costus lactone
costunolide

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  CODE101640 CODE101640
  Product(s):
  553-21-9 Costunolide >98%
  Costunolide, a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 mM, also inhibits telomerase with IC50 of 65-90 mM.

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  Product(s):
  C2921 Costunolide >95.0%(HPLC)
  SDS

Name: (3aS,6Z,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one CAS Number: 553-21-9 3D/inchi Other(deleted CASRN): 11028-78-7 FDA UNII: 4IK578SA7Z MDL: MFCD00210262 XlogP3: 2.10 (est) Molecular Weight: 232.32280000 Formula: C15 H20 O2 BioActivity Summary: listing NMR Predictor: Predict (works with chrome, Edge or firefox) Category:natural substances and extractives   US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: Google Scholar: Search Google Books: Search Google Scholar: with word "volatile" Search Google Scholar: with word "flavor" Search Google Scholar: with word "odor" Search Google Patents: Search US Patents: Search EU Patents: Search Pubchem Patents: Search PubMed: Search NCBI: Search   Physical Properties: Assay: 95.00 to 100.00 Food Chemicals Codex Listed: No Specific Gravity: 1.08910 @ 21.00 °C. Refractive Index: 1.53043 @ 20.00 °C. Boiling Point: 205.00 to 211.00 °C. @ 13.00 mm Hg Boiling Point: 385.00 to 386.00 °C. @ 760.00 mm Hg (est) Vapor Pressure: 0.000003 mmHg @ 25.00 °C. (est) Flash Point: 324.00 °F. TCC ( 162.00 °C. ) (est) logP (o/w): 4.049 (est) Soluble in:   alcohol   water, 9.376 mg/L @ 25 °C (est) Insoluble in:   water   Organoleptic Properties: Odor and/or flavor descriptions from others (if found).   Cosmetic Information: None found   Suppliers: Alfa Biotechnology For experimental / research use only. Costunolide 98% BOC Sciences For experimental / research use only. Costunolide >98% Odor: characteristic Use: Costunolide, a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 mM, also inhibits telomerase with IC50 of 65-90 mM. Coompo For experimental / research use only. Costunolide from Plants ≥96% Odor: characteristic Use: Costunolide exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. It showed potent inhibitory effects on the IBMX-induced melanogenesis, in dose-dependent manners, with IC50 values of 3 µg/mL. Costunolide induces the ROS-mediated mitochondrial permeability transition and resultant cytochrome c release. This is the first report on the mechanism of the anti-cancer effect of costunolide. Costunolide (CTN), together with parthenolide (PTN) by its strong inhibition of LPS-induced NF-?B activation. CTN, which showed more potent inhibition than PTN in the NF-?B activation, strongly suppressed nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. RT-PCR and Western blot analyses demonstrated that CTN suppressed the expression of iNOS mRNA and protein in a dose-dependent manner. CTN also significantly inhibited LPS-induced DNA-binding activity of NF-?B as well as the LPS-induced degradation of I?B-a and -β. Furthermore, CTN inhibited LPS-induced phosphorylation of I?B-a. These findings support that CTN inhibits NO production by down-regulating iNOS expression, at least, in part through the inhibition of I?Bs' phosphorylation and degradation, which are essential for the activation of NF-?B. ExtraSynthese For experimental / research use only. Costunolide (HPLC) ≥95% Santa Cruz Biotechnology For experimental / research use only. Costunolide ≥98% Sigma-Aldrich: Sigma For experimental / research use only. Costunolide ≥97% (HPLC) sds TCI AMERICA For experimental / research use only. Costunolide >95.0%(HPLC) sds   Safety Information: Preferred SDS: View   Hazards identification   Classification of the substance or mixture GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) None found. GHS Label elements, including precautionary statements   Pictogram   Hazard statement(s) None found. Precautionary statement(s) None found. Oral/Parenteral Toxicity: Not determined Dermal Toxicity: Not determined Inhalation Toxicity: Not determined   Safety in Use Information: Category: natural substances and extractives Recommendation for costus lactone usage levels up to:   not for fragrance use.   Recommendation for costus lactone flavor usage levels up to:   not for flavor use.   Safety References: EPI System: View Chemical Carcinogenesis Research Information System:Search AIDS Citations:Search Cancer Citations:Search Toxicology Citations:Search EPA ACToR:Toxicology Data EPA Substance Registry Services (SRS):Registry Laboratory Chemical Safety Summary :6436243 National Institute of Allergy and Infectious Diseases:Data WGK Germany:3 (3aS,6Z,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one Chemidplus:0000553219   References:   (3aS,6Z,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one NIST Chemistry WebBook: Search Inchi Pubchem (cid): 6436243 Pubchem (sid): 135029944   Other Information: (IUPAC): Atomic Weights of the Elements 2011 (pdf) Videos: The Periodic Table of Videos tgsc: Atomic Weights use for this web site (IUPAC): Periodic Table of the Elements KEGG (GenomeNet): C09382 HMDB (The Human Metabolome Database): HMDB36688 FooDB: FDB015618 Export Tariff Code: 2932.29.6000 VCF-Online: VCF Volatile Compounds in Food ChemSpider: View Wikipedia: View EFSA Update of results on the monitoring of furan levels in food: Read Report EFSA Previous report: Results on the monitoring of furan levels in food: Read Report EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report   Potential Blenders and core components note None Found   Potential Uses: None Found   Occurrence (nature, food, other):note   bay laurel fruit Search Trop Picture   bay laurel leaf Search Trop Picture   bay laurel root Search Trop Picture   costus root oil Search Trop Picture   tarragon plant Search Trop Picture   Synonyms:   costunolid   costunolide   cyclodeca(b)furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS-(3aR*,6E,10E,11aS*))- (3aS,6Z,10E,11aR)-6,10- dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one   germacra-1(10),4,11(13)-trien-12-oic acid, 6-a-hydroxy-, g-lactone, (E,E)- (3aS-(3aR*,6E,10E,11aS*))-3a,4,5,8,9,11a- hexahydro-6,10-dimethyl-3-methylene cyclodeca(b)furan-2(3H)-one (E,E)-6-alpha- hydroxygermacra-1(10),4,11(13)-trien-12-oic acid gamma-lactone   Articles:   None found yet. 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Notes: Constit. of costus root (Saussurea lappa)