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sodium pyrophosphate
tetrasodium pyrophosphate

Sponsors

Name:tetrasodium phosphonato phosphate
CAS Number: 7722-88-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:231-767-1
FDA UNII:O352864B8Z
Nikkaji Web:J9.299A
MDL:MFCD00003513
Molecular Weight:265.90100112
Formula:Na4 O7 P2
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:emulsifiers, buffering agents, emulsifying agents, sequestrants
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
182.6760 Sodium pyrophosphate View-review
JECFA Food Additive: Tetrasodium Pyrophosphate
GSFA Codex: Tetrasodium diphosphate (450(iii))
FDA Mainterm: SODIUM PYROPHOSPHATE
FDA Regulation:
FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.169 Pasteurized process cheese.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.173 Pasteurized process cheese food.


FDA PART 133 -- CHEESES AND RELATED CHEESE PRODUCTS
Subpart B--Requirements for Specific Standardized Cheese and Related Products
Sec. 133.179 Pasteurized process cheese spread.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.210 Acrylate ester copolymer coating.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS
Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.29 Stabilizers.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart G--Sequestrants1
Sec. 182.6787 Sodium pyrophosphate.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart G--Sequestrants1
Sec. 182.6789 Tetra sodium pyrophosphate.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart A--General Provisions
Sec. 182.70 Substances migrating from cotton and cotton fabrics used in dry food packaging.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 988.00 °C. @ 760.00 mm Hg
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): -3.420 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
 
Organoleptic Properties:
Odor Description:at 100.00 %. odorless
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: anticaking agents
buffering agents
chelating agents
oral care agents
 
Suppliers:
Allan Chemical
Sodium Pyrophosphate
American Elements
Sodium Pyrophosphate Tetrabasic 99%
Odor: characteristic
Use: Sodium Pyrophosphate Tetrabasic is generally immediately available in most volumes. High purity, submicron and nanopowder forms may be considered. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia) and follows applicable ASTM testing standards.
American International Chemical, LLC.
TETRASODIUM PYROPHOSPHATE ANHYDROUS FCC GRANULAR
BOC Sciences
For experimental / research use only.
Tetrasodium pyrophosphate anhydrous, Technical
Foodchem International
TetraSodium Pyrophosphate
Graham Chemical
Tetrasodium Pyrophosphate
Kraft Chemical
Tetrasodium Phyrophosphate
Penta International
SODIUM PYROPHOSPHATE ANHYDROUS POWDER FCC
Penta International
TETRASODIUM PYROPHOSPHATE
Prinova
TETRASODIUM PYROPHOSPHATE
Santa Cruz Biotechnology
For experimental / research use only.
Sodium pyrophosphate tetrabasic ≥95%
Sigma-Aldrich: Aldrich
For experimental / research use only.
Sodium pyrophosphate tetrabasic ≥95%
Zhong Ya Chemical
Tetrasodium Pyrophosphate
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/39 - Wear suitable clothing and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 4000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 172, 1957.

oral-mouse LD50 2980 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 445, 1957.

intravenous-mouse LD50 69 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 445, 1957.

intraperitoneal-rat LD50 59 mg/kg
BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 108, Pg. 117, 1953.

intravenous-rat LD50 100 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 172, 1957.

Dermal Toxicity:
skin-rabbit LD50 > 300 mg/kg
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 47, 1990.

subcutaneous-mouse LD50 400 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 7, Pg. 445, 1957.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: emulsifiers, buffering agents, emulsifying agents, sequestrants
Recommendation for sodium pyrophosphate usage levels up to:
 not for fragrance use.
 
Recommendation for sodium pyrophosphate flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):
Assessment of one published review on health risks associated with phosphate additives in food
View page or View pdf
EPI System: View
Daily Med:search
NIOSH International Chemical Safety Cards:search
NIOSH Pocket Guide:search
NLM Hazardous Substances Data Bank:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):7722-88-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :24403
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
tetrasodium phosphonato phosphate
Chemidplus:0007722885
EPA/NOAA CAMEO:hazardous materials
RTECS:7722-88-5
 
References:
 tetrasodium phosphonato phosphate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:7722-88-5
Pubchem (cid):24403
Pubchem (sid):134989345
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D05873
HMDB (The Human Metabolome Database):Search
FooDB:FDB013382
FDA Listing of Food Additive Status:View
Haz-Map:View
Household Products:Search
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
•tspp is used in vanilla instant pudding-mix at levels of 2.8 g113.4 g of mix 2.8 g127.6 g of chocolate mix. patent 2,607,692. from table •curafos used in...microbiological inhibitory experiments contained 15% tspp, 70% stpp, and 15% shmp; fibrisol contained 25% sapp, 15% tspp, 10% shmp, and 50% nacl. phosphates •tspp is used in vanilla instant pudding-mix at levels of 1.5 g92.3 g of mix & 1.5 g113.8 g of chocolate mix. patent 2,801,924. tspp is used in unflavored instant pudding-mix at 2.2 g100.0 g of mix. patent 3,231,391. from table •grades: pure crystals; dried; fused; cp; fcc. •manufacturers: ...commercial mixtures of phosphates normally used in curing meat products are (curafos and fibrisol, manufactured by ja benckiser)...
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 buffering agents
 chelating agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 anhydrous tetrasodium pyrophosphate
 calgon
 diphosphoric acid tetrasodium salt
 diphosphoric acid, tetrasodium salt
 giltex
 hagan phosphate
 micromet
 phosphotex
 pyrophosphoric acid tetrasodium salt
 pyrophosphoric acid, tetrasodium salt
 quadrafos
 sodium diphosphate anhydrous
 sodium diphosphate tetrabasic
 sodium diphosphate, anhydrous
 sodium metaphosphates
 sodium phosphate (pyro)
 sodium pyrophosphate
 sodium pyrophosphate anhydrous powder FCC
 tetrasodium diphosphate
 tetrasodium phosphonato phosphate
 tetrasodium phyrophosphate
 tetrasodium pyrophosphate
 tetrasodium pyrophosphate (food grade)
 tetrasodium pyrophosphate anhydrous FCC powder
 tetrasodiumpyrophosphate
 TSPP
 victor TSPP
 

Articles:

PubMed:Physicochemical and sensory characteristics of fermented sheepmeat sausage.
PubMed:The effectiveness of antibrowning dip treatments to reduce after-cooking darkening in potatoes.
PubMed:Effects of Different End-Point Cooking Temperatures on the Efficiency of Encapsulated Phosphates on Lipid Oxidation Inhibition in Ground Meat.
PubMed:Comparison of the cryoprotective effects of trehalose, alginate, and its oligosaccharides on peeled shrimp (Litopenaeus vannamei) during frozen storage.
PubMed:Physicochemical and sensory characteristics of fermented sheepmeat sausage.
PubMed:Heightened avidity for trisodium pyrophosphate in mice lacking Tas1r3.
PubMed:Preparation and anti-osteoporotic activities in vivo of phosphorylated peptides from Antarctic krill (Euphausia superba).
PubMed:Encapsulated phosphates reduce lipid oxidation in both ground chicken and ground beef during raw and cooked meat storage with some influence on color, pH, and cooking loss.
PubMed:Calcium and α-tocopherol suppress cured-meat promotion of chemically induced colon carcinogenesis in rats and reduce associated biomarkers in human volunteers.
PubMed:Oil bulking agents based on polysaccharide gels in meat batters: a Raman spectroscopic study.
PubMed:The effectiveness of antibrowning dip treatments to reduce after-cooking darkening in potatoes.
PubMed:Effect of emulsifying salts on the physicochemical properties of processed cheese made from Mozzarella.
PubMed:Effect of the type of emulsifying salt on microstructure and rheological properties of "requeijão cremoso" processed cheese spreads.
PubMed:Nitrite-cured color and phosphate-mediated water binding of pork muscle proteins as affected by calcium in the curing solution.
PubMed:Mild protein oxidation enhanced hydration and myofibril swelling capacity of fresh ground pork muscle packaged in high oxygen atmosphere.
PubMed:In vitro evaluation of the erosive potential of orange juice modified by food additives in enamel and dentine.
PubMed:Survival of Escherichia coli O157:H7 in meat product brines containing antimicrobials.
PubMed:Purification and characterization of myosin-tripolyphosphatase from rabbit Psoas major muscle: research note.
PubMed:Effects of salt, sodium pyrophosphate, and sodium lactate on the probability of growth of Escherichia coli O157:H7 in ground beef.
PubMed:Quality of low fat pork sausage containing milk-co-precipitate.
PubMed:Evaluation of brining ingredients and antimicrobials for effects on thermal destruction of Escherichia coli O157:H7 in a meat model system.
PubMed:Effect of phosphate and meat (pork) types on the germination and outgrowth of Clostridium perfringens spores during abusive chilling.
PubMed:Protein hydrolysate of salted duck egg white as a substitute of phosphate and its effect on quality of Pacific white shrimp (Litopenaeus vannamei).
PubMed:Effect of tetrasodium pyrophosphate on the physicochemical properties of yogurt gels.
PubMed:Effects of pH on the textural properties and meltability of pasteurized process cheese made with different types of emulsifying salts.
PubMed:Influence of emulsifying salts on the textural properties of nonfat process cheese made from direct acid cheese bases.
PubMed:A comparative study on the effects of glucose monohydrate, hot water, and sodium pyrophosphate on quality parameters and microbial flora of deboned and matured brisket.
PubMed:Properties of milk protein gels formed by phosphates.
PubMed:Effect of chilling, polyphosphate and bicarbonate on quality characteristics of broiler breast meat.
PubMed:Effects of two types of emulsifying salts on the functionality of nonfat pasta filata cheese.
PubMed:Effects of emulsifying salts on the turbidity and calcium-phosphate-protein interactions in casein micelles.
PubMed:Characterization of an acid phosphatase from Lactobacillus pentosus: regulation and biochemical properties.
PubMed:Cations reduce antimicrobial efficacy of lysozyme-chelator combinations.
PubMed:A predictive model to determine the effects of temperature, sodium pyrophosphate, and sodium chloride on thermal inactivation of starved Listeria monocytogenes in pork slurry.
PubMed:Predictive thermal inactivation model for Listeria monocytogenes with temperature, pH, NaCl, and sodium pyrophosphate as controlling factors.
PubMed:Effect of sodium phytate, sodium pyrophosphate and sodium tripolyphosphate on physico-chemical characteristics of restructured beef.
PubMed:Growth of Clostridium perfringens from spore inocula in sous-vide turkey products.
PubMed:Apparent retardation of aging in Drosophila melanogaster by inhibitors of reverse transcriptase.
PubMed:Effects of infused glucose, sodium and potassium chlorides and polyphosphates on palatability of hot-boned pork.
PubMed:Potato tuber succinate semialdehyde dehydrogenase: purification and characterization.
PubMed:Winged bean in human nutrition.
PubMed:Stability of fat during irradiation and subsequent storage of irradiated buffalo meat.
 
Notes:
Used in foods as a buffering agent, pH control agent, alkalinity source, dispersing agent, protein modifier, coagulant and sequestrant
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