EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes

polysorbate 20
tween 20

Supplier Sponsors

CAS Number: 9005-64-5
Other(deleted CASRN):118955-39-8
ECHA EC Number:500-018-3
Category:emulsifiers, surfactants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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 FDA/DG SANTE Petitions, Reviews, Notices:
EU SANCO Polyoxyethylene sorbitan monolaurate (polysorbate 20) View - review
EU SANCO Polysorbates View - review
JECFA Food Additive: Polyoxyethylene (20) Sorbitan Monolaurate
GSFA Codex: Polyoxyethylene (20) sorbitan monolaurate (432)
DG SANTE Food Additives:polysorbate 20
DG SANTE Food Contact Materials:polysorbate 20
FEMA Number:2915 polysorbate 20
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):9005-64-5 ; POLYSORBATE 20
FDA Regulation:
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.

Subpart D--Specific Usage Additives
Sec. 173.310 Boiler water additives.

Subpart B--Substances for Use Only as Components of Adhesives
Sec. 175.105 Adhesives.

Subpart D--Certain Adjuvants and Production Aids
Sec. 178.3400 Emulsifiers and/or surface-active agents.
Physical Properties:
Appearance:pale yellow clear viscous liquid (est)
Assay: 96.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity:1.09100 to 1.09600 @ 25.00 °C.
Pounds per Gallon - (est).: 9.078 to 9.120
Refractive Index:1.45900 to 1.47000 @ 20.00 °C.
Acid Value: 3.00 max. KOH/g
PH Number:5.71
Flash Point:> 230.00 °F. TCC ( > 110.00 °C. )
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage:store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
Organoleptic Properties:
Odor Strength:low
Substantivity:400 Hour(s)
Odor Description:at 100.00 %. mild alcohol odor
Odor and/or flavor descriptions from others (if found).
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: surfactants
surfactant - emulsifying
Allan Chemical
Polysorbate 20
Augustus Oils
Polysorbate 20
BOC Sciences
For experimental / research use only.
Tween(R) 20 Hydroxyl number: 96-1
Camden-Grey Essential Oils
Polysorbate 20, Bulk
Odor: characteristic
Use: Our Polysorbate 20 (polyoxyethylene [20] sorbitan monolaurate) is derived from coconut oil. It is a non-toxic, nonionic surfactant/emulsifier and a water-soluble yellowish liquid used as a dispersing agent which allows oil and water to mix without the use of alcohol. It?s a fragrance solubilizer and stabilizer; it lubricates and has a soothing effect on the skin. This skin- safe ingredient is used extensively in oil-in-water emulsions (lotions, conditioners, cream rinses, shampoos, liquid soaps, body polishes or scrubs, etc.) and also for body mists and linen sprays. Will be found as an ingredient in the majority of body toiletries, cosmetics and wipes now in the market. Polysorbates are generally used in combination with other emulsifiers such as mono- and diglycerides or sorbitan monostearates for various purposes such as to disperse flavors and colors, to make essential oils and vitamins soluble and to improve volume and texture in baked goods. Use Polysorbate 20 when very little foaming action (or none at all) is desired in the finished product.
Charkit Chemical
Chemical-navi - Nikkol
Odor: characteristic
Use: Hydrophilic emulsifier; solubilizer; dispersant; water soluble
Covalent Chemical
Polysorbate 20
Tween™ 20
Odor: characteristic
Use: Super Refining removes polar impurities, preventing adverse interactions with APIs and enhancing the stability of pharmaceutical formulations. Offer the complete solution when formulating parenteral, oral, ophthalmic and topical pharmaceutical products. Super Refined Polysorbate 20 ensures effective delivery of actives by minimising drug interaction with the excipient. Recommended topical usage levels of 0.5-5%.
ECSA Chemicals
ECSA Chemicals
ECSA Chemicals
Glentham Life Sciences
Tween 20, BP, Ph. Eur., USP/NF grade
Glentham Life Sciences
Tween 20
Graham Chemical
Polysorbate 20
Indenta Group
Polysorbate 20
Kao Corporation
Flavor: characteristic
It is a highly hydrophilic surfactant and approved as a food additives. It is a usuful emulsifier, dispersant and solubilizer for aroma chemiclas and oils. Combination of EMASOL L-120V and highly lipophlic one of EMASOL-series lead to a giving an excellent emulsifier.
Kao Corporation
Odor: characteristic
Use: It is a highly hydrophilic surfactant and approved as a food additives. It is a usuful emulsifier, dispersant and solubilizer for aroma chemiclas and oils. Combination of EMASOL L-120V and highly lipophlic one of EMASOL-series lead to a giving an excellent emulsifier.
Kao Corporation
Odor: characteristic
Use: Emulsifier and conditioning agent (low substantive effect). Detoxifying agent in shampoos (low irritation). Fragrances solubilizer.
Kao Corporation
Odor: characteristic
Use: Emulsifier for pharmaceuticals and cosmetics, Stabilizer for color materials, Stabilizer for emulsion polymerizations, Emulsifier for adjuvant of agrochemicals, Emulsifier for water based metal process cutting oils, Surface coating type antistatic agents.
Kraft Chemical
Polysorbate 20
Lipo Chemicals
Liposorb® L-20
Odor: characteristic
Use: Liposorb® L-20 is an oil-in-water emulsifier. Primarily used in combination with Lipo® GMS. The pair of emulsifiers produces medium, fine-textured lotions and creams in skin and hair care products. Liposorb® L-20 also acts as a spreading aid for bath oils, adds water dispersibility to anhydrous systems and is a solubilizer for oils and fragrances.
Lluch Essence
Lonza Group
Glycosperse™ L-20 KFG
Lonza Group
Lonzest™ SML-20
M&U International
Tween 20
Mohini Organics
Odor: characteristic
Use: MONEBAT® - 20 is a nonionic, solubilizer, o/w emulsifier, antistat and fiber lubricant used in textile industry, wetting agent, viscosity modifier, suspending agent used in food, cosmetics, drugs, textile and metal working industries, solubilizer for perfumes and flavours, insecticides, herbicides, paints and inks, pharmaceuticals.
LanCos EMP-20
Penta International
Penta International
Penta International
Penta International
Penta International
Solubiliser Polysorbate 20
Plants Power
Polysorbate 20
Polysorbate 20, FG
Certified Food Grade Products
SysKem Chemie
Polysorbate 20
Polysorbate 20
Zschimmer & Schwarz
Mulsifan SML-20
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-hamster LD50 18 mL/kg
Food Research. Vol. 21, Pg. 348, 1956.

intraperitoneal-mouse LD50 2640 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.

intravenous-mouse LD50 1420 mg/kg
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 316, 1970.

oral-mouse LD50 > 33000 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.

intraperitoneal-rat LD50 3850 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.

intravenous-rat LD50 770 mg/kg
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.

oral-rat LD50 36700 uL/kg
Food Research. Vol. 21, Pg. 348, 1956.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Safety in Use Information:
emulsifiers, surfactants
Recommendation for polysorbate 20 usage levels up to:
  50.0000 % in the fragrance concentrate.
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: 200.000001000.00000
beverages(nonalcoholic): -180.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: -380.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -500.00000
fruit ices: -500.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: 200.000001000.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on the re-evaluation of polyoxyethylene sorbitan monolaurate (E 432), polyoxyethylene sorbitan monooleate (E 433), polyoxyethylene sorbitan monopalmitate (E 434), polyoxyethylene sorbitan monostearate (E 435) and polyoxyethylene
View page or View pdf

EPI System: View
Daily Med:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):9005-64-5
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
RTECS:TR7400000 for cas# 9005-64-5
Canada Domestic Sub. List:9005-64-5
Pubchem (sid):135288054
Other Information:
FDA Substances Added to Food (formerly EAFUS):View
FDA Indirect Additives used in Food Contact Substances:View
KEGG (GenomeNet):C11624
HMDB (The Human Metabolome Database):HMDB37182
Export Tariff Code:3402.13.2020
FDA Listing of Food Additive Status:View
Potential Blenders and core components note
None Found
Potential Uses:
 emulsifying agents
 essential oils solublizer
 fragrance solublizer
Occurrence (nature, food, other):note
 not found in nature
 alkamuls PSML-20
 cremophor PS 20
 emasol L-120V
 glycosperse L-20 KFG
 hetsorb L-20
 kaopan TW-L-120
 liposorb L-20
 lonzest SML-20
 monebatt - 20
 mulsifan SML-20
 nikkol TL-10
 norfox sorbo T-20
 peg-20 sorbitan laurate
 peg-20 sorbitan monolaurate
 polyethylene glycol (20) sorbitan laurate
 polyethylene glycol (20) sorbitan monolaurate
 polyoxyethylene (20) sorbitan laurate
 polyoxyethylene (20) sorbitan monolaurate
 rheodol TW-L120
 super refined polysorbate 20
 T-maz 20K
 tween 20


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PubMed:Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: maternal and prenatal evaluations.
PubMed:Front-face fluorescence spectroscopy study of globular proteins in emulsions: influence of droplet flocculation.
PubMed:Front-face fluorescence spectroscopy study of globular proteins in emulsions: displacement of BSA by a nonionic surfactant.
PubMed:Effects of acid adaptation and modified marinades on survival of postdrying Salmonella contamination on beef jerky during storage.
PubMed:Temperature- and surfactant-induced membrane modifications that alter Listeria monocytogenes nisin sensitivity by different mechanisms.
PubMed:PC-SPES inhibits colon cancer growth in vitro and in vivo.
PubMed:Inactivation of acid-adapted and nonadapted Escherichia coli O157:H7 during drying and storage of beef jerky treated with different marinades.
PubMed:Effect of emulsifier on oxidation properties of fish oil-based structured lipid emulsions.
PubMed:Influence of lipid fraction, emulsifier fraction, and mean particle diameter of oil-in-water emulsions on the release of 20 aroma compounds.
PubMed:Fats and fatty acids as growth factors for Lactobacillus delbrueckii.
PubMed:Improved amperometric method for the rapid and quantitative measurement of lipoxygenase activity in vegetable tissue crude homogenates.
PubMed:Effectiveness of spraying with tween 20 and lactic acid in decontaminating inoculated Escherichia coli O157:H7 and indigenous Escherichia coli biotype I on beef.
PubMed:Enzyme-linked immunosorbent assay based on a polyclonal antibody for the detection of the insecticide fenitrothion. Evaluation of antiserum and application to the analysis of water samples.
PubMed:Sodium sulphite inhibition of potato and cherry polyphenolics in nucleic acid extraction for virus detection by RT-PCR.
PubMed:Impact of tween 20 hydroperoxides and iron on the oxidation of methyl linoleate and salmon oil dispersions.
PubMed:Occurrence of ochratoxin A in black pepper, coriander, ginger and turmeric in India.
PubMed:Cholesterol solubilization in aqueous micellar solutions of quillaja saponin, bile salts, or nonionic surfactants.
PubMed:Development of a blocking enzyme-linked immunosorbent assay for detection of turkey antibodies to Mycoplasma meleagridis.
PubMed:Viscoelastic Properties of Protein-Stabilized Emulsions: Effect of Protein-Surfactant Interactions.
PubMed:Kinetics of Crystallization in n-Hexadecane and Cocoa Butter Oil-in-Water Emulsions Accounting for Droplet Collision-Mediated Nucleation.
PubMed:Effect of freezing on the activity of catalase in apple flesh tissue.
PubMed:Addition of sugars influences color of oil-in-water emulsions.
PubMed:Monitoring Protein Fouling of Metal Surfaces via a Quartz Crystal Microbalance.
PubMed:Interfacial shear rheology of aged and heat-treated beta-lactoglobulin films: displacement by nonionic surfactant.
PubMed:Mechanisms of the antioxidant activity of a high molecular weight fraction of whey.
PubMed:Protein extraction from Atriplex lampa leaves: potential use as forage for animals used for human diets.
PubMed:Creaming and Rheology of Oil-in-Water Emulsions Containing Sodium Dodecyl Sulfate and Sodium Caseinate.
PubMed:Iron-accelerated cumene hydroperoxide decomposition in hexadecane and trilaurin emulsions.
PubMed:Nondestructive Monitoring of Sucrose Diffusion in Oil-in-Water Emulsions by Ultrasonic Velocity Profiling.
PubMed:The use of emulsions for the determination of methylmercury and inorganic mercury in fish-eggs oil by cold vapor generation in a flow injection system with atomic absorption spectrometric detection.
PubMed:Development of monoclonal ELISAs for azinphos-methyl. 2. Assay optimization and water sample analysis.
PubMed:Ability of iron to promote surfactant peroxide decomposition and oxidize alpha-tocopherol.
PubMed:The effects of surfactant type, pH, and chelators on the oxidation of salmon oil-in-water emulsions.
PubMed:Influence of competitive adsorption on flocculation and rheology of high-pressure-treated milk protein-stabilized emulsions.
PubMed:Change in the positional specificity of lipoxygenase 1 due to insertion of fatty acids into phosphatidylcholine deoxycholate mixed micelles.
PubMed:Identification of unacceptable background caused by non-specific protein adsorption to the plastic surface of 96-well immunoassay plates using a standardized enzyme-linked immunosorbent assay procedure.
PubMed:Stability of Emulsions Containing Both Sodium Caseinate and Tween 20.
PubMed:Orogenic Displacement of Protein from the Air/Water Interface by Competitive Adsorption.
PubMed:The composition of NF-defined emulsifiers: sorbitan monolaurate, monopalmitate, monostearate, monooleate, polysorbate 20, polysorbate 40, polysorbate 60, and polysorbate 80.
PubMed:Isolation of Mycobacterium paratuberculosis from milk by immunomagnetic separation.
PubMed:DNA Extraction and PCR Methods for the Detection of Listeria monocytogenes in Cold-Smoked Salmon.
PubMed:Development of a flow injection analysis (FIA) immunosensor for the detection of Escherichia coli.
PubMed:Separation of beta-lactoglobulin A, B and C variants of bovine whey using capillary zone electrophoresis.
PubMed:Influence of various dust sampling and extraction methods on the measurement of airborne endotoxin.
PubMed:Kinetic study on the nitrosation of dibenzylamine in a model system.
PubMed:Immunomagnetic separation as a sensitive method for isolating Escherichia coli O157 from food samples.
PubMed:An investigation of the antibacterial effect of carrot on Listeria monocytogenes.
PubMed:Isolation of salmonellas by immunomagnetic separation.
PubMed:Soybean lipoxygenase catalysed oxygenation of unsaturated fatty acid encapsulated in cyclodextrin.
PubMed:Voluntary food consumption and gastric emptying in rats given intravenous Triton WR-1339.
sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals. Emulsifier, stabiliser, flavouring agent, dispersant Polysorbate 20 is a polysorbate surfactant whose stability and relative non-toxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications. It is a polyoxyethylene derivative of sorbitan monolaurate, and is distinguished from the other members in the polysorbate range by the length of the polyoxyethylene chain and the fatty acid ester moiety.
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