates focal inflammatory reaction following permanent middle cerebral artery occlusion in rats.
PubMed: Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers.
PubMed: Synthesis and anthelmintic activity of osthol analogs against Dactylogyrus intermedius in goldfish.
PubMed: Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma.
PubMed: Osthole, a herbal compound, alleviates nucleus pulposus-evoked nociceptive responses through the suppression of overexpression of acid-sensing ion channel 3 (ASIC3) in rat dorsal root ganglion.
PubMed: Isolation and identification of metabolites of osthole in rats.
PubMed: [Effect of osthol on apoptosis and bone resorption of osteoclasts cultured in vitro].
PubMed: Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-κB-mediated matrix metalloproteinase-9 expression.
PubMed: Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti.
PubMed: Analysis of herbal dietary supplements for sexual performance enhancement: first characterization of propoxyphenyl-thiohydroxyhomosildenafil and identification of sildenafil, thiosildenafil, phentolamine and tetrahydropalmatine as adulterants.
PubMed: Aliphatic esters as targets of esterase activity in the parsnip webworm (Depressaria pastinacella).
PubMed: Mechanism of osthole inhibition of vascular Ca(v)1.2 current.
PubMed: [Effects of platycodin D in combination with different active ingredients of Chinese herbs on proliferation and invasion of 4T1 and MDA-MB-231 breast cancer cell lines].
PubMed: Neuroprotective effects of osthole pretreatment against traumatic brain injury in rats.
PubMed: Osthole enhances glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cells.
PubMed: N-[4-(7-Meth-oxy-2-oxo-2H-chromen-8-yl)-2-methyl-butan-2-yl]propionamide.
PubMed: Involvement of the cGMP pathway in the osthole-facilitated glutamate release in rat hippocampal nerve endings.
PubMed: Main constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activity.
PubMed: [Inhibitory effects of osthole, psoralen and aconitine on invasive activities of breast cancer MDA-MB-231BO cell line and the mechanisms].
PubMed: Stimulation of Airway and Intestinal Mucosal Secretion by Natural Coumarin CFTR Activators.
PubMed: [Effects and mechanisms of osthole on sciatica induced by lumber disc herniation].
PubMed: Reduction of isoprenaline-induced myocardial TGF-β1 expression and fibrosis in osthole-treated mice.
PubMed: [Inhibitory acting mechanism of psoralen-osthole on bone metastasis of breast cancer--an expatiation viewing from OPG/RANKL/RANK system].
PubMed: Osthole suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition via repression of the c-Met/Akt/mTOR pathway in human breast cancer cells.
PubMed: Insights into structure-activity relationship of GABAA receptor modulating coumarins and furanocoumarins.
PubMed: Application of hollow fiber liquid phase microextraction coupled with high-performance liquid chromatography for the study of the osthole pharmacokinetics in cerebral ischemia hypoperfusion rat plasma.
PubMed: Osthol, a coumarin isolated from common cnidium fruit, enhances the differentiation and maturation of osteoblasts in vitro.
PubMed: Simultaneous quantification of 17 constituents from Yuanhu Zhitong tablet using rapid resolution liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry.
PubMed: Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.
PubMed: Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression.
PubMed: Neuroprotective effect of osthole against oxygen and glucose deprivation in rat cortical neurons: involvement of mitogen-activated protein kinase pathway.
PubMed: Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway.
PubMed: Identification and quantification of coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS.
PubMed: [Effect of water-soluble polymers on the inhibition of osthole crystallization].
PubMed: Osthole, a natural coumarin, improves neurobehavioral functions and reduces infarct volume and matrix metalloproteinase-9 activity after transient focal cerebral ischemia in rats.
PubMed: Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.
PubMed: HPLC-based activity profiling of Angelica pubescens roots for new positive GABAA receptor modulators in Xenopus oocytes.
PubMed: Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells.
PubMed: Discovery of novel osthole derivatives as potential anti-breast cancer treatment.
PubMed: Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress.
PubMed: [Effect of Osthol on the proliferation and differentiate of osteoblasts in vitro].
PubMed: Anthelmintic activity of the crude extracts, fractions, and osthole from Radix angelicae pubescentis against Dactylogyrus intermedius in goldfish (Carassius auratus) in vivo.
PubMed: Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats.
PubMed: Osthole regulates inflammatory mediator expression through modulating NF-κB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species.
PubMed: Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats.
PubMed: [Optimization of extraction process for compund kaliziran gel with orthogonal design].
PubMed: Antifungal activity of the osthol derivative JS-B against Phytophthora capsici.
PubMed: The effect of the major components of Fructus Cnidii on osteoblasts in vitro.
PubMed: Effects of osthole on migration and invasion in breast cancer cells.
PubMed: Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production.
PubMed: Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.
PubMed: Osthole improves chronic cerebral hypoperfusion induced cognitive deficits and neuronal damage in hippocampus.
PubMed: Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway.
PubMed: Synthesis of N-hydroxycinnamides capped with a naturally occurring moiety as inhibitors of histone deacetylase.
PubMed: Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling.
PubMed: Fast separation and determination of coumarins in Fructus cnidii extracts by CEC using poly(butyl methacrylate-co-ethylene dimethacrylate-co-[2-(methacryloyloxy)ethyl] trimethylammonium chloride) monolithic columns.
PubMed: Efficacy of osthol, a potent coumarin compound, in controlling powdery mildew caused by Sphaerotheca fuliginea.
PubMed: Effects of osthole on apoptosis and TGF-beta1 of hypertrophic scar fibroblasts.
PubMed: [Metabolism of osthol in isolated hepatocytes of rat].
PubMed: Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine.
PubMed: Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.
PubMed: Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole, a natural coumarin.
PubMed: On-line concentration by field-enhanced sample injection with reverse migrating micelles in micellar electrokinetic capillary chromatography for the analysis of coumarins from traditional Chinese medicine and human serum.
PubMed: A vascular smooth muscle/cell membrane chromatography-offline-gas chromatography/mass spectrometry method for recognition, separation and identification of active components from traditional Chinese medicines.
PubMed: Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice.
PubMed: Immunomodulatory and anti-inflammatory activity of selected osthole derivatives.
PubMed: Osthol is a use-dependent blocker of voltage-gated Na+ channels in mouse neuroblastoma N2A cells.
PubMed: Separation and determination of coumarins in Fructus cnidii extracts by pressurized capillary electrochromatography using a packed column with a monolithic outlet frit.
PubMed: Anticonvulsant and acute neurotoxic effects of imperatorin, osthole and valproate in the maximal electroshock seizure and chimney tests in mice: a comparative study.
PubMed: Osthole: a promising lead compound for drug discovery from a traditional Chinese medicine (TCM).
PubMed: Fusarium graminearum growth inhibition due to glucose starvation caused by osthol.
PubMed: Anti-inflammatory and antinociceptive activity of coumarins from Seseli gummiferum subsp. corymbosum (Apiaceae).
PubMed: Determination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC-MS/MS.
PubMed: Osthole suppresses seizures in the mouse maximal electroshock seizure model.
PubMed: [Purification technology of Rhizoma et Radix Notopterygii and Radix Angelicae Pubescentis in Fufang Xuelian dropping pills by macroporous resin].
PubMed: Identification and quantification of the volatile constituents in Cnidium monnieri using supercritical fluid extraction followed by GC-MS.
PubMed: Effect of the Chinese herb extract osthol on IL-4-induced eotaxin expression in BEAS-2B cells.
PubMed: Attempts to bridge the gap between scientific mechanism-based medicine and Chinese herbal extract treatment for asthma.
PubMed: Osthole and imperatorin, the active constituents of Cnidium monnieri (L.) Cusson, facilitate glutamate release from rat hippocampal nerve terminals.
PubMed: Osthol and isopimpinellin from Fructus cnidii for the control of Dactylogyrus intermedius in Carassius auratus.
PubMed: Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats.
PubMed: Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7.
PubMed: Micelle-mediated extraction and cloud-point preconcentration of osthole and imperatorin from Cnidium monnieri with analysis by high performance liquid chromatography.
PubMed: Isolation and identification of insecticidal components from Citrus aurantium fruit peel extract.
PubMed: Identification of natural coumarin compounds that rescue defective DeltaF508-CFTR chloride channel gating.
PubMed: [Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model].
PubMed: Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats.
PubMed: [In situ rats single pass perfusion intestinal absorption of the effectivein components in Radix Angelicae Pubescentis].
PubMed: Inhibitory effect of osthole on alcohol-induced fatty liver in mice.
PubMed: Determination and pharmacokinetic study of indirubin in rat plasma by high-performance liquid chromatography.
PubMed: Chemical and antibacterial constituents of Skimmia anquetelia.
PubMed: Determination of osthole in rat plasma by high-performance liquid chromatograph using cloud-point extraction.
PubMed: [Simultaneous determination of 5 active components in Fructus Cnidii by HPLC].
PubMed: Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC-MS/MS.
PubMed: Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression.
PubMed: Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida.
PubMed: A survey of Chinese herbal ingredients with liver protection activities.
PubMed: Fluorimetric and mass spectrometric study of the interaction of beta-cyclodextrin and osthole.
PubMed: Effects of osthol on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats.
PubMed: Coumarins from Cnidium monnieri and their antiosteoporotic activity.
PubMed: Therapeutic effect of osthole on hyperlipidemic fatty liver in rats.
PubMed: Synthetic derivatives of osthole for the prevention of hepatitis.
PubMed: Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study.
PubMed: Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa.
PubMed: Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals.
PubMed: Chemical constituents of Selinum cryptotaenium.
PubMed: Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker.
PubMed: [Studies on chemical constituents in roots of Heracleum rapula].
PubMed: Anti-inflammatory effect and mechanism of osthole in rats.
PubMed: Toxic epidermal necrolysis associated with high intake of sildenafil and its response to infliximab.
PubMed: [Progress in study of chemical constituents and anti-tumor activities of Cnidium monnieri].
PubMed: HPLC determination and pharmacokinetics of osthole in rat plasma after oral administration of Fructus Cnidii extract.
PubMed: [Study on extraction of coumarins in Cnidium monieri by supercritical CO2 and separation of compositions analysis].
PubMed: [Determination of osthol in Shefengshi liqueur by HPLC].
PubMed: Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells.
PubMed: Chemical aspects of coumarin compounds for the prevention of hepatocellular carcinomas.
PubMed: [Advances in study on the pharmacological effects of active components of Chinese herbs on Alzheimer's disease].
PubMed: [Determination of isoimperatorin and osthol in ganmao yixiaoshi capsule by RP-HPLC].
PubMed: Genetic variation in primary metabolites of Pastinaca sativa; can herbivores act as selective agents?
PubMed: Preparative isolation and purification of coumarins from Cnidium monnieri (L.) Cusson by high-speed counter-current chromatography.
PubMed: [Effects of osthol on androgen level and nitric oxide synthase activity in castrate rats].
PubMed: Coumarins from Cnidium monnieri (L.) and their proliferation stimulating activity on osteoblast-like UMR106 cells.
PubMed: Osthole improves aspects of spatial performance in ovariectomized rats.
PubMed: Preparative isolation of osthol and xanthotoxol from Common Cnidium Fruit (Chinese traditional herb) using stepwise elution by high-speed counter-current chromatography.
PubMed: Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines.
PubMed: [Pharmacokinetics of osthole in rabbits].
PubMed: Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas.
PubMed: Effect of enhancers on percutaneous absorption of osthol across the excised full thickness rat skin.
PubMed: [Advances in the study of chemical constituents and pharmacological actions of Cnidium monnieri (L.) Cusson].
PubMed: [Effect of osthol on memory impairment of mice in AlCl3-induced acute senile model].
PubMed: Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway.
PubMed: 8-(2-bromo-3-methoxy-3-methylbutyl)-7-methoxycoumarin.
PubMed: [Determination of columbianetin, columbianetin acetate and osthol in Angelica pubescens Maxim. f. biserrata Shan et Yuan by HPLC].
PubMed: Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol.
PubMed: Effects of osthole on postmenopausal osteoporosis using ovariectomized rats; comparison to the effects of estradiol.
PubMed: Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON).
PubMed: Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells.
PubMed: Essential oil from herb and rhizome of Peucedanum ostruthium (L. Koch.) ex DC.
PubMed: Inhibition of itch-scratch response by fruits of Cnidium monnieri in mice.
PubMed: Antiproliferative effect of isopentenylated coumarins on several cancer cell lines.
PubMed: Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum.
PubMed: The coumarin osthol attenuates the binding of thyrotropin-releasing hormone in rat pituitary GH4C1 cells.
PubMed: Inhibition of concanavalin A-induced mice hepatitis by coumarin derivatives.
PubMed: Coumarins from Ferulago capillaris and F. brachyloba.
PubMed: Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitro.
PubMed: Antiproliferative constituents from umbelliferae plants. V. A new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica.
PubMed: Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase.
PubMed: 5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea.
PubMed: [Effects of coumarins from cnidium monnieri on the function of pituitary-adrenocortical axis in kidney yang deficiency rats].
PubMed: [Effect of osthol and total coumarins of fructus cnidii on thyroid hormone and thyrotropic hormone in kidney-yang deficiency rats].
PubMed: Osthole increases glycosylation of hepatitis B surface antigen and suppresses the secretion of hepatitis B virus in vitro.
PubMed: Pharmacological and biochemical actions of simple coumarins: natural products with therapeutic potential.
PubMed: Pharmacokinetics of osthole in rat plasma using high-performance liquid chromatography.
PubMed: Antiproliferative effect in rat vascular smooth muscle cells by osthole, isolated from Angelica pubescens.
PubMed: [Quantitative study on the effect of osthole on proximal tibiae in ovariectomized (OVX) rats].
PubMed: Effects of Chinese herbal products on mammalian retinal functions.
PubMed: [Effects of osthol and total-coumarins from Cnidium monnieri on immunological function in kidney yang deficiency mice].
PubMed: Effects of osthole on isolated guinea pig heart atria.
PubMed: Anti-inflammatory and analgesic activities from roots of Angelica pubescens.
PubMed: Inhibitory effects of phenolics on xanthine oxidase.
PubMed: The relaxant action of osthole isolated from Angelica pubescens in guinea-pig trachea.
PubMed: [Effects of osthole on the isolated guinea-pig ileum and taeniae coli].
PubMed: Vasorelaxation of rat thoracic aorta caused by osthole isolated from Angelica pubescens.
PubMed: Identification of eight coumarins occurring with psoralen, xanthotoxin, and bergapten on leaf surfaces.
PubMed: Antihaemostatic and antithrombotic effect of some antiplatelet agents isolated from Chinese herbs.
PubMed: Determination of osthole and columbianetin acetate in Angelica pubescens by reversed phase HPLC.
PubMed: [Determination of osthol and imperatorin in Cnidium monnieri (L.) cuss by fluorometry TLC scanning].
PubMed: Inhibition of platelet thromboxane formation and phosphoinositides breakdown by osthole from Angelica pubescens.
PubMed: [Studies of the active constituents of the Chinese drug "duhuo" Angelica pubescents].
PubMed: Plant antimutagenic agents, 3. Coumarins.
PubMed: [The anti-allergic activity of osthol extracted from the fruits of Cnidium monnieri (L.) Cusson].
PubMed: Biologically active principles of crude drugs. Anti-allergic principles in "Cnidii monnieri".
PubMed: Effect of osthol on arterial blood gases of dogs under barbiturate narcosis.
PubMed: Comparison of circulatory and respiratory stimulant effects of 'osthol' with nikethamide, pentylenetetrazole and prethcamide and its antagonism to various CNS depressants.
PubMed: 7-METHOXY-8-ISO-PENTENYL COUMARIN (OSTHOL) -- TOXICITY AND ITS MECHANISM OF RESPIRATORY STIMULANT ACTION.
PubMed: Pharmacological properties of a crystalline substance (Osthol) isolated from Prangos pabularia Lindl.
PubMed: Identification of osthole in Hseh Tsuang seed.
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