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butylated hydroxyanisole
BHA

Sponsors

Name:2-tert-butyl-4-methoxyphenol;3-tert-butyl-4-methoxyphenol
CAS Number: 25013-16-5Picture of molecule3D/inchi
Other:1336-31-8
ECHA EINECS - REACH Pre-Reg:246-563-8
FDA UNII:REK4960K2U
Beilstein Number:1867499
MDL:MFCD01779059
XlogP3:3.20 (est)
Molecular Weight:360.49384000
Formula:C22 H32 O4
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:antioxidants and preservatives for fragrance and flavor
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist:Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
182.3169 Butylated Hydroxyanisole (BHA) View-review
EU SANCO Gallates, TBHQ and BHA View-review
EU SANCO Butylated hydroxyanisole View-review
JECFA Food Additive: Butylated Hydroxyanisole
GSFA Codex: Butylated hydroxyanisole (320)
DG SANTE Food Additives:BHA
DG SANTE Food Contact Materials:BHA
FEMA Number:2183 butylated hydroxyanisole
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: BUTYLATED HYDROXYANISOLE
FDA Regulation:
FDA PART 166 -- MARGARINE
Subpart B--Requirements for Specific Standardized Margarine
Sec. 166.110 Margarine.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart B--Food Preservatives
Sec. 172.110 BHA.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart B--Food Preservatives
Sec. 172.115 BHT.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart B--Food Preservatives
Sec. 172.185 TBHQ.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.


FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart G--Gums, Chewing Gum Bases and Related Substances
Sec. 172.615 Chewing gum base.


FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION
Subpart D--Specific Usage Additives
Sec. 173.340 Defoaming agents.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.125 Pressure-sensitive adhesives.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.380 Xylene-formaldehyde resins condensed with 4,4'-isopropylidenediphenol-epichlorohydrin epoxy resins.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.390 Zinc-silicon dioxide matrix coatings.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.170 Components of paper and paperboard in contact with aqueous and fatty foods.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.210 Defoaming agents used in the manufacture of paper and paperboard.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1010 Acrylic and modified acrylic plastics, semirigid and rigid.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1210 Closures with sealing gaskets for food containers.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1350 Ethylene-vinyl acetate copolymers.


FDA PART 178 -- INDIRECT FOOD ADDITIVES: ADJUVANTS, PRODUCTION AIDS, AND SANITIZERS
Subpart D--Certain Adjuvants and Production Aids
Sec. 178.3570 Lubricants with incidental food contact.


FDA PART 179 -- IRRADIATION IN THE PRODUCTION, PROCESSING AND HANDLING OF FOOD
Subpart C--Packaging Materials for Irradiated Foods
Sec. 179.45 Packaging materials for use during the irradiation of prepackaged foods.


FDA PART 181 -- PRIOR-SANCTIONED FOOD INGREDIENTS
Subpart B--Specific Prior-Sanctioned Food Ingredients
Sec. 181.24 Antioxidants.


FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE
Subpart D--Chemical Preservatives
Sec. 182.3169 Butylated hydroxyanisole.
 
Physical Properties:
Appearance:white to pale yellow solid (est)
Assay: 98.00 to 100.00
Food Chemicals Codex Listed: Yes
Melting Point: 58.00 to 60.00 °C. @ 760.00 mm Hg
Boiling Point: 268.00 to 269.00 °C. @ 760.00 mm Hg
Vapor Pressure:0.004000 mm/Hg @ 25.00 °C. (est)
Vapor Density:6.2 ( Air = 1 )
Flash Point: 235.00 °F. TCC ( 112.78 °C. )
logP (o/w): 3.087 (est)
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 water, 212.8 mg/L @ 25 °C (est)
Insoluble in:
 water
 
Organoleptic Properties:
Odor Strength:low
Odor Description:at 100.00 %. mild rubbery
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: antioxidants
masking agents
 
Suppliers:
Aceto
BHA Food Grade NF
Anhui Haibei
BHA
Augustus Oils
butylated Hydroxy Anisole
Services
BOC Sciences
For experimental / research use only.
Butylhydroxyanisole 95%
Charkit Chemical
BUTYLATED HYDROXYANISOLE BHA
Eastman Chemical
Eastman Tenox™ BHA Food Grade Antioxidant, Flake, Kosher
ECSA Chemicals
butylated Hydroxyanisole
Company Profile
Graham Chemical
BHA
Indenta Group
BHA
Kraft Chemical
BHA
Lluch Essence
BHA
Moellhausen
BHA,
OQEMA
Butylated Hydroxy Anisole (BHA)
Penta International
BUTYLARED HYDROXY ANISOLE (BHA) NF / FCC GRADE, Kosher, Halal
Penta International
BUTYLATED HYDROXY ANISOLE (BHA) EP/NF POWDER (40 MESH), Kosher, Halal
Penta International
BUTYLATED HYDROXY ANISOLE EP GRADE, Kosher, Halal
Penta International
BUTYLATED HYDROXYANISOLE (BHA) EP / IP GRADE
Penta International
BUTYLATED HYDROXYANISOLE (BHA) EP / NF GRADE, Kosher, Halal
Penta International
BUTYLATED HYDROXYANISOLE (BHA) FCC, Kosher, Halal
Penta International
BUTYLATED HYDROXYANISOLE (BHA) N.F., Kosher, Halal
Penta International
BUTYLATED HYDROXYANISOLE (BHA) NF/FCC POWDER (40 MESH), Kosher, Halal
PerfumersWorld
BHT Butylated Hydroxy Anisole - anti-oxidant
Perfumery Laboratory
BHT ANTIOXIDATOR (Butylated Hydroxy Anisole)
Prinova
BHA
Santa Cruz Biotechnology
For experimental / research use only.
butylated Hydroxyanisole
Sigma-Aldrich
Butylated hydroxyanisole, 99%, FCC, FG
Certified Food Grade Products
Silver Fern Chemical
Butylated Hydroxyanisole (BHA)
Odor: characteristic
Use: Butylated hydroxyanisole (BHA) is a white or slightly yellow, waxy solid with a faint characteristic odor. It is not naturally water soluble, but can be treated to be so. It is freely soluble in alcohol and propylene glycol.
Treatt
B.H.A.
Vigon International
BHA
 
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 40 - Possible risks of irreversable effects.
S 02 - Keep out of the reach of children.
S 22 - Do not breath dust.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 2000 mg/kg
BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 22, Pg. 231, 1970.

intraperitoneal-rat LD50 881 mg/kg
BLOOD: HEMORRHAGE
Toxicology Letters. Vol. 27, Pg. 15, 1985.

oral-mouse LD50 1100 mg/kg
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. Vol. 22, Pg. 231, 1970.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category: antioxidants and preservatives for fragrance and flavor
Recommendation for butylated hydroxyanisole usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
 average usual ppmaverage maximum ppm
baked goods: -2.80000
beverages(nonalcoholic): -0.82000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: -13.00000
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: -230.00000
fish products: --
frozen dairy: -0.81000
fruit ices: -0.81000
gelatins / puddings: -0.54000
granulated sugar: --
gravies: --
hard candy: -9.60000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: -5.00000
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of butylated hydroxyanisole – BHA (E 320) as a food additive
View page or View pdf

Statement on the safety assessment of the exposure to butylated hydroxyanisole E 320 (BHA) by applying a new exposure assessment methodology
View page or View pdf

Safety and efficacy of butylated hydroxyanisole (BHA) as a feed additive for all animal species
View page or View pdf

EPI System: View
NLM Hazardous Substances Data Bank:Search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
Env. Mutagen Info. Center:Search
NLM Developmental and Reproductive Toxicity:Search
EPA Substance Registry Services (TSCA):25013-16-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :24667
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
2-tert-butyl-4-methoxyphenol;3-tert-butyl-4-methoxyphenol
Chemidplus:0025013165
EPA/NOAA CAMEO:hazardous materials
RTECS:SL1945000 for cas# 25013-16-5
 
References:
 2-tert-butyl-4-methoxyphenol;3-tert-butyl-4-methoxyphenol
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:25013-16-5
Pubchem (cid):24667
Pubchem (sid):134996929
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2009
(IUPAC):Atomic Weights of the Elements 2009 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS):View
CHEBI:View
CHEMBL:View
KEGG (GenomeNet):C15469
HMDB (The Human Metabolome Database):HMDB31848
FooDB:FDB008532
FDA Listing of Food Additive Status:View
Haz-Map:View
Household Products:Search
ChemSpider:View
Wikipedia:View
RSC Learn Chemistry:View
Formulations/Preparations:
•the commercial prepn of bha sold under name of tenox bha (eastman chem inc) contains about 85% of 3-tert-butyl-4-hydroxyanisole & 15% of 2-tert-butyl-4-hydroxyanisole. •food grade, 98.5+%.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
 antioxidants
 preservatives
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 antioxyne B
 B.H.A.
 BHA
 BHA food grade NF
 butyl hydroxyanisole
tert-butyl hydroxyanisole
2(3)-t-butyl-4-hydroxyanisole
2(3)-tert-butyl-4-hydroxyanisole
tert-butyl-4-hydroxyanisole
2(3)-tert-butyl-4-methoxyphenol
tert-butyl-4-methoxyphenol
2-tert-butyl-4-methoxyphenol;3-tert-butyl-4-methoxyphenol
3-tert-butyl-4-methoxyphenyl and 2tert-butyl-4-methoxyphenol
2-tert-butyl-4-methoxyphenyl and 3-tert-butyl-4-methoxyphenol
2(3)-(tert-butyl)-4-methoxyphenol
tert-butylhydroxyanisole
(1,1-dimethyl ethyl)-4-methoxyphenol
2(3)-(1,1-dimethylethyl)-4-(methyloxy)phenol
2(3)-(1,1-dimethylethyl)-4-methoxy-phenol
2(or 3)-(1,1-dimethylethyl)-4-methoxyphenol
 embanox
butylated hydroxy anisole (BHA) EP/NF powder (40 mesh)
butylated hydroxy anisole (BHA) NF / FCC grade
butylated hydroxy anisole EP grade
4-hydroxy-2(3)-tert-butylanisole
butylated hydroxyanisole (BHA) EP / IP grade
butylated hydroxyanisole (BHA) EP / NF grade
butylated hydroxyanisole (BHA) FCC
butylated hydroxyanisole (BHA) N.F.
butylated hydroxyanisole (BHA) NF/FCC powder (40 mesh)
4-methoxy-2(3)-tert-butylphenol
 phenol, (1,1-dimethylethyl)-4-methoxy-
 phenol, 2(3)-(1,1-dimethylethyl)-4-methoxy-
 phenol, 2(3)-t-butyl-4-methoxy-
 phenol, 2(3)-tert-butyl-4-methoxy-
 phenol, t-butyl-4-methoxy-
 tenox BHA food grade antioxidant, flake
 

Articles:

Info:EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
PubMed:Oxidative stability of cooked, frozen, reheated beef patties: effect of antioxidants.
PubMed:Effects of sodium lactate and acetic acid derivatives on the quality and sensory characteristics of hot-boned pork sausage patties.
PubMed:Evaluation of antioxidant activity of green tea extract and its effect on the biscuits lipid fraction oxidative stability.
PubMed:Antioxidants in bakery products: a review.
PubMed:Antioxidant properties of dried plum ingredients in raw and precooked pork sausage.
PubMed:Antioxidant and antimicrobial effects of garlic in chicken sausage.
PubMed:Effect of enrobing and antioxidants on quality characteristics of precooked pork patties under chilled and frozen storage conditions.
PubMed:Effect of antioxidants on the flavor characteristics and the gas chromatography/olfactometry profiles of champagne extracts.
 
Notes:
mixture of 2- and 3-tert-butyl-4-methoxyphenols that is used as an antioxidant in foods, cosmetics, and pharmaceuticals. Antioxidant. Used in foods Butylated hydroxyanisole (BHA) is an antioxidant consisting of a mixture of two isomeric organic compounds, 2-tert-butyl-4-hydroxyanisole and 3-tert-butyl-4-hydroxyanisole. It is prepared from 4-methoxyphenol and isobutylene. It is a waxy solid used in certain amounts as a food additive with the E number E320.
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