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Category:flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | pale yellow to brown crystals (est) |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 495.90 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 0.000000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 489.00 °F. TCC ( 253.70 °C. ) (est)
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| logP (o/w): | 3.440 (est) |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | refrigerate in tightly sealed containers. |
| Soluble in: |
| | alcohol | | | glycerin | | | water, 1.782e+005 mg/L @ 25 °C (est) | | | water, 1.08E+04 mg/L @ 25 °C (exp) |
Organoleptic Properties:
| Odor Strength:none |
| Odor Description:at 100.00 %. odorless |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
R 42/43 - May cause sensitization by inhalation and skin contact.
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37 - Wear suitable protective clothing and gloves.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | flavoring agents |
| Recommendation for quinine bisulfate usage levels up to: | | | not for fragrance use.
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| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | - |
| beverages(nonalcoholic): | 95.00000 | 100.00000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | - |
| fruit ices: | - | - |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
| | (5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol; sulfuric acid |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 549-56-4 |
| Pubchem (cid): | 11069 |
| Pubchem (sid): | 134978198 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | HMDB40183 |
| FooDB: | FDB019895 |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations:
•quinidine sulfate contains 82% of quinidine base by weight .
•quinidine sulfate available capsules, contain 100 mg of the drug; tablets of quinidine polygalacturonate contain 275 mg, equivalent to 200 mg of quinidine sulfate. prepn for slow absorption are also available as 300 mg extended release tablet of quinidine sulfate & a 324 mg tablet of gluconate. quinidine sulfate is also available as an injection in 1 ml ampule containing 200 mgml. the necessary dose is diluted to 800 mg50 ml in 5% glucose solution and is injected at the rate of 16 mgmin, with continuous observation of the patient & of the ecg.
•oral tablets extended release 324 mg (equivalent to quinidine 202 mg), quinaglute dura-tabs, berlex, quinatime, cmc; 330 mg (equivalent to quinidine 206 mg), duraquine (with povidone), warner chilcott; parenteral injection, 80 mg (equivalent to quinidine 50 mg) per ml, quinidine gluconate injection (with edetate disodium and phenol). lilly quinidine gluconate
•oral tablets 275 mg (equivalent to quinidine sulfate 200 mg), cardioquin (with povidone; scored), purdue frederick. quinidine polygalacturonate
•oral tablets, 200 mg, 300 mg, quinora, key; tablets, extended-released, 300 mg, quinidex extentabs, robins quinidine sulfate
•capsules and tablets 100, 200, and 300 mg. controlled release tablets, 300 mg. ampules, 200 mgml.
•quinidine sulfate is available as tablets (100 to 300 mg) capsules 200, and 300 mg. 300 mg substained release tablets (quinidex) are available, as is an injection (200 mgml). preparations of the gluconate and polygalacturonate salts are also marketed.
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cinchonan-9-ol, 6'-methoxy-, (8a,9R)-, sulfate (1:1) (salt) | | | cinchonan-9-ol, 6'-methoxy-, sulfate (1:1) (salt) | | (5- | ethenyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol; sulfuric acid | | (6- | methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol | | 6'- | methoxycinchonan-9-ol sulfate (1:1) | | 8alpha,9R-6'- | methoxycinchonan-9-ol sulfate (1:1) salt | | 6'- | methoxycinchonan-9-ol sulfate, (8a,9R)-, (1:1) | | 8a,9R-6'- | methoxycinchonan-9-ol, sulfate (1:1) salt | | | quinidine bisulfate | | | quinidine, sulfate (2:1) (salt) | | | quinine hydrogen sulfate | | | quinine hydrogen sulphate | | | quinine sulfate (1:1) salt | | | quinine sulphate | | | quinine, sulfate (1:1) (salt) |
Articles:
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Bitter flavouring
Used in tonics and bitter drinks Quinine is a natural white crystalline alkaloid having antipyretic, antimalarial, analgesic, anti-inflammatory properties and a bitter taste. It is a stereoisomer of quinidine which, unlike quinine, is an anti-arrhythmic. Though it has been synthesized in the lab, the bark of the cinchona tree is the only known natural source of quinine. Quinine was the first effective treatment for malaria caused by Plasmodium falciparum, appearing in therapeutics in the 17th century. It remained the antimalarial drug of choice until the 1940s, when other drugs replaced it. (Wikipedia)
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3D/inchi
