EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

2,6-diisopropyl phenol
2,6-bis(1-methylethyl)phenol

Supplier Sponsors

Name:2,6-di(propan-2-yl)phenol
CAS Number: 2078-54-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:218-206-6
FDA UNII:YI7VU623SF
Nikkaji Web:J102.606B
Beilstein Number:1866484
MDL:MFCD00008885
XlogP3:3.80 (est)
Molecular Weight:178.27466000
Formula:C12 H18 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless to pale yellow clear liquid (est)
Assay: 96.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:0.96200 @ 25.00 °C.
Refractive Index:1.51400 @ 20.00 °C.
Melting Point: 18.00 °C. @ 760.00 mm Hg
Boiling Point: 254.00 to 256.00 °C. @ 764.00 mm Hg
Vapor Pressure:0.010000 mmHg @ 25.00 °C. (est)
Vapor Density:5.6 ( Air = 1 )
Flash Point: 235.00 °F. TCC ( 112.78 °C. )
logP (o/w): 3.790
Soluble in:
 alcohol
 water, 123.8 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Strength:low
Odor Description:at 100.00 %. mild phenolic
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
None found
 
Suppliers:
Berjé
2,6-Diiso Propyl Phenol
Happening at Berje
BOC Sciences
For experimental / research use only.
Propofol >98%
Odor: characteristic
Use: Propofol, a hypnotic alkylphenol derivative, is a general anesthetic for surgery or other medical procedures.
Penta International
2,6-DIISOPROPYLPHENOL
Sigma-Aldrich: Aldrich
For experimental / research use only.
2,6-Diisopropylphenol 97%
Synerzine
2,6-Di-isopropylphenol
Vigon International
Diisopropyl-2 6 Phenol
Odor: FAINT, PHENOLIC
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intravenous-dog LD50 30 mg/kg
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 1117, 1996.

intravenous-man LDLo 386 mg/kg/14D-
LUNGS, THORAX, OR RESPIRATION: PLEURAL THICKENING
Critical Care Medicine. Vol. 23, Pg. 1928, 1995.

unreported-man TDLo 2857 ug/kg/1D-
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: REGIDITY BEHAVIORAL: IRRITABILITY
Anaesthesia. Vol. 43, Pg. 170, 1988.

intraperitoneal-mouse LD50 170 mg/kg
Journal of Medicinal and Pharmaceutical Chemistry. Vol. 2, Pg. 201, 1960.

intravenous-mouse LD50 50 mg/kg
BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: ANALGESIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.

oral-mouse LD50 1100 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.

intravenous-rabbit LDLo 20 mg/kg
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: GENERAL ANESTHETIC BEHAVIORAL: SLEEP
Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.

intravenous-rat LD50 42 mg/kg
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 11, 1993.

oral-rat LD50 500 mg/kg
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: flavor and fragrance agents
 
 
Safety References:
EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):2078-54-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :4943
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:3
2,6-di(propan-2-yl)phenol
Chemidplus:0002078548
RTECS:SL0810000 for cas# 2078-54-8
 
References:
 2,6-di(propan-2-yl)phenol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:2078-54-8
Pubchem (cid):4943
Pubchem (sid):134981564
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C07523
HMDB (The Human Metabolome Database):Search
Export Tariff Code:2907.19.5000
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
trade name: diprivan from table
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 cheese parmesan cheese
Search PMC Picture
 cheese romano cheese
Search PMC Picture
 
Synonyms:
 ampofol
 aquafol
 aquavan
2,6-di-iso-propylphenol
2,6-di-isopropylphenol
2,6-di(propan-2-yl)phenol
2,6-diiso propyl phenol
 diisopropyl-2 6 phenol
2,6-diisopropyl-phenol
 diisopropylphenol
2,6-diisopropylphenol
 dipravan
 diprivan 10
2,6-dipropan-2-ylphenol
 disoprivan
 disoprofol
 fresofol
 ivofol
2,6-bis(1-methylethyl)benzolol
2,6-bis(methylethyl)phenol
2,6-bis(1-methylethyl)phenol
 phenol, 2,6-bis(1-methylethyl)-
 phenol, 2,6-diisopropyl-
2,6-bis(propan-2-yl)phenol
 propofol
 propofolum
2,6-bis(isopropyl) phenol
2,6-bis(isopropyl)-phenol
2,6-bis(isopropyl)phenol
 rapinovet
 recofol
 

Articles:

PubMed:Propofol infusion associated metabolic acidosis in patients undergoing neurosurgical anesthesia: a retrospective study.
PubMed:Protective effect of acetyl-L-carnitine on propofol-induced toxicity in embryonic neural stem cells.
PubMed:Propofol administration is safe in adult eosinophilic esophagitis patients sensitized to egg, soy, or peanut.
PubMed:Drugs and the death penalty.
PubMed:Effects of propofol on expression of hippocampal neuronal nitric oxide synthase and carboxy-terminal PDZ ligand of neuronal nitric oxide synthase in stressed rats undergoing electroconvulsive shock.
PubMed:Entropy correlates with Richmond Agitation Sedation Scale in mechanically ventilated critically ill patients.
PubMed:Simultaneous determination of 11 related impurities in propofol by gas chromatography/tandem mass spectrometry coupled with pulsed splitless injection technique.
PubMed:Acitretin exhibits inhibitory effects towards UDP-glucuronosyltransferase (UGT)1A9-mediated 4-methylumbelliferone (4-MU) and propofol glucuronidation reaction.
PubMed:Anaesthetic considerations for endoscopic retrograde cholangio-pancreatography procedures.
PubMed:US Propofol Drug Shortages: A Review of the Problem and Stakeholder Analysis.
PubMed:Claw amphiphiles with a dendrimer core: nanoparticle stability and drug encapsulation are directly proportional to the number of digits.
PubMed:Assessment of oxidative stress and antioxidant property using electron spin resonance (ESR) spectroscopy.
PubMed:Evaluation of sigmoidal maturation and allometric models: prediction of propofol clearance in neonates and infants.
PubMed:Self-administration of propofol is mediated by dopamine D1 receptors in nucleus accumbens in rats.
PubMed:Effects of propofol on the activation of hippocampal CaMKII╬▒ in depressed rats receiving electroconvulsive therapy.
PubMed:Propofol allergy: assessing for patient risks.
PubMed:[Fospropofol: A new prodrug of propofol].
PubMed:Dexmedetomidine: a guide to its use for sedation in the US.
PubMed:Identification of UDP-glucuronosyltransferase isoforms involved in hepatic and intestinal glucuronidation of phytochemical carvacrol.
PubMed:When one drug affects 2 patients: a review of medication for the management of nonlabor-related pain, sedation, infection, and hypertension in the hospitalized pregnant patient.
PubMed:Safe injection practices for administration of propofol.
PubMed:Dependence potential of propofol: behavioral pharmacology in rodents.
PubMed:Potential hypersensitivity due to the food or food additive content of medicinal products in Spain.
PubMed:Pharmacokinetics of ketamine and propofol combination administered as ketofol via continuous infusion in cats.
PubMed:Propofol sedation for ERCP procedures: a dilemna? Observations from an anesthesia perspective.
PubMed:Differential involvement of GABAA and GABAB receptors in propofol self-administration in rats.
PubMed:Drug shortage.
PubMed:Procedural sedation practices in Australian Emergency Departments.
PubMed:Anaesthesia of three young grey seals (Halichoerus grypus) for fracture repair.
PubMed:Non-anaesthesiologists should not be allowed to administer propofol for procedural sedation: a Consensus Statement of 21 European National Societies of Anaesthesia.
PubMed:Anesthesia in the patient with multiple drug allergies: are all allergies the same?
PubMed:Allergic reactions to propofol in egg-allergic children.
PubMed:Computer-assisted personalized sedation.
PubMed:My patient is allergic to eggs, can i use propofol? A case report and review.
PubMed:Why are there so many drug shortages?
PubMed:Administration of propofol.
PubMed:The reality of drug shortages--the case of the injectable agent propofol.
PubMed:Identification of the human UDP-glucuronosyltransferases involved in the glucuronidation of combretastatin A-4.
PubMed:[Unexpected vomiting during anesthetic induction in a patient with a history of anterosternal esophageal reconstruction].
PubMed:Off-label medication use in an academic hospital pediatric critical care unit.
PubMed:Schedule of controlled substances; placement of fospropofol into schedule IV. Final rule.
PubMed:Fospropofol: a new sedative-hypnotic agent for monitored anesthesia care.
PubMed:Fospropofol disodium, a water-soluble prodrug of the intravenous anesthetic propofol (2,6-diisopropylphenol).
PubMed:Effect of administration of propofol and xylazine hydrochloride on recovery of horses after four hours of anesthesia with desflurane.
PubMed:Anesthesia or sedation for gastroenterologic endoscopies.
PubMed:The effect of postoperative fasting on vomiting in children and their assessment of pain.
PubMed:Self-limited febrile syndromes temporally associated with the use of propofol for sedation in gastrointestinal endoscopic procedures.
PubMed:Fospropofol approved for monitored anesthesia care.
PubMed:Delirium at the end of life.
PubMed:Use of propofol in patients with food allergies.
PubMed:Questions unanswered: propofol use in the pediatric intensive care unit.
PubMed:[Elective colon resection in Germany. A survey of the perioperative anesthesiological management].
PubMed:Use of anesthetic agents in neonates and young children.
PubMed:Delirium at the end of life.
PubMed:Respiratory failure due to morbid obesity in a patient with Prader-Willi syndrome: an experience of long-term mechanical ventilation.
PubMed:Reports of death with use of propofol (Diprivan) for nonprocedural (long-term) sedation and literature review.
PubMed:Nurse-administered propofol sedation: a review of current evidence.
PubMed:Electroconvulsive therapy (ECT) in a six-year-old girl suffering from major depressive disorder with catatonic features.
PubMed:The propofol controversy.
PubMed:The propofol debate continues.
PubMed:Sedation and analgesia for gastrointestinal endoscopy during pregnancy.
PubMed:The major role of clinicians in the discovery of off-label drug therapies.
PubMed:Use of intravenous steroids at induction of anaesthesia for adult tonsillectomy to reduce post-operative nausea and vomiting and pain: a double-blind randomized controlled trial.
PubMed:Propofol 6% as sedative in children under 2 years of age following major craniofacial surgery.
PubMed:Droperidol and dolasetron alone or in combination for prevention of postoperative nausea and vomiting after vitrectomy.
PubMed:Safety of sodium phosphate tablets in patients receiving propofol-based sedation for colonoscopy.
PubMed:Efficacy and safety of endoscopic dilation of esophageal strictures in epidermolysis bullosa.
PubMed:Glucuronidation as a mechanism of intrinsic drug resistance in human colon cancer: reversal of resistance by food additives.
PubMed:The FDA warning against prolonged sedation with propofol in children remains warranted.
PubMed:Pediatric drug labeling: improving the safety and efficacy of pediatric therapies.
PubMed:[Caloric overload in critically ill patients treated with parenteral nutrition].
PubMed:Differential role of leptin receptors at the hypothalamic paraventricular nucleus in tonic regulation of food intake and cardiovascular functions.
PubMed:Propofol syndrome in children.
PubMed:Possible anaphylaxis after propofol in a child with food allergy.
PubMed:Gastroenterologist-administered propofol versus meperidine and midazolam for advanced upper endoscopy: a prospective, randomized trial.
PubMed:Propofol does not modify the hemodynamic status of children with intracardiac shunts undergoing cardiac catheterization.
PubMed:Microchip vagal pacing reduces food intake and body mass.
PubMed:The effect of propofol administered intravenously on appetite stimulation in dogs.
PubMed:Enhanced intestinal motility influences absorption in anaesthetized rat.
PubMed:Propofol improves recovery from paraquat acute toxicity in vitro and in vivo.
PubMed:'Diprivan': a change of formulation.
PubMed:Comparison of the intravenous reinforcing effects of propofol and methohexital in baboons.
PubMed:Propofol containing sulfite-potential for injury.
PubMed:Antioxidant effects of propofol in human hepatic microsomes: concentration effects and clinical relevance.
PubMed:"Preservatives" in propofol.
PubMed:Effect of enteral versus parenteral feeding on hepatic blood flow and steady state propofol pharmacokinetics in ICU patients.
PubMed:Muscimol-like discriminative stimulus effects of GABA agonists in rats.
PubMed:[Ban of the use of metomidate (Hypnodil) in swine. Background, consequences and alternatives].
PubMed:Pharmacologic influence on nutrition support therapy: use of propofol in a patient receiving combined enteral and parenteral nutrition support.
PubMed:The publication of commercially supported supplements statement.
PubMed:How do anesthesiologists select patients when introducing a new drug into practice?
PubMed:The initial clinical experience of 1819 physicians in maintaining anesthesia with propofol: characteristics associated with prolonged time to awakening.
PubMed:Endogenous Candida endophthalmitis after intravenous anesthesia with propofol.
PubMed:A method for quantitative analysis of flavor-tainting alkylphenols and aromatic thiols in fish.
 
Notes:
an intravenous anesthetic agent which has the advantage of a very rapid onset after infusion or bolus injection plus a very short recovery period of a couple of minutes. (from smith and reynard, textbook of pharmacology, 1992, 1st ed, p206). propofol has been used as anticonvulsants and antiemetics.
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