malonic acid
methanedicarboxylic acid
 
Notes:
Malonic acid (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2. The ionised form of malonic acid, as well as its esters and salts, are known as malonates. For example, diethyl malonate is malonic acid's ethyl ester. The name originates from Latin malum, meaning apple. Malonic acid is the archetypal example of a competitive inhibitor: it acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.; Malonic acid (IUPAC systematic name: propanedioic acid) is a dicarboxylic acid with structure CH2(COOH)2. The ionised form of malonic acid, as well as its esters and salts, are known as malonates. For example, diethyl malonate is malonic acid's ethyl ester. The name originates from the Greek word ????? (malon) meaning 'apple'.
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
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      10766 Malonic acid
       
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      Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals.
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      MALONIC ACID
       
  • M&U International
    • M&U International LLC
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      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. We warmly welcome your inquiries, come witness our solemn commitment for yourself.
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      A0215 MALONIC ACID, Kosher
       
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  • Sunaux International
    • Sunaux International
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      Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
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      A0102 Malonic Acid
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
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      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 27,000 products as well as custom synthesis. TCI established overseas facilities in North America, Europe, China and India to serve customers worldwide.
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      M0028 Malonic Acid >99.0%(T)
       
Synonyms   Articles   Notes   Search
propanedioic acid (Click)
CAS Number: 141-82-2Picture of molecule
ECHA EINECS - REACH Pre-Reg: 205-503-0
FDA UNII: 9KX7ZMG0MK
Nikkaji Web: J2.541K
Beilstein Number: 1751370
MDL: MFCD00002707
CoE Number: 2264
XlogP3: -0.80 (est)
Molecular Weight: 104.06168000
Formula: C3 H4 O4
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: buffering agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Flavis Number: 08.053 (Old)
DG SANTE Food Flavourings: 08.053  malonic acid
DG SANTE Food Contact Materials: malonic acid
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Physical Properties:
Appearance: white to tan crystalline solid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.63100 @  25.00 °C.
Melting Point: 135.00 °C. @ 760.00 mm Hg
Boiling Point: 264.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.001500 mm/Hg @ 25.00 °C.
Flash Point: 395.00 °F. TCC ( 201.67 °C. )
logP (o/w): -0.910
Soluble in:
 alcohol
 water, 763000 mg/100ml @ 20 °C (exp)
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Organoleptic Properties:
  
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: buffering agents
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Suppliers:
Beijing Lys Chemicals
Malonic acid
BOC Sciences
For experimental / research use only.
Propanedioic Acid
Charkit Chemical
MALONIC ACID
M&U International
MALONIC ACID, Kosher
Penta International
MALONIC ACID TECHNICAL GRADE, Kosher
Penta International
MALONIC HIGH PURITY PHARMACEUTICAL GRADE
Sigma-Aldrich: Aldrich
For experimental / research use only.
Malonic Acid sublimed grade, ≥99.95% trace metals basis
Sunaux International
Malonic Acid
SysKem Chemie
Malonic Acid
TCI AMERICA
For experimental / research use only.
Malonic Acid >99.0%(T)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 20/22 - Harmful by inhalation and if swallowed.
R 41 - Risk of serious damage to eyes.
S 02 - Keep out of the reach of children.
S 20/21 - When using do not eat, drink or smoke.
S 22 - Do not breath dust.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  1300 mg/kg
(Bio-Fax, 1971)

intraperitoneal-rat LD50  1500 mg/kg
"Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2n rev. ed. in 1985.Vol. 2C, Pg. 4937, 1982.

oral-mouse LD50  4000 mg/kg
Biochemical Journal. Vol. 34, Pg. 1196, 1940.

intraperitoneal-mouse LD50  300 mg/kg
National Technical Information Service. Vol. AD277-689

oral-rat LD50  1310 mg/kg
LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 22-3/1971

Dermal Toxicity:
skin-rabbit LDLo 10000 mg/kg
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 22-3/1971

Inhalation Toxicity:
inhalation-rat LC50 > 8900 mg/m3/1H
BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. Vol. 22-3/1971

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Safety in Use Information:
Category: buffering agents
Recommendation for malonic acid usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.0012 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 3200 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 3.0000015.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 2.0000010.00000
Edible ices, including sherbet and sorbet (03.0): 3.0000015.00000
Processed fruit (04.1): 2.0000010.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000050.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 5.0000025.00000
Bakery wares (07.0): 10.0000050.00000
Meat and meat products, including poultry and game (08.0): 2.0000010.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 2.0000010.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 5.0000025.00000
Foodstuffs intended for particular nutritional uses (13.0): 10.0000050.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 3.0000015.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000050.00000
Ready-to-eat savouries (15.0): 15.0000075.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 5.0000025.00000
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Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 64 (FGE.64): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab)
View page or View pdf
Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1]
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 10, Revision 3 (FGE.10Rev3): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf
EPI System: View
NIOSH International Chemical Safety Cards: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 141-82-2
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 867
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 1
 propanedioic acid
Chemidplus: 0000141822
EPA/NOAA CAMEO: hazardous materials
RTECS: 141-82-2
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References:
 propanedioic acid
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 141-82-2
Pubchem (cid): 867
Pubchem (sid): 134975575
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
KEGG (GenomeNet): C00383
HMDB (The Human Metabolome Database): HMDB00691
FooDB: FDB008117
Export Tariff Code: 2917.19.3500
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 antioxidants 
 appleFR
 buffering agents 
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Occurrence (nature, food, other): note
 banana leaf
Search Trop  Picture
 barley
Search Trop  Picture
 barley seed
Search Trop  Picture
 bean black bean fruit
Search Trop  Picture
 bean green bean seed
Search Trop  Picture
 bean scarlet runner bean
Search Trop  Picture
 beet
Search Trop  Picture
 beet root
Search Trop  Picture
 cantaloupe leaf
Search Trop  Picture
 cayenne leaf
Search Trop  Picture
 celery root
Search Trop  Picture
 corn plant
Search Trop  Picture
 fig fruit
Search Trop  Picture
 fig fruit juice
Search Trop  Picture
 lime fruit
Search Trop  Picture
 mandarin fruit
Search Trop  Picture
 oat hull husk
Search Trop  Picture
 oat husk
Search Trop  Picture
 orange fruit
Search Trop  Picture
 peach fruit
Search Trop  Picture
 pepper bell pepper fruit
Search Trop  Picture
 pepper bell pepper leaf
Search Trop  Picture
 sunflower leaf
Search Trop  Picture
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Synonyms:
 carboxyacetic acid
 dicarboxylic acid
 methane dicarboxylic acid
 methanedicarbonic acid
 methanedicarboxylic acid
 propane dioic acid
 propanedioic acid
1,3-propanedioic acid
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