EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

calcium acetate
acetic acid, calcium salt

Supplier Sponsors

Name:calcium diacetate
CAS Number: 62-54-4Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:200-540-9
FDA UNII:Y882YXF34X
Nikkaji Web:J4.823B
Beilstein Number:3692527
MDL:MFCD00012448
Molecular Weight:158.16662000
Formula:C4 H6 Ca O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:sequestrants, antimold and antirope agents, stabilizers, buffering agents, acidity regulators
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1185 Calcium acetate View - review
EU SANCO Calcium acetate View - review
GRN 712 Calcium acetate View - notice PDF
JECFA Food Additive: Calcium Acetate
GSFA Codex: Calcium acetate (263)
DG SANTE Food Additives:calcium acetate
FEMA Number:2228 calcium acetate
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):62-54-4 ; CALCIUM ACETATE
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS
Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.29 Stabilizers.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart G--Sequestrants1
Sec. 182.6197 Calcium diacetate.


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1185 Calcium acetate.
 
Physical Properties:
Appearance:white granular powder (est)
Assay: 99.00 to 100.00
Food Chemicals Codex Listed: Yes
Boiling Point: 117.10 °C. @ 760.00 mm Hg (est)
Vapor Pressure:13.900000 mmHg @ 25.00 °C. (est)
Flash Point: 104.00 °F. TCC ( 40.00 °C. ) (est)
logP (o/w): -0.285 (est)
Soluble in:
 water, 1e+006 mg/L @ 25 °C (est)
Insoluble in:
 alcohol
 
Organoleptic Properties:
Odor Strength:none
Odor Description:at 100.00 %. mild acetic
Luebke, William tgsc, (2007)
Odor sample from: Sigma-Aldrich
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: masking agents
viscosity controlling agents
 
Suppliers:
Allan Chemical
Calcium Acetate
Amecan
Calcium Acetate
American Elements
Calcium Acetate 99%
Odor: characteristic
Use: Calcium Acetate is a moderately water soluble crystalline Calcium source that decomposes to Calcium oxide on heating. It is generally immediately available in most volumes. All metallic acetates are inorganic salts of a metal cation and the acetate anion, a univalent (-1 charge) polyatomic ion composed of two carbon atoms ionically bound to three hydrogen and two oxygen atoms (Symbol: CH3COO) for a total formula weight of 59.05. Acetates are excellent precursors for production of ultra high purity compounds, catalysts, and nanoscale materials.We also produce Calcium Acetate Solution. American Elements produces to many standard grades when applicable, including Mil Spec (military grade); ACS, Reagent and Technical Grade; Food, Agricultural and Pharmaceutical Grade; Optical Grade, USP and EP/BP (European Pharmacopoeia/British Pharmacopoeia)and follows applicable ASTM testing standards.
American International Chemical, LLC.
CALCIUM ACETATE FCC AGGLOMERATE
Barium & Chemicals
Calcium Acetate Monohydrate
Odor: characteristic
Use: Manufacture of acetone, acetic acid, acetates, mordant in dyeing and printing of textiles, stabilizer in resins, additive to calcium soap lubricants, and a corrosion inhibitor.
BOC Sciences
For experimental / research use only.
Calcium Acetate
Charkit Chemical
CALCIUM ACETATE 18.5% SOLUTION
ECSA Chemicals
Calcium Acetate
Company Profile
Jarchem Industries
Jarace™ CA-FCC
Odor: characteristic
Use: Is employed as a thickening agent; as a preservative and or as a buffer for pH in some processes. Is used as a thickening agent (cake batters, puddings, pie fillings). As a buffer in controlling the pH of food during various stages of processing, as well as the finished product.Serves as a preservative to prevent microbial growth.Is used as a calcium supplement in pet products.
Jarchem Industries
Jarace™ CA
Odor: characteristic
Use: Is utilized in dyeing and printing. Is used in metallic soaps (lubricants).
Parchem
Calcium Acetate, FCC
Penta International
CALCIUM ACETATE USP CRYSTALLINE POWDER
Sigma-Aldrich
For experimental / research use only.
Calcium Acetate Pharmaceutical Secondary Standard; Certified Reference Material
Sinofi Food Ingredients
Calcium Acetate
Odor: characteristic
Use: Preservative, Cosmetics, Feed, Pharmaceutical, Antimicrobial, Antifungal, Antibacterial, Firming Agent, pH Control Agent, Processing Aid, Sequestrant, Stabilizer, Texturizer, Food Thickener, Sauces, Baking Food, Food Colors, Cake Mixes, Fillings, Gelatins, Syrups, Toppings, Packing Materials.
 
Safety Information:
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
intraperitoneal-mouse LD50 75 mg/kg
Acta Biologica et Medica Germanica. Vol. 6, Pg. 447, 1961.

intravenous-mouse LD50 203 mg/kg
Journal of Laboratory and Clinical Medicine. Vol. 29, Pg. 809, 1944.

intravenous-rat LDLo 147 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 71, Pg. 1, 1941.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: sequestrants, antimold and antirope agents, stabilizers, buffering agents, acidity regulators
Recommendation for calcium acetate usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -500.00000
beverages(nonalcoholic): -200.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Calcium acetate, calcium pyruvate, calcium succinate, magnesium pyruvate magnesium succinate and potassium malate added for nutritional purposes to food supplements
View page or View pdf

Scientific Opinion on the safety and efficacy of acetic acid, sodium diacetate and calcium acetate as preservatives for feed for all animal species
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):62-54-4
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :6116
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
calcium diacetate
Chemidplus:0000062544
RTECS:62-54-4
 
References:
 calcium diacetate
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:62-54-4
Pubchem (cid):6116
Pubchem (sid):134971516
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):D00931
HMDB (The Human Metabolome Database):Search
FooDB:FDB015443
Export Tariff Code:2915.29.0000
FDA Listing of Food Additive Status:View
Haz-Map:View
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
•grades: technical (80% basis); reagent; cp; pure; brown; gray; fcc monohydrate •powder: food, pharmaceutical grades; agglomerated, technical, usp, fcc grades; purified grade
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 viscosity controlling agents
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 acetate of lime
 acetic acid calcium salt
 acetic acid, calcium salt
 calcium acetate FCC agglomerate
 calcium acetate powder USP
 calcium acetate technical agglomerate
 calcium di(acetate)
 calcium diacetate
 calcium ethanoate
 calcium(II) acetate
 lime acetate
 lime pyrolignite
 phoslo
 teltozan
 

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PubMed:Effect of calcium on the kinetics of free fatty acid release during in vitro lipid digestion in model emulsions.
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PubMed:Relative transcription of Listeria monocytogenes virulence genes in liver pâtés with varying NaCl content.
PubMed:Astringent drug products that produce aluminum acetate; skin protectant drug products for over-the-counter human use; technical amendment. Final rule; technical amendment.
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PubMed:Cadmium toxicity in cultured tomato cells--role of ethylene, proteases and oxidative stress in cell death signaling.
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PubMed:Interactions between iron(III)-hydroxide polymaltose complex and commonly used medications / laboratory studies in rats.
PubMed:Suppression of mast cell-mediated allergic reaction by Amomum xanthiodes.
PubMed:Control of hyperphosphatemia among patients with ESRD.
PubMed:Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate, levels in brain.
PubMed:Application of central composite design and response surface methodology to the fermentation of olive juice by Lactobacillus plantarum and Debaryomyces hansenii.
PubMed:Calcium-enriched bread for treatment of uremic hyperphosphatemia.
PubMed:Inulin effects on bioavailability of soy isoflavones and their calcium absorption enhancing ability.
PubMed:Different Mg to Fe ratios in the mixed metal MgFe hydroxy-carbonate compounds and the effect on phosphate binding compared with established phosphate binders.
PubMed:Antimicrobial efficacy of preservative combinations in South African brown bread.
PubMed:Role of calcium carbonate administration timing in relation to food intake on its efficiency in controlling hyperphosphatemia in patients on maintenance dialysis.
PubMed:Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants.
PubMed:Gastrointestinal absorption of calcium from milk and calcium salts.
PubMed:[A method for differentiating between vinegar produced by fermentation and vinegar made from synthetic acetic acid based on the determination of the specific 3H-radioactivity (author's transl)].
PubMed:[A method for differentiating between vinegar produced by fermentation and vinegar made from synthetic acetic acid based on determination of the 13C/12C-isotope ratio by mass spectrometry (author's transl)].
PubMed:[A contribution to the distinction of biogenic vinegar and vinegar made from synthetic acetic acid by determining the specific 14C-radioactivity (author's transl)].
 
Notes:
a principal compound used as phosphate binders in patients with chronic renal failure. Used in foods as a firming agent, acidity regulator, sequestrant, stabiliser and thickener, and nutrient supplement (Ca source). Used as an acidifier/preservative in bread, and in some gelling mixtures Calcium acetate is a food additive, mainly in candy products.; Calclacite is a name for calcium acetate chloride pentahydrate, which is treated as mineral species but possess anthropogenic origin.; Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcification. The mechanism by which phosphate retention leads to hyperparathyroidism is not clearly delineated. Therapeutic efforts directed toward the control of hyperphosphatemia include reduction in the dietary intake of phosphate, inhibition of absorption of phosphate in the intestine with phosphate binders, and removal of phosphate from the body by more efficient methods of dialysis. The rate of removal of phosphate by dietary manipulation or by dialysis is insufficient. Dialysis patients absorb 40% to 80% of dietary phosphorus. Therefore, the fraction of dietary phosphate absorbed from the diet needs to be reduced by using phosphate binders in most renal failure patients on maintenance dialysis. Calcium acetate when taken with meals combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces. Maintenance of serum phosphorus below 6.0 mg/dl is generally considered as a clinically acceptable outcome of treatment with phosphate binders. Calcium acetate is highly soluble at neutral pH, making the calcium readily available for binding to phosphate in the proximal small intestine.
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