adipic acid
hexanedioic acid
 
Notes:
Constit. of beet juice, pork fat, guava fruit (Psidium guajava), papaya (Carica papaya) and raspberry (Rubus idaeus). Food acidulant Adipic acid is a compound of the class of carboxylic acids that is derived from oxidation of various fats. It is a white crystalline powder appearing as an acid in aqueous circumstances, though it is not highly soluble (wikipedia); Adipic acid, like most carboxylic acids, is a mild skin irritant. It is mildly toxic, with LD50 of 3600 mg/kg for oral ingestion by rats.; By far the majority of the 2.5 billion kg of adipic acid produced annually is used as monomer for the production of nylon by a polycondensation reaction with hexamethylene diamine forming 6,6-nylon. Other major applications also involve polymers: it is a monomer for production of Polyurethane and its esters are plasticizers, especially in PVC.
  • Charkit Chemical
    • Charkit Chemical Corporation
      The Specialty Chemical Specialists
      Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.
      Since 1982, Charkit has been committed to expanding the markets we serve and our roster of products and services continues to grow with us. Personal care ingredients now include a substantial array of luxury and exotic components. Substantial inroads have been made in the nutraceutical and resins markets, with a growing roster of versatile and unique ingredients. And we continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions.
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      Product(s):
      ADIPIC ACID
       
  • Penta International
  • Sigma-Aldrich
    • Sigma-Aldrich
      Complete Supply Chain
      The perfect blend of products and services that bring your creativity to life.
      Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards.
      Email: Information
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      Certified Food Grade Products
      Product(s):
      W201103 Adipic acid, ≥99.5%
      SDS
       
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hexanedioic acid (Click)
CAS Number: 124-04-9Picture of molecule
Other: 1186514-28-2
ECHA EINECS - REACH Pre-Reg: 204-673-3
FDA UNII: 76A0JE0FKJ
Nikkaji Web: J10.057I
Beilstein Number: 1209788
MDL: MFCD00004420
CoE Number: 26
XlogP3: 0.10 (est)
Molecular Weight: 146.14250000
Formula: C6 H10 O4
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
EFSA/JECFA Comments: ADI: 0-5 (JECFA, 1978a).
Category: flavoring agents and adjuvants, curing and pickling agents, flavor enhancers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
IBM Patents: Obtain
Obtain
Pubchem Patents: Search
PubMed: Search
NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1009 Adipic acid View-review
EU SANCO Adipic acid View-review
JECFA Food Flavoring: 623  adipic acid
JECFA Food Additive: Adipic Acid
GSFA Codex: Adipic acid (355)
Flavis Number: 08.026 (Old)
DG SANTE Food Flavourings: 08.026  adipic acid
DG SANTE Food Additives: adipic acid
DG SANTE Food Contact Materials: adipic acid
FEMA Number: 2011  adipic acid
FDA Mainterm: ADIPIC ACID
FDA Regulation:
FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.300 Resinous and polymeric coatings.


FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS
Subpart C--Substances for Use as Components of Coatings
Sec. 175.320 Resinous and polymeric coatings for polyolefin films.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.170 Components of paper and paperboard in contact with aqueous and fatty foods.


FDA PART 176 -- INDIRECT FOOD ADDITIVES: PAPER AND PAPERBOARD COMPONENTS
Subpart B--Substances for Use Only as Components of Paper and Paperboard
Sec. 176.180 Components of paper and paperboard in contact with dry food.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1200 Cellophane.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1390 Laminate structures for use at temperatures of 250 deg. F and above.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1500 Nylon resins.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1630 Polyethylene phthalate polymers.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart B--Substances for Use as Basic Components of Single and Repeated Use Food Contact
Sec. 177.1680 Polyurethane resins.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2420 Polyester resins, cross-linked.


FDA PART 177 -- INDIRECT FOOD ADDITIVES: POLYMERS
Subpart C--Substances for Use Only as Components of Articles Intended for Repeated Use
Sec. 177.2600 Rubber articles intended for repeated use.


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1009 Adipic acid.
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Physical Properties:
Appearance: white powder crystals (est)
Assay: 99.00 to 100.00 % 
Food Chemicals Codex Listed: Yes
Melting Point: 152.00 to  154.00 °C. @ 760.00 mm Hg
Boiling Point: 265.00 °C. @ 100.00 mm Hg
Boiling Point: 216.00 °C. @ 15.00 mm Hg
Vapor Pressure: 1.000000 mm/Hg @ 159.00 °C.
Vapor Density: 5.0 ( Air = 1 )
Flash Point: 385.00 °F. TCC ( 196.11 °C. )
logP (o/w): 0.080
Soluble in:
 alcohol
 water, hot water
 water, slightly soluble in cold water
 water, 30800 mg/L @ 34C (exp)
Insoluble in:
 paraffin oil
Similar Items: note
butane dicarboxylic anhydride
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Organoleptic Properties:
Odor Strength: none
Odor Description:
at 100.00 %. 
odorless
  
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: buffering agents
masking agents
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Suppliers:
Allan Chemical
Adipic Acid
Anhui Haibei
Hexanedioic Acid
BioAmber
Adipic Acid
Odor: characteristic
Use: BioAmber is leveraging its flexible succinic acid platform to expand its product base to C6 building block chemicals. BioAmber has begun development of bio-adipic acid and also plans to produce bio-based caprolactam and bio-based hexamethylene diamine (HMDA) from renewable feedstocks.
Charkit Chemical
ADIPIC ACID
Covalent Chemical
Adipic Acid
EMD Millipore
For experimental / research use only.
Adipic Acid
Graham Chemical
Adipic Acid
Kraft Chemical
Adipic Acid
Penta International
ADIPIC ACID FCC, Kosher
Penta International
ADIPIC ACID USP EP GRADE
Penta International
ADIPIC ACID USP GRADE, Kosher
Rainbow Chemical
Adipic Acid 99.70
Santa Cruz Biotechnology
For experimental / research use only.
Adipic Acid
Sigma-Aldrich
Adipic acid, ≥99.5%
Certified Food Grade Products
Silver Fern Chemical
Adipic Acid
Odor: odorless
Use: Adipic Acid is primarily produced for use as a precursor for the production of nylon. Other major applications also involve polymers. Small but significant amounts of Adipic Acid are used as a food ingredient as a flavorant and gelling aid.
Solvay - Rhodia
RHODIACID™ ADIPIC ACID
Odor: characteristic
Use: High purity Adipic Acid used for the production of nylon 66 and for a wide range of applications : resins, adhesives, coatings, plastics, paper, plasticizers, detergency.
SysKem Chemie
Adipic Acid
TCI AMERICA
For experimental / research use only.
Adipic Acid >99.0%(GC)(T)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36 - Irritating to eyes.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Serious eye damage (Category 1), H318
Acute aquatic toxicity (Category 3), H402
GHS Label elements, including precautionary statements
 
Pictogramcorrosion.jpg
 
Signal word Danger
Hazard statement(s)
H318 - Causes serious eye damage
H402 - Harmful to aquatic life
Precautionary statement(s)
P273 - Avoid release to the environment.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310 - Immediately call a POISON CENTER or doctor/physician.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Oral/Parenteral Toxicity:
oral-rat LD50  > 11000 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(9), Pg. 72, 1983.

oral-mouse LD50  [sex: M] 1900 mg/kg
Dosed as a 6% suspension in 0.5% methyl cellulose.
(Horn et al., 1957)

intraperitoneal-rat LD50  275 mg/kg
GASTROINTESTINAL: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: HEMORRHAGE
Journal of Agricultural and Food Chemistry. Vol. 5, Pg. 759, 1957.

oral-rabbit LD50  > 11000 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(9), Pg. 72, 1983.

intravenous-mouse LD50  680 mg/kg
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BLOOD: HEMORRHAGE
Journal of Agricultural and Food Chemistry. Vol. 5, Pg. 759, 1957.

oral-mouse LD50  1900 mg/kg
GASTROINTESTINAL: OTHER CHANGES
Journal of Agricultural and Food Chemistry. Vol. 5, Pg. 759, 1957.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavoring agents and adjuvants, curing and pickling agents, flavor enhancers
Recommendation for adipic acid usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 11.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): -40.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: -5000.00000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 64 (FGE.64): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab)
View page or View pdf
Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1]
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf
Review of substances/agents that have direct beneficial effect on the environment: mode of action and assessment of efficacy
View page or View pdf
EPI System: View
NIOSH International Chemical Safety Cards: search
NLM Hazardous Substances Data Bank: Search
Chemical Carcinogenesis Research Information System: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
Env. Mutagen Info. Center: Search
NLM Developmental and Reproductive Toxicity: Search
EPA Substance Registry Services (TSCA): 124-04-9
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 196
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 3077
WGK Germany: 1
 hexanedioic acid
Chemidplus: 0000124049
EPA/NOAA CAMEO: hazardous materials
RTECS: 124-04-9
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References:
 hexanedioic acid
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 124-04-9
Pubchem (cid): 196
Pubchem (sid): 134974898
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
Metabolomics Database: Search
UM BBD: Search
KEGG (GenomeNet): C06104
HMDB (The Human Metabolome Database): HMDB00448
FooDB: FDB008309
Export Tariff Code: 2917.12.1000
FDA Listing of Food Additive Status: View
Haz-Map: View
Household Products: Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
RSC Learn Chemistry: View
Read: Under the conditions of intended use - New developments in the FEMA GRAS program and the safety assessment of flavor ingredients
Read: A GRAS assessment program for flavor ingredients
Read: Sensory testing for flavorings with modifying properties. Food Technology
Read: Criteria for the safety evaluation of flavoring substances
Read: A procedure for the safety evaluation of natural flavor complexes used as ingredients in food: essential oils
Read: FEMA Expert Panel: 30 Years of safety evaluation for the flavor industry
Read: Consumption ratio and food predominance of flavoring materials
FAO: ADIPIC ACID
FAO: Adipic acid
Formulations/Preparations:
grades: technical; fcc grades of purity: commercial, 99.8% food grades
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
 buffering agents 
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Occurrence (nature, food, other): note
 beet juice
Search Trop  Picture
 beet root
Search Trop  Picture
 guava fruit
Search Trop  Picture
 pork fat
Search  Picture
 raspberry red raspberry
Search Trop  Picture
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Synonyms:
 acide adipique
 acifloctin
 acinetten
 adi-pure
 adilactetten
 adipic acid FCC
 adipicacid
 adipinic acid
 asapic
1,4-butane dicarboxylic acid
 butane-1,4-dicarboxylic acid
1,4-butanedicarboxylic acid
 hexane dioic acid
1,6-hexane dioic acid
 hexanedioic acid
 hexanedioicacid
 inipol DS
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