EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

polysorbate 60
tween 60

Supplier Sponsors

CAS Number: 9005-67-8Picture of molecule3D/inchi
Other(deleted CASRN):1014699-55-8
ECHA ELINCS - REACH Pre-Reg:500-020-4
Molecular Weight:1311.68742000
Formula:C64 H126 O26
NMR Predictor:Predict (works with chrome, Edge or firefox)
Category:emulsifiers, surfactants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
EU SANCO Polysorbates View - review
EU SANCO Polyoxyethylene sorbitan monostearate (polysorbate 60) View - review
JECFA Food Additive: Polyoxyethylene (20) Sorbitan Monostearate
GSFA Codex: Polyoxyethylene (20) sorbitan monostearate (435)
DG SANTE Food Additives:polysorbate 60
DG SANTE Food Contact Materials:polysorbate 60
FEMA Number:2916 polysorbate 60
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):9005-67-8 ; POLYSORBATE 60
FDA Regulation:
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.

Subpart I--Multipurpose Additives
Sec. 172.836 Polysorbate 60.

Subpart I--Multipurpose Additives
Sec. 172.838 Polysorbate 65.

Subpart I--Multipurpose Additives
Sec. 172.840 Polysorbate 80.

Subpart I--Multipurpose Additives
Sec. 172.842 Sorbitan monostearate.

Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.

Subpart D--Specific Usage Additives
Sec. 173.340 Defoaming agents.

Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.

Subpart D--Certain Adjuvants and Production Aids
Sec. 178.3400 Emulsifiers and/or surface-active agents.

Subpart B--Drugs
Sec. 73.1001 Diluents in color additive mixtures for drug use exempt from certification.
Physical Properties:
Appearance:pale yellow to yellow solid paste (est)
Assay: 96.00 to 100.00
Food Chemicals Codex Listed: Yes
Specific Gravity:1.04400 @ 25.00 °C.
Acid Value: 5.00 max. KOH/g
Saponification Value:55.00 to 70.00
Flash Point: 302.00 °F. TCC ( 150.00 °C. )
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 water, 0.01269 mg/L @ 25 °C (est)
Organoleptic Properties:
Odor Strength:low
Substantivity:400 Hour(s)
Odor Description:at 100.00 %. mild alcoholic
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: surfactants
surfactant - emulsifying
American International Chemical, LLC.
BOC Sciences
For experimental / research use only.
Polysorbat 60 95%
Chemical-navi - Nikkol
Odor: characteristic
Use: Hydrophilic emulsifier; solubilizer; dispersant; water soluble; plant-derived
Chemical-navi - Nikkol
Odor: characteristic
Use: Hydrophilic emulsifier; solubilizer; dispersant; water soluble; plant-derived
Covalent Chemical
Polysorbate 60
Tween™ 60
Odor: characteristic
Use: Super Refining removes polar impurities, preventing adverse interactions with APIs and enhancing the stability of pharmaceutical formulations. Offer the complete solution when formulating parenteral, oral, ophthalmic and topical pharmaceutical products. Super Refined Polysorbate 60 is an extremely mild and effective O/W emulsifier and solubiliser. Recommended topical usage levels of 0.5-5%.
ECSA Chemicals
Glentham Life Sciences
Tween 60, BP, Ph. Eur., USP/NF grade
Glentham Life Sciences
Tween 60
Graham Chemical
Polysorbate 60
Kao Corporation
Flavor: characteristic
It is a highly hydrophilic surfactant and approved as a food additives. It is a usuful emulsifier, dispersant and solubilizer for aroma chemiclas and oils. Combination of EMASOL S-120V and highly lipophlic one of EMASOL-series lead to a giving an excellent emulsifier.
Kao Corporation
Odor: characteristic
Use: Emulsifier and conditioning agent (low substantive effect). Detoxifying agent in shampoos (low irritation). Fragrances solubilizer.
Kao Corporation
Odor: characteristic
Use: Emulsifier for pharmaceuticals and cosmetics, Stabilizer for color materials, Stabilizer for emulsion polymerizations, Emulsifier for adjuvant of agrochemicals, Emulsifier for water based metal process cutting oils, Surface coating type antistatic agents.
Kraft Chemical
Polysorbate 60
Lipo Chemicals
Liposorb® S-20
Odor: characteristic
Use: Liposorb® S-20 is an oil-in-water emulsifier. Primarily used in combination with Liposorb® S or Lipo® GMS-450. The pair of emulsifiers produces medium, fine-textured lotions and creams in skin and hair care products. Liposorb® S-20 also acts as a spreading aid for bath oils, adds water-dispersibility to anhydrous systems and is a solubilizer for oils and fragrances.
Lonza Group
Glycosperse™ S-20 KFG
Lonza Group
Lonzest™ SMS-20
Mohini Organics
Odor: characteristic
Use: MONEBAT® - 60 is used as a emulsifier for cosmetics and pharmaceuticals, dispersant for insecticides, herbicides, cattle dyes, penetrant, levelling agent, lubricant, antistat.
Penta International
Penta International
Polysorbate 60
Certified Food Grade Products
SysKem Chemie
Polysorbate 60
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 > 60 ml/kg
Food Research. Vol. 21, Pg. 348, 1956.

intravenous-mouse LDLo 1000 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 685, 1956.

intravenous-rat LD50 1220 mg/kg
FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 254, 1974.

intraperitoneal-rat LDLo > 4000 mg/kg
Journal of Pharmacy and Pharmacology. Vol. 11, Pg. 150, 1959.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
emulsifiers, surfactants
Recommendation for polysorbate 60 usage levels up to:
 not for fragrance use.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -1600.00000
beverages(nonalcoholic): -110.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -28.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -150.00000
fruit ices: -150.00000
gelatins / puddings: -100.00000
granulated sugar: --
gravies: --
hard candy: -280.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -4000.00000
sugar substitutes: --
sweet sauces: --
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene
View page or View pdf

EPI System: View
Chemical Carcinogenesis Research Information System:Search
EPA Substance Registry Services (TSCA):9005-67-8
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :24832100
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
RTECS:WG2934000 for cas# 9005-67-8
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:9005-67-8
Pubchem (cid):24832100
Pubchem (sid):135303486
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
HMDB (The Human Metabolome Database):HMDB37183
Export Tariff Code:2915.70.0000
FDA Listing of Food Additive Status:View
Potential Blenders and core components note
None Found
Potential Uses:
 emulsifying agents
 essential oils solublizer
 fragrance solublizer
Occurrence (nature, food, other):note
 not found in nature
 emasol S-120V
 glycosperse S-20
 glycosperse S-20 KFG
 hetsorb S-20
 kaopan TW-S-120
 liposorb S-20
 lonzest SMS-20
 monebat - 60
 nikkol TS-10MV
 norfox sorbo T-60
 poe-20 sorbitan monostearate
 polyethyleneglycol sorbitan monostearate
 polyoxyethylene (20) sorbitan monostearate
 polysorbate 60 FCC
 polysorbate 60 USP/NF
 rheodol TW-S120V
 tween 60


PubMed:Optimization and preparation of nanocapsules for food applications using two methodologies.
PubMed:Retention and release of oil-in-water emulsions from filled hydrogel beads composed of calcium alginate: impact of emulsifier type and pH.
PubMed:Development, optimization and evaluation of surfactant-based pulmonary nanolipid carrier system of paclitaxel for the management of drug resistance lung cancer using Box-Behnken design.
PubMed:A new topical formulation for psoriasis: development of methotrexate-loaded nanostructured lipid carriers.
PubMed:Enhanced production and characterization of a solvent stable amylase from solvent tolerant Bacillus tequilensis RG-01: thermostable and surfactant resistant.
PubMed:Production, purification, and characterization of a cellulase-free thermostable endo-xylanase from Thermoanaerobacterium thermosaccharolyticum DSM 571.
PubMed:Drug compartmentalization as strategy to improve the physico-chemical properties of diclofenac sodium loaded niosomes for topical applications.
PubMed:Influence of co-surfactants on crystallization and stability of solid lipid nanoparticles.
PubMed:A new cold-adapted, organic solvent stable lipase from mesophilic Staphylococcus epidermidis AT2.
PubMed:Isolation and characterization of novel lipase gene LipHim1 from the DNA isolated from soil samples.
PubMed:Nonionic surfactant-based vesicular system for transdermal drug delivery.
PubMed:Cost-effective endo-mannanase from Bacillus sp. CFR1601 and its application in generation of oligosaccharides from guar gum and as detergent additive.
PubMed:Growth-dependent catalase localization in Exiguobacterium oxidotolerans T-2-2T reflected by catalase activity of cells.
PubMed:[The evaluation of lipolytic activity of strains of Enterococcus faecium].
PubMed:Formulation, characterization and pharmacokinetics of Morin hydrate niosomes prepared from various non-ionic surfactants.
PubMed:Influence of emulsifier structure on lipid bioaccessibility in oil-water nanoemulsions.
PubMed:Novel sample preparation method for surfactant containing suppositories: effect of micelle formation on drug recovery.
PubMed:Formulation and evaluation of Ketoconazole niosomal gel drug delivery system.
PubMed:Effects of selected polysorbate and sucrose ester emulsifiers on the physicochemical properties of astaxanthin nanodispersions.
PubMed:Transcriptional control of lipid metabolism by the MarR-like regulator FamR and the global regulator GlxR in the lipophilic axilla isolate Corynebacterium jeikeium K411.
PubMed:Comparative analysis of heterologous expression, biochemical characterization optimal production of an alkaline α-amylase from alkaliphilic Alkalimonas amylolytica in Escherichia coli and Pichia pastoris.
PubMed:Doxorubicin loaded magneto-niosomes for targeted drug delivery.
PubMed:Encapsulation of functional lipophilic components in surfactant-based colloidal delivery systems: vitamin E, vitamin D, and lemon oil.
PubMed:Structure-based replacement of methionine residues at the catalytic domains with serine significantly improves the oxidative stability of alkaline amylase from alkaliphilic Alkalimonas amylolytica.
PubMed:Nanoparticles modified by encapsulation of ligands with a long alkyl chain to affect multispecific and multimodal imaging.
PubMed:Carboxylesterase-triggered hydrolysis of nanoparticle PEGylating agents.
PubMed:Single non-ionic surfactant based self-nanoemulsifying drug delivery systems: formulation, characterization, cytotoxicity and permeability enhancement study.
PubMed:Preparation and evaluation of fenoterol hydrobromide suppositories.
PubMed:Solid lipid nanoparticles as intracellular drug transporters: an investigation of the uptake mechanism and pathway.
PubMed:In vitro assessment of the effectiveness of non-nutritive sorbent materials as binding agents for boar taint compounds.
PubMed:Efficacy of non-nutritive sorbent materials as intestinal-binding agents for the control of boar taint.
PubMed:Effect of tween series on growth and Cis-9, trans-11 conjugated linoleic acid production of Lactobacillus acidophilus F0221 in the presence of bile salts.
PubMed:[The evaluation of lipolytic activity of strains of Staphylococcus epidermidis and Staphylococcus haemolyticus].
PubMed:Physicochemical properties and skin permeation of Span 60/Tween 60 niosomes of ellagic acid.
PubMed:Mycoplasma mobile cells elongated by detergent and their pivoting movements in gliding.
PubMed:Improved spreading rates for monolayers applied as emulsions to reduce water evaporation.
PubMed:Nanoemulsions prepared by a low-energy emulsification method applied to edible films.
PubMed:Solubilization of fullerene C60 in micellar solutions of different solubilizers.
PubMed:O/W emulsions stabilised by both low molecular weight surfactants and colloidal particles: The effect of surfactant type and concentration.
PubMed:Adsorbed Tween 80 is unique in its ability to improve the stability of gold nanoparticles in solutions of biomolecules.
PubMed:Formulation and in vitro evaluation of ciprofloxacin containing niosomes for pulmonary delivery.
PubMed:Formulation and evaluation of a proniosome hydrocortisone gel in comparison with a commercial cream.
PubMed:Polymeric micelle-templated synthesis of hydroxyapatite hollow nanoparticles for a drug delivery system.
PubMed:Oceanobacillus neutriphilus sp. nov., isolated from activated sludge in a bioreactor.
PubMed:In vitro study on tamsulosin release kinetics from biodegradable PLGA in situ implants.
PubMed:Three-layered microcapsules as a long-term sustained release injection preparation.
PubMed:Formation and characterization of ordered bicontinuous microemulsions.
PubMed:Impact of surfactant properties on oxidative stability of beta-carotene encapsulated within solid lipid nanoparticles.
PubMed:Comparison of the orogenic displacement of sodium caseinate with the caseins from the air-water interface by nonionic surfactants.
PubMed:Biosynthesis of polyhydroxyalkanotes in wild type yeasts.
PubMed:Isolation of 19 strains of Malassezia dermatis from healthy human skin in Korea.
PubMed:Role of surfactants in optimizing fluorene assimilation and intermediate formation by Rhodococcus rhodochrous VKM B-2469.
PubMed:Intestinal lymphatic transport of halofantrine in rats assessed using a chylomicron flow blocking approach: the influence of polysorbate 60 and 80.
PubMed:Effects of several surfactants and high-molecular-weight organic compounds on decomposition of trichloroethylene with zerovalent iron powder.
PubMed:Viability and permeability across Caco-2 cells of CBZ solubilized in fully dilutable microemulsions.
PubMed:The preparation of pellets containing non-ionic surfactants by extrusion/spheronization.
PubMed:Niosome-encapsulated gentamicin for ophthalmic controlled delivery.
PubMed:Biomimetic synthesis of oriented hydroxyapatite mediated by nonionic surfactants.
PubMed:The effects of surfactants on the estimation of bacterial density in petroleum samples.
PubMed:Oral bioavailability enhancement of acyclovir by self-microemulsifying drug delivery systems (SMEDDS).
PubMed:Influence of nutrients on enhancing laccase production by Botryosphaeria rhodina MAMB-05.
PubMed:Production of L2 lipase by Bacillus sp. strain L2: nutritional and physical factors.
PubMed:Improved solubilization of carbamazepine and structural transitions in nonionic microemulsions upon aqueous phase dilution.
PubMed:Purification and characterization of two cold-adapted extracellular tannin acyl hydrolases from an Antarctic strain Verticillium sp. P9.
PubMed:Friction and adsorption of aqueous polyoxyethylene (Tween) surfactants at hydrophobic surfaces.
PubMed:Sorbitan ester organogels for transdermal delivery of sumatriptan.
PubMed:Combined photocontact dermatitis to benzydamine hydrochloride and the emulsifiers, Span 60 and Tween 60 contained in Tantum cream.
PubMed:Surfactant effect on persistence of oxadiazolyl 3(2H)-pyridazinones against Pseudaletia separata walker.
PubMed:S5 Lipase: an organic solvent tolerant enzyme.
PubMed:[Hydrolytic and haemolytic activity of Klebsiella pneumoniae and Klebsiella oxytoca].
PubMed:Phenotypic characterization and ecological features of Coccidioides spp. from Northeast Brazil.
PubMed:Effects of solubilizing surfactants and loading of antiviral, antimicrobial, and antifungal drugs on their release rates from ethylene vinyl acetate copolymer.
PubMed:Photophysical studies of Merocyanine 540 dye in aqueous micellar dispersions of different surfactants and in different solvents.
PubMed:[Photochemical degradation of chlorothalonil in aqueous solution].
PubMed:Tween 40-based precipitate production observed on modified chromogenic agar and development of biological identification kit for Malassezia species.
PubMed:Lipolytic activity and radial daily growth rate changes during incubation of thermomyces lanuginosus on natural and synthetic fatty substrates.
PubMed:Selection of surfactants for stable paraffin-in-water dispersions, undergoing solid-liquid transition of the dispersed particles.
PubMed:Improved solubilization of Celecoxib in U-type nonionic microemulsions and their structural transitions with progressive aqueous dilution.
PubMed:Stabilization of solid dispersions of nimodipine and polyethylene glycol 2000.
PubMed:Development and stability of semisolid preparations based on a supercritical CO2 Arnica extract.
PubMed:Vital growth factors of Malassezia species on modified CHROMagar Candida.
PubMed:Release studies on niosomes containing fatty alcohols as bilayer stabilizers instead of cholesterol.
PubMed:Single-crystalline platinum nanosheets from nonionic surfactant 2-D self-assemblies at solid/aqueous solution interfaces.
PubMed:Nitrincola lacisaponensis gen. nov., sp. nov., a novel alkaliphilic bacterium isolated from an alkaline, saline lake.
PubMed:Composition analysis of two batches of polysorbate 60 using MS and NMR techniques.
PubMed:Enhancement of melatonin photostability by encapsulation in lipospheres.
PubMed:Regioselective hydroxylation of adamantane by Streptomyces griseoplanus cells.
PubMed:Anaerobic biodegradability of Tween surfactants used as a carbon source for the microbial reductive dechlorination of hexachlorobenzene.
PubMed:Characterization and dissolution properties of ketoprofen in binary and ternary solid dispersions with polyethylene glycol and surfactants.
PubMed:Synthesis of high surface area hydroxyapatite nanoparticles by mixed surfactant-mediated approach.
PubMed:Purification and characterization of a serine alkaline protease from Bacillus clausii GMBAE 42.
PubMed:Fluorometric sensing of alkali metal and alkaline earth metal cations by novel photosensitive monoazacryptand derivatives in aqueous micellar solutions.
PubMed:Acid-base equilibrium of anionic dyes partially bound to micelles of nonionic surfactants.
PubMed:Effect of organogel components on in vitro nasal delivery of propranolol hydrochloride.
PubMed:The effect of ionic strength and hardness of water on the non-ionic surfactant-enhanced remediation of perchloroethylene contamination.
PubMed:Effect of biosurfactants on crude oil desorption and mobilization in a soil system.
PubMed:Physical characterizations of microemulsion systems using tocopheryl polyethylene glycol 1000 succinate (TPGS) as a surfactant for the oral delivery of protein drugs.
PubMed:Stimulation of triglyceride-rich lipoprotein secretion by polysorbate 80: in vitro and in vivo correlation using Caco-2 cells and a cannulated rat intestinal lymphatic model.
PubMed:High-level heterologous expression and properties of a novel lipase from Ralstonia sp. M1.
PubMed:[Biochemical properties of Corynebacterium amycolatum strains].
PubMed:Influence of emulsifier type and content on functional properties of polysaccharide lipid-based edible films.
PubMed:Phase distribution of hexachlorobenzene in a suspended-growth culture amended with a polysorbate surfactant.
PubMed:Effect of surfactant type on surfactant--protein interactions at the air-water interface.
PubMed:Effect of processing on the displacement of whey proteins: applying the orogenic model to a real system.
PubMed:Description of a new yeast species, Malassezia japonica, and its detection in patients with atopic dermatitis and healthy subjects.
PubMed:Evaluation of phloxine B as a possible control agent against citrus thrips (Thysanoptera: Thripidae).
PubMed:Rheology and stability of acidified food emulsions treated with high pressure.
PubMed:Self-diffusion nuclear magnetic resonance, microstructure transitions, and solubilization capacity of phytosterols and cholesterol in Winsor IV food-grade microemulsions.
PubMed:Enhanced secretion and low temperature stabilization of a hyperthermostable and Ca2+-independent alpha-amylase of Geobacillus thermoleovorans by surfactants.
PubMed:Investigation of physical and hypoglycaemic properties of rectal suppositories with chosen insulin.
PubMed:Enhanced fluorescence of triphenylmethane dyes in aqueous surfactant solutions at supramicellar concentrations--effect of added electrolyte.
PubMed:Determination of iodine values using 1,3-dibromo-5,5-dimethylhydantoin (DBH) without the employment of chlorinated hydrocarbons. Analytical methods of pharmacopoeias with DBH in respect to environmental and economical concern. Part 17.
PubMed:Development and characterization of rosin-based polymer and its application as a cream base.
PubMed:Influence of alcohol cosurfactants on surfactant-enhanced flushing of diesel-contaminated soil.
PubMed:Furfural-cysteine model reaction in food grade nonionic oil/water microemulsions for selective flavor formation.
PubMed:Improved polygalacturonase production from Bacillus sp. MG-cp-2 under submerged (SmF) and solid state (SSF) fermentation.
PubMed:Fats and fatty acids as growth factors for Lactobacillus delbrueckii.
PubMed:Effects of E047/1, a new antiarrhythmic drug, on experimental atrial fibrillation in anesthetized dogs.
PubMed:Solubility and dissolution rate of ibuprofen in ionic and non-ionic micellar systems.
PubMed:Characterization of de-emulsification capabilities of a Micrococcus species.
PubMed:Development of hexachlorobenzene-dechlorinating mixed cultures using polysorbate surfactants as a carbon source.
PubMed:Evaluation and preparation of controlled release lipid micropheres of sulphamethizole by a congealable disperse phase encapsulation method.
PubMed:Cell-bound and extracellular carboxylesterases from Streptomyces: hydrolytic and synthetic activities.
PubMed:Phytoene synthase from tomato (Lycopersicon esculentum) chloroplasts--partial purification and biochemical properties.
PubMed:[Studies on fermentation of decane 1,10-dicarboxylic acid(DC12)].
PubMed:Effects of Tween 60 and Tween 80 on protease activity, thiol group reactivity, protein adsorption, and cellulose degradation by rumen microbial enzymes.
PubMed:Effects of some non-ionic surfactants on transepithelial permeability in Caco-2 cells.
PubMed:The use of some ingredients for microemulsion preparation containing retinol and its esters.
PubMed:Analysis of some commercial polysorbate formulations using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
PubMed:Enhanced inhibition of platelet aggregation in-vitro by niosome-encapsulated indomethacin.
PubMed:Evaluation of dietary supplements of lipase, detergent, and crude porcine pancreas on fat utilization by young broiler chicks.
PubMed:Comparison of cytotoxicity of various surfactants tested on normal human fibroblast cultures using the neutral red test, MTT assay and LDH release.
PubMed:Development of a topically active imiquimod formulation.
PubMed:The composition of NF-defined emulsifiers: sorbitan monolaurate, monopalmitate, monostearate, monooleate, polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80.
PubMed:Intramolecular Excited State Proton Transfer of 2-(2'-Hydroxyphenyl)benzimidazole in Nonionic Micelles: Tweens.
PubMed:[Experiences with the rectal use of chemotherapeutic agents. 2. Pharmacokinetic examinations with animals].
PubMed:Experiences with the rectal use of trimethoprim.
PubMed:Biological microemulsions V: mutual mixing of oils, amphiphiles and water in ternary and quaternary combinations.
PubMed:Phospholipase activity in Malassezia furfur pathogenic strains.
PubMed:Hydrolase activity of 150 Malassezia furfur isolates of different clinical origin.
PubMed:SOD-like Activity of Copper Salicylate Complex in Tween Micellar Systems.
PubMed:In vitro release of ketoprofren and ibuprofen from viscoelastic gels.
PubMed:Lipase from Pseudomonas fragi CRDA 323: partial purification, characterization and interesterification of butter fat.
PubMed:Chronic toxicity of tar from heavy-duty diesel exhaust following intratracheal instillations to the lungs of hamsters.
PubMed:Pityrosporum ovale culture from the forehead of healthy children.
PubMed:The purification of phytoene dehydrogenase from Phycomyces blakesleeanus.
PubMed:Covalent immobilization of protein monolayers for biosensor applications.
PubMed:An improved method for quantitative culture of Malassezia furfur.
PubMed:Induction of proliferin gene expression by diverse chemical agents that promote morphological transformation in C3H/10T1/2 cultures.
PubMed:Improvement of clonazepam release from a Carbopol hydrogel.
PubMed:In vivo evaluation in man by two noninvasive methods of the stratum corneum barrier function after physical and chemical modifications.
PubMed:The frequency of spontaneously-occurring neoplasms in the male Syrian golden hamster.
PubMed:[Skin permeability modifications in vivo in men after application of surfactants. Importance of experimental conditions in the determination of transepidermal insensible water loss].
PubMed:Evaluation of the anticancer activities of Tweens 20, 40 and 60 in SJL/J mice.
PubMed:Effect of polyoxyethylene sorbate compounds (Tweens) on colonial morphology, growth, and ultrastructure of Mycobacterium paratuberculosis.
PubMed:Effect of Agitation on Ligninase Activity and Ligninase Production by Phanerochaete chrysosporium.
PubMed:[The lipolytic activity of dermatophytes].
PubMed:In vitro release of propranolol from oil/water microemuisions.
PubMed:Solubilization, characterization and partial purification of [3H]mepyramine-binding protein, a possible histamine H1 receptor, from rat liver membrane.
PubMed:Teratology study of Tween 60 in rats.
PubMed:Preliminary observation on pancreatic duct adenocarcinoma induced by intraductal administration of N-ethyl-N'-nitro-N-nitrosoguanidine in dogs.
PubMed:A study on the cell kinetics of the canine gastric mucosa by the cytofluorometric method: an evaluation of chemically induced gastric cancer.
PubMed:Effects of various tumor promoters on expression of cartilage phenotypes in rabbit costal chondrocytes in culture.
PubMed:Modification of reversed-phase separations of small molecules using non-ionic surfactants and mixed ionic-non-ionic surfactants.
PubMed:Effect of gavage vehicle on hepatotoxicity of carbon tetrachloride in CD-1 mice: corn oil versus Tween-60 aqueous emulsion.
PubMed:Effect of protein deficiency and Tween 60 on the pharmacokinetics of butylated hydroxyanisole and metabolites in male Sprague-Dawley rats.
PubMed:Lack of efficacy of polysorbate 60 in the treatment of male pattern baldness.
PubMed:Spectrophotometric method for quantitation of peroxides in sorbitan monooleate and monostearate.
PubMed:Influence of surface-active food additives on the integrity and permeability of rat intestinal mucosa.
PubMed:Skin irritancy of surfactants as assessed by water vapor loss measurements.
PubMed:A rapid, simple screening method for skin-tumor promoters using mouse peritoneal macrophages in vitro.
PubMed:Cytological effects of the insecticide tetrachlorvinphos.
PubMed:Comparative lethality of coca and cocaine.
PubMed:Mechanisms of toxicities of some detergents added to a diet and of the ameliorating effect of dietary fiber in the rat.
PubMed:Effects of NaCl, Tween 60 and a low dose of N-ethyl-N'-nitro-N-nitrosoguanidine on gastric carcinogenesis of rat given a single dose of N-methyl-N'-nitro-N-nitrosoguanidine.
PubMed:Extreme vertexes design in formulation development: solubility of butoconazole nitrate in a multicomponent system.
PubMed:A short-term in vitro assay for promoter substances using human lymphoblastoid cells latently infected with Epstein-Barr virus.
PubMed:Inhibiton of phorbol ester-stimulated chemiluminescence in human polymorphonuclear leukocytes by retinoic acid and 5,6-epoxyretinoic acid.
PubMed:Chemotherapeutic study on canine gastric cancer induced by N-ethyl-N'-nitro-N-nitrosoguanidine.
PubMed:Interactions between tumor-promoting agents and histones studied by circular dichroism.
PubMed:Promoting action of croton oil on gastrocarcinogenesis by N-methyl-N'-nitro-N-nitrosoguanidine in rats.
PubMed:Mitochondrial biogenesis during fungal spore germination: effects of the antilipogenic antibiotic cerulenin upon Botryodiplodia spores.
PubMed:Experimental chronic obstructive lung disease. I. Bronchopulmonary changes induced in rabbits by prolonged exposure to formaldehyde.
PubMed:Quantitative determination of polysorbate to in non-standard salad dressings.
PubMed:Induction of plasminogen activator in cultured cells by macrocyclic plant diterpene esters and other agents related to tumor promotion.
PubMed:Adenocarcinomas of the stomach induced in beagle dogs by oral administration of N-ethyl-N'-nitro-N-nitrosoguanidine.
PubMed:Contact urticaria to a corticosteroid cream: polysorbate 60.
PubMed:Effect of iodoacetamide or Tween 60 on methylnitrosocyanamide carcinogenesis in rat glandular and forestomach.
PubMed:[Influence of the physical structure of phospholipid membranes on peroxidation induced by Fe2+ ions].
PubMed:Histoenzymology of the lung. II. The behaviour of lung hydrolytic enzymes during some experimental pulmonary processes.
PubMed:Histoenzymology of the lung. I. Enzyme activities of the lung tissue of acult humans; relationships between structure and functions.
PubMed:[Therapeutical action of urea on the skin (author's transl)].
PubMed:[Liberation of solubilized active substances from ointment bases. IV. Effect of some solvents on the liberation of detreomycin from emulsion ointments made of white petrolatum with the addition of 3% Tween 60].
PubMed:Utilization of kerosene by a hydrocarbon-assimilating strain of Fusarium oxisporum.
PubMed:Effects of growth conditions on the ion composition of Bifidobacterium bifidum subsp. pennsylvanicum.
PubMed:Effects of growth conditions on the lipid composition of Bifidobacterium bifidum subsp. pennsylvanicum.
PubMed:Methods for rapidly altering the permeability of mammalian cells.
PubMed:Biological and immunological studies on two substrains, c-1 and c-3, derived from the Nakayama-NIH strain of Japanese encephalitis virus.
PubMed:Decrease of epidermal histidase activity by tumor-promoting phorbol esters.
PubMed:Effect of polysorbate 60 on interphase transport of cholesterol.
PubMed:Induction of the polyamine-biosynthetic enzymes in mouse epidermis and their specificity for tumor promotion.
PubMed:Sequential morphological changes of ulceration in the glandular stomach of rats induced by iodoacetamide.
PubMed:[Toxic effects of Tween 60 and 80 on thrombocytes (spindle cells) in frog blood].
PubMed:Cell kinetics of gastric carcinoma and other gastric lesions in rats by N-methyl-N'-nitro-N-nitrosoguanidine with or without Tween 60.
PubMed:[Comparative study of the effect of nonionic detergents as inhibitors of respiration of tumor ascites cells].
PubMed:Comparison of lung cancer and amyloidosis in rabbits induced by chemical carcinogens.
PubMed:Effect of tweens on the production of ergot alkaloids by Aspergillus fumigatus.
PubMed:Method for performing aerobic plate counts of anhydrous cosmetics utilizing Tween 60 and Arlacel 80 as dispersing agents.
PubMed:The determination of polysorbate 60 in foods.
PubMed:Reversible alterations of the surface of ascites tumour cells induced by a surface-active substance, Tween 60.
PubMed:[Studies of the effects of Tween 60 aerosols on isolated guinea pig lungs].
PubMed:Effects of tween 60 on benzo(a)pyrene uptake by Tetrahymena pyriformis and by isolated rat liver mitochondria.
PubMed:[The effects of inhibitors of RNA-, protein- and ATP-synthesis on the development of reversible changes in cells, induced by tween 60].
PubMed:Microimmunoelectrophoresis on nitrocellulose membranes impregnated with Tween 60.
PubMed:Comparative microelectrophoresis of different sera on nitrocellulose membranes impregnated with Tween 60.
PubMed:The influence of Tween 60 on the microelectrophoretic patterns of human serum on nitrocellulose and acetylcellulose membranes.
PubMed:Effect of various nonionic surfactants on growth of Escherichia coli.
PubMed:[On the activity of serum esterases in infectious hepatitis (measured with tween 60)].
PubMed:[On the mechanism of artificial tumorigenesis. XI. Skin tumor formation in CF 1 mice and CFW mice of the Swiss group induced with Tween 60].
PubMed:[On the mechanism of artificial tumorigenesis. XII. Light- and polarization-microscopic changes in the epidermis of tumor-sensitive CF 1 mice and CFW mice of the Swiss group induced with Tween 60].
PubMed:[On the mechanism of artifical tumorigenesis. XIII. Ultrastructural changes in the epidermis of tumor-sensitive CF 1 mice and CFW mice of the Swiss group, induced with Tween 60].
PubMed:[Tween 60 as a substrate for the determination of esterase activity in the serum of heparinized rats].
PubMed:The effect of five ulcerating doses of alkyldimethylbenzylammoniumchloride (Zephiran) on the tumor promoting action of polyoxyethylene sorbitan monostearate (tween 60). An analysis of the dermal condition in tumor promotion.
PubMed:Mechanism of experimental tumorigenesis. V. Ultrastructural alterations in mouse epidermis caused by Span 60 and Tween 60-type agents.
PubMed:The effect of the solvent concentration on skin tumorigenesis: following painting of mouse skin with 9, 10-dimethyl-1,2-benzanthracene solubilized by tween 20, tween 60, and tween 81.
PubMed:Beneficial effects of alfalfa meal and other bulk-containing or bulk-forming materials on symptoms of tween 60 toxicity in the immature mouse.
PubMed:Studies of the action of polyoxyethylene sorbitan monostearate (tween 60) in skin carcinogenesis in the mouse.
PubMed:The production of skin tumors in mice by oral treatment with urethane, isopropyl-N-phenyl carbamate or isopropyl-N-chlorophenyl carbamate in combination with skin painting with croton oil and tween 60.
PubMed:[Experimental studies of the diphasic doctrine of cutaneous carcinogenesis in various animal species. I. Effect of urethane (initiating factor) and of croton oil and tween 60 (promoting factors); experiments with rabbits].
PubMed:The evaluation of various emulsifiers including polyoxyethlene sorbitan monostearate (tween 60) for parenteral fat emulsions.
PubMed:Effect of subperitoneally injected tween 60 and tween 80 on rats.
PubMed:The effect of feeding large amounts of emulsifiers polyoxyethylene (20) sorbitan monostearate (tween 60) and sorbitan monostearate (span 60) to humans.
PubMed:The effect of emulsifying agents (tween 60 and span 60) on the gastrointestinal tract.
Emulsifier, opacifier, protective coating, dough conditioner, dispersant, wetting agent, stabiliser, defoamer, poultry scald agent, flavour. Polysorbates are a class of emulsifiers used in some pharmaceuticals and food preparation. They are often used in cosmetics to solubilize essential oils into water-based products. Polysorbates are oily liquids derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids. (Wikipedia)
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