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 Category:antioxidants, hair conditioning, humectants 
  
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information: 
  
Physical Properties: 
| Food Chemicals Codex Listed:  | No |  
 
  
Organoleptic Properties: 
| Odor and/or flavor descriptions from others (if found). |  
 
  
Cosmetic Information: 
  
Suppliers: 
  
Safety Information: 
|   |  
| Hazards identification |  
|   |  
|  Classification of the substance or mixture |  
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |  
| None found. |  
|  GHS Label elements, including precautionary statements |  
|   |  
| Pictogram |  |  
|   |  
                                                                     
| Hazard statement(s) |  
| None found. |  
| Precautionary statement(s) |  
| None found. |  
| Oral/Parenteral Toxicity:  |  
| 
Not determined
 |  
| Dermal Toxicity:  |  
| 
Not determined
 |  
| Inhalation Toxicity:  |  
| 
Not determined
 |  
 
  
Safety in Use Information: 
| Category:  |  | antioxidants, hair conditioning, humectants |  
| Recommendation for pelargonium sidoides callus usage levels up to:  |  |   | not for fragrance use.
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|   |  
| Recommendation for pelargonium sidoides callus flavor usage levels up to:  |  
|   | not for flavor use.
 |  
 
  
Safety References: 
  
References: 
  
Other Information: 
  
Potential Blenders and core components  note 
  
Potential Uses: 
  
Occurrence (nature, food, other): note 
  
Synonyms: 
|   | callus of pelargonium sidoides grown in culture |  | south african  | geranium callus |  |   | umckaloabo callus |  
 
  
Articles:
| PubMed:Herbal Medicine for Cough: a Systematic Review and Meta-Analysis. |  
| PubMed:Anti-proliferative properties of commercial Pelargonium sidoides tincture, with cell-cycle G0/G1 arrest and apoptosis in Jurkat leukaemia cells. |  
| PubMed:Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study. |  
| PubMed:A review of commercially important African medicinal plants. |  
| PubMed:The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes. |  
| PubMed:Reproduction of the Medicinal Plant Pelargonium sidoides via Somatic Embryogenesis. |  
| PubMed:Evaluation of pharmacodynamic activities of EPs® 7630, a special extract from roots of Pelargonium sidoides, in animals models of cough, secretolytic activity and acute bronchitis. |  
| PubMed:[Herbal medicines against respiratory diseases--traditional empiricism or pharmacological evidence?]. |  
| PubMed:The root extract of the medicinal plant Pelargonium sidoides is a potent HIV-1 attachment inhibitor. |  
| PubMed:Medicinal properties and conservation of Pelargonium sidoides DC. |  
| PubMed:EPs7630(®) from Pelargonium sidoides increases stress resistance in Caenorhabditis elegans probably via the DAF-16/FOXO pathway. |  
| PubMed:Pelargonium sidoides extract for treating acute respiratory tract infections. |  
| PubMed:Positioning of the Bronchitis Severity Score (BSS) for standardised use in clinical studies. |  
| PubMed:Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts. |  
| PubMed:Conservation strategy for Pelargonium sidoides DC: phenolic profile and pharmacological activity of acclimatized plants derived from tissue culture. |  
| PubMed:Herbal hepatotoxicity: suspected cases assessed for alternative causes. |  
| PubMed:Herbal medicine, randomised controlled trials and global core competencies. |  
| PubMed:Randomised, double-blind, placebo-controlled trial of EPs 7630 in adults with COPD. |  
| PubMed:Adverse effects of herbal medicines: an overview of systematic reviews. |  
| PubMed:Can the Pelargonium sidoides root extract EPs® 7630 prevent asthma attacks during viral infections of the upper respiratory tract in children? |  
| PubMed:Treatment of the common cold in children and adults. |  
| PubMed:African Geranium (EPs 7630), part 2: the efficacy of Pelargonium sidoides (EPs 7630) in the treatment of acute bronchitis in adults and children. |  
| PubMed:Adverse drug reactions for CAM and conventional drugs detected in a network of physicians certified to prescribe CAM drugs. |  
| PubMed:The efficacy of Pelargonium sidoides in the treatment of upper respiratory tract infections in children with transient hypogammaglobulinemia of infancy. |  
| PubMed:Spontaneous reports of primarily suspected herbal hepatotoxicity by Pelargonium sidoides: Was causality adequately ascertained? |  
| PubMed: Initially purported hepatotoxicity by Pelargonium sidoides: the dilemma of pharmacovigilance and proposals for improvement. |  
| PubMed:Synergistic Antimycobacterial Actions of Knowltonia vesicatoria (L.f) Sims. |  
| PubMed:EPs® 7630 (Umckaloabo®), an extract from Pelargonium sidoides roots, exerts anti-influenza virus activity in vitro and in vivo. |  
| PubMed:Spontaneous reports of primarily suspected herbal hepatotoxicity by Pelargonium sidoides: was causality adequately ascertained? |  
| PubMed:Treatment of acute bronchitis with EPs 7630: randomized, controlled trial in children and adolescents. |  
| PubMed:African geranium (EPs 7630), part I: a proprietary root extract of Pelargonium sidoides (EPs 7630) is found to be effective in resolving symptoms associated with the common cold in adults. |  
| PubMed:[Pelargonium sidoides - oral (Kaloban).]. |  
| PubMed:[Pelargonium sidoides in acute bronchitis - Health-related quality of life and patient-reported outcome in adults receiving EPs 7630 treatment]. |  
| PubMed:Anti-infective activities of Pelargonium sidoides (EPS® 7630): effects of induced NO production on Leishmania major in infected macrophages and antiviral effects as assessed in a fibroblast-virus protection assay. |  
| PubMed:Investigation of the influence of EPs® 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses. |  
| PubMed:Anti-adhesive activities of flavan-3-ols and proanthocyanidins in the interaction of group A-streptococci and human epithelial cells. |  
| PubMed:Evaluation of an aqueous-ethanolic extract from Pelargonium sidoides (EPs® 7630) for its activity against group A-streptococci adhesion to human HEp-2 epithelial cells. |  
| PubMed:Immune responses induced by Pelargonium sidoides extract in serum and nasal mucosa of athletes after exhaustive exercise: modulation of secretory IgA, IL-6 and IL-15. |  
| PubMed:An evidence-based systematic review of umckaloabo (Pelargonium sidoides) by the Natural Standard Research Collaboration. |  
| PubMed:Genetic alterations for increased coumarin production lead to metabolic changes in the medicinally important Pelargonium sidoides DC (Geraniaceae). |  
| PubMed:Determination of umckalin in commercial tincture and phytopreparations containing Pelargonium sidoides by HPLC: comparison of sample preparation procedures. |  
| PubMed:Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides. |  
| PubMed:Efficacy and tolerability of EPs 7630 in children and adolescents with acute bronchitis - a randomized, double-blind, placebo-controlled multicenter trial with a herbal drug preparation from Pelargonium sidoides roots. |  
| PubMed:Efficacy and tolerability of EPs 7630 in patients (aged 6-18 years old) with acute bronchitis. |  
| PubMed:Benzopyranones and their sulfate esters from Pelargonium sidoides. |  
| PubMed:Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPs 7630: a randomized, double-blind, placebo-controlled trial. |  
| PubMed:Components derived from Pelargonium stimulate macrophage killing of Mycobacterium species. |  
| PubMed:A historical, scientific and commercial perspective on the medicinal use of Pelargonium sidoides (Geraniaceae). |  
| PubMed:Efficacy of an aqueous Pelargonium sidoides extract against herpesvirus. |  
| PubMed:Pelargonium sidoides extract for acute respiratory tract infections. |  
| PubMed:Anti-infective mode of action of EPs 7630 at the molecular level. |  
| PubMed:A broad review of commercially important southern African medicinal plants. |  
| PubMed:EPs 7630 improves acute bronchitic symptoms and shortens time to remission. Results of a randomised, double-blind, placebo-controlled, multicentre trial. |  
| PubMed:A detailed view on the constituents of EPs 7630. |  
| PubMed:Extract of Pelargonium sidoides (EPs 7630) displays anti-infective properties by enhanced phagocytosis and differential modulation of host-bacteria interactions. |  
| PubMed:Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. |  
| PubMed:Aqueous ethanolic extract of the roots of Pelargonium sidoides--new scientific evidence for an old anti-infective phytopharmaceutical. |  
| PubMed:Efficacy of a pelargonium sidoides preparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trial. |  
| PubMed:[Pelargonium sidoides-extract (EPs 7630): registration confirms efficacy and safety]. |  
| PubMed:Allergic reactions to medicines derived from Pelargonium species. |  
| PubMed:Large molecules as anti-adhesive compounds against pathogens. |  
| PubMed:An extract of Pelargonium sidoides (EPs 7630) inhibits in situ adhesion of Helicobacter pylori to human stomach. |  
| PubMed:Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs 7630): a randomised, double-blind, placebo-controlled, multicentre study. |  
| PubMed:Liquid herbal drug preparation from the root of Pelargonium sidoides is effective against acute bronchitis: results of a double-blind study with 124 patients. |  
| PubMed:Mass spectroscopic characterisation of oligomeric proanthocyanidins derived from an extract of Pelargonium sidoides roots (EPs 7630) and pharmacological screening in CNS models. |  
| PubMed:In vitro evaluation of antibacterial and immunomodulatory activities of Pelargonium reniforme, Pelargonium sidoides and the related herbal drug preparation EPs 7630. |  
| PubMed:Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin. |  
| PubMed:EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells. |  
| PubMed:Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo. |  
| PubMed:EPs 7630-solution--an effective therapeutic option in acute and exacerbating bronchitis. |  
| PubMed:Extract of Pelargonium sidoides (EPs 7630) improves phagocytosis, oxidative burst, and intracellular killing of human peripheral blood phagocytes in vitro. |  
| PubMed:Pelargonium sidoides preparation (EPs 7630) in the treatment of acute bronchitis in adults and children. |  
| PubMed:Inhibition of lipopolysaccharid-induced sickness behavior by a dry extract from the roots of Pelargonium sidoides (EPs 7630) in mice. |  
| PubMed:Extract of Pelargonium sidoides (EPs 7630) inhibits the interactions of group A-streptococci and host epithelia in vitro. |  
| PubMed:Nitric oxide synthase and cytokines gene expression analyses in Leishmania-infected RAW 264.7 cells treated with an extract of Pelargonium sidoides (Eps 7630). |  
| PubMed:Treatment of acute bronchitis in adults with a pelargonium sidoides preparation (EPs 7630): a randomized, double-blind, placebo-controlled trial. |  
| PubMed:Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells. |  
| PubMed:A new approach to pharmacological effects on ciliary beat frequency in cell cultures--exemplary measurements under Pelargonium sidoides extract (EPs 7630). |  
| PubMed:Efficacy of extract of Pelargonium sidoides in children with acute non-group A beta-hemolytic streptococcus tonsillopharyngitis: a randomized, double-blind, placebo-controlled trial. |  
| PubMed:Pharmacological profile of extracts of Pelargonium sidoides and their constituents. |  
| PubMed:Efficacy and safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A randomised, double-blind, placebo-controlled trial. |  
| PubMed:Immunomodulatory principles of Pelargonium sidoides. |  
| PubMed:Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. |  
 
  
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